KEGG   PATHWAY: bsu03440
Entry
bsu03440                    Pathway                                

Name
Homologous recombination - Bacillus subtilis subsp. subtilis 168
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
bsu03440  Homologous recombination
bsu03440

Other DBs
GO: 0000724
Organism
Bacillus subtilis subsp. subtilis 168 [GN:bsu]
Gene
BSU27620  recJ; single-stranded-dna-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
BSU20350  yorK; single-strand DNA-specific exonuclease YorK [KO:K07462] [EC:3.1.-.-]
BSU40900  ssbA; single-stranded DNA-binding protein [KO:K03111]
BSU00040  recF; DNA replication and repair protein RecF [KO:K03629]
BSU25280  recO; DNA repair protein RecO [KO:K03584]
BSU00210  recR; recombination protein RecR [KO:K06187]
BSU16940  recA; recombinase RecA [KO:K03553]
BSU29090  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
BSU27740  ruvA; holliday junction ATP-dependent DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
BSU27730  ruvB; holliday junction ATP-dependent DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
BSU15870  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
BSU27480  yrrC; hypothetical protein [KO:K03581] [EC:3.1.11.5]
BSU29230  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
BSU20340  yorL; DNA polymerase YorL [KO:K02337] [EC:2.7.7.7]
BSU16580  polC; DNA polymerase III PolC-type [KO:K03763] [EC:2.7.7.7]
BSU00020  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
BSU00190  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
BSU25560  holA; hypothetical protein [KO:K02340] [EC:2.7.7.7]
BSU00310  holB; DNA polymerase III subunit delta [KO:K02341] [EC:2.7.7.7]
BSU15710  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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