KEGG   Desmodus rotundus (common vampire bat): 112304122
Entry
112304122         CDS       T05907                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
dro  Desmodus rotundus (common vampire bat)
Pathway
dro00562  Inositol phosphate metabolism
dro01100  Metabolic pathways
dro04015  Rap1 signaling pathway
dro04020  Calcium signaling pathway
dro04022  cGMP-PKG signaling pathway
dro04062  Chemokine signaling pathway
dro04070  Phosphatidylinositol signaling system
dro04071  Sphingolipid signaling pathway
dro04072  Phospholipase D signaling pathway
dro04081  Hormone signaling
dro04082  Neuroactive ligand signaling
dro04261  Adrenergic signaling in cardiomyocytes
dro04270  Vascular smooth muscle contraction
dro04310  Wnt signaling pathway
dro04371  Apelin signaling pathway
dro04540  Gap junction
dro04611  Platelet activation
dro04613  Neutrophil extracellular trap formation
dro04621  NOD-like receptor signaling pathway
dro04713  Circadian entrainment
dro04720  Long-term potentiation
dro04723  Retrograde endocannabinoid signaling
dro04724  Glutamatergic synapse
dro04725  Cholinergic synapse
dro04726  Serotonergic synapse
dro04728  Dopaminergic synapse
dro04730  Long-term depression
dro04742  Taste transduction
dro04750  Inflammatory mediator regulation of TRP channels
dro04911  Insulin secretion
dro04912  GnRH signaling pathway
dro04915  Estrogen signaling pathway
dro04916  Melanogenesis
dro04918  Thyroid hormone synthesis
dro04919  Thyroid hormone signaling pathway
dro04921  Oxytocin signaling pathway
dro04922  Glucagon signaling pathway
dro04924  Renin secretion
dro04925  Aldosterone synthesis and secretion
dro04926  Relaxin signaling pathway
dro04927  Cortisol synthesis and secretion
dro04928  Parathyroid hormone synthesis, secretion and action
dro04929  GnRH secretion
dro04933  AGE-RAGE signaling pathway in diabetic complications
dro04934  Cushing syndrome
dro04935  Growth hormone synthesis, secretion and action
dro04961  Endocrine and other factor-regulated calcium reabsorption
dro04970  Salivary secretion
dro04971  Gastric acid secretion
dro04972  Pancreatic secretion
dro04973  Carbohydrate digestion and absorption
dro05010  Alzheimer disease
dro05016  Huntington disease
dro05017  Spinocerebellar ataxia
dro05022  Pathways of neurodegeneration - multiple diseases
dro05142  Chagas disease
dro05143  African trypanosomiasis
dro05146  Amoebiasis
dro05163  Human cytomegalovirus infection
dro05200  Pathways in cancer
dro05415  Diabetic cardiomyopathy
dro05417  Lipid and atherosclerosis
Module
dro_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:dro00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112304122 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    112304122 (PLCB4)
   04310 Wnt signaling pathway
    112304122 (PLCB4)
   04371 Apelin signaling pathway
    112304122 (PLCB4)
   04020 Calcium signaling pathway
    112304122 (PLCB4)
   04070 Phosphatidylinositol signaling system
    112304122 (PLCB4)
   04072 Phospholipase D signaling pathway
    112304122 (PLCB4)
   04071 Sphingolipid signaling pathway
    112304122 (PLCB4)
   04022 cGMP-PKG signaling pathway
    112304122 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    112304122 (PLCB4)
   04081 Hormone signaling
    112304122 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112304122 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112304122 (PLCB4)
   04613 Neutrophil extracellular trap formation
    112304122 (PLCB4)
   04621 NOD-like receptor signaling pathway
    112304122 (PLCB4)
   04062 Chemokine signaling pathway
    112304122 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    112304122 (PLCB4)
   04922 Glucagon signaling pathway
    112304122 (PLCB4)
   04929 GnRH secretion
    112304122 (PLCB4)
   04912 GnRH signaling pathway
    112304122 (PLCB4)
   04915 Estrogen signaling pathway
    112304122 (PLCB4)
   04921 Oxytocin signaling pathway
    112304122 (PLCB4)
   04926 Relaxin signaling pathway
    112304122 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    112304122 (PLCB4)
   04918 Thyroid hormone synthesis
    112304122 (PLCB4)
   04919 Thyroid hormone signaling pathway
    112304122 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    112304122 (PLCB4)
   04916 Melanogenesis
    112304122 (PLCB4)
   04924 Renin secretion
    112304122 (PLCB4)
   04925 Aldosterone synthesis and secretion
    112304122 (PLCB4)
   04927 Cortisol synthesis and secretion
    112304122 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112304122 (PLCB4)
   04270 Vascular smooth muscle contraction
    112304122 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    112304122 (PLCB4)
   04971 Gastric acid secretion
    112304122 (PLCB4)
   04972 Pancreatic secretion
    112304122 (PLCB4)
   04973 Carbohydrate digestion and absorption
    112304122 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    112304122 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    112304122 (PLCB4)
   04725 Cholinergic synapse
    112304122 (PLCB4)
   04728 Dopaminergic synapse
    112304122 (PLCB4)
   04726 Serotonergic synapse
    112304122 (PLCB4)
   04720 Long-term potentiation
    112304122 (PLCB4)
   04730 Long-term depression
    112304122 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    112304122 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    112304122 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    112304122 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    112304122 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112304122 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    112304122 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112304122 (PLCB4)
   05142 Chagas disease
    112304122 (PLCB4)
   05143 African trypanosomiasis
    112304122 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112304122 (PLCB4)
   05016 Huntington disease
    112304122 (PLCB4)
   05017 Spinocerebellar ataxia
    112304122 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    112304122 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112304122 (PLCB4)
   05415 Diabetic cardiomyopathy
    112304122 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    112304122 (PLCB4)
   04934 Cushing syndrome
    112304122 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dro04131]
    112304122 (PLCB4)
Enzymes [BR:dro01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     112304122 (PLCB4)
Membrane trafficking [BR:dro04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    112304122 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    112304122 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 112304122
NCBI-ProteinID: XP_024415514
Position
Unknown
AA seq 1212 aa
MVLNIIMAKPYEFNWQKEVPSFLQEGAIFDRYEEESFLFEPNCLFKVDEFGFFLTWKSEG
KEGQVLECSLINSIRLGATPKDPKILAALEAVGKSESDLEGRIVCVCSGTDLVNISFTYM
VAENLEVTKQWVDGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFA
SGKTEKVIFQALKELGLPSGKNDEIEPAAFTFEKFYELTQKICPRTDIEDLFKKINGDKT
DYLTVDQLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDLKQKGLISSDGFCR
YLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYKQVLLAGC
RCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSK
YQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEQKQL
EALKSMMEAGESAAPVNILEDYNEEETENADQEEEAHPEYKYGNELSADDLGHKEAVANS
VKKVSDDLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHV
AEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNA
GCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAAT
CSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKV
ILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKT
YVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAK
TNVTPQSSSELRPTTTTALGSGMEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSL
KKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKI
QTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQT
QQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEER
KRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQ
TSNSSVKLQNTN
NT seq 3639 nt   +upstreamnt  +downstreamnt
atggtcttgaatataatcatggccaaaccttatgaatttaactggcagaaggaagttcct
tcctttttgcaagaaggagcaatttttgacagatatgaagaggaatcctttctgtttgaa
cccaactgcctcttcaaagtggatgaatttggcttctttctgacctggaaaagtgaaggc
aaggaaggacaagtgctagaatgctccctcatcaacagtattcggttgggagccacacca
aaggatcccaaaatcctggctgcccttgaagctgttggaaaatcagaaagtgatctggaa
gggcggatagtttgtgtctgcagtggaacggatctggtgaacatcagtttcacgtacatg
gtggctgaaaacctagaagtgactaagcaatgggtagatggcctaagatcaatcatacac
aacttcagggccaacaacgtcagtccgatgacatgcctcaagaaacactggatgaaattg
gcatttatgaccaacacaaatggtaaaatcccagttaggagtattactagaacctttgca
tcggggaaaacagaaaaggtgatctttcaagcactgaaggagttaggtcttcccagtgga
aagaatgatgaaattgagcctgcagcttttacttttgaaaagttctatgaactgacacaa
aagatttgtcctcggacagatatagaggatctttttaaaaaaatcaatggagacaaaact
gattatttaacggtagaccaattagtgagctttctaaatgaacatcaacgagaccctcga
ctgaatgaaattttattcccgttttacgacactaaaagggcaatgcagatcattgagatg
tatgagcctgatgaagacttgaagcaaaaaggccttatatcaagtgatggattttgcaga
tatctgatgtcagatgaaaatgcacccgtcttcctagatcgtttagaactttaccaagaa
atggaccatcctctggctcactacttcatcagttcttcccacaacacctatctcactggc
cgacaattcggcgggaaatcttcagtagaaatgtataaacaggttctcctggctgggtgc
agatgtgtggaactcgactgctgggatgggaagggcgaagaccaggaaccaataataact
cacgggaaagcgatgtgcacagatatcctcttcaaggatgttattcaagccatcaaggaa
actgcatttgtcacatctgaatatcctgtaattctctcctttgaaaatcactgcagcaaa
tatcaacagtacaagatgtccaaatattgcgaagatctatttggggatctcctgttgaaa
caagcactcgaatcccatccactcgaaccaggcaggccgttgccatcccccaatgacctc
aaaagaaaaatactcatcaaaaataaacgactgaaacctgaggttgaacaaaagcagctc
gaagctttgaaaagcatgatggaagctggagaatccgctgctccagttaacatcttagag
gattacaatgaggaggaaacagaaaatgctgaccaagaagaagaagctcaccctgaatac
aaatatggaaatgaactttctgctgatgacttgggtcacaaggaagctgttgcaaatagt
gtcaagaaggtttctgatgaccttgaacatgaaatcaacaaaaagggcctggttactgta
gaagatgagcaggcatggatggcatcttataaatatgtaggtgctaccaccaatatccat
ccatatttgtccacaatgatcaactatgcacagcccgtgaagtttcaaggtttccacgtt
gctgaagaacgcaatattcattataacatgtcttcttttaacgagtccgtcggtctaggc
tacttgaagacacacgcgattgaatttgtgaattataacaaacggcaaatgagtcgcatt
taccccaagggaggccgagtcgattccagtaattacatgcctcagattttctggaacgct
ggctgccagatggtttcactgaactatcaaaccccagatttagcgatgcaattgaatcag
gggaaatttgagtataatggatcgtgcgggtaccttctcaaaccagatttcatgagacgg
cctgatcgaacgtttgatcctttctctgagacccctgtcgatggggttattgcagccacg
tgctcagtgcaggtcatatcaggccaattcttatcagataagaaaatcggcacatatgta
gaagtggacatgtatgggctgcccacagacactatacgtaaggaattccgaactcgcatg
gtgatgaacaacggactcaatccggtttacaatgaagaatcattcgtgtttcggaaggta
atcctccctgacctggcagtcttgagaatagcagtgtatgatgacaacaacaagctcatt
ggccagaggattctcccactggacggcctccaagccggctatcgacacatttcccttcga
aatgaggggaataaacctttatcactgccaacaattttctgcaatattgttcttaaaaca
tatgtgcctgatggatttggagatattgtggatgctttatcagatccaaagaagtttctt
tcaattacggaaaaaagagcagaccaaatgagagctatgggcatcgaaactagtgacata
gccgatgtgcccagtgacacttctaagaatgacaagaaaggaaaggccaacactgccaaa
acaaatgtgactccgcagagcagctctgaactcagaccaaccaccacgaccgccctgggg
tctggcatggaagccaaaaaaggtattgaacttatccctcaagtgaggatagaagattta
aagcagatgaaggcttacttgaagcatttaaagaaacagcagaaggaattaaattcttta
aaaaagaaacatgcaaaggagcacagtaccatgcagaagttacactgcacacaagtggac
aaaattgtggcccagtacgacaaagagaagtccactcatgaaaaaatcctggagaaggca
atgaagaagaaagggggaagtaattgtcttgaaatgaaaaaagaaacagaaattaaaatt
cagacactgacatcagatcacaaatctaaggtcaaggagattgtggcacagcacacaaaa
gagtggtcagagatgatcaacacgcacagcgctgaggagcaggaaatccgggacctgcac
ctgagccagcagtgcgagctgctgagaaagctcctgatcaacgcccatgagcagcaaacc
cagcagctgaaactgtcccatgacagggaaagcaaggaaatgagagcacaccaggctaag
atctctatggaaaatagcaaagccatcagccaagataaatctatcaagaacaaagcagaa
cgggaaaggcgagtcagggagttaaacagcagcaacactaaaaagtttctggaagaaaga
aagagactcgcaatgaaacagtccaaagaaatggatcagttgaaaaaagtccagcttgaa
cacctagagttcctagagaagcaaaacgagcagcttttgaaatcctgtcatgcagtgtcc
caaactcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatggaccgcag
accagcaacagtagtgtgaaactccagaacacaaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (24)   
   RefSeq(pep) (24)   
DNA sequence (24)   
   RefSeq(nuc) (24)   
Protein domain (9)   
   Pfam (9)   
All databases (59)   

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