KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101135298
Entry
101135298         CDS       T02442                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo01521  EGFR tyrosine kinase inhibitor resistance
ggo01522  Endocrine resistance
ggo01524  Platinum drug resistance
ggo04012  ErbB signaling pathway
ggo04014  Ras signaling pathway
ggo04015  Rap1 signaling pathway
ggo04024  cAMP signaling pathway
ggo04062  Chemokine signaling pathway
ggo04066  HIF-1 signaling pathway
ggo04068  FoxO signaling pathway
ggo04070  Phosphatidylinositol signaling system
ggo04071  Sphingolipid signaling pathway
ggo04072  Phospholipase D signaling pathway
ggo04081  Hormone signaling
ggo04140  Autophagy - animal
ggo04145  Phagocytosis
ggo04150  mTOR signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04152  AMPK signaling pathway
ggo04210  Apoptosis
ggo04211  Longevity regulating pathway
ggo04213  Longevity regulating pathway - multiple species
ggo04218  Cellular senescence
ggo04360  Axon guidance
ggo04370  VEGF signaling pathway
ggo04380  Osteoclast differentiation
ggo04510  Focal adhesion
ggo04517  IgSF CAM signaling
ggo04518  Integrin signaling
ggo04550  Signaling pathways regulating pluripotency of stem cells
ggo04611  Platelet activation
ggo04613  Neutrophil extracellular trap formation
ggo04620  Toll-like receptor signaling pathway
ggo04625  C-type lectin receptor signaling pathway
ggo04630  JAK-STAT signaling pathway
ggo04650  Natural killer cell mediated cytotoxicity
ggo04660  T cell receptor signaling pathway
ggo04662  B cell receptor signaling pathway
ggo04664  Fc epsilon RI signaling pathway
ggo04666  Fc gamma R-mediated phagosome formation
ggo04668  TNF signaling pathway
ggo04670  Leukocyte transendothelial migration
ggo04722  Neurotrophin signaling pathway
ggo04725  Cholinergic synapse
ggo04750  Inflammatory mediator regulation of TRP channels
ggo04810  Regulation of actin cytoskeleton
ggo04910  Insulin signaling pathway
ggo04914  Progesterone-mediated oocyte maturation
ggo04915  Estrogen signaling pathway
ggo04917  Prolactin signaling pathway
ggo04919  Thyroid hormone signaling pathway
ggo04923  Regulation of lipolysis in adipocytes
ggo04926  Relaxin signaling pathway
ggo04929  GnRH secretion
ggo04930  Type II diabetes mellitus
ggo04931  Insulin resistance
ggo04932  Non-alcoholic fatty liver disease
ggo04933  AGE-RAGE signaling pathway in diabetic complications
ggo04935  Growth hormone synthesis, secretion and action
ggo04960  Aldosterone-regulated sodium reabsorption
ggo04973  Carbohydrate digestion and absorption
ggo05010  Alzheimer disease
ggo05017  Spinocerebellar ataxia
ggo05020  Prion disease
ggo05100  Bacterial invasion of epithelial cells
ggo05135  Yersinia infection
ggo05142  Chagas disease
ggo05146  Amoebiasis
ggo05160  Hepatitis C
ggo05161  Hepatitis B
ggo05162  Measles
ggo05163  Human cytomegalovirus infection
ggo05164  Influenza A
ggo05165  Human papillomavirus infection
ggo05166  Human T-cell leukemia virus 1 infection
ggo05167  Kaposi sarcoma-associated herpesvirus infection
ggo05168  Herpes simplex virus 1 infection
ggo05169  Epstein-Barr virus infection
ggo05170  Human immunodeficiency virus 1 infection
ggo05171  Coronavirus disease
ggo05200  Pathways in cancer
ggo05203  Viral carcinogenesis
ggo05205  Proteoglycans in cancer
ggo05206  MicroRNAs in cancer
ggo05207  Chemical carcinogenesis - receptor activation
ggo05208  Chemical carcinogenesis - reactive oxygen species
ggo05210  Colorectal cancer
ggo05211  Renal cell carcinoma
ggo05212  Pancreatic cancer
ggo05213  Endometrial cancer
ggo05214  Glioma
ggo05215  Prostate cancer
ggo05218  Melanoma
ggo05220  Chronic myeloid leukemia
ggo05221  Acute myeloid leukemia
ggo05222  Small cell lung cancer
ggo05223  Non-small cell lung cancer
ggo05224  Breast cancer
ggo05225  Hepatocellular carcinoma
ggo05226  Gastric cancer
ggo05230  Central carbon metabolism in cancer
ggo05231  Choline metabolism in cancer
ggo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ggo05415  Diabetic cardiomyopathy
ggo05417  Lipid and atherosclerosis
ggo05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101135298 (PIK3R2)
   04014 Ras signaling pathway
    101135298 (PIK3R2)
   04015 Rap1 signaling pathway
    101135298 (PIK3R2)
   04370 VEGF signaling pathway
    101135298 (PIK3R2)
   04630 JAK-STAT signaling pathway
    101135298 (PIK3R2)
   04668 TNF signaling pathway
    101135298 (PIK3R2)
   04066 HIF-1 signaling pathway
    101135298 (PIK3R2)
   04068 FoxO signaling pathway
    101135298 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    101135298 (PIK3R2)
   04072 Phospholipase D signaling pathway
    101135298 (PIK3R2)
   04071 Sphingolipid signaling pathway
    101135298 (PIK3R2)
   04024 cAMP signaling pathway
    101135298 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    101135298 (PIK3R2)
   04152 AMPK signaling pathway
    101135298 (PIK3R2)
   04150 mTOR signaling pathway
    101135298 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101135298 (PIK3R2)
   04517 IgSF CAM signaling
    101135298 (PIK3R2)
   04518 Integrin signaling
    101135298 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    101135298 (PIK3R2)
   04140 Autophagy - animal
    101135298 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    101135298 (PIK3R2)
   04218 Cellular senescence
    101135298 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101135298 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101135298 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101135298 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101135298 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    101135298 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    101135298 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    101135298 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    101135298 (PIK3R2)
   04660 T cell receptor signaling pathway
    101135298 (PIK3R2)
   04662 B cell receptor signaling pathway
    101135298 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    101135298 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    101135298 (PIK3R2)
   04670 Leukocyte transendothelial migration
    101135298 (PIK3R2)
   04062 Chemokine signaling pathway
    101135298 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101135298 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    101135298 (PIK3R2)
   04929 GnRH secretion
    101135298 (PIK3R2)
   04915 Estrogen signaling pathway
    101135298 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    101135298 (PIK3R2)
   04917 Prolactin signaling pathway
    101135298 (PIK3R2)
   04926 Relaxin signaling pathway
    101135298 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    101135298 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    101135298 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101135298 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101135298 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    101135298 (PIK3R2)
   04722 Neurotrophin signaling pathway
    101135298 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101135298 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    101135298 (PIK3R2)
   04380 Osteoclast differentiation
    101135298 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    101135298 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    101135298 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101135298 (PIK3R2)
   05206 MicroRNAs in cancer
    101135298 (PIK3R2)
   05205 Proteoglycans in cancer
    101135298 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    101135298 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101135298 (PIK3R2)
   05203 Viral carcinogenesis
    101135298 (PIK3R2)
   05230 Central carbon metabolism in cancer
    101135298 (PIK3R2)
   05231 Choline metabolism in cancer
    101135298 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101135298 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101135298 (PIK3R2)
   05212 Pancreatic cancer
    101135298 (PIK3R2)
   05225 Hepatocellular carcinoma
    101135298 (PIK3R2)
   05226 Gastric cancer
    101135298 (PIK3R2)
   05214 Glioma
    101135298 (PIK3R2)
   05221 Acute myeloid leukemia
    101135298 (PIK3R2)
   05220 Chronic myeloid leukemia
    101135298 (PIK3R2)
   05218 Melanoma
    101135298 (PIK3R2)
   05211 Renal cell carcinoma
    101135298 (PIK3R2)
   05215 Prostate cancer
    101135298 (PIK3R2)
   05213 Endometrial cancer
    101135298 (PIK3R2)
   05224 Breast cancer
    101135298 (PIK3R2)
   05222 Small cell lung cancer
    101135298 (PIK3R2)
   05223 Non-small cell lung cancer
    101135298 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101135298 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    101135298 (PIK3R2)
   05161 Hepatitis B
    101135298 (PIK3R2)
   05160 Hepatitis C
    101135298 (PIK3R2)
   05171 Coronavirus disease
    101135298 (PIK3R2)
   05164 Influenza A
    101135298 (PIK3R2)
   05162 Measles
    101135298 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    101135298 (PIK3R2)
   05163 Human cytomegalovirus infection
    101135298 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101135298 (PIK3R2)
   05169 Epstein-Barr virus infection
    101135298 (PIK3R2)
   05165 Human papillomavirus infection
    101135298 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101135298 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    101135298 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101135298 (PIK3R2)
   05142 Chagas disease
    101135298 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101135298 (PIK3R2)
   05017 Spinocerebellar ataxia
    101135298 (PIK3R2)
   05020 Prion disease
    101135298 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101135298 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    101135298 (PIK3R2)
   05415 Diabetic cardiomyopathy
    101135298 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101135298 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    101135298 (PIK3R2)
   04931 Insulin resistance
    101135298 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101135298 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101135298 (PIK3R2)
   01524 Platinum drug resistance
    101135298 (PIK3R2)
   01522 Endocrine resistance
    101135298 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ggo04131]
    101135298 (PIK3R2)
Membrane trafficking [BR:ggo04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101135298 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9 ODF2_C
Other DBs
NCBI-GeneID: 101135298
NCBI-ProteinID: XP_030860367
Ensembl: ENSGGOG00000016197
Position
20:join(24598959..24599280,24603544..24603636,24603992..24604042,24604127..24604258,24604352..24604568,24605039..24605124,24605274..24605382,24605480..24605578,24606039..24606219,24606335..24606460,24609231..24609373,24610190..24610366,24611536..24611607,24611798..24611968,24612160..24612367)
AA seq 728 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
PGPPPAAR
NT seq 2187 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgctctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtagtgagccgggcggccttgcaggcg
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aacgagcgcacacggcagcgaggtgacttccctggcacctacgtggagttcctggggccc
gtggccctggcccggcccggccctcgcccacggggcccccgcccactgcccgccaggccc
cgtgatggggcccctgagccaggcctcacactccccgacttgcccgagcagttctcccca
cctgatgtggctccccctcttctggtgaagcttgtggaggccattgaaaggacagggctg
gacagcgaatctcactaccgcccggagctgcccgcaccgcgtacagactggtccctgagc
gacgtcgatcagtgggacacggcagccctggctgacggcattaagagcttcctgctggca
ctgcccgcgccgctcgtgacccccgaggcctcggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagccaccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgcgtggcccgccgcgccccggccctgggt
cccgcggtccgggccctgggcgccacctttgggccgctgctgctgcgcgcgccgccgccg
ccgtcctcgccgccgccagggggcgctcccgacgggagtgagcccagccctgacttcccg
gcgctgctggtggagaagttgcttcaggaacacttggaagagcaggaggttgcgccccca
gcgctgccgcctaaaccccccaaggcaaagccggcccccacagtcctggccaatggaggg
agcccaccctccctgcaggatgctgagtggtactggggggacatttcaagggaggaggtg
aacgagaaactccgggacactcccgatggcaccttcctagtccgagatgcttctagcaag
atccagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctgatcaaggtc
ttccaccgagatgggcactatggcttctcagagccactcaccttctgctccgttgtggac
ctcatcaatcactaccgccacgagtctctggcccagtacaacgccaagctggacacacgg
ctcctctaccctgtgtccaaataccagcaggaccagattgtcaaggaggacagcgtggag
gcagtgggcgcccagcttaaggtctatcaccagcagtaccaggacaagagccgcgagtat
gaccagctttatgaagagtacacacggacctcccaggagctgcagatgaagcgtactgca
attgaggccttcaatgagactatcaagatctttgaagagcagggccagactcaagagaaa
tgcagcaaggaatacctggagcgcttccggcgtgagggcaacgagaaagagatgcaaagg
atcctgctgaactccgagcggctcaagtcccgcattgccgagatccatgagagccgcacg
aagctggagcagcagctgcgggcccaggcctcggacaacagagagatcgacaagcgcatg
aacagcctcaagccggacctcatgcagctgcgcaagatccgagaccagtacctcgtgtgg
ctcacccagaaaggcgcccggcagaagaaaatcaacgagtggctggggattaaaaatgag
actgaggaccagtacgcactcatggaggacgaggacgatctcccgcaccacgaggaacgc
acttggtacgtgggcaagatcaaccgcacgcaggcagaggagatgctgagcggcaagcgg
gatggcaccttcctcatccgcgagagcagccagcggggctgctatgcctgctccgtggta
gtggacggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcg
gagccctacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcg
ctggtgcagcacaacgacgcgctcaccgtcaccctggcgcacccagtgcgcgccccgggc
cccggcccgccgcctgccgcccgctga

  All links  
Gene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (14)   

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