KEGG   Capra hircus (goat): 102180505
Entry
102180505         CDS       T02910                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
chx  Capra hircus (goat)
Pathway
chx00562  Inositol phosphate metabolism
chx01100  Metabolic pathways
chx04015  Rap1 signaling pathway
chx04020  Calcium signaling pathway
chx04022  cGMP-PKG signaling pathway
chx04062  Chemokine signaling pathway
chx04070  Phosphatidylinositol signaling system
chx04071  Sphingolipid signaling pathway
chx04072  Phospholipase D signaling pathway
chx04081  Hormone signaling
chx04082  Neuroactive ligand signaling
chx04261  Adrenergic signaling in cardiomyocytes
chx04270  Vascular smooth muscle contraction
chx04310  Wnt signaling pathway
chx04371  Apelin signaling pathway
chx04540  Gap junction
chx04611  Platelet activation
chx04613  Neutrophil extracellular trap formation
chx04621  NOD-like receptor signaling pathway
chx04713  Circadian entrainment
chx04720  Long-term potentiation
chx04723  Retrograde endocannabinoid signaling
chx04724  Glutamatergic synapse
chx04725  Cholinergic synapse
chx04726  Serotonergic synapse
chx04728  Dopaminergic synapse
chx04730  Long-term depression
chx04742  Taste transduction
chx04750  Inflammatory mediator regulation of TRP channels
chx04911  Insulin secretion
chx04912  GnRH signaling pathway
chx04915  Estrogen signaling pathway
chx04916  Melanogenesis
chx04918  Thyroid hormone synthesis
chx04919  Thyroid hormone signaling pathway
chx04921  Oxytocin signaling pathway
chx04922  Glucagon signaling pathway
chx04924  Renin secretion
chx04925  Aldosterone synthesis and secretion
chx04926  Relaxin signaling pathway
chx04927  Cortisol synthesis and secretion
chx04928  Parathyroid hormone synthesis, secretion and action
chx04929  GnRH secretion
chx04933  AGE-RAGE signaling pathway in diabetic complications
chx04934  Cushing syndrome
chx04935  Growth hormone synthesis, secretion and action
chx04961  Endocrine and other factor-regulated calcium reabsorption
chx04970  Salivary secretion
chx04971  Gastric acid secretion
chx04972  Pancreatic secretion
chx04973  Carbohydrate digestion and absorption
chx05010  Alzheimer disease
chx05016  Huntington disease
chx05017  Spinocerebellar ataxia
chx05022  Pathways of neurodegeneration - multiple diseases
chx05142  Chagas disease
chx05143  African trypanosomiasis
chx05146  Amoebiasis
chx05163  Human cytomegalovirus infection
chx05200  Pathways in cancer
chx05415  Diabetic cardiomyopathy
chx05417  Lipid and atherosclerosis
Module
chx_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:chx00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102180505 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102180505 (PLCB4)
   04310 Wnt signaling pathway
    102180505 (PLCB4)
   04371 Apelin signaling pathway
    102180505 (PLCB4)
   04020 Calcium signaling pathway
    102180505 (PLCB4)
   04070 Phosphatidylinositol signaling system
    102180505 (PLCB4)
   04072 Phospholipase D signaling pathway
    102180505 (PLCB4)
   04071 Sphingolipid signaling pathway
    102180505 (PLCB4)
   04022 cGMP-PKG signaling pathway
    102180505 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102180505 (PLCB4)
   04081 Hormone signaling
    102180505 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102180505 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102180505 (PLCB4)
   04613 Neutrophil extracellular trap formation
    102180505 (PLCB4)
   04621 NOD-like receptor signaling pathway
    102180505 (PLCB4)
   04062 Chemokine signaling pathway
    102180505 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    102180505 (PLCB4)
   04922 Glucagon signaling pathway
    102180505 (PLCB4)
   04929 GnRH secretion
    102180505 (PLCB4)
   04912 GnRH signaling pathway
    102180505 (PLCB4)
   04915 Estrogen signaling pathway
    102180505 (PLCB4)
   04921 Oxytocin signaling pathway
    102180505 (PLCB4)
   04926 Relaxin signaling pathway
    102180505 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    102180505 (PLCB4)
   04918 Thyroid hormone synthesis
    102180505 (PLCB4)
   04919 Thyroid hormone signaling pathway
    102180505 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    102180505 (PLCB4)
   04916 Melanogenesis
    102180505 (PLCB4)
   04924 Renin secretion
    102180505 (PLCB4)
   04925 Aldosterone synthesis and secretion
    102180505 (PLCB4)
   04927 Cortisol synthesis and secretion
    102180505 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102180505 (PLCB4)
   04270 Vascular smooth muscle contraction
    102180505 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    102180505 (PLCB4)
   04971 Gastric acid secretion
    102180505 (PLCB4)
   04972 Pancreatic secretion
    102180505 (PLCB4)
   04973 Carbohydrate digestion and absorption
    102180505 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102180505 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    102180505 (PLCB4)
   04725 Cholinergic synapse
    102180505 (PLCB4)
   04728 Dopaminergic synapse
    102180505 (PLCB4)
   04726 Serotonergic synapse
    102180505 (PLCB4)
   04720 Long-term potentiation
    102180505 (PLCB4)
   04730 Long-term depression
    102180505 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    102180505 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    102180505 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    102180505 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102180505 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102180505 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102180505 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102180505 (PLCB4)
   05142 Chagas disease
    102180505 (PLCB4)
   05143 African trypanosomiasis
    102180505 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102180505 (PLCB4)
   05016 Huntington disease
    102180505 (PLCB4)
   05017 Spinocerebellar ataxia
    102180505 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    102180505 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102180505 (PLCB4)
   05415 Diabetic cardiomyopathy
    102180505 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102180505 (PLCB4)
   04934 Cushing syndrome
    102180505 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:chx04131]
    102180505 (PLCB4)
Enzymes [BR:chx01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102180505 (PLCB4)
Membrane trafficking [BR:chx04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102180505 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102180505 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 102180505
NCBI-ProteinID: XP_013823863
UniProt: A0A452FTU9
Position
13
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGAIPKDPKILAALEALGKSENDLEGRIVCVCSGADLVNISFTYMVAENPE
ITKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKQGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSV
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANSVKKASD
DLDHENSKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKLTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSDMINTHSAEEQEVRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCV
KLQDTN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtagatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggccaggtgcta
gaatgttccctcatcaacagtgttcggctgggagccataccaaaggatcccaaaattttg
gctgctcttgaagctcttggcaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggtgcagatctggtgaacatcagtttcacgtacatggtggctgaaaatccagaa
ataactaagcaatgggtcgaaggcctgagatccatcattcacaacttcagggccaacaac
gtcagcccgatgacgtgcctcaagaagcactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgag
cctgccgcatttacttacgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcctgatgaagat
ttgaagaaacaaggcctcatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aatgcccccgtcttcctagatcgtctagagctgtaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcagacagtttggtgggaaa
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaagaaccgataataactcatggaaaagcgatgtgc
acagatatccttttcaaggatgttattcaagccatcaaggaaactgcctttgtcacgtcg
gaataccctgtgattctctcctttgaaaaccactgcagcaaatatcaacagtacaagatg
tccaaatattgtgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccactggaaccaggcagacccttgccatccccgaatgacctcaaaagaaaaatactcatc
aaaaacaaacgactgaaacctgaggttgaaaaaaaacagcttgaagctttgaaaagtgtg
atggaagcaggagaatccgctgccccagtgaacatcctagaggatgacaatgaagaggaa
atagaaagtgctgagcaagaggaggaagctcaccctgaatacaaatatggaaatgaactt
tctgcagatgacttgggtcacaaggaagctattgccaatagtgtcaagaaggcttcagat
gaccttgaccatgaaaacagcaaaaagggcctggttaccgtagaagatgagcaggcgtgg
atggcgtcttacaaatatgtgggtgctaccactaatatccatccgtatttgtccacaatg
atcaactacgcacagcctgtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattacaacatgtcttcttttaatgagtcagtcggtctaggctacttgaagacacacgcc
atagagtttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtggactccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcaggggaaatttgagtataat
ggatcctgcgggtaccttctcaagccagatttcatgagacggcccgatcgaacattcgac
cctttctctgaaacgcctgttgacggggttattgcagccacttgctccgtgcaggtcata
tcaggtcagttcttatcagataagaaaattggcacatatgtagaagtggacatgtatggg
ctgcccacggacactatccgaaaggagttccgcactcgcatggtgatgaacaacggtctc
aatcccgtttacaatgaagagtcatttgtgtttcggaaggtgatcctccccgacctggct
gtcttgaggatcgccgtgtatgatgacaacaacaagctgatcggccagaggattctgcct
ctggacggcctccaagcaggctatcgacacatatccctccggaatgagggaaataaacct
ttatcgctgccaaccattttctgcaacattgtcctaaaaacatatgtgcctgatggattc
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcggatcaaatgagagctatgggcattgaaactagtgacatcgccgatgtgcccagtgac
acttcaaagaacgacaagaaagggaaagccaacacagccaaagcgaatgtgacccctcag
agcagctcggagctcaggccaaccaccacagctgccctgggggctggcctggaggccaag
aaaggtattgaactgatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaagagctcaattctttaaagaagaaacatgcaaag
gaacacagtaccatgcagaaactacattgcacgcaagttgacaagattgtggcacagtac
gacaaggagaaattgactcatgagaaaatcctcgagaaggcaatgaagaagaaaggggga
agtaactgtcttgaaatgaagaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaggagattgtggcacagcacacaaaggagtggtcagacatgatc
aacacccacagtgcggaggagcaggaggtccgggacctgcacctcagccagcagtgcgaa
ctgctcagaaagctgctgatcagcgcccacgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaagagatgcgagcccaccaagctaagatttctatggaaaatagc
aaagccatcagccaagataaatccatcaagaataaagcagaacgggaaaggagagtcagg
gagttaaatagcagcaacactaaaaagtttctggaagaaagaaagagactcgccatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagctggagcacctcgaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaactcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagttgtgtg
aaactccaggacacaaactga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   RefSeq(pep) (8)   
DNA sequence (12)   
   RefSeq(nuc) (8)   
   GenBank (2)   
   EMBL (2)   
Protein domain (9)   
   Pfam (9)   
All databases (33)   

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