KEGG   Hyperoodon ampullatus (northern bottlenose whale): 307055237
Entry
307055237         CDS       T11951                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
hamp  Hyperoodon ampullatus (northern bottlenose whale)
Pathway
hamp00562  Inositol phosphate metabolism
hamp01100  Metabolic pathways
hamp04015  Rap1 signaling pathway
hamp04020  Calcium signaling pathway
hamp04022  cGMP-PKG signaling pathway
hamp04062  Chemokine signaling pathway
hamp04070  Phosphatidylinositol signaling system
hamp04071  Sphingolipid signaling pathway
hamp04072  Phospholipase D signaling pathway
hamp04081  Hormone signaling
hamp04082  Neuroactive ligand signaling
hamp04261  Adrenergic signaling in cardiomyocytes
hamp04270  Vascular smooth muscle contraction
hamp04310  Wnt signaling pathway
hamp04371  Apelin signaling pathway
hamp04540  Gap junction
hamp04611  Platelet activation
hamp04613  Neutrophil extracellular trap formation
hamp04621  NOD-like receptor signaling pathway
hamp04713  Circadian entrainment
hamp04720  Long-term potentiation
hamp04723  Retrograde endocannabinoid signaling
hamp04724  Glutamatergic synapse
hamp04725  Cholinergic synapse
hamp04726  Serotonergic synapse
hamp04728  Dopaminergic synapse
hamp04730  Long-term depression
hamp04742  Taste transduction
hamp04750  Inflammatory mediator regulation of TRP channels
hamp04911  Insulin secretion
hamp04912  GnRH signaling pathway
hamp04915  Estrogen signaling pathway
hamp04916  Melanogenesis
hamp04918  Thyroid hormone synthesis
hamp04919  Thyroid hormone signaling pathway
hamp04921  Oxytocin signaling pathway
hamp04922  Glucagon signaling pathway
hamp04924  Renin secretion
hamp04925  Aldosterone synthesis and secretion
hamp04926  Relaxin signaling pathway
hamp04927  Cortisol synthesis and secretion
hamp04928  Parathyroid hormone synthesis, secretion and action
hamp04929  GnRH secretion
hamp04933  AGE-RAGE signaling pathway in diabetic complications
hamp04934  Cushing syndrome
hamp04935  Growth hormone synthesis, secretion and action
hamp04961  Endocrine and other factor-regulated calcium reabsorption
hamp04970  Salivary secretion
hamp04971  Gastric acid secretion
hamp04972  Pancreatic secretion
hamp04973  Carbohydrate digestion and absorption
hamp05010  Alzheimer disease
hamp05016  Huntington disease
hamp05017  Spinocerebellar ataxia
hamp05022  Pathways of neurodegeneration - multiple diseases
hamp05142  Chagas disease
hamp05143  African trypanosomiasis
hamp05146  Amoebiasis
hamp05163  Human cytomegalovirus infection
hamp05200  Pathways in cancer
hamp05415  Diabetic cardiomyopathy
hamp05417  Lipid and atherosclerosis
Module
hamp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:hamp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    307055237 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    307055237 (PLCB3)
   04310 Wnt signaling pathway
    307055237 (PLCB3)
   04371 Apelin signaling pathway
    307055237 (PLCB3)
   04020 Calcium signaling pathway
    307055237 (PLCB3)
   04070 Phosphatidylinositol signaling system
    307055237 (PLCB3)
   04072 Phospholipase D signaling pathway
    307055237 (PLCB3)
   04071 Sphingolipid signaling pathway
    307055237 (PLCB3)
   04022 cGMP-PKG signaling pathway
    307055237 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    307055237 (PLCB3)
   04081 Hormone signaling
    307055237 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    307055237 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    307055237 (PLCB3)
   04613 Neutrophil extracellular trap formation
    307055237 (PLCB3)
   04621 NOD-like receptor signaling pathway
    307055237 (PLCB3)
   04062 Chemokine signaling pathway
    307055237 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    307055237 (PLCB3)
   04922 Glucagon signaling pathway
    307055237 (PLCB3)
   04929 GnRH secretion
    307055237 (PLCB3)
   04912 GnRH signaling pathway
    307055237 (PLCB3)
   04915 Estrogen signaling pathway
    307055237 (PLCB3)
   04921 Oxytocin signaling pathway
    307055237 (PLCB3)
   04926 Relaxin signaling pathway
    307055237 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    307055237 (PLCB3)
   04918 Thyroid hormone synthesis
    307055237 (PLCB3)
   04919 Thyroid hormone signaling pathway
    307055237 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    307055237 (PLCB3)
   04916 Melanogenesis
    307055237 (PLCB3)
   04924 Renin secretion
    307055237 (PLCB3)
   04925 Aldosterone synthesis and secretion
    307055237 (PLCB3)
   04927 Cortisol synthesis and secretion
    307055237 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    307055237 (PLCB3)
   04270 Vascular smooth muscle contraction
    307055237 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    307055237 (PLCB3)
   04971 Gastric acid secretion
    307055237 (PLCB3)
   04972 Pancreatic secretion
    307055237 (PLCB3)
   04973 Carbohydrate digestion and absorption
    307055237 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    307055237 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    307055237 (PLCB3)
   04725 Cholinergic synapse
    307055237 (PLCB3)
   04728 Dopaminergic synapse
    307055237 (PLCB3)
   04726 Serotonergic synapse
    307055237 (PLCB3)
   04720 Long-term potentiation
    307055237 (PLCB3)
   04730 Long-term depression
    307055237 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    307055237 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    307055237 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    307055237 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    307055237 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    307055237 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    307055237 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    307055237 (PLCB3)
   05142 Chagas disease
    307055237 (PLCB3)
   05143 African trypanosomiasis
    307055237 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    307055237 (PLCB3)
   05016 Huntington disease
    307055237 (PLCB3)
   05017 Spinocerebellar ataxia
    307055237 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    307055237 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    307055237 (PLCB3)
   05415 Diabetic cardiomyopathy
    307055237 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    307055237 (PLCB3)
   04934 Cushing syndrome
    307055237 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hamp04131]
    307055237 (PLCB3)
Enzymes [BR:hamp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     307055237 (PLCB3)
Membrane trafficking [BR:hamp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    307055237 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    307055237 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 307055237
NCBI-ProteinID: XP_079563404
Position
7:complement(10780136..>10795787)
AA seq 1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPSGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLITVVAGPDPVNTSFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGVPDS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEAGLEKPSLEPQKSLGE
ESLQRGPDALGSAYREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANAVRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETSQETQSQQP
GSQLTPNPTPSPLDASPRRPPGPITSSTSTSLSSPGQRDDLIASVLSEVAPAPLDELRGH
KALVKLQSRQERDFRELHKKHQRKAVALTRRLLDNLAQARAESRCRHRPGVLGGEDEREE
EEEVKRYQEFQKKQVRCLLELREAQADTEAERRLEHLRQAQQRLREIVMDAHTTQFKRLK
EMNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRQERLVAAQQQILQQLTEEEPKLLAQLAQECQEQRERLPQEIRRSLLGEMPEGLGDGHL
VACASNGHAPGSSGHLSGADSESQEETTKL
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtcgtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaatctg
gtaactctgcgcgtagaccccagtggcttcttcctgtactggacaggacccaacatggag
gtggacacactggacatcagttccatcagggacacgaggacaggccgttatgcccgccta
cccaaggaccccaagattcgggaggtgttgggctttgggggccctgatgcccggttggag
gagaagctgataacagtggtggccgggccagacccggtgaatacatcgtttttgaacttc
atggccgtgcaggatgacacagccaaggtctggtctgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcttgcgcaaagcgtacacgaagctg
aaactgcaggtgaaccaggatggacggatcccggtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtagaaactgcgctggaatcctgtggcctcaatttcaaccggagc
gagtccatccggcctgacgagttttccttggaaatcttcgagaggttcttgaacaagctt
tgtctgcggccggacattgacaagatcctgctggagataggtgccaagggcaaaccatac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaat
gaagtgctgtacccgcctctgcggccctcccaggcccggctgcttattgagaagtatgag
cccaaccagcaattcctggagagagaccagatgtccatggagggcttcagccgctacctg
ggaggtgaggagaatggcatcctgcccctagaggccctggatctgagcgcagacatgacc
cagccgctcagtgcctacttcatcaactcctcacacaacacctatctcactgcggggcag
ctggcgggaacctcgtcggtggagatgtaccggcaggcactgctgtggggctgccgctgc
gtggagctggacgtgtggaaagggcggccgcctgaggaggagcccttcatcacccacggc
ttcaccatgaccacggaggtgccactgcgagatgtgctggaggccattgcggagaccgcc
ttcaagacctcgccctaccccgtcatcctctcctttgagaaccatgtggactcggcaaag
cagcaggccaagatggctgagtactgccgctccatctttggggacgcgctgctcatcgac
cccctggacaagtacccgctggccccgggcgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcggcaccggcccagcactggcgttcccgacagc
tccgtgcgcaagcggccgctggagcagagcaactcggccctgagcgagagctccgcggcc
accgagccctcctcgccccagctcgggtcccccagctctgacagctgcccaggcctgagc
aatggggaggaggcgggccttgagaagcccagcctggagcctcagaagtctctgggtgag
gagagtttgcagcggggccctgatgctcttggatcggcctaccgtgaggatgaggaagag
gatgaggaagaggaggaacagacggaccccaaaaagccgaccaccgatgagggcactgcc
agcagtgaggtcaatgccactgaggaaatgtcgacccttgtcaactacatcgagcccgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaagtgctttgagatgtcatccttt
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacacgcgtggactcgtccaactacatg
ccccagctcttctggaacgtgggctgccagctcgtcgcgctcaacttccagaccctggat
gtggccatgcagctcaacgcgggcgtgttcgagtacaacgggcgcagtggctacctactc
aagcccgagttcatgcggcggccggacaagtcctttgaccccttcaccgaggtcatcgtg
gacggcatcgtggccaatgccgtgcgggtcaaggtgatctcggggcagttcctgtctgac
aggaaggtgggcatctacgtggaggtggatatgttcggcctccctgtcgacacgcggcgc
aagtaccgcactcggacctctcaggggaactcgttcaaccccgtgtgggatgaggagccc
ttcgacttccccaaggtggtgctgcccacgctggcttcgctgcgcatcgcggcctttgag
gagggtggcaagttcgtggggcaccggatcctgcctgtctctgccatccgctcagggtac
cactacatctgcctgcggaacgaggccaaccagccgctgtgcctgccggccctgctcatc
tacactgaggcctctgactacatccccgatgaccaccaggactacgcagaggccctgatc
aatcccatcaagcacgtcagcctgatggaccagagggccaagcagctggccgccctcatt
ggggagagtgaggctcaggctggcccggagacaagccaggagacccagtctcagcagcca
gggtcccagctgaccccaaaccccacacccagcccactggacgcctccccccgccggcct
ccaggccccatcacctcctccaccagcacctccctcagcagcccaggtcagcgcgatgac
ctcattgccagcgtcctctcagaggtggccccggccccgctggatgagctccgaggccac
aaggccctggtgaagctccagagccggcaagagcgagactttcgagagctgcacaagaag
catcagcggaaggcggttgccctcacacgccggttgctcgacaacctggcccaggctcgg
gccgagagcaggtgccggcaccggccgggtgtcctaggcggggaggatgagagggaggag
gaggaagaggtgaagaggtatcaagagttccaaaagaaacaggtgcggtgtctgctggag
ctgagggaggcccaggcggacacagaggccgagcggaggctggagcacctgagacaggct
cagcagaggctcagggagattgtcatggatgctcacaccactcagttcaagagactgaag
gagatgaacgagagggagaagaaggaactgcagaagatcctggacaggaagcgccacaac
agtatctcagaggcaaagaccagggagaaacataagaaggaggcggaactgacagagatt
aaccgtcggcacatcactgagtcggtcaactccatccgtcggctggaggaggcccagaag
cagcggcaggaacgccttgtggccgcgcagcagcagattctccaacagctgacagaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgggagaggctgccc
caggagatccgccggagcctgctgggcgagatgccggagggactgggggacgggcatctg
gtggcctgtgccagcaatggtcacgcgcctgggagcagtgggcacctgtccggcgctgat
tcggagagccaagaggagactacaaagctctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (7)   
   Pfam (7)   
All databases (13)   

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