| Entry |
|
|---|
| Name |
Inotersen sodium (USAN);
Tegsedi (TN) |
|---|
| Formula |
C230H299N69O121P19S19. 19Na
|
|---|
| Exact mass |
7595.7129
|
|---|
| Mol weight |
7600.81
|
|---|
| Sequence |
DNA, d(P-thio) ([2'-O-(2-methoxyethyl)
]m5rU-[2'-O-(2-methoxyethyl) ]m5rC-[2'-O-(2-methoxyethyl)
]m5rU-[2'-O-(2-methoxyethyl) ]m5rU-[2'-O-(2-methoxyethyl)
]rG-G-T-T-A-m5C-A-T-G-A-A-[2'-O-(2-methoxyethyl)
]rA-[2'-O-(2-methoxyethyl) ]m5rU-[2'-O-(2-methoxyethyl)
]m5rC-[2'-O-(2-methoxyethyl) ]m5rC-[2'-O-(2-methoxyethyl) ]m5rC) |
|---|
| Type |
Nucleotide |
|---|
| Remark |
|
|---|
| Efficacy |
Neuroprotectant, Prealbumin expression inhibitor |
|---|
| Disease |
Hereditary transthyretin-mediated amyloidosis [DS: H00845] |
|---|
| Type |
Antisense oligonucleotide |
|---|
| Comment |
Hereditary ATTR amyloidosis treatment
|
|---|
| Target |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07X OTHER NERVOUS SYSTEM DRUGS
N07XX Other nervous system drugs
N07XX15 Inotersen
D10941 Inotersen sodium (USAN)
Target-based classification of drugs [BR:br08310]
Transporters
Other transporters
Others
TTR
D10941 Inotersen sodium (USAN)
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D10941
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10941
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D10941
|
|---|
| Other DBs |
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