KEGG   DISEASE: 小細胞肺癌
エントリ  
H00013                                                             

名称    
小細胞肺癌
概要    
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  肺および胸膜のがん
   H00013  小細胞肺癌
ICD-11 による疾患分類 [BR:jp08403]
 02 Neoplasms
  Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of middle ear, respiratory or intrathoracic organs
     2C25  Malignant neoplasms of bronchus or lung
      H00013  小細胞肺癌
パスウェイ 
hsa05222  小細胞肺癌
関連パスウェイ
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
ネットワーク
nt06267  Small cell lung cancer
  エレメント
N00051  Deleted PTEN to PI3K signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00074  Loss of RB1 to cell cycle G1/S
N00075  Mutation-inactivated RB1 to cell cycle G1/S
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00100  BCL2-overexpression to intrinsic apoptotic pathway
N00115  Mutation-inactivated TP53 to transcription
病因遺伝子 
c-MYC (amplification) [HSA:4609] [KO:K04377]
RAR-beta (promoter hypermethylation) [HSA:5915] [KO:K08528]
FHIT (mutation) [HSA:2272] [KO:K01522]
p53 (LOH, mutation) [HSA:7157] [KO:K04451]
RB1 (LOH, mutation) [HSA:5925] [KO:K06618]
PTEN (mutation, deletion) [HSA:5728] [KO:K01110]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
発癌物質  
Arsenic and arsenic compounds [CPD:C06269]
Asbestos [CPD:C16442]
Beryllium and beryllium compounds [CPD:C16460]
Bis(chloromethyl)ether and chloromethyl methyl ether (technical-grade)
N'-Nitrosonornicotine (NNN) and 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone(NNK) [CPD:C16452 C16453]
Radon-222 and its decay products
Silica, crystalline (inhaled in the form of quartz orcristobalite from occupational sources) [CPD:C16459]
Tobacco smoking and tobacco smoke
*Aluminium production
*Benzo[a]pyrene [CPD:C07535]
*Cadmium and cadmium compounds
*Chimney sweeping
*Coal gasification
*Coal-tar pitches [CPD:C16451]
*Coal-tars
*Coke production
*Furniture and cabinet making
*Haematite mining (underground) with exposure to radon
*Household combustion of coal, indoor emissions from
*Involuntary smoking (exposure to secondhand or environmental tobacco smoke)
*Iron and steel founding
*Mineral oils, untreated and mildly treated
*Painter (occupational exposure as a)
*Paving and roofing with coal-tar pitch
*Shale-oils [CPD:C16458]
*Soots
*Strong-inorganic-acid mists containing sulfuric acid
*Talc containing asbestiform fibres
*2,3,7,8-Tetrachlorodibenzo-para-dioxin
*X- and gamma-radiation
*: Although this is a risk factor for lung cancer in general, the strength of association with different histological tumor types is not well understood.
治療薬   
シクロホスファミド水和物 [DR:D00287]
イホスファミド [DR:D00343]
ニムスチン塩酸塩 [DR:D01059]
フルオロウラシル [DR:D00584]
シタラビン [DR:D00168]
テガフール・ウラシル [DR:D02131]
マイトマイシンC [DR:D00208]
ブレオマイシン塩酸塩 [DR:D03229]
ドキソルビシン塩酸塩 [DR:D01275]
アクラルビシン塩酸塩 [DR:D01911]
アムルビシン塩酸塩 [DR:D07100]
ビンデシン硫酸塩 [DR:D01769]
エトポシド [DR:D00125]
ノギテカン塩酸塩 [DR:D02168]
イリノテカン塩酸塩水和物 [DR:D01061]
シスプラチン [DR:D00275]
カルボプラチン [DR:D01363]
デュルバルマブ [DR:D10808]
アテゾリズマブ [DR:D10773]
ネダプラチン [DR:D01416]
ポルフィマーナトリウム [DR:D03327]
タラポルフィンナトリウム [DR:D01985]
ストレプトコックス・ピオゲネス(A群3型)Su株ペニシリン処理凍結乾燥粉末 [DR:D08756]
コメント  
ICD-O: 8041/3, Tumor type: Small cell carcinoma
リンク   
ICD-11: 2C25.1
ICD-10: C34
MeSH: D055752
文献    
PMID:12741677 (gene, tumor type)
  著者
Yokota J, Nishioka M, Tani M, Kohno T.
  タイトル
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  雑誌
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
文献    
PMID:12711111 (tumor type)
  著者
Sanchez-Cespedes M.
  タイトル
Dissecting the genetic alterations involved in lung carcinogenesis.
  雑誌
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
文献    
  著者
Mitsuuchi Y, Testa JR.
  タイトル
Cytogenetics and molecular genetics of lung cancer.
  雑誌
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
文献    
  著者
Panani AD, Roussos C.
  タイトル
Cytogenetic and molecular aspects of lung cancer.
  雑誌
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
文献    
PMID:15322513 (carcinogen)
  著者
Boffetta P.
  タイトル
Epidemiology of environmental and occupational cancer.
  雑誌
Oncogene 23:6392-403 (2004)
DOI:10.1038/sj.onc.1207715
文献    
PMID:2831418 (carcinogen)
  著者
Adachi S, Takemoto K.
  タイトル
[Occupational lung cancer. A comparison between humans and experimental animals]
  雑誌
Sangyo Igaku 29:345-57 (1987)
DOI:10.1539/joh1959.29.345
文献    
PMID:17375514 (carcinogen)
  著者
O'Reilly KM, Mclaughlin AM, Beckett WS, Sime PJ.
  タイトル
Asbestos-related lung disease.
  雑誌
Am Fam Physician 75:683-8 (2007)
文献    
PMID:15660110 (carcinogen)
  著者
Luch A.
  タイトル
Nature and nurture - lessons from chemical carcinogenesis.
  雑誌
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
文献    
PMID:12082370 (carcinogen)
  著者
Gottschall EB.
  タイトル
Occupational and environmental thoracic malignancies.
  雑誌
J Thorac Imaging 17:189-97 (2002)
DOI:10.1097/00005382-200207000-00003
文献    
PMID:17630920 (carcinogen)
  著者
Grozio A, Catassi A, Cavalieri Z, Paleari L, Cesario A, Russo P.
  タイトル
Nicotine, lung and cancer.
  雑誌
Anticancer Agents Med Chem 7:461-6 (2007)
DOI:10.2174/187152007781058587
文献    
PMID:10076528 (carcinogen)
  著者
Schuller HM, Orloff M.
  タイトル
Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells.
  雑誌
Biochem Pharmacol 55:1377-84 (1998)
DOI:10.1016/S0006-2952(97)00651-5
文献    
PMID:16155477 (carcinogen)
  著者
Graff JJ, Sathiakumar N, Macaluso M, Maldonado G, Matthews R, Delzell E.
  タイトル
Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality.
  雑誌
J Occup Environ Med 47:916-32 (2005)
DOI:10.1097/01.jom.0000172866.16615.db
文献    
PMID:16299089 (carcinogen)
  著者
Sathiakumar N, Graff J, Macaluso M, Maldonado G, Matthews R, Delzell E.
  タイトル
An updated study of mortality among North American synthetic rubber industry workers.
  雑誌
Occup Environ Med 62:822-9 (2005)
DOI:10.1136/oem.2004.018176
文献    
PMID:11886955 (carcinogen)
  著者
Verma DK, Purdham JT, Roels HA.
  タイトル
Translating evidence about occupational conditions into strategies for prevention.
  雑誌
Occup Environ Med 59:205-13; quiz 214 (2002)
DOI:10.1136/oem.59.3.156
文献    
PMID:9358915 (carcinogen)
  著者
Honma K, Chiyotani K, Kimura K.
  タイトル
Silicosis, mixed dust pneumoconiosis, and lung cancer.
  雑誌
文献    
PMID:15489140 (carcinogen)
  著者
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.
  タイトル
Environmental and chemical carcinogenesis.
  雑誌
Semin Cancer Biol 14:473-86 (2004)
DOI:10.1016/j.semcancer.2004.06.010
文献    
PMID:15552776 (carcinogen)
  著者
Sasco AJ, Secretan MB, Straif K.
  タイトル
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
  雑誌
Lung Cancer 45 Suppl 2:S3-9 (2004)
DOI:10.1016/j.lungcan.2004.07.998
文献    
PMID:9498904 (carcinogen)
  著者
Boffetta P, Jourenkova N, Gustavsson P.
  タイトル
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons.
  雑誌
Cancer Causes Control 8:444-72 (1997)
DOI:10.1023/a:1018465507029
文献    
PMID:17530489 (carcinogen)
  著者
Abnet CC.
  タイトル
Carcinogenic food contaminants.
  雑誌
Cancer Invest 25:189-96 (2007)
DOI:10.1080/07357900701208733
文献    
PMID:17589590 (carcinogen)
  著者
Zhang JJ, Smith KR.
  タイトル
Household air pollution from coal and biomass fuels in china: measurements, health impacts, and interventions.
  雑誌
Environ Health Perspect 115:848-55 (2007)
DOI:10.1289/ehp.9479
文献    
PMID:17882278 (carcinogen)
  著者
Sun S, Schiller JH, Gazdar AF.
  タイトル
Lung cancer in never smokers--a different disease.
  雑誌
Nat Rev Cancer 7:778-90 (2007)
DOI:10.1038/nrc2190
文献    
PMID:10723042 (carcinogen)
  著者
Stern FB, Ruder AM, Chen G.
  タイトル
Proportionate mortality among unionized roofers and waterproofers.
  雑誌
文献    
PMID:17032693 (carcinogen)
  著者
Hsu YM, Wu CY, Lundgren DA, Birky BK.
  タイトル
Size-resolved sulfuric acid mist concentrations at phosphate fertilizer manufacturing facilities in Florida.
  雑誌
Ann Occup Hyg 51:81-9 (2007)
DOI:10.1093/annhyg/mel066
文献    
PMID:9498905 (carcinogen)
  著者
Blair A, Kazerouni N.
  タイトル
Reactive chemicals and cancer.
  雑誌
Cancer Causes Control 8:473-90 (1997)
DOI:10.1023/a:1018417623867
文献    
PMID:15070562 (carcinogen)
  著者
Berrington de Gonzalez A, Darby S.
  タイトル
Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries.
  雑誌
Lancet 363:345-51 (2004)
DOI:10.1016/S0140-6736(04)15433-0

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