KEGG   Bubalus kerabau (carabao): 129625261
Entry
129625261         CDS       T11435                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bke  Bubalus kerabau (carabao)
Pathway
bke00562  Inositol phosphate metabolism
bke01100  Metabolic pathways
bke04015  Rap1 signaling pathway
bke04020  Calcium signaling pathway
bke04022  cGMP-PKG signaling pathway
bke04062  Chemokine signaling pathway
bke04070  Phosphatidylinositol signaling system
bke04071  Sphingolipid signaling pathway
bke04072  Phospholipase D signaling pathway
bke04081  Hormone signaling
bke04082  Neuroactive ligand signaling
bke04261  Adrenergic signaling in cardiomyocytes
bke04270  Vascular smooth muscle contraction
bke04310  Wnt signaling pathway
bke04371  Apelin signaling pathway
bke04540  Gap junction
bke04611  Platelet activation
bke04613  Neutrophil extracellular trap formation
bke04621  NOD-like receptor signaling pathway
bke04713  Circadian entrainment
bke04720  Long-term potentiation
bke04723  Retrograde endocannabinoid signaling
bke04724  Glutamatergic synapse
bke04725  Cholinergic synapse
bke04726  Serotonergic synapse
bke04728  Dopaminergic synapse
bke04730  Long-term depression
bke04742  Taste transduction
bke04750  Inflammatory mediator regulation of TRP channels
bke04911  Insulin secretion
bke04912  GnRH signaling pathway
bke04915  Estrogen signaling pathway
bke04916  Melanogenesis
bke04918  Thyroid hormone synthesis
bke04919  Thyroid hormone signaling pathway
bke04921  Oxytocin signaling pathway
bke04922  Glucagon signaling pathway
bke04924  Renin secretion
bke04925  Aldosterone synthesis and secretion
bke04926  Relaxin signaling pathway
bke04927  Cortisol synthesis and secretion
bke04928  Parathyroid hormone synthesis, secretion and action
bke04929  GnRH secretion
bke04933  AGE-RAGE signaling pathway in diabetic complications
bke04934  Cushing syndrome
bke04935  Growth hormone synthesis, secretion and action
bke04961  Endocrine and other factor-regulated calcium reabsorption
bke04970  Salivary secretion
bke04971  Gastric acid secretion
bke04972  Pancreatic secretion
bke04973  Carbohydrate digestion and absorption
bke05010  Alzheimer disease
bke05016  Huntington disease
bke05017  Spinocerebellar ataxia
bke05022  Pathways of neurodegeneration - multiple diseases
bke05142  Chagas disease
bke05143  African trypanosomiasis
bke05146  Amoebiasis
bke05163  Human cytomegalovirus infection
bke05200  Pathways in cancer
bke05415  Diabetic cardiomyopathy
bke05417  Lipid and atherosclerosis
Module
bke_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bke00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129625261 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    129625261 (PLCB1)
   04310 Wnt signaling pathway
    129625261 (PLCB1)
   04371 Apelin signaling pathway
    129625261 (PLCB1)
   04020 Calcium signaling pathway
    129625261 (PLCB1)
   04070 Phosphatidylinositol signaling system
    129625261 (PLCB1)
   04072 Phospholipase D signaling pathway
    129625261 (PLCB1)
   04071 Sphingolipid signaling pathway
    129625261 (PLCB1)
   04022 cGMP-PKG signaling pathway
    129625261 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    129625261 (PLCB1)
   04081 Hormone signaling
    129625261 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    129625261 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129625261 (PLCB1)
   04613 Neutrophil extracellular trap formation
    129625261 (PLCB1)
   04621 NOD-like receptor signaling pathway
    129625261 (PLCB1)
   04062 Chemokine signaling pathway
    129625261 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    129625261 (PLCB1)
   04922 Glucagon signaling pathway
    129625261 (PLCB1)
   04929 GnRH secretion
    129625261 (PLCB1)
   04912 GnRH signaling pathway
    129625261 (PLCB1)
   04915 Estrogen signaling pathway
    129625261 (PLCB1)
   04921 Oxytocin signaling pathway
    129625261 (PLCB1)
   04926 Relaxin signaling pathway
    129625261 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    129625261 (PLCB1)
   04918 Thyroid hormone synthesis
    129625261 (PLCB1)
   04919 Thyroid hormone signaling pathway
    129625261 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    129625261 (PLCB1)
   04916 Melanogenesis
    129625261 (PLCB1)
   04924 Renin secretion
    129625261 (PLCB1)
   04925 Aldosterone synthesis and secretion
    129625261 (PLCB1)
   04927 Cortisol synthesis and secretion
    129625261 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    129625261 (PLCB1)
   04270 Vascular smooth muscle contraction
    129625261 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    129625261 (PLCB1)
   04971 Gastric acid secretion
    129625261 (PLCB1)
   04972 Pancreatic secretion
    129625261 (PLCB1)
   04973 Carbohydrate digestion and absorption
    129625261 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    129625261 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    129625261 (PLCB1)
   04725 Cholinergic synapse
    129625261 (PLCB1)
   04728 Dopaminergic synapse
    129625261 (PLCB1)
   04726 Serotonergic synapse
    129625261 (PLCB1)
   04720 Long-term potentiation
    129625261 (PLCB1)
   04730 Long-term depression
    129625261 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    129625261 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    129625261 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    129625261 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    129625261 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129625261 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    129625261 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    129625261 (PLCB1)
   05142 Chagas disease
    129625261 (PLCB1)
   05143 African trypanosomiasis
    129625261 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129625261 (PLCB1)
   05016 Huntington disease
    129625261 (PLCB1)
   05017 Spinocerebellar ataxia
    129625261 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    129625261 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129625261 (PLCB1)
   05415 Diabetic cardiomyopathy
    129625261 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    129625261 (PLCB1)
   04934 Cushing syndrome
    129625261 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bke04131]
    129625261 (PLCB1)
Enzymes [BR:bke01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     129625261 (PLCB1)
Membrane trafficking [BR:bke04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    129625261 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    129625261 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 129625261
NCBI-ProteinID: XP_055399338
Position
13
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWEDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLDKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARPTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDNKKKSEPSSPDHVSSTIEQDLAALDAEMTQKLVDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPLMTSDSGKLNQKPPSS
EELEGENPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggcacagcctggagtgcacgcgctgcaactcaagccggtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggaggatgactccactattgtcactccg
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctgttagatctcagccttgtcaaagacgccagatgtgggaaacatgccaaggcg
cccaaggaccctaaattacgtgaacttctggatgtggggaacattgggcgcctggaacat
cgcatgatcacagtggtgtatgggcctgacttagtgaacatctcccatttgaacctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaagttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggacgcatttctggaaaaggcgtatactaaacttaag
ctgcaagtcactccagaaggacgcattcctctcaaaaacatataccgcctgttctcagca
gaccggaagcgagtcgagacagcattagaggcttgtagtcttccatcttcaaggaatgat
tcgatacctcaagaagatttcactcctgaagtgtacagagttttcctgaacaacctttgt
cctcgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccatacctt
acagttgatcagatgatggattttatcaacctcaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagagcaagtccaagtgttgattgagaagtatgaacct
aacaacagcctcgccaaaaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcattaattcctcacacaacacctacctcacagctggccagctg
gctggaaactcctccgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagctggactgctggaagggacgaactgcagaagaggagccagtcatcacccatgggttc
accatgaccacagaaatatccttcaaggaagtgattgaagccattgctgaatgtgcattt
aagacttcaccttttccaattctgctttcatttgagaaccatgtggactcgccgaagcag
caggccaagatggcggagtactgcagactcatcttcggcgacgccctcctcatggagccg
ctggacaagtacccgttggaatctggagttccccttccaagtcctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcacacaagtcgtcagaaggaagtggcaagaag
aagctctcagaacaagcttccaacacgtacagcgactcctccagtgtgtttgagccctcg
tccccaggagccggagaagctgatacagagagtgacgatgatgacgatgatgatgactgt
aaaaagtcttcaatggatgaggggaccgcagggagcgaggccatggccacagaagagatg
tctaatctggtgaactatatccagccagtcaagttcgagtcatttgaaatttcaaaaaaa
agaaatagaagcttcgagatgtcttcctttgtggaaaccaaaggtcttgagcaacttaca
aagtctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaag
ggaacacgcgtggattcatctaactatatgcctcagctcttctggaatgcaggctgccaa
atggttgcccttaatttccaaacagtggacctggctatgcagataaacatggggatgtat
gaatacaatgggaagagtggctacaggctgaagccggagttcatgaggagacctgacaag
cactttgatccattcacagaaggcatcgtggacggcatagtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagtcgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaagga
aacgctgtaaatcccatctgggaagaagaacccattgtattcaaaaaggtggttcttcct
tcgctagcctgtctgaggatagcagtttatgaagaaggaggtaaatttattggtcaccga
atcttgccagtacaagcaattcggccaggctatcactacatctgtctgaggaacgagagg
aaccagcctctgatgctgccagcgctctttgtctacatagaggtgaaggactatgtccca
gacacatatgcagatgtgattgaagctttgtcaaatccaatccgatatgtgaatctgatg
gagcagagagctaaacaactggctgctttaacactggaagatgaagaagaagtgaagaaa
gaggctgatcctggggaaacaccatcagaagctccgagtgaagccaggccaactccagca
gaaaacggggtgaatcacacgacgtccctgacacccaaaccaccctcccaggctctgcac
agccaaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtagaagcgcagacgattgaagagctaaagcagcagaagtcgtttgtg
aaacttcaaaagaagcactacaaggaaatgaaagacctggttaagagacaccacaagaaa
accaccgacctcatcaaagagcacactacgaaatacaatgaaatccagaacgactacttg
agaaggagagcagctctggaaaagacagccaaaaaggacaataagaaaaaatcagaaccc
agtagccctgaccacgtctcatcaacaattgagcaagaccttgctgccctggatgccgaa
atgacccaaaagttagtagatctgaaggacaaacaacagcagcagctgcttaatcttcga
caagagcaatactatagcgaaaaataccagaagcgagaacacattaaactgcttattcaa
aaattgactgatgttgctgaagaatgtcagaataatcagttaaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagcaaaatccaaagacaaaagccagatggaggaggaaaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaactcgtagagaaacacaaagaaatccgccagcagatcctggatgaaaagccc
aagctacaggtggaactggagcaggaataccaagacaagttcaaaaggctgcccctggag
attttggaatttgtgcaggaagccatgaaagggaagattagtgaagacagcaatcacagc
tctgcccctcccctgatgacctcagactctggaaaactaaaccagaagcctccttccagt
gaagaattggaaggagaaaacccaggaaaagagtttgatacccctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (6)   
   Pfam (6)   
All databases (14)   

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