KEGG   DISEASE: Botulism
Entry
H00339                      Disease                                

Name
Botulism
  Supergrp
Anaerobic infection [DS:H01410]
Description
Botulism is an acute neuroparalytic illness caused by a botulinum toxin produced by Clostridium botulinum, an anaerobic, gram-positive bacterium. Botulism occurs in four forms: foodborne, wound, infant botulism, and adult intestinal toxemia. Botulinum toxin blocks acetylcholine release in a dose-dependent fashion, resulting in symmetrical, descending, and progressive muscle weakness. Delay in treatment may allow progression of paralysis.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by Gram-positive bacteria
   H00339  Botulism
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Gastroenteritis or colitis of infectious origin
   Bacterial foodborne intoxications
    1A11  Botulism
     H00339  Botulism
Pathogen
Clostridium botulinum [GN:cbo cba cbh cby cbl cbb cbi cbt cbf cbm cbj]
Clostridium butyricum
Clostridium baratii
botulinum neurotoxin (BoNT) [KO:K06011]
hyaluronidase/collagenase [KO:K01387 K08587]
pore-forming toxin [KO:K06442 K11068]
Drug
Penicillin G potassium [DR:D01053]
Penicillin G sodium [DR:D05408]
Other DBs
ICD-11: 1A11
ICD-10: A05.1
MeSH: D001906
MedlinePlus: 000598
Reference
  Authors
Zhang JC, Sun L, Nie QH
  Title
Botulism, where are we now?
  Journal
Clin Toxicol (Phila) 48:867-79 (2010)
DOI:10.3109/15563650.2010.535003
Reference
  Authors
Dembek ZF, Smith LA, Rusnak JM
  Title
Botulism: cause, effects, diagnosis, clinical and laboratory identification, and treatment modalities.
  Journal
Disaster Med Public Health Prep 1:122-34 (2007)
DOI:10.1097/DMP.0b013e318158c5fd
Reference
  Authors
Brook I
  Title
Botulism: the challenge of diagnosis and treatment.
  Journal
Rev Neurol Dis 3:182-9 (2006)
Reference
  Authors
Chalk C, Benstead TJ, Keezer M
  Title
Medical treatment for botulism.
  Journal
Cochrane Database Syst Rev CD008123 (2011)
DOI:10.1002/14651858.CD008123.pub2
Reference
  Authors
Robinson RF, Nahata MC
  Title
Management of botulism.
  Journal
Ann Pharmacother 37:127-31 (2003)
DOI:10.1345/aph.1C034

» Japanese version

DBGET integrated database retrieval system