KEGG   REACTION: R08518
Entry
R08518                      Reaction                               
Name
17alpha-hydroxyprogesterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
Definition
17alpha-Hydroxyprogesterone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Androstenedione + Acetate + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C01176 + C03024 + C00007 <=> C00280 + C00033 + C03161 + C00001
Comment
17alpha-hydroxylase/17,20-lyase
Reaction class
RC00607  C00280_C01176
RC00923  C00033_C01176
Enzyme
1.14.14.32
Pathway
rn00140  Steroid hormone biosynthesis
Orthology
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Reference
1  [PMID:6971291]
  Authors
Nakajin S, Hall PF.
  Title
Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase).
  Journal
J Biol Chem 256:3871-6 (1981)
Reference
2  [PMID:12693981]
  Authors
Gilep AA, Estabrook RW, Usanov SA
  Title
Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species.
  Journal
Biochemistry (Mosc) 68:86-98 (2003)
DOI:10.1023/a:1022101703670

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (514)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (513)   
All databases (527)   

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