KEGG   Canis lupus familiaris (dog): 489644
Entry
489644            CDS       T01007                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa01524  Platinum drug resistance
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04081  Hormone signaling
cfa04140  Autophagy - animal
cfa04145  Phagocytosis
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04152  AMPK signaling pathway
cfa04210  Apoptosis
cfa04211  Longevity regulating pathway
cfa04213  Longevity regulating pathway - multiple species
cfa04218  Cellular senescence
cfa04360  Axon guidance
cfa04370  VEGF signaling pathway
cfa04380  Osteoclast differentiation
cfa04510  Focal adhesion
cfa04517  IgSF CAM signaling
cfa04518  Integrin signaling
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04625  C-type lectin receptor signaling pathway
cfa04630  JAK-STAT signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagosome formation
cfa04668  TNF signaling pathway
cfa04670  Leukocyte transendothelial migration
cfa04722  Neurotrophin signaling pathway
cfa04725  Cholinergic synapse
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04915  Estrogen signaling pathway
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04923  Regulation of lipolysis in adipocytes
cfa04926  Relaxin signaling pathway
cfa04929  GnRH secretion
cfa04930  Type II diabetes mellitus
cfa04931  Insulin resistance
cfa04932  Non-alcoholic fatty liver disease
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa04960  Aldosterone-regulated sodium reabsorption
cfa04973  Carbohydrate digestion and absorption
cfa05010  Alzheimer disease
cfa05017  Spinocerebellar ataxia
cfa05020  Prion disease
cfa05100  Bacterial invasion of epithelial cells
cfa05132  Salmonella infection
cfa05135  Yersinia infection
cfa05142  Chagas disease
cfa05146  Amoebiasis
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05162  Measles
cfa05163  Human cytomegalovirus infection
cfa05164  Influenza A
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05168  Herpes simplex virus 1 infection
cfa05169  Epstein-Barr virus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease
cfa05200  Pathways in cancer
cfa05203  Viral carcinogenesis
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05212  Pancreatic cancer
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05218  Melanoma
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05222  Small cell lung cancer
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    489644 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    489644 (PIK3CD)
   04014 Ras signaling pathway
    489644 (PIK3CD)
   04015 Rap1 signaling pathway
    489644 (PIK3CD)
   04370 VEGF signaling pathway
    489644 (PIK3CD)
   04630 JAK-STAT signaling pathway
    489644 (PIK3CD)
   04668 TNF signaling pathway
    489644 (PIK3CD)
   04066 HIF-1 signaling pathway
    489644 (PIK3CD)
   04068 FoxO signaling pathway
    489644 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    489644 (PIK3CD)
   04072 Phospholipase D signaling pathway
    489644 (PIK3CD)
   04071 Sphingolipid signaling pathway
    489644 (PIK3CD)
   04024 cAMP signaling pathway
    489644 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    489644 (PIK3CD)
   04152 AMPK signaling pathway
    489644 (PIK3CD)
   04150 mTOR signaling pathway
    489644 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    489644 (PIK3CD)
   04517 IgSF CAM signaling
    489644 (PIK3CD)
   04518 Integrin signaling
    489644 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    489644 (PIK3CD)
   04140 Autophagy - animal
    489644 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    489644 (PIK3CD)
   04218 Cellular senescence
    489644 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    489644 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    489644 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    489644 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    489644 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    489644 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    489644 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    489644 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    489644 (PIK3CD)
   04660 T cell receptor signaling pathway
    489644 (PIK3CD)
   04662 B cell receptor signaling pathway
    489644 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    489644 (PIK3CD)
   04666 Fc gamma R-mediated phagosome formation
    489644 (PIK3CD)
   04670 Leukocyte transendothelial migration
    489644 (PIK3CD)
   04062 Chemokine signaling pathway
    489644 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    489644 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    489644 (PIK3CD)
   04929 GnRH secretion
    489644 (PIK3CD)
   04915 Estrogen signaling pathway
    489644 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    489644 (PIK3CD)
   04917 Prolactin signaling pathway
    489644 (PIK3CD)
   04926 Relaxin signaling pathway
    489644 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    489644 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    489644 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    489644 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    489644 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    489644 (PIK3CD)
   04722 Neurotrophin signaling pathway
    489644 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    489644 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    489644 (PIK3CD)
   04380 Osteoclast differentiation
    489644 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    489644 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    489644 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    489644 (PIK3CD)
   05206 MicroRNAs in cancer
    489644 (PIK3CD)
   05205 Proteoglycans in cancer
    489644 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    489644 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    489644 (PIK3CD)
   05203 Viral carcinogenesis
    489644 (PIK3CD)
   05230 Central carbon metabolism in cancer
    489644 (PIK3CD)
   05231 Choline metabolism in cancer
    489644 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    489644 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    489644 (PIK3CD)
   05212 Pancreatic cancer
    489644 (PIK3CD)
   05225 Hepatocellular carcinoma
    489644 (PIK3CD)
   05226 Gastric cancer
    489644 (PIK3CD)
   05214 Glioma
    489644 (PIK3CD)
   05221 Acute myeloid leukemia
    489644 (PIK3CD)
   05220 Chronic myeloid leukemia
    489644 (PIK3CD)
   05218 Melanoma
    489644 (PIK3CD)
   05211 Renal cell carcinoma
    489644 (PIK3CD)
   05215 Prostate cancer
    489644 (PIK3CD)
   05213 Endometrial cancer
    489644 (PIK3CD)
   05224 Breast cancer
    489644 (PIK3CD)
   05222 Small cell lung cancer
    489644 (PIK3CD)
   05223 Non-small cell lung cancer
    489644 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    489644 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    489644 (PIK3CD)
   05161 Hepatitis B
    489644 (PIK3CD)
   05160 Hepatitis C
    489644 (PIK3CD)
   05171 Coronavirus disease
    489644 (PIK3CD)
   05164 Influenza A
    489644 (PIK3CD)
   05162 Measles
    489644 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    489644 (PIK3CD)
   05163 Human cytomegalovirus infection
    489644 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    489644 (PIK3CD)
   05169 Epstein-Barr virus infection
    489644 (PIK3CD)
   05165 Human papillomavirus infection
    489644 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    489644 (PIK3CD)
   05135 Yersinia infection
    489644 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    489644 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    489644 (PIK3CD)
   05142 Chagas disease
    489644 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    489644 (PIK3CD)
   05017 Spinocerebellar ataxia
    489644 (PIK3CD)
   05020 Prion disease
    489644 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    489644 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    489644 (PIK3CD)
   05415 Diabetic cardiomyopathy
    489644 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    489644 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    489644 (PIK3CD)
   04931 Insulin resistance
    489644 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    489644 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    489644 (PIK3CD)
   01524 Platinum drug resistance
    489644 (PIK3CD)
   01522 Endocrine resistance
    489644 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    489644 (PIK3CD)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     489644 (PIK3CD)
Membrane trafficking [BR:cfa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    489644 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 489644
NCBI-ProteinID: XP_005620563
Ensembl: ENSCAFG00000019735
VGNC: 44557
UniProt: A0A8I3Q525
Position
5:62900181..62953014
AA seq 1044 aa
MPPGVDCPMEFWTKEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLVNSQISLL
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAARRQQLGWEAWLQYCFPLQLEPSARSWGP
GTLRVPSRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGKHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
TKPPPIPMKKPSSLSLWSLEQPFCVELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECCLYMWPSVPDEKGELLNPTGTVRSNPNTESAAALVICLPEVAP
YPVYYPTLDKILELGRHGEHGRFSEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
RFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKELMHLCMR
QEAYLEALSNLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWVMYSNEEAGSDGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgccccctggggttgactgccccatggaattctggaccaaggaggagaatcagagtgtg
gctgttgacttcctgttgcccactggggtctatctgaatttccctgtgtcccggaatgcc
aacctcagcaccatcaagaaggtgttgtggcaccgagcccagtatgagccactcttccac
atgctcagcgaccctgaggcctatgtgttcacctgcgtcaaccagactgcggagcagcag
gagctggaagatgagcagcggcggctatgtgacatccaacccttcctgccagtgctgcgc
ctggtggcccgagagggtgacagggtgaagaagcttgtcaactcacagatcagcctcctc
atcggcaaaggcctccatgagttcgactccttgcgggaccctgaggtgaatgactttcgc
accaagatgcgccagttctgtgaggaggcggccgcccggcggcagcaactgggctgggag
gcctggcttcagtattgcttccccctgcagctggagccctccgcccggagctgggggcct
ggcaccctgcgggtccccagccgggccctcctggtcaacgtcaagttcgagggcagcgag
gagagcttcaccttccaggtgtccaccaaggatgtgccgctggcgctgatggcctgtgcc
ctccggaagaaggccacggtgttccggcagccgctggtggagcagccggaggactacacg
ctgcaggtgaacgggaagcacgagtacctgtatggcagctaccccctctgccagttccag
tacatctgcagctgcctgcacagcgggctgaccccccacctgaccatggtgcactcttcc
tccatcctcgccatgcgggacgagcagagcaaccctgccccccaagtccaaaaaccacgc
accaaaccaccccccattcccatgaagaagccttcttccttgtccctgtggtccctggag
cagcctttctgcgtggagctgatccagggcagcaaagtgaatgccgatgagcggatgaag
ctggtggtgcaggctgggcttttccacggcaatgagacgctgtgcaagacggtgtcgagc
tcggaggtgagcgtgtgctcagagcctgtgtggaaacagcgactggagttcgacatcaac
gtgtgtgacctgcctcgcatggcccgtctctgctttgcactttatgctgtgatcgagaag
gccaagaaggctcgctcgaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gccaacctcatgctgtttgactataaggaccagctcaagaccggtgaatgctgcctgtac
atgtggccctccgtcccagacgagaaaggggagctgctgaaccccacaggaacagtgcgg
agtaaccccaacacagagagcgcagcggccctggtcatctgcctgcctgaggtggctccc
taccccgtctactaccccaccctggacaagattctggagctggggcgacacggcgagcat
gggcgcttcagtgaggaggagcagctacagctgcgggaaatcctggagcggcgggggtcc
ggggagctgtatgagcacgagaaggacctggtgtggaagatgcggcacgaggtccaggag
cgcttccccgaggcgctggcccgcctgctgctggtcaccaagtggaacaagcatgaggat
gtggcccagatgctctacctgctgtgctcgtggcctgagctgcccgtcctgagcgccctg
gagctgctggacttcagcttcccggaccgccacgtgggctccttcgccatcaagtctctg
cggaagctgacggacgatgagcttttccagtacctgctgcagctggtgcaggtgctcaag
tacgaatcctacctcgactgcgaactgaccaagttcctgctggaccgggccctggccaac
cgcaagattggccacttcctcttctggcacctccgctccgagatgcacgtgccatccgtg
gctctgcgcttcggcctcatcatggaggcctactgcaggggcagcacccaccacatgaag
gtgctcatgaagcagggggaggcgctgagcaaactgaaggctctaaacgactttgtcaaa
gtgagctcccagaagaccaccaagccccagaccaaggagctgatgcacctgtgcatgcgc
caggaggcctacctggaggccctctccaacctgcagtccccactggaccccagtaccctg
ctggctgaagtctgcgtggagcagtgcaccttcatggactctaagatgaagcccctgtgg
gtcatgtacagcaacgaggaggcaggcagtgatggcagcgtgggcatcatcttcaagaat
ggggacgacctccgccaggacatgctgactttacagatgatccagctcatggacgtcctg
tggaagcaggagggattggacctgaggatgaccccctatggctgcctctccaccggggac
cgcacaggcctcatcgaggtggtgcttcactcggacaccatcgccaacatccagctaaac
aaaagcaacatggcggccacagctgccttcaacaaggatgccctgctcaactggctcaag
tccaagaacccaggggaggccttggatcgagccattgaggagttcaccctctcctgtgcc
ggctactgtgtggccacttacgtgctgggcatcggtgatcggcacagcgacaacatcatg
atccgcgagaatgggcagctgttccacatcgattttggccactttctgggtaatttcaag
accaagtttggaatcaaccgtgagcgagtcccgttcatcctcacatatgactttgtgcac
gtgatccagcaagggaagacgaataacagtgagaaatttgaaagattccgaggttactgt
gagcgagcctacaccatcctgcggcgccatgggctgctcttcctccacctctttgccctg
atgcgggctgccggcctgcctgagctcagctgctccaaagacatccagtacctcaaggac
tctctggcgttgggaaagacagaggaggaggctctaaagcacttccgagtgaagtttaac
gaagccctccgggagagctggaagaccaaagtgaactggctggcccacaatgtgtccaaa
gataacaggcaatag

  All links  
Gene (12)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (51)   
   UniProt (1)   
   RefSeq(pep) (50)   
DNA sequence (50)   
   RefSeq(nuc) (50)   
Protein domain (5)   
   Pfam (5)   
All databases (118)   

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