KEGG   Homo sapiens (human): 10846
Entry
10846             CDS       T01001                                 
Symbol
PDE10A, ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19
Name
(RefSeq) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3
  KO
K18438  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:3.1.4.17 3.1.4.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa04024  cAMP signaling pathway
hsa05032  Morphine addiction
Disease
H01570  Autosomal dominant striatal degeneration
H02388  Infantile-onset limb and orofacial dyskinesia
Drug target
Aminophylline (DG01062): D00227 D05429<JP> D11630<US>
Balipodect: D11245
Bemoradan: D03075
Bucladesine (DG00230): D01238<JP> D07546
Choline theophyllinate: D02017
Diprophylline: D00691<JP>
Enprofylline: D04006
Flavoxate (DG00477): D00718<JP/US> D07961
Gemlapodect: D13073
Mardepodect: D11171
Moxaverine (DG00045): D07089 D08238
Oxagrelate: D05278
Papaverine (DG00043): D02218<JP> D07425 D07439
Prinoxodan: D05612
Proxyphylline: D01771
Theophylline (DG01061): D00371<JP/US> D01712 D06103 D06104
Theosalicin: D09822
Tibenelast sodium: D06132
Trapidil: D01220<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    10846 (PDE10A)
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    10846 (PDE10A)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    10846 (PDE10A)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.17  3',5'-cyclic-nucleotide phosphodiesterase
     10846 (PDE10A)
    3.1.4.35  3',5'-cyclic-GMP phosphodiesterase
     10846 (PDE10A)
SSDB
Motif
Pfam: PDEase_I GAF GAF_2 GAF_3 HD SpoVT_C PEX15_N DUF7334
Other DBs
NCBI-GeneID: 10846
NCBI-ProteinID: NP_001372008
OMIM: 610652
HGNC: 8772
Ensembl: ENSP00000438284.3
UniProt: Q9Y233
Structure
Position
6:complement(165327289..165988052)
AA seq 1055 aa
MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
NT seq 3168 nt   +upstreamnt  +downstreamnt
atggccagcctcgaggagcctcttgctccccgcccccagggtcccctgccagcggccggg
gacgagccgggctgcggccccggcaaactccgcccggaaccccggctcagcgcggccggc
ggggggagcgcggcgggcccgggcccggcccccgagtggcctggccgtggccgggcggag
cgcgccgcgcccccgcgcccgcccctctcctccgcaggccgccccagccccgctgggggc
cccggcgccctctctgcgcgcggcggcggctgcggctgggtcgcggcccgcgctcccttg
gcgctcgccttctcgtcccgggtcccctcctcctctccatctttcttttacttctggccg
ccgccccccccgccccctccctcttttctcccctcctcatctgcctttcacctccccgtg
cgtctcccaggaagggagggcgcagcggcggcggcggcggcgggaggaggcggcgatgct
ggcggaggaggaggaggaggacaagaggcagctcccttgagcgtccccaccagcagtagt
caccgcggcggcggtggcagcggcggcgggcggcggcggctcttcctctcgcctgcgctc
cagggcttgctgcttccagcccgtgccggtccccggccgccgccgccgccccggctcccc
cttggccaggccgcccgccgcgcgggctcccccggcttccccggcgccggcccaggcggc
ggcggccaaactccgcggcgtccccagggcgccagcttcgccctcgccgccgcggccgcg
ctgctcttcggctccgacatggaagatggaccttctaataatgcgagctgcttccgaagg
ctgaccgagtgcttcctgagccccagtttgacagatgaaaaagtgaaggcatatctttct
cttcacccccaggtattagatgaatttgtatctgaaagtgttagtgcagagacagtagag
aaatggctgaagaggaagaacaacaaatcagaagatgaatcagctcctaaggaagtcagc
aggtaccaagatacgaatatgcagggagttgtatatgaactaaacagctatatagaacaa
cggttggacacaggaggagacaaccagctactcctctatgaactgagcagcatcattaaa
atagccacaaaagccgatggatttgcactgtatttccttggagagtgcaataatagcctg
tgtatattcacgccacctgggataaaggaaggaaaaccccgcctcatccctgctgggccc
atcactcagggcaccaccgtctctgcttatgtggccaagtccaggaaaacactgctagta
gaagacatccttggagatgaacgatttccaagaggtactggactggaatcagggactcgt
atccagtctgttctttgcttaccaattgtcactgcaattggtgacttgattggtattctc
gagctgtatcggcactggggcaaagaagccttctgtcttagtcaccaggaggttgcaaca
gcaaatcttgcctgggcttcagtagcaatacatcaggtgcaggtatgcagaggccttgcc
aaacagacagaattgaatgacttcctactcgacgtatcaaaaacatattttgataacata
gttgcaatagattctctacttgaacacataatgatatatgcaaaaaacctggtgaatgcc
gatcgttgtgcgcttttccaggtggaccataagaacaaggagttatattcagaccttttt
gatattggagaggaaaaggaaggaaaacctgtcttcaagaagaccaaagagataagattt
tcaattgagaaaggaattgctggccaagtagcaagaacaggggaagtcctgaacattcca
gatgcctatgcagacccacgctttaacagagaagtagacttgtacacaggctacaccacg
cggaacatcctgtgcatgcccatcgtcagccgaggcagcgtgataggtgtggtgcagatg
gtcaacaaaatcagtggcagtgccttctctaaaacagatgaaaacaacttcaaaatgttt
gccgtcttttgtgctttagccttacactgtgctaatatgtatcatagaattcgccactca
gagtgcatttaccgggtaacgatggaaaagctgtcctaccatagcatttgtacttcagaa
gagtggcaaggtctcatgcaattcacccttcccgtgcgtctctgcaaagaaattgaatta
ttccactttgacattggtccttttgaaaacatgtggcctggaatttttgtctacatggtt
catcggtcctgtgggacatcctgctttgagcttgaaaagttgtgtcgttttattatgtct
gtgaagaagaactatcggcgggttccttatcacaactggaagcatgcggtcactgtagca
cactgcatgtatgccatacttcagaacaatcacacgcttttcacagaccttgagcgcaaa
ggactgctgattgcgtgtctgtgtcatgacctggaccacaggggcttcagtaacagctac
ctgcagaagttcgaccaccctctggccgctctctactccacttccaccatggagcagcac
cacttctcccagactgtgtccatcctccagttggaagggcacaatatcttctccactctg
agctccagtgaatatgagcaggtgcttgagatcatccgcaaagccatcattgccacagac
cttgctttatactttggaaacaggaagcagttggaagagatgtaccagaccggatcacta
aaccttaataatcaatcacatagagaccgtgtaattggtttgatgatgactgcctgtgac
ctttgttctgtgacaaaactgtggcccgttacaaaattgacggcaaatgatatatatgca
gaattctgggctgagggtgatgaaatgaagaaattgggaatacagcctattcctatgatg
gacagagacaagaaggatgaagtcccccaaggccagcttgggttctacaatgccgtggcc
attccctgctatacaacccttacccagatcctccctcccacggagcctcttctgaaagca
tgcagggataatctcagtcagtgggagaaggtgattcgaggggaggagactgcaacctgg
atttcatccccatccgtggctcagaaggcagctgcatctgaagattga

  All links  
Disease (3)   
   OMIM (3)   
Gene (15)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (25)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (23)   
DNA sequence (86)   
   RefSeq(nuc) (24)   
   GenBank (31)   
   EMBL (31)   
3D Structure (358)   
   PDB (358)   
Protein domain (8)   
   Pfam (8)   
All databases (495)   

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