KEGG   Bos mutus (wild yak): 102273347
Entry
102273347         CDS       T02919                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bom  Bos mutus (wild yak)
Pathway
bom00562  Inositol phosphate metabolism
bom01100  Metabolic pathways
bom04015  Rap1 signaling pathway
bom04020  Calcium signaling pathway
bom04022  cGMP-PKG signaling pathway
bom04062  Chemokine signaling pathway
bom04070  Phosphatidylinositol signaling system
bom04071  Sphingolipid signaling pathway
bom04072  Phospholipase D signaling pathway
bom04081  Hormone signaling
bom04082  Neuroactive ligand signaling
bom04261  Adrenergic signaling in cardiomyocytes
bom04270  Vascular smooth muscle contraction
bom04310  Wnt signaling pathway
bom04371  Apelin signaling pathway
bom04540  Gap junction
bom04611  Platelet activation
bom04613  Neutrophil extracellular trap formation
bom04621  NOD-like receptor signaling pathway
bom04713  Circadian entrainment
bom04720  Long-term potentiation
bom04723  Retrograde endocannabinoid signaling
bom04724  Glutamatergic synapse
bom04725  Cholinergic synapse
bom04726  Serotonergic synapse
bom04728  Dopaminergic synapse
bom04730  Long-term depression
bom04742  Taste transduction
bom04750  Inflammatory mediator regulation of TRP channels
bom04911  Insulin secretion
bom04912  GnRH signaling pathway
bom04915  Estrogen signaling pathway
bom04916  Melanogenesis
bom04918  Thyroid hormone synthesis
bom04919  Thyroid hormone signaling pathway
bom04921  Oxytocin signaling pathway
bom04922  Glucagon signaling pathway
bom04924  Renin secretion
bom04925  Aldosterone synthesis and secretion
bom04926  Relaxin signaling pathway
bom04927  Cortisol synthesis and secretion
bom04928  Parathyroid hormone synthesis, secretion and action
bom04929  GnRH secretion
bom04933  AGE-RAGE signaling pathway in diabetic complications
bom04934  Cushing syndrome
bom04935  Growth hormone synthesis, secretion and action
bom04961  Endocrine and other factor-regulated calcium reabsorption
bom04970  Salivary secretion
bom04971  Gastric acid secretion
bom04972  Pancreatic secretion
bom04973  Carbohydrate digestion and absorption
bom05010  Alzheimer disease
bom05016  Huntington disease
bom05017  Spinocerebellar ataxia
bom05022  Pathways of neurodegeneration - multiple diseases
bom05142  Chagas disease
bom05143  African trypanosomiasis
bom05146  Amoebiasis
bom05163  Human cytomegalovirus infection
bom05200  Pathways in cancer
bom05415  Diabetic cardiomyopathy
bom05417  Lipid and atherosclerosis
Module
bom_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bom00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102273347 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102273347 (PLCB1)
   04310 Wnt signaling pathway
    102273347 (PLCB1)
   04371 Apelin signaling pathway
    102273347 (PLCB1)
   04020 Calcium signaling pathway
    102273347 (PLCB1)
   04070 Phosphatidylinositol signaling system
    102273347 (PLCB1)
   04072 Phospholipase D signaling pathway
    102273347 (PLCB1)
   04071 Sphingolipid signaling pathway
    102273347 (PLCB1)
   04022 cGMP-PKG signaling pathway
    102273347 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102273347 (PLCB1)
   04081 Hormone signaling
    102273347 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102273347 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102273347 (PLCB1)
   04613 Neutrophil extracellular trap formation
    102273347 (PLCB1)
   04621 NOD-like receptor signaling pathway
    102273347 (PLCB1)
   04062 Chemokine signaling pathway
    102273347 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    102273347 (PLCB1)
   04922 Glucagon signaling pathway
    102273347 (PLCB1)
   04929 GnRH secretion
    102273347 (PLCB1)
   04912 GnRH signaling pathway
    102273347 (PLCB1)
   04915 Estrogen signaling pathway
    102273347 (PLCB1)
   04921 Oxytocin signaling pathway
    102273347 (PLCB1)
   04926 Relaxin signaling pathway
    102273347 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    102273347 (PLCB1)
   04918 Thyroid hormone synthesis
    102273347 (PLCB1)
   04919 Thyroid hormone signaling pathway
    102273347 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    102273347 (PLCB1)
   04916 Melanogenesis
    102273347 (PLCB1)
   04924 Renin secretion
    102273347 (PLCB1)
   04925 Aldosterone synthesis and secretion
    102273347 (PLCB1)
   04927 Cortisol synthesis and secretion
    102273347 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102273347 (PLCB1)
   04270 Vascular smooth muscle contraction
    102273347 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    102273347 (PLCB1)
   04971 Gastric acid secretion
    102273347 (PLCB1)
   04972 Pancreatic secretion
    102273347 (PLCB1)
   04973 Carbohydrate digestion and absorption
    102273347 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102273347 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    102273347 (PLCB1)
   04725 Cholinergic synapse
    102273347 (PLCB1)
   04728 Dopaminergic synapse
    102273347 (PLCB1)
   04726 Serotonergic synapse
    102273347 (PLCB1)
   04720 Long-term potentiation
    102273347 (PLCB1)
   04730 Long-term depression
    102273347 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    102273347 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    102273347 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    102273347 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102273347 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102273347 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102273347 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102273347 (PLCB1)
   05142 Chagas disease
    102273347 (PLCB1)
   05143 African trypanosomiasis
    102273347 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102273347 (PLCB1)
   05016 Huntington disease
    102273347 (PLCB1)
   05017 Spinocerebellar ataxia
    102273347 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    102273347 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102273347 (PLCB1)
   05415 Diabetic cardiomyopathy
    102273347 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102273347 (PLCB1)
   04934 Cushing syndrome
    102273347 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bom04131]
    102273347 (PLCB1)
Enzymes [BR:bom01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102273347 (PLCB1)
Membrane trafficking [BR:bom04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102273347 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102273347 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 102273347
NCBI-ProteinID: XP_070238103
Position
13
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWEDDSTVVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLDKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARPTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDNKKKSEPSSPDHVSSTIEQDLAALDAEMTQKLVDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPLMTSDSGKLNQKPPSS
EELEGENPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggcacagcctggagtgcacgcgctgcaactcaagccggtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggaggatgactccactgttgtcactccg
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctgttagatctcagccttgtcaaagacgccagatgtgggaaacatgccaaggcg
cccaaggaccctaaattacgtgaacttctggatgtggggaacattgggcgcctggaacat
cgcatgatcacagtggtgtatgggcctgacttagtgaacatctcccatttgaacctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggacgcatttctggaaaaggcgtatactaaacttaag
ctgcaagtcactccagaaggacgcattcctctcaaaaacatataccgcctgttctcagca
gaccggaagcgagtcgagacagctttagaggcttgtagtcttccatcttcaaggaatgat
tcgatacctcaagaagatttcactcctgaagtgtacagagttttcctgaacaacctttgt
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
acagttgatcagatgatggattttatcaacctcaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagagcaagtccaagtgttgattgagaagtatgaacct
aacaacagcctcgccaaaaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcattaattcctcacacaacacctacctcacagctggccagctg
gctggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagctggactgctggaagggacgaactgcagaagaggagccagtcatcacccatgggttc
accatgaccacagaaatatccttcaaggaagtgattgaagccattgctgaatgtgcattt
aagacttcaccttttccaattctgctttcatttgagaaccatgtggactcgccgaagcag
caagccaagatggcggagtactgcagactcatctttggcgacgccctcctcatggagccg
ctggacaagtacccgttggaatctggagttccccttccaagtcctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcacacaagtcgtcagaaggaagtggcaagaag
aagctctcagaacaagcttccaacacgtacagcgactcctccagtgtgtttgagccctcg
tccccaggagccggagaagctgatacagagagtgacgatgatgacgatgatgatgactgt
aaaaagtcttcaatggatgaggggaccgcagggagcgaggccatggccacagaagagatg
tctaatctggtgaactatatccagccagtcaagttcgagtcatttgaaatttcaaaaaaa
agaaatagaagcttcgagatgtcttcctttgtggaaaccaaaggtcttgagcaacttaca
aagtctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaag
ggaacacgcgtggattcatctaactatatgcctcagctcttctggaatgcaggctgccaa
atggttgctcttaatttccaaacagtggacctggctatgcagataaacatggggatgtat
gaatacaatgggaagagtggctacaggctgaagccggagttcatgaggagacctgacaag
cactttgatccattcacagaaggcatcgtggacggcatagtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagtcgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaagga
aacgctgtaaatcccatctgggaagaagaacccattgtattcaaaaaggtggttcttcct
tcgctagcctgtctgaggatagcagtttatgaagaaggaggtaaatttattggtcaccga
atcttgccagtacaagcaattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctcatgctgccagcgctctttgtctacatagaggtgaaggactatgtccca
gacacatatgcagatgtgattgaagctttgtcaaatccaatccgatatgtgaatctgatg
gagcagagagctaaacaactggctgctttgacactggaagatgaagaagaagtgaagaaa
gaggctgatcctggggaaacaccatcagaagctccaagtgaagccaggccaactccagca
gaaaacggggtgaatcacacaacgtccctgacacccaaaccaccctcccaggctctgcac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtagaagcgcagacgattgaagagctaaagcagcagaagtcgtttgtg
aaacttcaaaagaagcactacaaggaaatgaaggacctggttaagagacaccacaagaaa
accaccgacctcatcaaagagcacactacaaagtacaatgaaatccagaacgactacttg
agaaggagagcagctctggaaaagacagccaaaaaggacaataagaaaaaatcagaaccc
agtagccctgaccacgtctcatcaacaattgagcaagaccttgctgccctggatgccgaa
atgacccaaaagttagtagatctgaaggacaaacagcagcagcagctgcttaatcttcga
caagagcaatactatagcgaaaaataccagaaacgagaacacattaaactgcttattcaa
aaattgactgatgttgctgaagaatgtcagaataatcagttaaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagcaaaatccaaagacaaaagccagatggaggaggaaaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcgcaaagtaaacgg
caagaaaaactcgtagagaaacacaaagaaatccgccagcagatcctggatgaaaagccc
aagctacaggtggaactggagcaggaataccaagacaagttcaaaaggctgcccctggag
attttggaatttgtgcaggaagccatgaaagggaagattagtgaagacagcaatcacagc
tctgcccctcccctgatgacctcagactctggaaaactaaaccagaagcctccttccagt
gaagaattggaaggagaaaacccaggaaaagagtttgatacccctctgtga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (13)   

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