KEGG   REACTION: R10052
Entry
R10052                      Reaction                               
Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
Equation
C04411 + C00003 <=> C00233 + C00011 + C00004 + C00080
Comment
two-step reaction (see R04426+R01652)
Reaction class
RC00001  C00003_C00004
RC03036  C00233_C04411
Enzyme
1.1.1.85
Pathway
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Orthology
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Other DBs
RHEA: 32274

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (7463)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (7461)   
All databases (7477)   

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KEGG   REACTION: R04426
Entry
R04426                      Reaction                               
Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
Equation
C04411 + C00003 <=> C04236 + C00004 + C00080
Comment
subsequently R01652
Reaction class
RC00001  C00003_C00004
RC00084  C04236_C04411
Enzyme
1.1.1.85
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Orthology
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Other DBs
RHEA: 10895

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (7463)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (7461)   
All databases (7481)   

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KEGG   REACTION: R01652
Entry
R01652                      Reaction                               
Definition
4-Methyl-2-oxopentanoate + CO2 <=> (2S)-2-Isopropyl-3-oxosuccinate
Equation
C00233 + C00011 <=> C04236
Comment
spontaneous (following EC 1.1.1.85 or R04426 reaction)
Reaction class
RC00577  C00233_C04236
Enzyme
1.1.1.85
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Other DBs
RHEA: 25081

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
All databases (15)   

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