KEGG   PATHWAY: ecb00062
Entry
ecb00062                    Pathway                                

Name
Fatty acid elongation - Equus caballus (horse)
Class
Metabolism; Lipid metabolism
Pathway map
ecb00062  Fatty acid elongation
ecb00062

Module
ecb_M00085  Fatty acid elongation in mitochondria [PATH:ecb00062]
ecb_M00415  Fatty acid elongation in endoplasmic reticulum [PATH:ecb00062]
Organism
Equus caballus (horse) [GN:ecb]
Gene
100069345  ACAA2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
100071371  HADHB; trifunctional enzyme subunit beta, mitochondrial [KO:K07509] [EC:2.3.1.16]
100072956  HADH; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
100071381  HADHA; trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
100066748  ECHS1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
100070598  MECR; enoyl-[acyl-carrier-protein] reductase, mitochondrial [KO:K07512] [EC:1.3.1.- 1.3.1.38]
100051483  lysosomal thioesterase PPT2 isoform X6 [KO:K01074] [EC:3.1.2.22]
100068301  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
100053305  ELOVL1; elongation of very long chain fatty acids protein 1 [KO:K10247] [EC:2.3.1.199]
100063624  ELOVL2; elongation of very long chain fatty acids protein 2 isoform X1 [KO:K10205] [EC:2.3.1.199]
100060081  ELOVL3; elongation of very long chain fatty acids protein 3 isoform X1 [KO:K10248] [EC:2.3.1.199]
100069512  ELOVL4; elongation of very long chain fatty acids protein 4 [KO:K10249] [EC:2.3.1.199]
100069400  ELOVL5; elongation of very long chain fatty acids protein 5 isoform X2 [KO:K10244] [EC:2.3.1.199]
100072829  ELOVL6; elongation of very long chain fatty acids protein 6 [KO:K10203] [EC:2.3.1.199]
100051272  ELOVL7; elongation of very long chain fatty acids protein 7 isoform X1 [KO:K10250] [EC:2.3.1.199]
100050075  HSD17B12; very-long-chain 3-oxoacyl-CoA reductase [KO:K10251] [EC:1.1.1.62 1.1.1.330]
100070719  very-long-chain 3-oxoacyl-CoA reductase-B-like isoform X1 [KO:K10251] [EC:1.1.1.62 1.1.1.330]
100070489  HACD2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 [KO:K10703] [EC:4.2.1.134]
100068422  HACD1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform X1 [KO:K10703] [EC:4.2.1.134]
100064435  HACD4; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 [KO:K10703] [EC:4.2.1.134]
100053192  HACD3; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform X2 [KO:K10703] [EC:4.2.1.134]
100065024  TECR; very-long-chain enoyl-CoA reductase isoform X4 [KO:K10258] [EC:1.3.1.93]
100050302  ACOT4; LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase 4 [KO:K01068] [EC:3.1.2.2]
100055927  acyl-coenzyme A thioesterase 1 isoform X1 [KO:K01068] [EC:3.1.2.2]
100147142  LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase 1 [KO:K01068] [EC:3.1.2.2]
106782520  LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase 4 [KO:K01068] [EC:3.1.2.2]
100059575  ACOT7; cytosolic acyl coenzyme A thioester hydrolase isoform X4 [KO:K17360] [EC:3.1.2.2]
100055681  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
100060159  THEM5; acyl-coenzyme A thioesterase THEM5 [KO:K22554] [EC:3.1.2.2]
102147639  acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K22554] [EC:3.1.2.2]
Compound
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00083  Malonyl-CoA
C00136  Butanoyl-CoA
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00249  Hexadecanoic acid
C00264  3-Oxoacyl-CoA
C00605  2,3-Dehydroacyl-CoA
C00638  Long-chain fatty acid
C00640  (3S)-3-Hydroxyacyl-CoA
C00658  trans-2,3-Dehydroacyl-CoA
C01832  Lauroyl-CoA
C01944  Octanoyl-CoA
C02593  Tetradecanoyl-CoA
C02843  Long-chain acyl-CoA
C03221  2-trans-Dodecenoyl-CoA
C05258  (S)-3-Hydroxyhexadecanoyl-CoA
C05259  3-Oxopalmitoyl-CoA
C05260  (S)-3-Hydroxytetradecanoyl-CoA
C05261  3-Oxotetradecanoyl-CoA
C05262  (S)-3-Hydroxydodecanoyl-CoA
C05263  3-Oxododecanoyl-CoA
C05264  (S)-Hydroxydecanoyl-CoA
C05265  3-Oxodecanoyl-CoA
C05266  (S)-3-Hydroxyoctanoyl-CoA
C05267  3-Oxooctanoyl-CoA
C05268  (S)-Hydroxyhexanoyl-CoA
C05269  3-Oxohexanoyl-CoA
C05270  Hexanoyl-CoA
C05271  trans-Hex-2-enoyl-CoA
C05272  trans-Hexadec-2-enoyl-CoA
C05273  trans-Tetradec-2-enoyl-CoA
C05274  Decanoyl-CoA
C05275  trans-Dec-2-enoyl-CoA
C05276  trans-Oct-2-enoyl-CoA
C20876  Very-long-chain acyl-CoA
C20877  Very-long-chain 3-oxoacyl-CoA
C20878  Very-long-chain (3R)-3-hydroxyacyl-CoA
C20879  Very-long-chain trans-2,3-dehydroacyl-CoA
Reference
PMID:4387390
  Authors
Seubert W, Lamberts I, Kramer R, Ohly B
  Title
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.
  Journal
Biochim Biophys Acta 164:498-517 (1968)
DOI:10.1016/0005-2760(68)90180-X
Reference
PMID:7150615
  Authors
El-Fakhri M, Middleton B
  Title
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
  Journal
Biochim Biophys Acta 713:270-9 (1982)
DOI:10.1016/0005-2760(82)90244-2
Reference
PMID:8190743
  Authors
Cassagne C, Lessire R, Bessoule JJ, Moreau P, Creach A, Schneider F, Sturbois B
  Title
Biosynthesis of very long chain fatty acids in higher plants.
  Journal
Prog Lipid Res 33:55-69 (1994)
DOI:10.1016/0163-7827(94)90009-4
Reference
  Authors
Jakobsson A, Westerberg R, Jacobsson A.
  Title
Fatty acid elongases in mammals: their regulation and roles in metabolism.
  Journal
Prog Lipid Res 45:237-49 (2006)
DOI:10.1016/j.plipres.2006.01.004
Reference
  Authors
Blacklock BJ, Jaworski JG
  Title
Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases.
  Journal
Biochem Biophys Res Commun 346:583-90 (2006)
DOI:10.1016/j.bbrc.2006.05.162
Reference
  Authors
Shepherd T, Wynne Griffiths D
  Title
The effects of stress on plant cuticular waxes.
  Journal
New Phytol 171:469-99 (2006)
DOI:10.1111/j.1469-8137.2006.01826.x
Reference
  Authors
Riezman H
  Title
The long and short of fatty acid synthesis.
  Journal
Cell 130:587-8 (2007)
DOI:10.1016/j.cell.2007.08.008
Reference
  Authors
Raffaele S, Leger A, Roby D
  Title
Very long chain fatty acid and lipid signaling in the response of plants to pathogens.
  Journal
Plant Signal Behav 4:94-9 (2009)
DOI:10.4161/psb.4.2.7580
Related
pathway
ecb00071  Fatty acid degradation
KO pathway
ko00062   

DBGET integrated database retrieval system