KEGG   REACTION: R06223
Entry
R06223                      Reaction                               

Name
squalene synthase
Definition
2 trans,trans-Farnesyl diphosphate + NADPH + H+ <=> Squalene + 2 Diphosphate + NADP+
Equation
Comment
two-step reaction (see R00702+R02872)
Reaction class
RC00001  C00005_C00006
RC02839  C00448_C00751
Enzyme
Pathway
rn01100  Metabolic pathways
Orthology
K00801  farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]
Other DBs
RHEA: 32298

KEGG   REACTION: R00702
Entry
R00702                      Reaction                               

Name
farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase
Definition
2 trans,trans-Farnesyl diphosphate <=> Diphosphate + Presqualene diphosphate
Equation
Comment
first step of two-step reaction (R06223, R00702+R02872)
first step of two-step reaction (R07652, R00702+R09793)
Reaction class
RC00362  C00448_C03428
Enzyme
2.5.1.21        2.5.1.96        2.5.1.103
Pathway
rn00100  Steroid biosynthesis
rn00906  Carotenoid biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00801  farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]
K10208  4,4'-diapophytoene synthase [EC:2.5.1.96]
Other DBs
RHEA: 22675

KEGG   REACTION: R02872
Entry
R02872                      Reaction                               

Name
presqualene-diphosphate diphosphate-lyase (reducing, squalene-forming)
Definition
Presqualene diphosphate + NADPH + H+ <=> Diphosphate + Squalene + NADP+
Equation
Comment
second step of two-step reaction (R06223, R00702+R02872)
following after R00702
Reaction class
RC00001  C00005_C00006
RC00796  C00751_C03428
Enzyme
1.3.1.96        2.5.1.21
Pathway
rn00100  Steroid biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00801  farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]
Other DBs
RHEA: 22235

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