KEGG   Chionomys nivalis (European snow vole): 130881178
Entry
130881178         CDS       T11437                                 
Symbol
Plcb1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cnl  Chionomys nivalis (European snow vole)
Pathway
cnl00562  Inositol phosphate metabolism
cnl01100  Metabolic pathways
cnl04015  Rap1 signaling pathway
cnl04020  Calcium signaling pathway
cnl04022  cGMP-PKG signaling pathway
cnl04062  Chemokine signaling pathway
cnl04070  Phosphatidylinositol signaling system
cnl04071  Sphingolipid signaling pathway
cnl04072  Phospholipase D signaling pathway
cnl04081  Hormone signaling
cnl04082  Neuroactive ligand signaling
cnl04261  Adrenergic signaling in cardiomyocytes
cnl04270  Vascular smooth muscle contraction
cnl04310  Wnt signaling pathway
cnl04371  Apelin signaling pathway
cnl04540  Gap junction
cnl04611  Platelet activation
cnl04613  Neutrophil extracellular trap formation
cnl04621  NOD-like receptor signaling pathway
cnl04713  Circadian entrainment
cnl04720  Long-term potentiation
cnl04723  Retrograde endocannabinoid signaling
cnl04724  Glutamatergic synapse
cnl04725  Cholinergic synapse
cnl04726  Serotonergic synapse
cnl04728  Dopaminergic synapse
cnl04730  Long-term depression
cnl04742  Taste transduction
cnl04750  Inflammatory mediator regulation of TRP channels
cnl04911  Insulin secretion
cnl04912  GnRH signaling pathway
cnl04915  Estrogen signaling pathway
cnl04916  Melanogenesis
cnl04918  Thyroid hormone synthesis
cnl04919  Thyroid hormone signaling pathway
cnl04921  Oxytocin signaling pathway
cnl04922  Glucagon signaling pathway
cnl04924  Renin secretion
cnl04925  Aldosterone synthesis and secretion
cnl04926  Relaxin signaling pathway
cnl04927  Cortisol synthesis and secretion
cnl04928  Parathyroid hormone synthesis, secretion and action
cnl04929  GnRH secretion
cnl04933  AGE-RAGE signaling pathway in diabetic complications
cnl04934  Cushing syndrome
cnl04935  Growth hormone synthesis, secretion and action
cnl04961  Endocrine and other factor-regulated calcium reabsorption
cnl04970  Salivary secretion
cnl04971  Gastric acid secretion
cnl04972  Pancreatic secretion
cnl04973  Carbohydrate digestion and absorption
cnl05010  Alzheimer disease
cnl05016  Huntington disease
cnl05017  Spinocerebellar ataxia
cnl05022  Pathways of neurodegeneration - multiple diseases
cnl05142  Chagas disease
cnl05143  African trypanosomiasis
cnl05146  Amoebiasis
cnl05163  Human cytomegalovirus infection
cnl05200  Pathways in cancer
cnl05415  Diabetic cardiomyopathy
cnl05417  Lipid and atherosclerosis
Module
cnl_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cnl00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    130881178 (Plcb1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    130881178 (Plcb1)
   04310 Wnt signaling pathway
    130881178 (Plcb1)
   04371 Apelin signaling pathway
    130881178 (Plcb1)
   04020 Calcium signaling pathway
    130881178 (Plcb1)
   04070 Phosphatidylinositol signaling system
    130881178 (Plcb1)
   04072 Phospholipase D signaling pathway
    130881178 (Plcb1)
   04071 Sphingolipid signaling pathway
    130881178 (Plcb1)
   04022 cGMP-PKG signaling pathway
    130881178 (Plcb1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    130881178 (Plcb1)
   04081 Hormone signaling
    130881178 (Plcb1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    130881178 (Plcb1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    130881178 (Plcb1)
   04613 Neutrophil extracellular trap formation
    130881178 (Plcb1)
   04621 NOD-like receptor signaling pathway
    130881178 (Plcb1)
   04062 Chemokine signaling pathway
    130881178 (Plcb1)
  09152 Endocrine system
   04911 Insulin secretion
    130881178 (Plcb1)
   04922 Glucagon signaling pathway
    130881178 (Plcb1)
   04929 GnRH secretion
    130881178 (Plcb1)
   04912 GnRH signaling pathway
    130881178 (Plcb1)
   04915 Estrogen signaling pathway
    130881178 (Plcb1)
   04921 Oxytocin signaling pathway
    130881178 (Plcb1)
   04926 Relaxin signaling pathway
    130881178 (Plcb1)
   04935 Growth hormone synthesis, secretion and action
    130881178 (Plcb1)
   04918 Thyroid hormone synthesis
    130881178 (Plcb1)
   04919 Thyroid hormone signaling pathway
    130881178 (Plcb1)
   04928 Parathyroid hormone synthesis, secretion and action
    130881178 (Plcb1)
   04916 Melanogenesis
    130881178 (Plcb1)
   04924 Renin secretion
    130881178 (Plcb1)
   04925 Aldosterone synthesis and secretion
    130881178 (Plcb1)
   04927 Cortisol synthesis and secretion
    130881178 (Plcb1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    130881178 (Plcb1)
   04270 Vascular smooth muscle contraction
    130881178 (Plcb1)
  09154 Digestive system
   04970 Salivary secretion
    130881178 (Plcb1)
   04971 Gastric acid secretion
    130881178 (Plcb1)
   04972 Pancreatic secretion
    130881178 (Plcb1)
   04973 Carbohydrate digestion and absorption
    130881178 (Plcb1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    130881178 (Plcb1)
  09156 Nervous system
   04724 Glutamatergic synapse
    130881178 (Plcb1)
   04725 Cholinergic synapse
    130881178 (Plcb1)
   04728 Dopaminergic synapse
    130881178 (Plcb1)
   04726 Serotonergic synapse
    130881178 (Plcb1)
   04720 Long-term potentiation
    130881178 (Plcb1)
   04730 Long-term depression
    130881178 (Plcb1)
   04723 Retrograde endocannabinoid signaling
    130881178 (Plcb1)
  09157 Sensory system
   04742 Taste transduction
    130881178 (Plcb1)
   04750 Inflammatory mediator regulation of TRP channels
    130881178 (Plcb1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    130881178 (Plcb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    130881178 (Plcb1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    130881178 (Plcb1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    130881178 (Plcb1)
   05142 Chagas disease
    130881178 (Plcb1)
   05143 African trypanosomiasis
    130881178 (Plcb1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    130881178 (Plcb1)
   05016 Huntington disease
    130881178 (Plcb1)
   05017 Spinocerebellar ataxia
    130881178 (Plcb1)
   05022 Pathways of neurodegeneration - multiple diseases
    130881178 (Plcb1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    130881178 (Plcb1)
   05415 Diabetic cardiomyopathy
    130881178 (Plcb1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    130881178 (Plcb1)
   04934 Cushing syndrome
    130881178 (Plcb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cnl04131]
    130881178 (Plcb1)
Enzymes [BR:cnl01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     130881178 (Plcb1)
Membrane trafficking [BR:cnl04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    130881178 (Plcb1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    130881178 (Plcb1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 130881178
NCBI-ProteinID: XP_057636515
Position
9
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVSPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTSEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVEQMMDFINFKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYVSLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EAEPGETSSEAPSEARTTPAENGVNHTTSLAPKPPSQAPHSQPAPGSVKAPAKTEDLVQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTAELLKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILEEKP
KLQMELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPPSLASDPGKVNHRSPSS
EEVEVENPGKEFDTSL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggctggggcacagcccggagtgcacgccttgcaactcaagccagtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgattccactattgtttctcca
attattttgaggactgatcctcagggatttttcttttactggacagatcaaaacaaggag
acagagctgttagacctcagccttgtcaaggatgccaggtgtgggaaacatgccaaagct
cccaaggaccccaagttacgtgaactcctggatgttgggaacattgggcacctggagcag
cgcatgataacggtggtgtatggacctgacctggtgaacatctctcacttgaatctcgtg
gctttccaagaggaggtggccaaggaatggacaagtgaagttttcagtttggcaacaaat
ctgctggctcaaaacatgtccagagacgcatttctggagaaagcatataccaagctcaag
cttcaggtcactccggaagggcgcattcctctcaaaaacatctaccgattgttttcagca
gaccggaagcgagttgaaactgcactagaggcttgtagtcttccatcttcaaggaatgat
tccatacctcaagaggatttcactccagatgtatacagagttttcctgaacaacctttgt
ccccgacctgaaatcgataacatcttttctgaatttggtgccaaaagcaaaccgtacctt
accgtcgagcagatgatggacttcatcaactttaagcagagagatccccggctcaatgaa
atactttacccacctctgaagcaagagcaggtccaagtgttgattgagaagtatgagccc
aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaacgaagacatgtctcag
cccctgtctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctgggaactcctctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgcgtg
gagctggactgctggaagggaaggaccgcagaggaagagcccgtcatcacccatggattc
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc
aagacgtcaccttttcccatcctcctgtcctttgagaaccatgtggattccccaaagcag
caagccaagatggctgagtattgccgattaatctttggtgatgccctccttatggagcca
ctggaaaaatacccactggaatctggggtacctcttccgagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaaatcgcacaaatcgtcggagggaagtggtaaaaag
aagctctctgagcaagcctccaacacgtacagtgactcctccagcgtgttcgagccctcg
tctccaggagctggagaagcggatacggagagcgacgatgacgacgacgatgacgactgt
aaaaagtcttccatggatgaggggactgccggcagtgaggccatggccacagaagagatg
tctaacctcgtgaactatattcaacctgtcaagtttgagtcctttgaaatttcaaaaaag
agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggacttgagcaacttaca
aagtctccagtggaatttgtagaatacaacaagatgcaacttagcaggatctatcccaaa
ggaacacgcgtggactcctccaactacatgccccagctcttctggaatgctggctgccag
atggtggcactcaatttccagaccgtggacctggctatgcagatcaatatgggcatgtat
gagtacaatgggaagagcggctacaggctaaagccagagttcatgaggaggccggacaag
cattttgatccatttactgaaggaattgtagatgggatagtggccaacactctatccgtt
aagattatttcaggccagtttctttctgataagaaggttgggacttacgtggaggtggat
atgtttggtttacctgtggacacaaggagaaaggcttttaaaaccaagacatcccaggga
aatgctgtgaatcctgtctgggaggaagaacctattgtgtttaaaaaggtagttctgcct
tctctggcatgtttgaggatagcagcatatgaagaaggaggtaaatttattggccaccgg
atcttgcctgtgcaggctattcggccaggctatcactatgtctccctgcggaatgagagg
aaccagcccctgatgctgccagctgtctttgtctacatagaagtcaaagactatgtgcca
gacacatatgcagatgtcatcgaagctctgtcaaacccaattcggtatgtcaacctgatg
gagcagagagcgaagcagctggccgcattgacgctggaggatgaagaggaagtcaagaag
gaggctgagcctggggaaacgtcatcagaggcgccgagtgaagccaggacaacgcctgca
gaaaatggggtgaatcacacaacatcccttgcccccaaaccaccttcccaagctccacac
agccagccagctccaggttctgttaaggcgcccgccaaaacagaagatctggtccagagt
gtcttaacagaagtagaggcgcaaaccattgaagagctcaagcaacagaaatcgttcgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggtcaagagacaccacaagaaa
accgccgagctcctcaaggagcacaccaccaagtacaatgagattcagaatgactacctg
aggaggagagcagccttggaaaagtctgccaagaaggacagcaagaaaaaatctgaaccc
agcagccctgaccatggctcatcagccattgagcaagacctcgctgccctggatgcagaa
atgacccagaagttaatagacttgaaggacaagcagcagcagcagctgctcaacctccgg
caagaacagtattacagcgagaagtaccagaagcgagaacacattaagctgcttattcag
aagttgacagatgttgccgaggagtgtcagaacaaccagctcaagaagctcaaggagatc
tgcgagaaagagaagaaggagttaaagaagaaaatggataagaagaggcaggagaagata
acggaagccaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccgg
tcgtacatccaggaggtggtgcagtacatcaagaggttagaggaagcacaaagtaaaaga
caagaaaagcttgtggagaaacacaaggagatccgccagcagatcctagaggagaagccc
aagctgcagatggagctggagcaagaataccaagacaagttcaaaagactgcccctggag
attctggagtttgtacaggaggccatgaaagggaagatcagtgaagacagcaatcacggt
tccgcccctccctccctggcctcagaccctggaaaggtgaaccacaggtctccctccagt
gaggaagtggaagttgagaacccaggaaaggagtttgatacttctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (12)   

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