KEGG   REACTION: R09191
Entry
R09191                      Reaction                               
Name
S-adenosyl-L-methionine:4-amino-anhydrotetracycline N-methyltransferase
Definition
4-Amino-anhydrotetracycline + 2 S-Adenosyl-L-methionine <=> Anhydrotetracycline + 2 S-Adenosyl-L-homocysteine
Equation
C06654 + 2 C00019 <=> C02811 + 2 C00021
Reaction class
RC00003  C00019_C00021
RC01515  C02811_C06654
Enzyme
Pathway
rn00253  Tetracycline biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Orthology
K14255  4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335]
Reference
1  [PMID:20522541]
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
2  [PMID:18422316]
  Authors
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J
  Title
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.
  Journal
J Am Chem Soc 130:6068-9 (2008)
DOI:10.1021/ja800951e

KEGG   RCLASS: RC01515
Entry
RC01515                     RClass                                 
Definition
N1a-N1c:*+*-C1a+C1a:C1y-C1y
Reactant pair
Related class
Reaction
Enzyme
2.1.1.234       2.1.1.235       2.1.1.236       2.1.1.324       
2.1.1.335       2.1.1.-
Pathway
rn00253  Tetracycline biosynthesis
rn00523  Polyketide sugar unit biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
RModule
RM035  Transamination and N,N-dimethylation in polyketide biosynthesis
Orthology
K13307  dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.235]
K13311  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.234]
K13326  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.- 2.1.1.234]
K13330  dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase [EC:2.1.1.324]
K13332  N,N-dimethyltransferase
K14255  4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335]
K20682  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase [EC:2.1.1.236]
K21327  N-methyltransferase [EC:2.1.1.-]

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