KEGG   REACTION: R12660
Entry
R12660                      Reaction                               
Definition
3 Malonyl-CoA + 5 Methylmalonyl-CoA + 7 NADPH + 7 H+ <=> Protomycinolide IV + 8 CoA + 8 CO2 + 4 H2O + 7 NADP+
Equation
3 C00083 + 5 C02557 + 7 C00005 + 7 C00080 <=> C15685 + 8 C00010 + 8 C00011 + 4 C00001 + 7 C00006
Comment
protomycinolide IV synthase,MycAI-AV
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Orthology
K24528  protomycinolide IV synthase 1
K24559  protomycinolide IV synthase 2
K24560  protomycinolide IV synthase 3
K24561  protomycinolide IV synthase 4
K24562  protomycinolide IV synthase 5
Reference
1  [PMID:15358416]
  Authors
Anzai Y, Ishii Y, Yoda Y, Kinoshita K, Kato F.
  Title
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study.
  Journal
FEMS Microbiol Lett 238:315-20 (2004)
DOI:10.1016/j.femsle.2004.07.050
Reference
2  [PMID:12583909]
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x

DBGET integrated database retrieval system