KEGG   DISEASE: Relapsing fever
Entry
H00427                      Disease                                

Name
Relapsing fever
Description
Relapsing fever is a bacterial infectious disease caused by spirochaetes belonging to the genus Borrelia and is transmitted by ticks or lice. Louse-borne relapsing fever is now geographically limited, but tick-borne relapsing fever still causes major health problems in Africa. The symptoms are variable. Although relapsing fever is considered a transient disease, it persists as a residual infection in the brain, which can be reactivated on immunosuppression.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by spirochaetes
   H00427  Relapsing fever
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   1C1J  Relapsing fever
    H00427  Relapsing fever
Pathogen
Borrelia recurrentis [GN:bre] (Louse-borne relapsing fever)
Borrelia duttonii [GN:bdu] (Tick-borne relapsing fever)
Borrelia hermsii [GN:bhr] (Tick-borne relapsing fever)
Borrelia turicatae [GN:btu] (Tick-borne relapsing fever)
Borrelia crocidurae [GN:bcw] (Tick-borne relapsing fever)
Drug
Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Demeclocycline hydrochloride [DR:D00290]
Comment
Vectors: Pediculus humanus (body louse), Ornithodoros moubata (African tick)
Other DBs
ICD-11: 1C1J
ICD-10: A68
MeSH: D012061
MedlinePlus: 001350
Reference
  Authors
Cutler SJ
  Title
Relapsing fever--a forgotten disease revealed.
  Journal
J Appl Microbiol 108:1115-22 (2010)
DOI:10.1111/j.1365-2672.2009.04598.x
Reference
  Authors
Larsson C, Andersson M, Bergstrom S
  Title
Current issues in relapsing fever.
  Journal
Curr Opin Infect Dis 22:443-9 (2009)
DOI:10.1097/QCO.0b013e32832fb22b
Reference
  Authors
Cutler SJ
  Title
Possibilities for relapsing fever reemergence.
  Journal
Emerg Infect Dis 12:369-74 (2006)
DOI:10.3201/eid1205.050899

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