KEGG   REACTION: R02347
Entry
R02347                      Reaction                               

Name
Estradiol-17alpha:NAD+ 17-oxidoreductase
Definition
Estradiol-17alpha + NAD+ <=> Estrone + NADH + H+
Equation
Comment
NADP+ (see R02349)
Reaction class
RC00001  C00003_C00004
RC00127  C00468_C02537
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
Other DBs
RHEA: 16704

KEGG   REACTION: R02349
Entry
R02349                      Reaction                               

Name
Estradiol-17alpha:NADP+ 16-oxidoreductase
Definition
Estradiol-17alpha + NADP+ <=> Estrone + NADPH + H+
Equation
Comment
NAD+ (see R02347)
Reaction class
RC00001  C00005_C00006
RC00127  C00468_C02537
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
Other DBs
RHEA: 16708

KEGG   RCLASS: RC00127
Entry
RC00127                     RClass                                 

Definition
C1y-C5x:*-*:C1x+C1z+O1a-C1x+C1z+O5x
Reactant pair
Related class
Reaction
Enzyme
1.1.1.51        1.1.1.62        1.1.1.64        1.1.1.148       
1.1.1.176       1.1.1.198       1.1.1.227       1.1.1.230       
1.1.1.238       1.1.1.239       1.1.1.241       1.1.1.295       
1.1.1.297       1.14.14.71
Pathway
rn00140  Steroid hormone biosynthesis
rn00902  Monoterpenoid biosynthesis
rn00903  Limonene and pinene degradation
rn00904  Diterpenoid biosynthesis
rn00984  Steroid degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K00044  17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
K05296  3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51]
K10207  testosterone 17beta-dehydrogenase (NADP+) [EC:1.1.1.64]
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
K13070  momilactone-A synthase [EC:1.1.1.295]
K13368  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.239]
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
K13370  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) / 3-oxoacyl-[acyl-carrier protein] reductase alpha subunit [EC:1.1.1.62 1.1.1.239]
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]

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