KEGG   DISEASE: 脂漏性皮膚炎
エントリ  
H01652                                                             
名称    
脂漏性皮膚炎
概要    
Seborrheic dermatitis (SD) is a common inflammatory dermatological disorder. The characteristic symptoms include scaling, erythema, and itching, which occur most often on the scalp, face, chest, back, axilla, and groin. Its incidence peaks during three age periods: in the first three months of life, during puberty, and in adulthood with an apex at 40 to 60 years of age. The cause of SD is unknown and the disease seems to be multifactorial. Malassezia yeasts are considered to play an important role. They cause an inflammatory reaction that seems to be mediated by free fatty acids, released from sebaceous triglycerides by fungal enzymes such as lipases. The lipid layer of Malassezia can also modulate pro-inflammatory cytokine production by keratinocytes. Although it can be associated with human immunodeficiency virus infection and neurologic disease (e.g., cerebrovascular event, Parkinson disease), SD typically occurs in healthy persons. Its prevalence is 1% to 3% in the general population and 34% to 83% in immunocompromised persons. Topical antifungal agents are the first-line therapy for acute and long-term treatment of SD of the face and body. Treatment includes over-the-counter shampoos and topical antifungals, calcineurin inhibitors, and corticosteroids.
カテゴリ  
皮膚および結合組織疾患
階層分類  
ヒト疾患 [BR:jp08402]
 皮膚疾患
  皮膚と軟部組織の疾患
   H01652  脂漏性皮膚炎
ICD-11 による疾患分類 [BR:jp08403]
 14 皮膚の疾患
  炎症性皮膚症
   皮膚炎及び湿疹
    EA81  脂漏性皮膚炎及び関連病状
     H01652  脂漏性皮膚炎
病原体   
Malassezia globosa [GN:mgl]
Malassezia restricta [GN:mrt]
治療薬   
デキサメタゾン [DR:D00292]
デキサメタゾンリン酸エステルナトリウム [DR:D00975]
ベタメタゾンリン酸エステルナトリウム [DR:D00972]
トリアムシノロンアセトニド [DR:D00983]
ヒドロコルチゾン [DR:D00088]
ヒドロコルチゾンコハク酸エステルナトリウム [DR:D00978]
コルチゾン酢酸エステル [DR:D00973]
トリアムシノロン [DR:D00385]
ベタメタゾン [DR:D00244]
プレドニゾロン [DR:D00472]
プレドニゾロンコハク酸エステルナトリウム [DR:D01239]
メチルプレドニゾロン [DR:D00407]
メチルプレドニゾロン酢酸エステル [DR:D00979]
レゾルシン [DR:D00133]
ヒドロコルチゾン酪酸エステル [DR:D01619]
ベタメタゾン酪酸エステルプロピオン酸エステル [DR:D02032]
ジフロラゾン酢酸エステル [DR:D01327]
ジフルプレドナート [DR:D01266]
デプロドンプロピオン酸エステル [DR:D01434]
ベタメタゾン吉草酸エステル・ゲンタマイシン硫酸塩 [DR:D04773]
ウフェナマート [DR:D01823]
ケトコナゾール [DR:D00351]
イオウ [DR:D00024]
カルプロニウム塩化物 [DR:D01175]
ピリドキシン塩酸塩 [DR:D02179]
ビオチン [DR:D00029]
リンク   
ICD-11: EA81
ICD-10: L21
MeSH: D012628
文献    
  著者
Borda LJ, Wikramanayake TC
  タイトル
Seborrheic Dermatitis and Dandruff: A Comprehensive Review.
  雑誌
J Clin Investig Dermatol 3 (2015)
DOI:10.13188/2373-1044.1000019
文献    
  著者
Naldi L, Diphoorn J
  タイトル
Seborrhoeic dermatitis of the scalp.
  雑誌
BMJ Clin Evid 2015:1713 (2015)
文献    
  著者
Clark GW, Pope SM, Jaboori KA
  タイトル
Diagnosis and treatment of seborrheic dermatitis.
  雑誌
Am Fam Physician 91:185-90 (2015)

» English version

DBGET integrated database retrieval system