KEGG   Heterocephalus glaber (naked mole-rat): 101712941
Entry
101712941         CDS       T02812                                 
Symbol
Pik3cd
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl00562  Inositol phosphate metabolism
hgl01100  Metabolic pathways
hgl01521  EGFR tyrosine kinase inhibitor resistance
hgl01522  Endocrine resistance
hgl01524  Platinum drug resistance
hgl04012  ErbB signaling pathway
hgl04014  Ras signaling pathway
hgl04015  Rap1 signaling pathway
hgl04024  cAMP signaling pathway
hgl04062  Chemokine signaling pathway
hgl04066  HIF-1 signaling pathway
hgl04068  FoxO signaling pathway
hgl04070  Phosphatidylinositol signaling system
hgl04071  Sphingolipid signaling pathway
hgl04072  Phospholipase D signaling pathway
hgl04081  Hormone signaling
hgl04140  Autophagy - animal
hgl04145  Phagocytosis
hgl04150  mTOR signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl04152  AMPK signaling pathway
hgl04210  Apoptosis
hgl04211  Longevity regulating pathway
hgl04213  Longevity regulating pathway - multiple species
hgl04218  Cellular senescence
hgl04360  Axon guidance
hgl04370  VEGF signaling pathway
hgl04380  Osteoclast differentiation
hgl04510  Focal adhesion
hgl04517  IgSF CAM signaling
hgl04518  Integrin signaling
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04611  Platelet activation
hgl04613  Neutrophil extracellular trap formation
hgl04620  Toll-like receptor signaling pathway
hgl04625  C-type lectin receptor signaling pathway
hgl04630  JAK-STAT signaling pathway
hgl04650  Natural killer cell mediated cytotoxicity
hgl04660  T cell receptor signaling pathway
hgl04662  B cell receptor signaling pathway
hgl04664  Fc epsilon RI signaling pathway
hgl04666  Fc gamma R-mediated phagosome formation
hgl04668  TNF signaling pathway
hgl04670  Leukocyte transendothelial migration
hgl04722  Neurotrophin signaling pathway
hgl04725  Cholinergic synapse
hgl04750  Inflammatory mediator regulation of TRP channels
hgl04810  Regulation of actin cytoskeleton
hgl04910  Insulin signaling pathway
hgl04914  Progesterone-mediated oocyte maturation
hgl04915  Estrogen signaling pathway
hgl04917  Prolactin signaling pathway
hgl04919  Thyroid hormone signaling pathway
hgl04923  Regulation of lipolysis in adipocytes
hgl04926  Relaxin signaling pathway
hgl04929  GnRH secretion
hgl04930  Type II diabetes mellitus
hgl04931  Insulin resistance
hgl04932  Non-alcoholic fatty liver disease
hgl04933  AGE-RAGE signaling pathway in diabetic complications
hgl04935  Growth hormone synthesis, secretion and action
hgl04960  Aldosterone-regulated sodium reabsorption
hgl04973  Carbohydrate digestion and absorption
hgl05010  Alzheimer disease
hgl05017  Spinocerebellar ataxia
hgl05020  Prion disease
hgl05100  Bacterial invasion of epithelial cells
hgl05132  Salmonella infection
hgl05135  Yersinia infection
hgl05142  Chagas disease
hgl05146  Amoebiasis
hgl05160  Hepatitis C
hgl05161  Hepatitis B
hgl05162  Measles
hgl05163  Human cytomegalovirus infection
hgl05164  Influenza A
hgl05165  Human papillomavirus infection
hgl05166  Human T-cell leukemia virus 1 infection
hgl05167  Kaposi sarcoma-associated herpesvirus infection
hgl05168  Herpes simplex virus 1 infection
hgl05169  Epstein-Barr virus infection
hgl05170  Human immunodeficiency virus 1 infection
hgl05171  Coronavirus disease
hgl05200  Pathways in cancer
hgl05203  Viral carcinogenesis
hgl05205  Proteoglycans in cancer
hgl05206  MicroRNAs in cancer
hgl05207  Chemical carcinogenesis - receptor activation
hgl05208  Chemical carcinogenesis - reactive oxygen species
hgl05210  Colorectal cancer
hgl05211  Renal cell carcinoma
hgl05212  Pancreatic cancer
hgl05213  Endometrial cancer
hgl05214  Glioma
hgl05215  Prostate cancer
hgl05218  Melanoma
hgl05220  Chronic myeloid leukemia
hgl05221  Acute myeloid leukemia
hgl05222  Small cell lung cancer
hgl05223  Non-small cell lung cancer
hgl05224  Breast cancer
hgl05225  Hepatocellular carcinoma
hgl05226  Gastric cancer
hgl05230  Central carbon metabolism in cancer
hgl05231  Choline metabolism in cancer
hgl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hgl05415  Diabetic cardiomyopathy
hgl05417  Lipid and atherosclerosis
hgl05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101712941 (Pik3cd)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101712941 (Pik3cd)
   04014 Ras signaling pathway
    101712941 (Pik3cd)
   04015 Rap1 signaling pathway
    101712941 (Pik3cd)
   04370 VEGF signaling pathway
    101712941 (Pik3cd)
   04630 JAK-STAT signaling pathway
    101712941 (Pik3cd)
   04668 TNF signaling pathway
    101712941 (Pik3cd)
   04066 HIF-1 signaling pathway
    101712941 (Pik3cd)
   04068 FoxO signaling pathway
    101712941 (Pik3cd)
   04070 Phosphatidylinositol signaling system
    101712941 (Pik3cd)
   04072 Phospholipase D signaling pathway
    101712941 (Pik3cd)
   04071 Sphingolipid signaling pathway
    101712941 (Pik3cd)
   04024 cAMP signaling pathway
    101712941 (Pik3cd)
   04151 PI3K-Akt signaling pathway
    101712941 (Pik3cd)
   04152 AMPK signaling pathway
    101712941 (Pik3cd)
   04150 mTOR signaling pathway
    101712941 (Pik3cd)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101712941 (Pik3cd)
   04517 IgSF CAM signaling
    101712941 (Pik3cd)
   04518 Integrin signaling
    101712941 (Pik3cd)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    101712941 (Pik3cd)
   04140 Autophagy - animal
    101712941 (Pik3cd)
  09143 Cell growth and death
   04210 Apoptosis
    101712941 (Pik3cd)
   04218 Cellular senescence
    101712941 (Pik3cd)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101712941 (Pik3cd)
   04550 Signaling pathways regulating pluripotency of stem cells
    101712941 (Pik3cd)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101712941 (Pik3cd)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101712941 (Pik3cd)
   04613 Neutrophil extracellular trap formation
    101712941 (Pik3cd)
   04620 Toll-like receptor signaling pathway
    101712941 (Pik3cd)
   04625 C-type lectin receptor signaling pathway
    101712941 (Pik3cd)
   04650 Natural killer cell mediated cytotoxicity
    101712941 (Pik3cd)
   04660 T cell receptor signaling pathway
    101712941 (Pik3cd)
   04662 B cell receptor signaling pathway
    101712941 (Pik3cd)
   04664 Fc epsilon RI signaling pathway
    101712941 (Pik3cd)
   04666 Fc gamma R-mediated phagosome formation
    101712941 (Pik3cd)
   04670 Leukocyte transendothelial migration
    101712941 (Pik3cd)
   04062 Chemokine signaling pathway
    101712941 (Pik3cd)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101712941 (Pik3cd)
   04923 Regulation of lipolysis in adipocytes
    101712941 (Pik3cd)
   04929 GnRH secretion
    101712941 (Pik3cd)
   04915 Estrogen signaling pathway
    101712941 (Pik3cd)
   04914 Progesterone-mediated oocyte maturation
    101712941 (Pik3cd)
   04917 Prolactin signaling pathway
    101712941 (Pik3cd)
   04926 Relaxin signaling pathway
    101712941 (Pik3cd)
   04935 Growth hormone synthesis, secretion and action
    101712941 (Pik3cd)
   04919 Thyroid hormone signaling pathway
    101712941 (Pik3cd)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101712941 (Pik3cd)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101712941 (Pik3cd)
  09156 Nervous system
   04725 Cholinergic synapse
    101712941 (Pik3cd)
   04722 Neurotrophin signaling pathway
    101712941 (Pik3cd)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101712941 (Pik3cd)
  09158 Development and regeneration
   04360 Axon guidance
    101712941 (Pik3cd)
   04380 Osteoclast differentiation
    101712941 (Pik3cd)
  09149 Aging
   04211 Longevity regulating pathway
    101712941 (Pik3cd)
   04213 Longevity regulating pathway - multiple species
    101712941 (Pik3cd)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101712941 (Pik3cd)
   05206 MicroRNAs in cancer
    101712941 (Pik3cd)
   05205 Proteoglycans in cancer
    101712941 (Pik3cd)
   05207 Chemical carcinogenesis - receptor activation
    101712941 (Pik3cd)
   05208 Chemical carcinogenesis - reactive oxygen species
    101712941 (Pik3cd)
   05203 Viral carcinogenesis
    101712941 (Pik3cd)
   05230 Central carbon metabolism in cancer
    101712941 (Pik3cd)
   05231 Choline metabolism in cancer
    101712941 (Pik3cd)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101712941 (Pik3cd)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101712941 (Pik3cd)
   05212 Pancreatic cancer
    101712941 (Pik3cd)
   05225 Hepatocellular carcinoma
    101712941 (Pik3cd)
   05226 Gastric cancer
    101712941 (Pik3cd)
   05214 Glioma
    101712941 (Pik3cd)
   05221 Acute myeloid leukemia
    101712941 (Pik3cd)
   05220 Chronic myeloid leukemia
    101712941 (Pik3cd)
   05218 Melanoma
    101712941 (Pik3cd)
   05211 Renal cell carcinoma
    101712941 (Pik3cd)
   05215 Prostate cancer
    101712941 (Pik3cd)
   05213 Endometrial cancer
    101712941 (Pik3cd)
   05224 Breast cancer
    101712941 (Pik3cd)
   05222 Small cell lung cancer
    101712941 (Pik3cd)
   05223 Non-small cell lung cancer
    101712941 (Pik3cd)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101712941 (Pik3cd)
   05170 Human immunodeficiency virus 1 infection
    101712941 (Pik3cd)
   05161 Hepatitis B
    101712941 (Pik3cd)
   05160 Hepatitis C
    101712941 (Pik3cd)
   05171 Coronavirus disease
    101712941 (Pik3cd)
   05164 Influenza A
    101712941 (Pik3cd)
   05162 Measles
    101712941 (Pik3cd)
   05168 Herpes simplex virus 1 infection
    101712941 (Pik3cd)
   05163 Human cytomegalovirus infection
    101712941 (Pik3cd)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101712941 (Pik3cd)
   05169 Epstein-Barr virus infection
    101712941 (Pik3cd)
   05165 Human papillomavirus infection
    101712941 (Pik3cd)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101712941 (Pik3cd)
   05135 Yersinia infection
    101712941 (Pik3cd)
   05100 Bacterial invasion of epithelial cells
    101712941 (Pik3cd)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101712941 (Pik3cd)
   05142 Chagas disease
    101712941 (Pik3cd)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101712941 (Pik3cd)
   05017 Spinocerebellar ataxia
    101712941 (Pik3cd)
   05020 Prion disease
    101712941 (Pik3cd)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101712941 (Pik3cd)
   05418 Fluid shear stress and atherosclerosis
    101712941 (Pik3cd)
   05415 Diabetic cardiomyopathy
    101712941 (Pik3cd)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101712941 (Pik3cd)
   04932 Non-alcoholic fatty liver disease
    101712941 (Pik3cd)
   04931 Insulin resistance
    101712941 (Pik3cd)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101712941 (Pik3cd)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101712941 (Pik3cd)
   01524 Platinum drug resistance
    101712941 (Pik3cd)
   01522 Endocrine resistance
    101712941 (Pik3cd)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hgl04131]
    101712941 (Pik3cd)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101712941 (Pik3cd)
Membrane trafficking [BR:hgl04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101712941 (Pik3cd)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2
Other DBs
NCBI-GeneID: 101712941
NCBI-ProteinID: XP_004863704
UniProt: A0A0P6J9T8
Position
Un
AA seq 1045 aa
MPPGVDCPMEFWTKEENQNVVVDFLLPTGIYLNFPVSLNANLRTIKQVLWYRAQYEPLFH
MLSGPEAYVFTCVNQTAEQQELEDEQRRLCDIRPFLPVLRVVAREGDRVKKLINSQISLL
IGKGLHEFDSLGDPEVNDFRAKMRQFCEEAAARRQQLGWEDWLQYSFPLQLEPSAGSWGP
STLRLPNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEDYV
LQVNGRLEYLYGSYPLCQFQYVCSCLHSGLTPHLTMVHSSSILAMRDGQGNPDPQVQKPH
PKPPPVPTKKPSSVSLWSLEQLFCIELIQGSKVNADERMKLVVQAGLFHGHEMLCKTVSS
SEVSVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAW
ANIMLFDYRDQLKTGERRLYMWPSVPDEKGELLNPAGSVHGNPNTESAAALVIFLPEVAP
HPVYYPALEKILELGRHGEQRGQGTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQ
EHFPDALARLLLVTKWHKHEDVAQMLYLLCSWPELPILSALELLDFSFPDCHVGSFAIRS
LRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPS
VALRFGLIMEAYCRGSTHHMKVLMKQGEALNKLKALNDFVKVSSQKTTKPQTKELMHLCM
RQETYLEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSKEAGTTGSVGIIFK
NGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQL
NKSNMAATAAFNKDALLNWLKSKNPGEALERAIEEFTLSCAGYCVATYVLGIGDRHSDNI
MIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGY
CERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKF
NEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3138 nt   +upstreamnt  +downstreamnt
atgccccccggggtcgactgccccatggagttctggaccaaggaggaaaatcagaacgtg
gtggtggacttcctgctccccacggggatctacctcaacttccctgtgtccctcaatgcc
aacctcaggaccatcaagcaggtgctgtggtatcgggcacagtatgagccgctcttccac
atgctcagcggtcctgaggcctacgtgttcacctgcgtcaaccagacagcagagcagcag
gagctggaggacgagcagcggcggctgtgcgacattcggcccttcctgccggtgctgcgc
gtggtggcccgggagggcgatcgagtcaagaagctcatcaactcccagatcagcctcctc
atcggcaaaggcctccacgagttcgactccctgggtgacccagaagtgaacgacttccgt
gccaagatgcgccagttctgcgaggaggcggctgcaaggcgccagcagctgggctgggag
gactggctgcagtatagcttccccctgcagctcgagccctcggccgggagctgggggccc
agcaccctgaggctccccaaccgggccctgctggtcaacgtcaaattcgagggcagcgag
gagagcttcaccttccaggtgtccaccaaggacatgccgctggcgctcatggcctgcgcc
ctgcgcaagaaggccacagtcttccggcagccgctggtggagcagccggaggactacgtg
ctgcaggtgaacgggcggctcgagtacctatacggcagctacccgctgtgccagttccag
tatgtctgcagctgcctgcacagtggactgaccccccacctcaccatggtgcactcctct
tctatcctggccatgcgggatgggcagggcaaccctgacccccaggtccagaagccccac
cccaagccgccccccgttcccaccaagaagccctcctccgtgtccctgtggtcgctggag
cagctgttctgcatcgagctcatccagggcagcaaggtgaatgcggatgagcgcatgaag
ctcgtggtgcaggccgggctcttccacggccatgagatgctatgcaagacagtgtccagc
tcagaggtcagcgtgtgctccgagcctgtgtggaagcagcggctggagtttgacatcagc
atctgcgacctgccgcgcatggcccggctctgcttcgcgctctatgccgtggtggagaaa
gccaagaaggcgcgctccaccaagaagaagtctaagaaggcggactgcccgatcgcctgg
gccaacatcatgctgttcgactaccgggaccagctgaagactggcgagcgccgcctgtac
atgtggccctcggtcccagatgagaaaggtgagctgctgaaccccgcggggagcgtgcac
ggaaaccccaacacagagagcgctgctgccctggtcatcttcctgcccgaggtggccccc
caccccgtgtactaccctgccctggagaagatcctggagctggggagacacggggagcag
cgcggacaaggcacggaggaggagcagctgcagctgagggagatcctggagcggcggggc
tcgggcgagctgtacgagcatgagaaggacctggtgtggaagatgcggcatgaggtccag
gagcacttcccagacgcgctggcccgcctgctgctggtcaccaagtggcacaagcacgag
gatgtggcccagatgctctacctcctgtgctcctggcccgagctgcccatcctgagtgcc
ctggagctgctggacttcagcttccctgactgtcacgtgggctcctttgccatcaggtcc
ctgcggaaactgacggatgatgagctcttccagtacctgctgcagctggtccaggtgctc
aagtatgagtcctacctggactgcgagctgaccaagttcttgctggaccgggcgctggcc
aaccgcaagatcggccacttcctcttctggcatctccgctctgagatgcacgtgccgtca
gtggccctgcgctttggcctcatcatggaggcctattgcaggggcagcacccaccacatg
aaggtgctgatgaagcagggggaagcactgaacaagctgaaggcgctgaatgacttcgtg
aaggtgagctcccagaagaccaccaagccccagaccaaggagctcatgcacctgtgcatg
cggcaggagacctatctggaggcactctcccacctgcagtccccactggacccaagcaca
ctgctggaggaagtgtgcgtggagcagtgcaccttcatggactccaagatgaagccgctg
tggatcatgtacagcagcaaggaggcgggcaccactggcagcgtgggcatcatcttcaag
aacggggatgacctccgccaggacatgctgaccctgcagatgatccagctcatggatgtg
ctatggaagcaggagggcctggacctgaggatgacgccctacggctgcctccccaccggg
gaccgcacgggcctcatcgaggtggtgctgcactcggacaccatcgccaacatccagctg
aacaagagcaacatggcagccacggccgccttcaacaaggacgccctgctcaactggctc
aagtccaagaaccctggggaggccctggagcgagccattgaagagttcaccctgtcctgt
gctggctactgtgtggccacctacgtgctgggcatcggtgaccggcacagcgacaacatc
atgatccgtgagagtgggcagctgttccacattgattttggccacttcctgggaaatttc
aagaccaagtttggaatcaaccgtgagcgggtcccgttcatcctcacctatgacttcgtc
cacgtgattcagcagggaaagacgaataacagcgagaaatttgaaaggttccggggctac
tgcgaacgagcctacaccatcctgcggcgccatggcctcctcttcctccacctctttgca
ctgatgcgggcagcgggcctgcctgagctcagctgctccaaagacatccagtacctcaag
gactccctggcgctggggaaaacagaggaggaggcgctgaagcacttccgggtgaagttc
aacgaagccctcagggagagctggaagaccaaagtgaactggctggcacacaacgtgtcc
aaagataacaggcagtag

  All links  
Gene (16)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   RefSeq(pep) (6)   
DNA sequence (8)   
   RefSeq(nuc) (6)   
   GenBank (1)   
   EMBL (1)   
Protein domain (5)   
   Pfam (5)   
All databases (36)   

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