KEGG   Dipodomys spectabilis (banner-tailed kangaroo rat): 122114401
Entry
122114401         CDS       T07891                                 
Symbol
Plcb2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
dsp  Dipodomys spectabilis (banner-tailed kangaroo rat)
Pathway
dsp00562  Inositol phosphate metabolism
dsp01100  Metabolic pathways
dsp04015  Rap1 signaling pathway
dsp04020  Calcium signaling pathway
dsp04022  cGMP-PKG signaling pathway
dsp04062  Chemokine signaling pathway
dsp04070  Phosphatidylinositol signaling system
dsp04071  Sphingolipid signaling pathway
dsp04072  Phospholipase D signaling pathway
dsp04081  Hormone signaling
dsp04082  Neuroactive ligand signaling
dsp04261  Adrenergic signaling in cardiomyocytes
dsp04270  Vascular smooth muscle contraction
dsp04310  Wnt signaling pathway
dsp04371  Apelin signaling pathway
dsp04540  Gap junction
dsp04611  Platelet activation
dsp04613  Neutrophil extracellular trap formation
dsp04621  NOD-like receptor signaling pathway
dsp04713  Circadian entrainment
dsp04720  Long-term potentiation
dsp04723  Retrograde endocannabinoid signaling
dsp04724  Glutamatergic synapse
dsp04725  Cholinergic synapse
dsp04726  Serotonergic synapse
dsp04728  Dopaminergic synapse
dsp04730  Long-term depression
dsp04742  Taste transduction
dsp04750  Inflammatory mediator regulation of TRP channels
dsp04911  Insulin secretion
dsp04912  GnRH signaling pathway
dsp04915  Estrogen signaling pathway
dsp04916  Melanogenesis
dsp04918  Thyroid hormone synthesis
dsp04919  Thyroid hormone signaling pathway
dsp04921  Oxytocin signaling pathway
dsp04922  Glucagon signaling pathway
dsp04924  Renin secretion
dsp04925  Aldosterone synthesis and secretion
dsp04926  Relaxin signaling pathway
dsp04927  Cortisol synthesis and secretion
dsp04928  Parathyroid hormone synthesis, secretion and action
dsp04929  GnRH secretion
dsp04933  AGE-RAGE signaling pathway in diabetic complications
dsp04934  Cushing syndrome
dsp04935  Growth hormone synthesis, secretion and action
dsp04961  Endocrine and other factor-regulated calcium reabsorption
dsp04970  Salivary secretion
dsp04971  Gastric acid secretion
dsp04972  Pancreatic secretion
dsp04973  Carbohydrate digestion and absorption
dsp05010  Alzheimer disease
dsp05016  Huntington disease
dsp05017  Spinocerebellar ataxia
dsp05022  Pathways of neurodegeneration - multiple diseases
dsp05142  Chagas disease
dsp05143  African trypanosomiasis
dsp05146  Amoebiasis
dsp05163  Human cytomegalovirus infection
dsp05200  Pathways in cancer
dsp05415  Diabetic cardiomyopathy
dsp05417  Lipid and atherosclerosis
Module
dsp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:dsp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122114401 (Plcb2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    122114401 (Plcb2)
   04310 Wnt signaling pathway
    122114401 (Plcb2)
   04371 Apelin signaling pathway
    122114401 (Plcb2)
   04020 Calcium signaling pathway
    122114401 (Plcb2)
   04070 Phosphatidylinositol signaling system
    122114401 (Plcb2)
   04072 Phospholipase D signaling pathway
    122114401 (Plcb2)
   04071 Sphingolipid signaling pathway
    122114401 (Plcb2)
   04022 cGMP-PKG signaling pathway
    122114401 (Plcb2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    122114401 (Plcb2)
   04081 Hormone signaling
    122114401 (Plcb2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    122114401 (Plcb2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122114401 (Plcb2)
   04613 Neutrophil extracellular trap formation
    122114401 (Plcb2)
   04621 NOD-like receptor signaling pathway
    122114401 (Plcb2)
   04062 Chemokine signaling pathway
    122114401 (Plcb2)
  09152 Endocrine system
   04911 Insulin secretion
    122114401 (Plcb2)
   04922 Glucagon signaling pathway
    122114401 (Plcb2)
   04929 GnRH secretion
    122114401 (Plcb2)
   04912 GnRH signaling pathway
    122114401 (Plcb2)
   04915 Estrogen signaling pathway
    122114401 (Plcb2)
   04921 Oxytocin signaling pathway
    122114401 (Plcb2)
   04926 Relaxin signaling pathway
    122114401 (Plcb2)
   04935 Growth hormone synthesis, secretion and action
    122114401 (Plcb2)
   04918 Thyroid hormone synthesis
    122114401 (Plcb2)
   04919 Thyroid hormone signaling pathway
    122114401 (Plcb2)
   04928 Parathyroid hormone synthesis, secretion and action
    122114401 (Plcb2)
   04916 Melanogenesis
    122114401 (Plcb2)
   04924 Renin secretion
    122114401 (Plcb2)
   04925 Aldosterone synthesis and secretion
    122114401 (Plcb2)
   04927 Cortisol synthesis and secretion
    122114401 (Plcb2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122114401 (Plcb2)
   04270 Vascular smooth muscle contraction
    122114401 (Plcb2)
  09154 Digestive system
   04970 Salivary secretion
    122114401 (Plcb2)
   04971 Gastric acid secretion
    122114401 (Plcb2)
   04972 Pancreatic secretion
    122114401 (Plcb2)
   04973 Carbohydrate digestion and absorption
    122114401 (Plcb2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    122114401 (Plcb2)
  09156 Nervous system
   04724 Glutamatergic synapse
    122114401 (Plcb2)
   04725 Cholinergic synapse
    122114401 (Plcb2)
   04728 Dopaminergic synapse
    122114401 (Plcb2)
   04726 Serotonergic synapse
    122114401 (Plcb2)
   04720 Long-term potentiation
    122114401 (Plcb2)
   04730 Long-term depression
    122114401 (Plcb2)
   04723 Retrograde endocannabinoid signaling
    122114401 (Plcb2)
  09157 Sensory system
   04742 Taste transduction
    122114401 (Plcb2)
   04750 Inflammatory mediator regulation of TRP channels
    122114401 (Plcb2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    122114401 (Plcb2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122114401 (Plcb2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    122114401 (Plcb2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122114401 (Plcb2)
   05142 Chagas disease
    122114401 (Plcb2)
   05143 African trypanosomiasis
    122114401 (Plcb2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122114401 (Plcb2)
   05016 Huntington disease
    122114401 (Plcb2)
   05017 Spinocerebellar ataxia
    122114401 (Plcb2)
   05022 Pathways of neurodegeneration - multiple diseases
    122114401 (Plcb2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122114401 (Plcb2)
   05415 Diabetic cardiomyopathy
    122114401 (Plcb2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122114401 (Plcb2)
   04934 Cushing syndrome
    122114401 (Plcb2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dsp04131]
    122114401 (Plcb2)
Enzymes [BR:dsp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     122114401 (Plcb2)
Membrane trafficking [BR:dsp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    122114401 (Plcb2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    122114401 (Plcb2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 122114401
NCBI-ProteinID: XP_042543500
Position
Unknown
AA seq 1191 aa
MSLLSPVLQPPQVKAYLSQGERFIKWDDDTALASPVILRVDPKGYYLYWTHQSKEMEFLD
ITSIRDTRFGKFAKTPKSQKLRDVFNMDFPDNHFLLKALTVVSGPDMVELTFHNFVSYKE
NVGKDWAEDLLALAKHPLTSNAPRSTFLDKILVKLKMQVNPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMNLCPRPEIDEIFTSHHAKAKPYMTKEH
LSKFINQKQRDSRLNSMLFPPARPEQVQRLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTLFGDTLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNPFSGPMAPSQERGGE
VEGGSPPSAPSGEDTVWAAEEEEEEEEEEEESGSLDEEELKKMQSDEGTAGLEVTAYEEM
SSLVNYIQPTKFVSFELSAQKNRSYIISSFTELKAYDLLSKASVQFVDYNKRQMSRVYPK
GTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRPDK
QFNPFAVDGIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPNT
NSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSES
NMPLTMPALFIFLEMKDYIPDTWADLTVALANPIKYFSAHDKKAAKLKEALGSLPETPFL
PGGPGAHQVNGASASASNGSAGANQSQRGPQSLRPSCAPAAARAREEAMKEVVEPQTASP
EELRELKGIVKLQRRQEKELRELERRGARRREELLQRGAAQLAELGLRGTGCRLRPNKGS
RKKRILPSDEPSGVAPGEGLEGPEGADLQVQELQARLEQELRLQGKEQQQGILKRKEQHV
AEQITKMTELAKERQAAELKAFKETWEIDTKEMKKKLEAKRLERIQAMTKVTPDKMAQER
LKREINNSHIQEVVQAVRQMTEALERSQEKLEEKQAACLGKIREMEKQFQQEALAEYEAR
MKELEAEVKELVRACLQVSCPSDAEDKPETSTGPGPLDPRADKADAQESRL
NT seq 3576 nt   +upstreamnt  +downstreamnt
atgtctctgctcagccctgtcctgcagccgccgcaggtgaaggcctatctgagccaagga
gagcgcttcatcaagtgggatgatgacaccgcgctggcctccccggttatcctccgtgtg
gaccccaagggctattacttatactggacgcatcagagcaaggagatggagtttctggat
atcactagcattcgagacacccgctttggaaagttcgccaagacgcccaagagccagaag
ctccgggacgtgttcaacatggacttccccgacaaccacttcctgctgaaggcgctcacc
gtggtgtcgggccctgacatggtggagctcaccttccacaatttcgtctcttacaaggag
aacgtggggaaggactgggctgaggatctgctggccctggctaagcacccgctgaccagc
aacgcgccccgcagcaccttcttggacaagatcctggtgaagctgaagatgcaggtcaac
cccgaggggaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaagcgc
gtcgaagctgccctcagtgcctgccacctggcaaagggcaagaatgacgctatcaaccct
gaggacttcccagaatctgtctacaagagcttcctcatgaacctctgtccgaggccagaa
attgacgagatcttcacttcccaccatgctaaggccaaaccgtacatgaccaaggagcac
ctgagtaaattcatcaaccagaagcagcgggactcccggctcaactccatgctcttcccg
cccgcgcggcccgagcaggtgcagcgcctcatcgacaagtacgagcccagcggcatcaac
gtgcagagaggccagctgtcacccgaaggcatggtgtggttcctttgtgggccggagaac
agcgttctggcccaggacaagctcctgctgcaccaggacatgacacagccgctcaatcac
tacttcatcaactcctcccacaacacctacctcacagccggccagttctcaggcctgtcc
tcggccgagatgtaccgccaggtcctgctggccggctgccgctgcgtggagctggactgc
tggaaggggaagcccccggacgaggagcccatcatcacccacggcttcaccatgaccaca
gacatcctgttcaaggaagcagtggaagccattgcagaaagcgcctttaagacctccccc
taccctgtcatcctgtcctttgaaaaccacgtggactcaccccgccaacaggccaagatg
gccgagtactgccggaccctgtttggggatacgctgctcacagaacctctagaaaagttc
cccctgaagcccggagtccctctgcccagtcctgaggacctccggggcaagatcctcatc
aagaacaagaagaatccgttttctggcccaatggcccccagccaggagcgtggtggggag
gtcgaggggggctctccacccagtgctccctctggggaggacacagtgtgggctgctgag
gaagaagaggaggaggaggaggaggaggaagagtcgggaagcctggacgaagaggagctc
aagaagatgcagtcagatgagggcacagcgggtctggaggtgacggcttatgaggagatg
tccagcctcgtcaattacatccagcccaccaagttcgtctcctttgagctgtcggcccag
aagaaccgaagttacatcatctcttccttcacggagctcaaggcttacgacctgctgtcc
aaggcctccgtgcagtttgtagactacaacaagcggcagatgagccgtgtttaccccaag
ggcacccgcatggactcgtccaactacatgccccagatgttctggaacgcggggtgccag
atggtcgccctcaactttcaaaccatggacctgcccatgcagcagaacatggcactgttc
gagttcaacgggcagagcggctacctcctcaagcacgagttcatgcgccggccggacaag
cagttcaatcccttcgcggtggacggcatcgacgtggtggtggccaccaccctgtccatc
acggtgatctctgggcagttcttgtcagagcgcagcgtgcgcacctatgtggaagtggag
ctgtttggccttcccggggaccccaagaggcgctaccgcaccaagctgtcccccaatacc
aactccatcaaccctgtctggaaagaggaaccctttgtctttgagaagatcctgatgccc
gagctggcctccctcagggtggcggtaatggaggaaggcaacaagtttctcggccaccgc
atcatccccatcaatgccctgaattctggctaccatcacctgtgcctgcacagcgagagc
aacatgcccctcaccatgcccgcgctcttcatcttcctggagatgaaggactacatcccc
gacacctgggcagatctcaccgtggccctggccaaccccatcaagtacttcagtgcccac
gataagaaggcggcgaagctcaaggaggccctgggaagtctgcctgagacgcccttcctg
cccgggggtccgggtgcccaccaggtcaatggggcctcagcctccgccagcaatggctca
gcaggagctaaccagagccaaaggggtccccaaagcctccgcccatcctgtgctcctgcg
gcagcccgggccagggaagaggccatgaaagaagttgtggagccacagacggccagcccc
gaggagctgcgggagctgaagggcatcgtgaagctgcagcgcaggcaggagaaggagctg
cgggagctggagcggcggggggcgcggcgccgggaggagctgctccagcgcggggcggcc
cagctggccgagctggggctgcggggcacgggctgccggctgaggcccaacaagggctcc
cggaagaagaggatcctgcctagtgatgagccctcaggggtggcgcccggcgagggtctg
gaaggcccggagggcgcagacctgcaagtgcaggagctgcaggccaggctggagcaggag
ctgcggctgcagggcaaggagcagcagcagggcatcctgaagcgcaaggagcagcacgtg
gcggagcaaatcaccaagatgacagagctggccaaagagaggcaggccgccgagctgaag
gccttcaaggagacctgggagattgacaccaaagagatgaagaaaaagctggaggccaag
aggctggagcggatccaggccatgacaaaagtcaccccggataagatggcccaggagagg
ctgaagagagagatcaacaactcccacatccaggaagtggtgcaggccgtcaggcagatg
acagaggccctggagcggagccaggagaagctggaggagaagcaggcggcttgcctgggc
aaaatccgggagatggaaaagcagttccagcaggaggctcttgcagagtacgaagccagg
atgaaggagctggaggcggaggtgaaggagttggtgagggcctgcctccaggtcagctgc
ccctcggatgccgaggacaagcccgagacctccacggggccggggcccctggacccacgc
gcagacaaggcagacgcgcaggagagccgtctctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (7)   
   Pfam (7)   
All databases (17)   

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