KEGG   Crocuta crocuta (spotted hyena): 144224658
Entry
144224658         CDS       T11532                                 
Symbol
PPP3CA
Name
(RefSeq) protein phosphatase 3 catalytic subunit alpha isoform X1
  KO
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
Organism
ccru  Crocuta crocuta (spotted hyena)
Pathway
ccru04010  MAPK signaling pathway
ccru04020  Calcium signaling pathway
ccru04022  cGMP-PKG signaling pathway
ccru04114  Oocyte meiosis
ccru04218  Cellular senescence
ccru04310  Wnt signaling pathway
ccru04360  Axon guidance
ccru04370  VEGF signaling pathway
ccru04380  Osteoclast differentiation
ccru04625  C-type lectin receptor signaling pathway
ccru04650  Natural killer cell mediated cytotoxicity
ccru04658  Th1 and Th2 cell differentiation
ccru04659  Th17 cell differentiation
ccru04660  T cell receptor signaling pathway
ccru04662  B cell receptor signaling pathway
ccru04720  Long-term potentiation
ccru04724  Glutamatergic synapse
ccru04728  Dopaminergic synapse
ccru04921  Oxytocin signaling pathway
ccru04922  Glucagon signaling pathway
ccru04924  Renin secretion
ccru05010  Alzheimer disease
ccru05014  Amyotrophic lateral sclerosis
ccru05020  Prion disease
ccru05022  Pathways of neurodegeneration - multiple diseases
ccru05031  Amphetamine addiction
ccru05152  Tuberculosis
ccru05163  Human cytomegalovirus infection
ccru05166  Human T-cell leukemia virus 1 infection
ccru05167  Kaposi sarcoma-associated herpesvirus infection
ccru05170  Human immunodeficiency virus 1 infection
ccru05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccru05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccru00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    144224658 (PPP3CA)
   04310 Wnt signaling pathway
    144224658 (PPP3CA)
   04370 VEGF signaling pathway
    144224658 (PPP3CA)
   04020 Calcium signaling pathway
    144224658 (PPP3CA)
   04022 cGMP-PKG signaling pathway
    144224658 (PPP3CA)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    144224658 (PPP3CA)
   04218 Cellular senescence
    144224658 (PPP3CA)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    144224658 (PPP3CA)
   04650 Natural killer cell mediated cytotoxicity
    144224658 (PPP3CA)
   04660 T cell receptor signaling pathway
    144224658 (PPP3CA)
   04658 Th1 and Th2 cell differentiation
    144224658 (PPP3CA)
   04659 Th17 cell differentiation
    144224658 (PPP3CA)
   04662 B cell receptor signaling pathway
    144224658 (PPP3CA)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    144224658 (PPP3CA)
   04921 Oxytocin signaling pathway
    144224658 (PPP3CA)
   04924 Renin secretion
    144224658 (PPP3CA)
  09156 Nervous system
   04724 Glutamatergic synapse
    144224658 (PPP3CA)
   04728 Dopaminergic synapse
    144224658 (PPP3CA)
   04720 Long-term potentiation
    144224658 (PPP3CA)
  09158 Development and regeneration
   04360 Axon guidance
    144224658 (PPP3CA)
   04380 Osteoclast differentiation
    144224658 (PPP3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    144224658 (PPP3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    144224658 (PPP3CA)
   05170 Human immunodeficiency virus 1 infection
    144224658 (PPP3CA)
   05163 Human cytomegalovirus infection
    144224658 (PPP3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    144224658 (PPP3CA)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    144224658 (PPP3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    144224658 (PPP3CA)
   05014 Amyotrophic lateral sclerosis
    144224658 (PPP3CA)
   05020 Prion disease
    144224658 (PPP3CA)
   05022 Pathways of neurodegeneration - multiple diseases
    144224658 (PPP3CA)
  09165 Substance dependence
   05031 Amphetamine addiction
    144224658 (PPP3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    144224658 (PPP3CA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ccru01009]
    144224658 (PPP3CA)
Enzymes [BR:ccru01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     144224658 (PPP3CA)
Protein phosphatases and associated proteins [BR:ccru01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Catalytic subunits
     144224658 (PPP3CA)
SSDB
Motif
Pfam: Metallophos
Other DBs
NCBI-GeneID: 144224658
NCBI-ProteinID: XP_077611864
Position
Unknown
AA seq 471 aa
MKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPAN
TRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKY
SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDI
LWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRM
YRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVF
TWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVF
SVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSF
EEAKGLDRINERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNIQ
NT seq 1416 nt   +upstreamnt  +downstreamnt
atgaaggagggcaggctggaagagagtgttgctttgagaataataacagaaggggcttca
attcttcgacaggaaaaaaatttgctggatatcgatgcaccagtcacagtttgtggggac
atccatggacaattctttgatttgatgaagctttttgaagtgggaggatctcctgccaac
actcgctacctcttcctaggggactatgttgacagagggtacttcagtatcgaatgtgtg
ctgtatttgtgggccttgaaaattctttaccccaaaacactgtttttacttcgtggaaat
catgaatgtagacatctaacagagtatttcacatttaaacaagaatgtaaaataaagtat
tcagaacgcgtatatgatgcctgcatggatgcctttgactgcctgcccctggctgccctg
atgaaccaacagttcctgtgtgtacacggcggtttgtctccagagattaacactttagat
gatatcagaaaattagaccgattcaaagaaccacctgcttatggacctatgtgtgatatc
ctgtggtcagaccccctggaggattttggaaatgagaagactcaggaacatttcactcac
aacacagtcagggggtgttcatacttctacagttacccagctgtatgtgaattcttacag
cacaataacttgttatctatactccgagcccatgaagcccaagatgcagggtatcgcatg
tacaggaaaagccaaacaacaggcttcccttctctaattacaattttttcagcaccaaat
tatttagatgtatacaataacaaagctgcagtattgaagtatgagaacaatgtcatgaac
atcaggcaattcaactgttctccacacccatactggcttccaaatttcatggatgttttc
acttggtccctgccatttgttggagaaaaagtgactgaaatgctggtaaatgtcctcaac
atctgctcagatgatgaactagggtcagaagaagatggatttgatggcgcaacagccgca
gcccggaaggaggtgataaggaacaagatccgagcaataggcaaaatggcccgagtgttc
tcagttctcagagaagagagtgagagcgtgctaacactgaaaggcttgactcccaccggc
atgctccccagcggagtgctttctggagggaagcagacactgcaaagcgctactgttgag
gctattgaggctgatgaagccatcaaaggattttcaccacaacataagatcactagcttc
gaggaggccaagggcttagaccgaattaatgagaggatgccaccccgcagagacgccatg
ccctctgacgccaaccttaactccatcaacaaggctctcgcctcagagactaacggcaca
gacagcaatggcagtaatagcagcaatatccagtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (1)   
   Pfam (1)   
All databases (7)   

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