KEGG   REACTION: R11478
Entry
R11478                      Reaction                               

Name
tetracycline:FADH2 oxidoreductase (7-halogenating)
Definition
Tetracycline + FADH2 + Cl- + Oxygen + H+ <=> Chlortetracycline + FAD + 2 H2O
Equation
Reaction class
RC00949  C06570_C06571
Enzyme
Pathway
rn00253  Tetracycline biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Orthology
K14257  tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]
Other DBs
RHEA: 50715

KEGG   RCLASS: RC00949
Entry
RC00949                     RClass                                 

Definition
C8x-C8y:*-X:C8x+C8y-C8x+C8y
Reactant pair
Related class
Reaction
Enzyme
1.11.1.8        1.14.14.-       1.14.19.9       1.14.19.49      
1.14.19.55      1.14.19.56      1.14.19.57      1.14.19.60      
1.14.19.-       1.21.1.1        1.21.1.2        1.21.99.3       
1.21.99.4       1.97.1.-        2.5.1.-
Pathway
rn00253  Tetracycline biosynthesis
rn00350  Tyrosine metabolism
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00363  Bisphenol degradation
rn00364  Fluorobenzoate degradation
rn00404  Staurosporine biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K00431  thyroid peroxidase [EC:1.11.1.8]
K14257  tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]
K14266  tryptophan 7-halogenase [EC:1.14.19.9]
K15239  2,5-dichlorohydroquinone reductive dechlorinase [EC:2.5.1.-]
K16431  FAD-dependent halogenase [EC:1.14.19.-]
K21185  flavin reductase

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