KEGG   DISEASE: 胃癌
エントリ  
H00018                                                             

名称    
胃癌
概要    
Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological classification gastric cancer is divided into two distinct histological groups - the intestinal and diffuse types. Several genetic changes have been identified in intestinal-type GC. The intestinal metaplasia is characterized by mutations in p53 gene, reduced expression of retinoic acid receptor beta (RAR-beta) and hTERT expression. Gastric adenomas furthermore display mutations in the APC gene, reduced p27 expression and cyclin E amplification. In addition, amplification and overexpression of c-ErbB2, reduced TGF-beta receptor type I (TGFBRI) expression and complete loss of p27 expression are commonly observed in more advanced GC. The main molecular changes observed in diffuse-type GCs include loss of E-cadherin function by mutations in CDH1and amplification of MET and FGFR2F.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  消化器系のがん
   H00018  胃癌
ICD-11 による疾患分類 [BR:jp08403]
 02 Neoplasms
  Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of digestive organs
     2B72  Malignant neoplasms of stomach
      H00018  胃癌
パスウェイ 
hsa05226  胃癌
関連パスウェイ
hsa05200  Pathways in cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
ネットワーク
nt06261  Gastric cancer
  エレメント
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00115  Mutation-inactivated TP53 to transcription
N00240  TERT-overexpression to telomerase activity
N00250  CDX2-overexpression to transcriptional activation
N00251  CDX2-overexpression to transcriptional repression
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00254  CDKN1B-reduced expression to p27-cell cycle G1/S
N00255  Amplified CCNE to cell cycle G1/S
N00256  TGFBR1-reduced expression to TGF-beta signaling pathway
N00257  Loss of CDH1 to beta-catenin signaling pathway
N00258  Mutation-inactivated CDH1 to beta-catenin signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00260  Amplified MET to PI3K signaling pathway
病因遺伝子 
CDX2 (overexpression) [HSA:1045] [KO:K22234]
p53 (mutation) [HSA:7157] [KO:K04451]
RARB (reduced expression) [HSA:5915] [KO:K08528]
APC (mutation) [HSA:324] [KO:K02085]
CTNNB1 (mutation) [HSA:1499] [KO:K02105]
TERT (overexpression) [HSA:7015] [KO:K11126]
ERBB2 (amplification) [HSA:2064] [KO:K05083]
KRAS (mutation) [HSA:3845] [KO:K07827]
NRAS (mutation) [HSA:4893] [KO:K07828]
MLH1 (methylation) [HSA:4292] [KO:K08734]
CDKN1B (reduced expression) [HSA:1027] [KO:K06624]
CCNE1 (amplification) [HSA:898] [KO:K06626]
TGFBR1 (reduced expression) [HSA:7046] [KO:K04674]
CDH1 (mutation) [HSA:999] [KO:K05689]
MET (amplification) [HSA:4233] [KO:K05099]
FGFR2 (amplification) [HSA:2263] [KO:K05093]
発癌物質  
Benzo[a]pyrene [CPD:C07535]
病原体   
Helicobacter pylori (infection with)
治療薬   
レボホリナートカルシウム [DR:D04715]
メトトレキサート [DR:D00142]
シクロホスファミド水和物 [DR:D00287]
ニムスチン塩酸塩 [DR:D01059]
フルオロウラシル [DR:D00584]
テガフール [DR:D01244]
カペシタビン [DR:D01223]
ドキシフルリジン [DR:D01309]
シタラビン [DR:D00168]
テガフール・ウラシル [DR:D02131]
テガフール・ギメラシル・オテラシルカリウム [DR:D06399]
マイトマイシンC [DR:D00208]
ドキソルビシン塩酸塩 [DR:D01275]
エピルビシン塩酸塩 [DR:D02214]
アクラルビシン塩酸塩 [DR:D01911]
ピラルビシン塩酸塩 [DR:D08386]
パクリタキセル [DR:D00491]
ドセタキセル水和物 [DR:D02165]
ドセタキセル [DR:D07866]
イリノテカン塩酸塩水和物 [DR:D01061]
シスプラチン [DR:D00275]
オキサリプラチン [DR:D01790]
トラスツズマブ [DR:D03257] (HER2過剰発現)
ニボルマブ [DR:D10316]
ラムシルマブ [DR:D09371]
トラスツズマブデルクステカン [DR:D11529] (HER2陽性)
トリフルリジン・チピラシル塩酸塩 [DR:D10526]
ポルフィマーナトリウム [DR:D03327]
レンチナン [DR:D01695]
ストレプトコックス・ピオゲネス(A群3型)Su株ペニシリン処理凍結乾燥粉末 [DR:D08756]
コメント  
ICD-O: 8140/3, Tumor type: Adenocarcinoma
ICD-O: 8144/3, Tumor type: intestinal type
ICD-O: 8145/3, Tumor type: diffuse type
リンク   
ICD-11: 2B72.0
ICD-10: C16
MeSH: D013274
文献    
PMID:11315254 (gene, tumor type)
  著者
Werner M, Becker KF, Keller G, Hofler H.
  タイトル
Gastric adenocarcinoma: pathomorphology and molecular pathology.
  雑誌
J Cancer Res Clin Oncol 127:207-16 (2001)
DOI:10.1007/s004320000195
文献    
PMID:15224192 (gene, tumor type)
  著者
Zheng L, Wang L, Ajani J, Xie K.
  タイトル
Molecular basis of gastric cancer development and progression.
  雑誌
Gastric Cancer 7:61-77 (2004)
DOI:10.1007/s10120-004-0277-4
文献    
  著者
Tan P, Yeoh KG
  タイトル
Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma.
  雑誌
Gastroenterology 149:1153-1162.e3 (2015)
DOI:10.1053/j.gastro.2015.05.059
文献    
  著者
Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
  タイトル
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
  雑誌
Oncotarget 6:24750-79 (2015)
DOI:10.18632/oncotarget.4990
文献    
  著者
Stock M, Otto F
  タイトル
Gene deregulation in gastric cancer.
  雑誌
Gene 360:1-19 (2005)
DOI:10.1016/j.gene.2005.06.026
文献    
  著者
Panani AD
  タイトル
Cytogenetic and molecular aspects of gastric cancer: clinical implications.
  雑誌
Cancer Lett 266:99-115 (2008)
DOI:10.1016/j.canlet.2008.02.053
文献    
  著者
Vauhkonen M, Vauhkonen H, Sipponen P
  タイトル
Pathology and molecular biology of gastric cancer.
  雑誌
Best Pract Res Clin Gastroenterol 20:651-74 (2006)
DOI:10.1016/j.bpg.2006.03.016
文献    
PMID:15760280 (carcinogen)
  著者
Schottenfeld D, Beebe-Dimmer JL.
  タイトル
Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions.
  雑誌
Annu Rev Public Health 26:37-60 (2005)
DOI:10.1146/annurev.publhealth.26.021304.144402
文献    
PMID:15660110 (carcinogen)
  著者
Luch A.
  タイトル
Nature and nurture - lessons from chemical carcinogenesis.
  雑誌
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546

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