KEGG   PATHWAY: bsu03430
bsu03430                    Pathway                                
Mismatch repair - Bacillus subtilis subsp. subtilis 168
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Genetic Information Processing; Replication and repair
Pathway map
bsu03430  Mismatch repair

Other DBs
GO: 0006298
Bacillus subtilis subsp. subtilis 168 [GN:bsu]
BSU17040  mutS; DNA mismatch repair protein MutS [KO:K03555]
BSU28580  mutSB; methyl-directed mismatch repair protein MutS [KO:K07456]
BSU17050  mutL; DNA mismatch repair protein MutL [KO:K03572]
BSU06610  pcrA; ATP-dependent DNA helicase PcrA [KO:K03657] [EC:]
BSU11820  yjcD; ATP-dependent DNA helicase [KO:K03657] [EC:]
BSU33450  helD; helicase IV [KO:K03657] [EC:]
BSU24300  xseA; exodeoxyribonuclease 7 large subunit [KO:K03601] [EC:]
BSU24290  xseB; exodeoxyribonuclease 7 small subunit [KO:K03602] [EC:]
BSU27620  recJ; single-stranded-dna-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
BSU20350  yorK; single-strand DNA-specific exonuclease YorK [KO:K07462] [EC:3.1.-.-]
BSU40900  ssbA; single-stranded DNA-binding protein [KO:K03111]
BSU29230  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:]
BSU20340  yorL; DNA polymerase YorL [KO:K02337] [EC:]
BSU16580  polC; DNA polymerase III PolC-type [KO:K03763] [EC:]
BSU00020  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:]
BSU00190  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:]
BSU25560  holA; hypothetical protein [KO:K02340] [EC:]
BSU00310  holB; DNA polymerase III subunit delta [KO:K02341] [EC:]
BSU06620  ligA; DNA ligase [KO:K01972] [EC:]
Jiricny J.
The multifaceted mismatch-repair system.
Nat Rev Mol Cell Biol 7:335-46 (2006)
Li GM.
Mechanisms and functions of DNA mismatch repair.
Cell Res 18:85-98 (2008)
Marti TM, Kunz C, Fleck O.
DNA mismatch repair and mutation avoidance pathways.
J Cell Physiol 191:28-41 (2002)
Ikejima M, Shimada T.
[Molecular mechanism of mismatch repair]
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway

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