KEGG   REACTION: R05521
Entry
R05521                      Reaction                               
Name
erythromycin-B,NADPH:oxygen oxidoreductase (12-hydroxylating)
Definition
Erythromycin B + NADPH + H+ + Oxygen <=> Erythromycin + NADP+ + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC01892  C01912_C06653
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01110  Biosynthesis of secondary metabolites
Orthology
K14370  erythromycin 12 hydroxylase [EC:1.14.13.154]
Reference
1  [PMID:19625248]
  Authors
Savino C, Montemiglio LC, Sciara G, Miele AE, Kendrew SG, Jemth P, Gianni S, Vallone B
  Title
Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.
  Journal
J Biol Chem 284:29170-9 (2009)
DOI:10.1074/jbc.M109.003590
Reference
2  [PMID:8416893]
  Authors
Stassi D, Donadio S, Staver MJ, Katz L
  Title
Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis.
  Journal
J Bacteriol 175:182-9 (1993)
DOI:10.1128/JB.175.1.182-189.1993

KEGG   RCLASS: RC01892
Entry
RC01892                     RClass                                 
Definition
C1y-C1z:*-O1a:C1a+C1y+C1y-C1a+C1y+C1y
Reactant pair
Related class
Reaction
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K14370  erythromycin 12 hydroxylase [EC:1.14.13.154]

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