KEGG   Bos taurus (cow): 287026
Entry
287026            CDS       T01008                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
bta00562  Inositol phosphate metabolism
bta01100  Metabolic pathways
bta04015  Rap1 signaling pathway
bta04020  Calcium signaling pathway
bta04022  cGMP-PKG signaling pathway
bta04062  Chemokine signaling pathway
bta04070  Phosphatidylinositol signaling system
bta04071  Sphingolipid signaling pathway
bta04072  Phospholipase D signaling pathway
bta04081  Hormone signaling
bta04082  Neuroactive ligand signaling
bta04261  Adrenergic signaling in cardiomyocytes
bta04270  Vascular smooth muscle contraction
bta04310  Wnt signaling pathway
bta04371  Apelin signaling pathway
bta04540  Gap junction
bta04611  Platelet activation
bta04613  Neutrophil extracellular trap formation
bta04621  NOD-like receptor signaling pathway
bta04713  Circadian entrainment
bta04720  Long-term potentiation
bta04723  Retrograde endocannabinoid signaling
bta04724  Glutamatergic synapse
bta04725  Cholinergic synapse
bta04726  Serotonergic synapse
bta04728  Dopaminergic synapse
bta04730  Long-term depression
bta04742  Taste transduction
bta04750  Inflammatory mediator regulation of TRP channels
bta04911  Insulin secretion
bta04912  GnRH signaling pathway
bta04915  Estrogen signaling pathway
bta04916  Melanogenesis
bta04918  Thyroid hormone synthesis
bta04919  Thyroid hormone signaling pathway
bta04921  Oxytocin signaling pathway
bta04922  Glucagon signaling pathway
bta04924  Renin secretion
bta04925  Aldosterone synthesis and secretion
bta04926  Relaxin signaling pathway
bta04927  Cortisol synthesis and secretion
bta04928  Parathyroid hormone synthesis, secretion and action
bta04929  GnRH secretion
bta04933  AGE-RAGE signaling pathway in diabetic complications
bta04934  Cushing syndrome
bta04935  Growth hormone synthesis, secretion and action
bta04961  Endocrine and other factor-regulated calcium reabsorption
bta04970  Salivary secretion
bta04971  Gastric acid secretion
bta04972  Pancreatic secretion
bta04973  Carbohydrate digestion and absorption
bta05010  Alzheimer disease
bta05016  Huntington disease
bta05017  Spinocerebellar ataxia
bta05022  Pathways of neurodegeneration - multiple diseases
bta05142  Chagas disease
bta05143  African trypanosomiasis
bta05146  Amoebiasis
bta05163  Human cytomegalovirus infection
bta05200  Pathways in cancer
bta05415  Diabetic cardiomyopathy
bta05417  Lipid and atherosclerosis
Module
bta_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    287026 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    287026 (PLCB1)
   04310 Wnt signaling pathway
    287026 (PLCB1)
   04371 Apelin signaling pathway
    287026 (PLCB1)
   04020 Calcium signaling pathway
    287026 (PLCB1)
   04070 Phosphatidylinositol signaling system
    287026 (PLCB1)
   04072 Phospholipase D signaling pathway
    287026 (PLCB1)
   04071 Sphingolipid signaling pathway
    287026 (PLCB1)
   04022 cGMP-PKG signaling pathway
    287026 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    287026 (PLCB1)
   04081 Hormone signaling
    287026 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    287026 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    287026 (PLCB1)
   04613 Neutrophil extracellular trap formation
    287026 (PLCB1)
   04621 NOD-like receptor signaling pathway
    287026 (PLCB1)
   04062 Chemokine signaling pathway
    287026 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    287026 (PLCB1)
   04922 Glucagon signaling pathway
    287026 (PLCB1)
   04929 GnRH secretion
    287026 (PLCB1)
   04912 GnRH signaling pathway
    287026 (PLCB1)
   04915 Estrogen signaling pathway
    287026 (PLCB1)
   04921 Oxytocin signaling pathway
    287026 (PLCB1)
   04926 Relaxin signaling pathway
    287026 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    287026 (PLCB1)
   04918 Thyroid hormone synthesis
    287026 (PLCB1)
   04919 Thyroid hormone signaling pathway
    287026 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    287026 (PLCB1)
   04916 Melanogenesis
    287026 (PLCB1)
   04924 Renin secretion
    287026 (PLCB1)
   04925 Aldosterone synthesis and secretion
    287026 (PLCB1)
   04927 Cortisol synthesis and secretion
    287026 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    287026 (PLCB1)
   04270 Vascular smooth muscle contraction
    287026 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    287026 (PLCB1)
   04971 Gastric acid secretion
    287026 (PLCB1)
   04972 Pancreatic secretion
    287026 (PLCB1)
   04973 Carbohydrate digestion and absorption
    287026 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    287026 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    287026 (PLCB1)
   04725 Cholinergic synapse
    287026 (PLCB1)
   04728 Dopaminergic synapse
    287026 (PLCB1)
   04726 Serotonergic synapse
    287026 (PLCB1)
   04720 Long-term potentiation
    287026 (PLCB1)
   04730 Long-term depression
    287026 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    287026 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    287026 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    287026 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    287026 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    287026 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    287026 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    287026 (PLCB1)
   05142 Chagas disease
    287026 (PLCB1)
   05143 African trypanosomiasis
    287026 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    287026 (PLCB1)
   05016 Huntington disease
    287026 (PLCB1)
   05017 Spinocerebellar ataxia
    287026 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    287026 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    287026 (PLCB1)
   05415 Diabetic cardiomyopathy
    287026 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    287026 (PLCB1)
   04934 Cushing syndrome
    287026 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bta04131]
    287026 (PLCB1)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     287026 (PLCB1)
Membrane trafficking [BR:bta04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    287026 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    287026 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 287026
NCBI-ProteinID: NP_777242
BGD-bta: BT29800
Ensembl: ENSBTAG00000008338
VGNC: 32980
UniProt: P10894
Position
13
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWEDDSTVVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLDKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARPTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDNKKKSEPSSPDHVSSTIEQDLAALDAEMTQKLVDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPLMTSDSGKLNQKPPSS
EELEGENPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggcacagcctggagtgcacgcgctgcaactcaagccggtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggaggatgactccactgttgtcactccg
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctgttagatctcagccttgtcaaagacgccagatgtgggaaacatgccaaggcg
cccaaggaccctaaattacgtgaacttctggatgtggggaacattgggcgcctggaacat
cgcatgatcacagtggtgtatgggcctgacttagtgaacatctcccatttgaacctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaggcgtatactaagcttaag
ctgcaagtcactccagaaggacgcattcctctcaaaaacatataccgcctgttctcagca
gaccggaagcgagtcgagacagctttagaggcttgtagtcttccatcttcaaggaatgat
tcgatacctcaagaagatttcactcctgaagtgtacagagttttcctgaacaacctttgt
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
acagttgatcagatgatggattttatcaacctcaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagagcaagtccaagtgttgattgagaagtatgaacct
aacaacagcctcgccaaaaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcattaattcctcacacaacacctacctcacagctggccagctg
gctggaaactcctccgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagctggactgctggaagggacgaactgcagaagaggagccagtcatcacccatgggttc
accatgaccacagaaatatccttcaaggaagtgattgaagccattgctgaatgtgcattt
aagacttcaccttttccaattctgctttcatttgagaaccatgtggactcgccgaagcag
caagccaagatggcggagtactgcagactcatcttcggcgacgccctcctcatggagccg
ctggacaagtacccgttggaatctggagttccccttccaagtcctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcacacaagtcgtcagaaggaagtggcaagaag
aagctctcagaacaagcttccaacacgtacagcgactcctccagtgtgtttgagccctcg
tccccaggagccggagaagctgatacagagagtgacgatgatgacgatgatgatgactgt
aaaaagtcttcaatggatgaggggaccgcagggagcgaggccatggccacagaagagatg
tctaatctggtgaactatatccagccagtcaagttcgagtcatttgaaatttcaaaaaaa
agaaatagaagcttcgagatgtcttcctttgtggaaaccaaaggtcttgagcaacttaca
aagtctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaag
ggaacacgcgtggattcatctaactatatgcctcagctcttctggaatgcaggctgccaa
atggttgctcttaatttccaaacagtggacctggctatgcagataaacatggggatgtat
gaatataatgggaagagtggctacaggctgaagccggagttcatgaggagacctgacaag
cactttgatccattcacagaaggcatcgtggacggcatagtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagtcgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaagga
aacgctgtaaatcccatctgggaagaagaacccattgtattcaaaaaggtggtccttcct
tcgctagcctgtttgaggatagcagtttatgaagaaggaggtaaatttattggtcaccga
atcttgccagtacaagcaattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctcatgctgccagcgctctttgtctacatagaggtgaaggactatgtccca
gacacatatgcagatgtgattgaagctttgtcaaatccaatccgatatgtgaatctgatg
gagcagagagctaaacaactggctgctttgacactggaagatgaagaagaagtgaagaaa
gaggctgatcctggggaaacaccatcagaagctccgagtgaagccaggccaactccagca
gaaaacggggtgaatcacacaacgtccctgacacccaaaccaccctcccaggctctgcac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtagaagcgcagacgattgaagagctaaagcagcagaagtcgtttgtg
aaacttcaaaagaagcactacaaggaaatgaaggacctggttaagagacaccacaagaaa
accaccgacctcatcaaagagcacactacaaaatacaatgaaatccagaatgactacttg
agaaggagagcagctctggaaaagacagccaaaaaggacaataagaaaaaatcagaaccc
agtagccctgaccacgtctcatcaacaattgagcaagaccttgctgccctggatgccgag
atgacccaaaagttagtagatctgaaggacaaacagcagcagcagctgcttaatcttcga
caagagcaatactatagcgaaaaataccagaaacgagaacacattaaactgcttattcaa
aaattgactgatgttgctgaagaatgtcagaataatcagttaaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagcaaaatccaaagacaaaagccagatggaggaggaaaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcgcaaagtaaacgg
caagaaaaactcgtagagaaacacaaagaaatccgccagcagatcctggatgaaaagccc
aagctacaggtggaactggagcaggaataccaagacaagttcaaaaggctgcccctggag
attttggaatttgtgcaggaagccatgaaagggaagattagtgaagacagcaatcacagc
tctgcccctcccctgatgacctcagactctggaaaactaaaccagaagcctccttccagt
gaagaattggaaggagaaaacccaggaaaagagtttgatacccctctgtga

  All links  
Gene (14)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (6)   
   Pfam (6)   
All databases (28)   

Download RDF
DBGET integrated database retrieval system