KEGG   Acanthamoeba castellanii: ACA1_065770
Entry
ACA1_065770       CDS       T02667                                 
Name
(RefSeq) phosphatidylinositol 3kinase
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
acan  Acanthamoeba castellanii
Pathway
acan00562  Inositol phosphate metabolism
acan01100  Metabolic pathways
acan04070  Phosphatidylinositol signaling system
acan04081  Hormone signaling
acan04145  Phagocytosis
acan04517  IgSF CAM signaling
acan04518  Integrin signaling
acan04620  Toll-like receptor signaling pathway
acan05100  Bacterial invasion of epithelial cells
Brite
KEGG Orthology (KO) [BR:acan00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    ACA1_065770
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    ACA1_065770
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    ACA1_065770
   04517 IgSF CAM signaling
    ACA1_065770
   04518 Integrin signaling
    ACA1_065770
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    ACA1_065770
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    ACA1_065770
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    ACA1_065770
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:acan04131]
    ACA1_065770
Enzymes [BR:acan01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     ACA1_065770
Membrane trafficking [BR:acan04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    ACA1_065770
SSDB
Motif
Pfam: PI3_PI4_kinase PH PI3Ka PI3K_C2 PI3K_rbd PH_11 PH_8
Other DBs
NCBI-GeneID: 14917986
NCBI-ProteinID: XP_004339770
UniProt: L8GXT7
Position
Unknown
AA seq 1982 aa
MNFLRGNRSDTSQFCKLRVILLLPKSHDEDGESAPHHGGLPAWPPSSSPSPPSSASPSPP
SPSSSTGLLQRHDFGAAGLNSKGTYDCEFPPKLSVEQIKANLFSTIPALFPLSRNDFYLA
LAKEMVLYEEEKRLVASHEVVAEKFFNKERITVFLLPKDECPPPPQTDNSALPEEKEMER
LAKEIERDESVWSTREIIVRAPSNLPCVPTHGISVDVWEQGESGLSPATPSPTTGSRSIF
QRKKPLAMSVDEQRSAGTAAAMAASKALRGEIAEKPEKVRRGSVFSRRRRNKELNDQKNS
ERLAGEYAGRFMSSSRSYDDLSRPREYSLDSGDTGSREASLDADDLAYGKQGADVFMSGY
LVKQGGNRKNWKKRFCVLTADSIRYYGKKKDPTPIAAIPLDEIMAIARAFSLIRLFWTLA
RKTHSCLTTQTRRRTYYMCAPNEEDLLAWMHATKLQLIERRKVMQEEEETGAGIEGWLTV
WVVVSPGNEANLGRGFSLRGRWKRYWCFISNSDHCLYYVKDPSTKDKREGNFPLQGVTVE
FSQQRRFCFSLKSQQKVLLLSADSEREMEEWMNAISQQPVDWEGRKTVQLQVLMPQGIVQ
KLDRLTLVQTANVLDVLSRIPPEEPEVLFFRKMMLITQREARQFDSLMINHFLPARLVPA
ALAASASDSASSPSPFSIPSPSSSSSSSSSSSSSSFLPATPSSPRGVAVGGGFSFAAPAS
TGSVAVPSPATGGTAHSDLMSSGFLTRTNSLPNLQYSSHHRSGGGGLGGQPSGSDLIATA
ATGLPSSSSSSLSTAHTAVAMSTSLSSVRTISGGGRKLNLYFHFFDVDSRQPAAPTPSER
GGGSSGGASGDDDAAAGSESTELTTPPVRRNGDVSAGFGYRRFNTEMLVSRQNTPLPPPP
VASRNGRAFLRTATGGSASDSDAAAASPDGADSSSSGSTQPAQKKPATSLVESLKFERPG
RRSLEVMGEEVIGDQPASPRATNPSASSSVPAIRRRPSDAAARGSNNMLSASHRNFSPHT
KLSLAINPDATIATAIAEVMSKYQRIYKKKQPSELEPESLDETKRAELGKFILQVKGRRE
YVFDSNDTTIAQLAYVANCLAHWDKIEFVIRERSALSGHIDDKIKYYKERVKQTTPRSRK
GEDSPQGTRSRRVAGRWNPATATATAGAGTVAAAPATSPPDSDAAVEVDTSDSAQDVGER
ERQESNDDDEPSVEIVEHQCYDVDGLDDVPLVLKILGVEQQQAEIFDVNPNMSVSVECGL
YYGPMQLGIYRTERMRKVNAWSDRPQVFHTHLPLSHIPKETRACFRLIAYQGKDEWAIGW
GNVALFDHAGRFLTGGFEVHMWEGDRPSLMAPCVPNFGSGVESVMRIRASSISPPSLVPI
AYTRPYTALAVSPAASVVPTSPALTDPACPSSEAFSDGFATPCAGSSPADPRSRFRADTV
AAPVDGLAPFRTSSFDEEDFIDHEMQILKQIINQDIFYELSTEEKQMMWKHRDACIREHP
RSLAKLLLSIDWLDRSAVRAFACRCLQNLSDEELAVYVPQLVQALKYDTYHHSALSQFLL
SRGLRSRLIVGQRLFWEVKVASQIERNVKPKWDPNVASSPASSGASDEREVRGSGGEAMA
LRYGLLAEAYLHGIGAQHREEIMKQVFVMEELLALSHALKKIPKNKRDAFLKYKLAQFPF
PKDGITLPLEPRMQVKGFVVDKCKALDSFTVPLRLVFDNKEDVGDPITVIYKAGDDLRQD
ALTLQLIRVMDTLWKDEGLDLRLTTYGVMATGEKEGIIEAVLNSTTVAEIAKEAGGATAV
FNPQTISNWLKQQNPDDTKYAMAVENFIYSCAGYCVACYILGIGDRHNDNIMVTKTGHMF
HIDFAHFLGNVLRFGPIVRDKAPFVLTPEMVYIMGGRESQQFQRFIRLCCRAYNVVRSHA
NVFTNLFAMLSSKNDMNYLMKALAPEMTEEEAAKTFTGLIYKSLDTKTTQLNFAVHILAH
RD
NT seq 5949 nt   +upstreamnt  +downstreamnt
atgaattttctgcgcggaaatcgatcggacacgtcccagttctgcaagctcagggtcatc
ctcctgctccccaagtcccacgacgaagatggggagagcgctcctcatcacggggggctg
ccggcctggcccccctcatcttcgccctcgcccccgtcgtctgcctcgccttccccgccc
tcgccctcctcctccacgggcctgctacagcgccacgacttcggcgccgcggggctcaac
agcaagggcacctacgactgcgagttccctcccaaactcagcgtcgagcaaatcaaggcc
aacctcttcagcacgatcccagcgctgtttccgctctcgcgaaacgatttctatctggcc
ctggccaaggaaatggtgctctacgaagaggagaagcggctggtggcgtctcacgaggtg
gttgctgagaagttcttcaacaaggaacggataacggtgttccttctgccgaaggacgag
tgtcccccgcctccgcaaacggacaacagcgccctccccgaggagaaggagatggagcga
ctcgccaaggaaatcgagcgcgacgaatccgtgtggtccacccgagagatcatcgtgcgc
gctccttccaatttgccgtgtgtgccgactcacggcatttcggtggatgtctgggaacag
ggggagagtggtctcagcccagccactccctcgccgacgaccggcagccgaagcatcttc
cagcgcaagaagccgctggcgatgagcgtggacgagcaacggagcgccggcactgcggcg
gccatggccgccagcaaggccctgcgcggcgagatcgccgagaagcccgagaaggtgcgg
cgcggcagcgtcttctcccgccgcagacgcaacaaggagctcaacgaccagaagaactcc
gagcggcttgccggagaatacgccggtcggttcatgagcagttcgcgttcctacgatgac
ctgagccgaccgcgcgagtactccctcgacagcggcgacaccggctcgcgagaggcctct
ctcgatgcggacgatttggcgtacgggaagcagggggcggacgtgttcatgtcgggctac
ctcgtcaagcagggcggcaaccgcaagaactggaagaagcgattctgcgtcctcaccgcc
gattccatccgctactacggcaagaagaaggatcccactccgatcgctgcaattccattg
gacgaaatcatggccatcgctcgcgcgttctctcttatccgcctcttctggaccctcgcc
agaaagactcattcatgcctcacaacacaaaccagacggcgcacctactacatgtgcgcg
cccaatgaagaggatctgctggcctggatgcacgccaccaaactgcagctcatcgagcgc
aggaaagtcatgcaagaggaagaggagactggagcgggcatcgagggctggctcacggtc
tgggtcgtcgtctcgcccggcaatgaggccaacctcggccgcgggttctccctgcggggc
cgatggaaacggtactggtgcttcatctccaattccgaccactgcctctactacgtcaag
gacccttccaccaaggacaagcgcgagggcaacttcccgctgcagggggtgacggtcgag
ttctcgcaacagagacggttctgtttctccctcaaatcacagcaaaaggtgctcctgctc
tcggccgacagtgagcgcgagatggaggagtggatgaacgcgatctctcagcaaccggtc
gattgggaaggccgcaagaccgtccagctgcaggtcctcatgccccaaggcatcgttcaa
aagttggatcggctcacgttggtgcagacggcgaacgttttggacgtgctctcccgcatc
ccacccgaagaacccgaagtgctcttcttccgcaaaatgatgctcatcacccagagagaa
gcgcgtcagttcgactcactgatgatcaaccatttcctccccgcgcgcctcgtgccggcc
gcgctcgctgcctccgcctccgattccgcctcttctccctcacccttctccattccttca
ccgtcttcctcctcttcttcttcgtcgtcatcttcgtcgtcttcgttcttgccggcgacg
ccctcctcgccgcgcggcgtggccgtgggcggcggcttctcctttgccgcgcccgcaagt
accggctcagtcgccgtgccgtcgcccgccaccggcgggactgcgcattcggacctcatg
tcgtccggtttcctcacccgcaccaactcgctgcccaacctgcagtacagcagccaccac
cgcagcggcggcggcggcttaggcggtcagccctcggggtcggacctcatcgccacggcg
gccacggggctgccgtcttcgtcgtcgtcaagtctgtcgacagcccataccgcggttgcg
atgtcgacatcactgtcgtcggtgcggaccatcagcggtggcggccgcaagctcaacctg
tacttccacttctttgatgtcgacagccgccagccagccgcaccgacgcccagcgagcgc
gggggcgggtctagcggaggcgcctcgggagacgatgacgctgcggccggcagcgagtcg
acagaactgacgacaccgcccgtgcggcggaacggcgacgtcagcgcaggcttcggctac
cgccggttcaacaccgagatgctggtctcgcgccagaacacgcctctgccacctccgccc
gtggcctctcgcaacggtcgcgcgttcctgcggactgccacgggcggatccgcctcggac
tcagacgccgccgccgcctcccccgacggcgcagacagcagcagcagcggcagcacccag
cctgctcagaagaagcccgcgacgagcctcgtcgagagcctcaaattcgagcgacccggg
cgtcgcagtctcgaagtcatgggtgaggaagtaatcggagaccagccggcgtcgccccga
gcgaccaacccgtcggcgtcgtcgtcagtgccagccatccggcgccgacccagcgatgcc
gcggcgcgaggcagcaacaacatgctctccgcgagccatcgcaacttctcgccacacacg
aagctgtcgcttgcaatcaatcccgatgccaccatcgccaccgcaatcgcagaggtgatg
agcaagtaccagcgcatctacaagaaaaaacagccgtccgagcttgagccggagtcgctg
gacgagaccaagcgtgctgagctgggcaaattcatcctgcaagtgaaagggcgacgcgaa
tacgtcttcgactcgaacgacaccacgatcgcgcagctggcgtacgtggccaactgtctg
gcgcactgggacaagatcgagttcgtcattcgcgagaggtccgccctcagcggccacatc
gatgacaagatcaagtactacaaggagcgggtgaagcaaacgactcctcgcagtcgcaag
ggcgaggactcgccgcagggaacgcgcagccgccgagtggccggccgctggaacccggca
acggcaacggcgaccgcaggggcaggcacagtcgctgccgcaccggccacgtccccgccc
gactcggacgcggccgtggaggtggacacaagcgactctgcgcaggacgtcggtgagagg
gaacgacaggagagcaacgacgacgacgagccctcggtggagatcgtcgagcatcagtgc
tacgatgtcgacggccttgacgacgtgccgctggtgctcaagatcctgggcgtcgaacag
cagcaggccgaaatcttcgacgtcaaccccaacatgtcggtctctgtcgagtgcggacta
tattatggccccatgcagctgggcatctaccgaacggagcgcatgcgcaaggtgaacgcc
tggtccgatcgcccgcaggtcttccacacccaccttcccctgtcgcacatccccaaggaa
acgagagcgtgcttccgcttgatcgcctaccaaggcaaggacgagtgggccatcggttgg
ggcaatgtggcgctgttcgaccatgccggcaggttcctcaccggcggcttcgaggtccac
atgtgggaaggcgaccggccttcgctgatggcgccgtgtgtgcccaacttcggatcggga
gtggagagcgtgatgcggatccgggcctcgtccatctccccgccctcgctcgtgcccatc
gcctacacgcggccctacaccgccctcgccgtctccccggccgcctccgtcgtccccacg
tcgccggcgctgaccgacccggcgtgtccgtcgtcggaggccttctccgacggctttgcc
acgccgtgcgccggctcctccccggcggacccgcggtcccgcttccgggccgacaccgtc
gcagcgcccgtcgatggcctcgcgcccttccgcacgtcgtcgttcgacgaggaggatttc
atcgaccacgagatgcaaatcctcaaacagatcatcaaccaagatatcttctacgagctc
agcacggaggagaagcagatgatgtggaagcaccgggacgcctgcatccgcgagcacccg
cggtcgctggccaagctcctgctctccatcgactggctcgaccgctccgccgtgcgcgcc
ttcgcctgccggtgcctccagaacctgtccgacgaagagctggccgtctacgtgccgcag
ctcgtccaggccctcaaatacgacacctaccaccactcggccctctctcagttcctcctc
tcccgagggctgcgttctcgattgattgtgggccagcgcctgttctgggaggtgaaggtg
gcgagccagatcgagcgcaacgtcaagcccaagtgggatcccaacgtggcctcgtcgccc
gccagcagcggagcctccgatgagcgcgaggtgcggggcagcggcggcgaagccatggcc
ctgcgctacggactcctcgccgaggcctaccttcacggtattggagcgcagcacagggag
gagatcatgaagcaggtgttcgtgatggaggagctgctggccctgtcgcacgcgctcaag
aagatccccaagaacaagcgcgacgccttcctcaagtacaagctcgcccagttccccttc
cccaaggacggcatcaccctgcccctcgagcctcgaatgcaggtgaagggcttcgttgtg
gacaagtgcaaggcgctcgattccttcaccgttccgttgcggctggtgttcgacaacaag
gaggacgtgggcgatccgatcacggtcatctacaaggccggcgacgacctgcgccaggac
gccctcaccctccaactcatccgcgtcatggacaccctgtggaaggacgaagggttggac
ctgcggctcaccacctatggtgtcatggccaccggcgagaaggagggcatcatcgaagct
gtcctcaattcgaccaccgtcgccgagatcgccaaggaggccggaggggccacggcggtg
ttcaacccgcagaccatctccaattggctcaagcaacagaaccccgacgacaccaagtac
gccatggccgtagagaatttcatctactcgtgcgccggctactgcgtcgcatgctacatt
ctcggcatcggcgatcggcacaacgacaacatcatggtgaccaagacgggccacatgttc
cacatcgactttgcacactttctaggaaacgtgctcaggtttggaccgatcgtgcgggac
aaggcgcccttcgtgttgactcccgagatggtgtacattatgggcggccgagagagccaa
cagttccaacgcttcattcggctgtgctgccgcgcctacaatgtggtccgcagccatgcc
aacgtcttcaccaacctcttcgccatgctgtcgtcaaagaacgacatgaactatctgatg
aaggcgctggcaccggagatgaccgaagaggaggccgccaagaccttcacgggtctcatc
tacaagagcctcgacaccaagaccacccaactcaattttgccgtacacatcctggcccac
cgcgactag

  All links  
Gene (79)   
   RefGene (76)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (89)   

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