KEGG   REACTION: R05522
Entry
R05522                      Reaction                               
Name
erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating)
Definition
Erythromycin D + NADPH + H+ + Oxygen <=> Erythromycin C + NADP+ + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC01892  C06616_C06633
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Orthology
K14370  erythromycin 12 hydroxylase [EC:1.14.13.154]
Reference
1  [PMID:19625248]
  Authors
Savino C, Montemiglio LC, Sciara G, Miele AE, Kendrew SG, Jemth P, Gianni S, Vallone B
  Title
Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.
  Journal
J Biol Chem 284:29170-9 (2009)
DOI:10.1074/jbc.M109.003590
Reference
2  [PMID:8416893]
  Authors
Stassi D, Donadio S, Staver MJ, Katz L
  Title
Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis.
  Journal
J Bacteriol 175:182-9 (1993)
DOI:10.1128/JB.175.1.182-189.1993
Reference
3  [PMID:7849045]
  Authors
Lambalot RH, Cane DE, Aparicio JJ, Katz L
  Title
Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK.
  Journal
Biochemistry 34:1858-66 (1995)
DOI:10.1021/bi00006a006
Other DBs
RHEA: 32634

KEGG   RCLASS: RC01892
Entry
RC01892                     RClass                                 
Definition
C1y-C1z:*-O1a:C1a+C1y+C1y-C1a+C1y+C1y
Reactant pair
Related class
Reaction
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K14370  erythromycin 12 hydroxylase [EC:1.14.13.154]

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