KEGG   Eulemur rufifrons (Bennett's brown lemur): 138400531
Entry
138400531         CDS       T11398                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
eruf  Eulemur rufifrons (Bennett's brown lemur)
Pathway
eruf00562  Inositol phosphate metabolism
eruf01100  Metabolic pathways
eruf04015  Rap1 signaling pathway
eruf04020  Calcium signaling pathway
eruf04022  cGMP-PKG signaling pathway
eruf04062  Chemokine signaling pathway
eruf04070  Phosphatidylinositol signaling system
eruf04071  Sphingolipid signaling pathway
eruf04072  Phospholipase D signaling pathway
eruf04081  Hormone signaling
eruf04082  Neuroactive ligand signaling
eruf04261  Adrenergic signaling in cardiomyocytes
eruf04270  Vascular smooth muscle contraction
eruf04310  Wnt signaling pathway
eruf04371  Apelin signaling pathway
eruf04540  Gap junction
eruf04611  Platelet activation
eruf04613  Neutrophil extracellular trap formation
eruf04621  NOD-like receptor signaling pathway
eruf04713  Circadian entrainment
eruf04720  Long-term potentiation
eruf04723  Retrograde endocannabinoid signaling
eruf04724  Glutamatergic synapse
eruf04725  Cholinergic synapse
eruf04726  Serotonergic synapse
eruf04728  Dopaminergic synapse
eruf04730  Long-term depression
eruf04742  Taste transduction
eruf04750  Inflammatory mediator regulation of TRP channels
eruf04911  Insulin secretion
eruf04912  GnRH signaling pathway
eruf04915  Estrogen signaling pathway
eruf04916  Melanogenesis
eruf04918  Thyroid hormone synthesis
eruf04919  Thyroid hormone signaling pathway
eruf04921  Oxytocin signaling pathway
eruf04922  Glucagon signaling pathway
eruf04924  Renin secretion
eruf04925  Aldosterone synthesis and secretion
eruf04926  Relaxin signaling pathway
eruf04927  Cortisol synthesis and secretion
eruf04928  Parathyroid hormone synthesis, secretion and action
eruf04929  GnRH secretion
eruf04933  AGE-RAGE signaling pathway in diabetic complications
eruf04934  Cushing syndrome
eruf04935  Growth hormone synthesis, secretion and action
eruf04961  Endocrine and other factor-regulated calcium reabsorption
eruf04970  Salivary secretion
eruf04971  Gastric acid secretion
eruf04972  Pancreatic secretion
eruf04973  Carbohydrate digestion and absorption
eruf05010  Alzheimer disease
eruf05016  Huntington disease
eruf05017  Spinocerebellar ataxia
eruf05022  Pathways of neurodegeneration - multiple diseases
eruf05142  Chagas disease
eruf05143  African trypanosomiasis
eruf05146  Amoebiasis
eruf05163  Human cytomegalovirus infection
eruf05200  Pathways in cancer
eruf05415  Diabetic cardiomyopathy
eruf05417  Lipid and atherosclerosis
Module
eruf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:eruf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    138400531 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    138400531 (PLCB1)
   04310 Wnt signaling pathway
    138400531 (PLCB1)
   04371 Apelin signaling pathway
    138400531 (PLCB1)
   04020 Calcium signaling pathway
    138400531 (PLCB1)
   04070 Phosphatidylinositol signaling system
    138400531 (PLCB1)
   04072 Phospholipase D signaling pathway
    138400531 (PLCB1)
   04071 Sphingolipid signaling pathway
    138400531 (PLCB1)
   04022 cGMP-PKG signaling pathway
    138400531 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    138400531 (PLCB1)
   04081 Hormone signaling
    138400531 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    138400531 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    138400531 (PLCB1)
   04613 Neutrophil extracellular trap formation
    138400531 (PLCB1)
   04621 NOD-like receptor signaling pathway
    138400531 (PLCB1)
   04062 Chemokine signaling pathway
    138400531 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    138400531 (PLCB1)
   04922 Glucagon signaling pathway
    138400531 (PLCB1)
   04929 GnRH secretion
    138400531 (PLCB1)
   04912 GnRH signaling pathway
    138400531 (PLCB1)
   04915 Estrogen signaling pathway
    138400531 (PLCB1)
   04921 Oxytocin signaling pathway
    138400531 (PLCB1)
   04926 Relaxin signaling pathway
    138400531 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    138400531 (PLCB1)
   04918 Thyroid hormone synthesis
    138400531 (PLCB1)
   04919 Thyroid hormone signaling pathway
    138400531 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    138400531 (PLCB1)
   04916 Melanogenesis
    138400531 (PLCB1)
   04924 Renin secretion
    138400531 (PLCB1)
   04925 Aldosterone synthesis and secretion
    138400531 (PLCB1)
   04927 Cortisol synthesis and secretion
    138400531 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    138400531 (PLCB1)
   04270 Vascular smooth muscle contraction
    138400531 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    138400531 (PLCB1)
   04971 Gastric acid secretion
    138400531 (PLCB1)
   04972 Pancreatic secretion
    138400531 (PLCB1)
   04973 Carbohydrate digestion and absorption
    138400531 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    138400531 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    138400531 (PLCB1)
   04725 Cholinergic synapse
    138400531 (PLCB1)
   04728 Dopaminergic synapse
    138400531 (PLCB1)
   04726 Serotonergic synapse
    138400531 (PLCB1)
   04720 Long-term potentiation
    138400531 (PLCB1)
   04730 Long-term depression
    138400531 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    138400531 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    138400531 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    138400531 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    138400531 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138400531 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    138400531 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    138400531 (PLCB1)
   05142 Chagas disease
    138400531 (PLCB1)
   05143 African trypanosomiasis
    138400531 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    138400531 (PLCB1)
   05016 Huntington disease
    138400531 (PLCB1)
   05017 Spinocerebellar ataxia
    138400531 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    138400531 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    138400531 (PLCB1)
   05415 Diabetic cardiomyopathy
    138400531 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    138400531 (PLCB1)
   04934 Cushing syndrome
    138400531 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:eruf04131]
    138400531 (PLCB1)
Enzymes [BR:eruf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     138400531 (PLCB1)
Membrane trafficking [BR:eruf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    138400531 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    138400531 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 138400531
NCBI-ProteinID: XP_069351551
Position
20:31509778..32162260
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGIKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNDSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLDSGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDESP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSASLSLSSDPGKVNHKPPSS
EELGGDIPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcatcaaattcgtcaagtgggatgatgactcaactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaataaggag
acagagctgttggatctcagccttgtcaaggatgccagatgtgggagacacgccaaagct
cccaaggatcccaaattacgtgaacttctggatgtggggaacatcgggcgactagagcac
cgcatgatcaccgtggtgtacgggcctgacctcgttaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaagttttcagtctggcaacaaac
ctgttggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
gaccggaagcgagttgaaactgctttagaagcttgtagtcttccatcttcaaggaatgat
tcgatacctcaagaagatttcactccagatgtgtacagagttttcctgaacaacctttgc
cctcgacctgaaattgataacatcttttcggaatttggtgccaaaagcaaaccatacctt
accgttgatcagatgatggattttatcaaccttaagcagcgagatccccggctaaatgaa
atactttacccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
aatgatagcctcgccaaaaaaggacagatatctgtggatggatttatgcgctatctgagc
ggagaagaaaatggagttgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccagctg
gctggaaactcctccgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagctagactgctggaaaggacggactgcagaagaggaacctgttatcacccatggattc
accatgacaactgaaatatccttcaaggaagtgatagaagcgatcgcggagtgtgcattt
aagacttcaccttttccaattctcctttcatttgagaaccatgtggattccccaaagcag
caggccaagatggcggagtactgccgactgatctttggggacgctcttctcatggagccg
ctggaaaaatacccactggactctggagttccccttccaagccctatggatttaatgtat
aaaattttggtgaaaaataagaagaaatcacacaagtcctcagaaggaagtggcaaaaag
aagctctcggaacaagcttccaacacgtacagcgactcttccagcgtgttcgagccttca
tccccaggagctggggaagctgatacagagagtgatgatgatgacgatgatgatgactgt
aaaaaatcttccatggatgaggggaccgctgggagtgaggccatggccacggaagagatg
tccaacctggtgaactatattcagccggtcaagttcgagtcatttgaaatttcaaaaaaa
agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaacttacg
aagtccccggtggaatttgtagaatataacaaaatgcagctcagcaggatatatccaaaa
ggcacacgtgtggattcatccaactatatgcctcagctcttctggaatgcaggctgtcag
atggtggcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtat
gaatacaacgggaaaagtggctacagactaaagccagagttcatgcggaggcctgacaag
cattttgatccatttactgaaggcatcgtagatgggatagtggccaacactttatctgtt
aagattatttcaggtcaatttctctctgataagaaagtggggacttatgtggaagtggat
atgtttggtttgcccgtggacacaaggaggaaggcatttaagaccaaaacatcccaagga
aatgctgtaaatcctatctgggaagaagaacctattgtgttcaaaaaggtggttcttcct
tctctggcctgcttgaggatagcagtttatgaagaaggaggtaaatttatcggccaccgg
atcttgccagtgcaagccattcggccaggctatcactatatctgtctgaggaatgaaaga
aaccagcccctgacgctgccagctgtgtttgtctacatagaagtgaaagactatgtgcca
gatacatatgcagatgtgattgaagctttgtcaaacccaatccgatatgtgaatctgatg
gagcagagagctaagcaactggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacaccatcagaggctccaagtgaagctaggacgactccagca
gaaaacggggtgaatcacactacgtctctggcacccaaaccaccctcccaggctctccac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagaccttattcagagt
gtcttaacagaagtggaggcgcagaccatcgaagagctaaagcaacagaaatcgtttgtg
aaacttcaaaagaaacactacaaagaaatgaaagacttagttaagaggcaccacaagaaa
accactgaccttatcaaagaacacactacaaaatacaatgaaattcagaatgactacttg
agaaggagagcggctttggaaaagactgccaaaaaagacagtaagaaaaaatcagaaccc
agtagccctgaccatggttcatcaacaattgaacaagaccttgctgccttggatgcagaa
atgacccaaaagttaatagatctgaaggacaaacaacagcagcagctgcttaatcttcgt
caagaacagtattatagtgaaaaataccagaagcgggaacatattaaactgcttattcaa
aagttgacagatgttgctgaagagtgtcagaacaatcagctaaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggaaaagatt
acagaagctaaatccaaagacaaaagtcagatggaagaggagaagacagaaatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcagcagatcctggatgaaagtccc
aagctgcaggtggagctggagcaagaataccaagacaagttcaaaagactgcccctagag
attttggagtttgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacggt
tcagcctctctatccttgtcctcagaccctggaaaagtgaaccacaagcctccttccagt
gaggagctgggaggagacatcccaggaaaagagtttgatactcctctgtaa

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (12)   

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