KEGG   REACTION: R02893
Entry
R02893                      Reaction                               
Name
17alpha,21-dihydroxy-5beta-pregnane-3,11,20-trione:NADP+ delta4-oxidoreductase
Definition
17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ <=> Cortisone + NADPH + H+
Equation
C05469 + C00006 <=> C00762 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00145  C00762_C05469
Enzyme
1.3.1.3
Pathway
rn00140  Steroid hormone biosynthesis
Orthology
K00251  3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]
Other DBs
RHEA: 14040

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
Gene (369)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (368)   
All databases (381)   

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KEGG   RCLASS: RC00145
Entry
RC00145                     RClass                                 
Definition
C1x-C2x:*-*:C1y+C5x-C2y+C5x
C1y-C2y:*-*:C1x+C1x+C1z-C1x+C2x+C1z
Reactant pair
C00280_C00674    C00280_C03772    C00410_C03681
C00410_C05479    C00535_C03917    C00535_C05293
C00599_C03091    C00599_C03238    C00619_C02797
C00619_C02940    C00735_C05471    C00762_C03588
C00762_C05469    C01780_C05473    C02140_C05475
C03205_C18040    C05451_C05455    C05453_C17339
C05458_C17339    C05477_C05490    C15785_C15786
C15796_C15797    C15800_C16253    C21469_C21910
C21471_C21909    C21905_C21906    C21907_C21908
C21911_C21912
Related class
Reaction
R01834 R01835 R02208 R02215 R02219 R02497 R02498 R02609
R02610 R02642 R02643 R02841 R02892 R02893 R03713 R03850
R04817 R04823 R04827 R07429 R07447 R07790 R08954 R08994
R10242 R12105 R12107 R12109 R12110 R12111
Enzyme
1.3.1.3         1.3.1.22        1.3.1.114       1.3.1.115       
1.3.1.116       1.3.99.5        1.3.99.6
Pathway
rn00120  Primary bile acid biosynthesis
rn00140  Steroid hormone biosynthesis
rn00905  Brassinosteroid biosynthesis
rn00984  Steroid degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K00251  3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]
K09591  steroid 5-alpha-reductase [EC:1.3.1.22]
K12343  3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]
K12344  3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:1.3.1.22]
K12345  3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:1.3.1.22 1.3.1.94]
K16051  3-oxo-5alpha-steroid 4-dehydrogenase [EC:1.3.99.5]

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Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (39)   
   KEGG ENZYME (7)   
   KEGG REACTION (30)   
   UMBBD-BT (2)   
Gene (6)   
   KEGG ORTHOLOGY (6)   
All databases (52)   

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