KEGG   Homo sapiens (human): 143
Entry
143               CDS       T01001                                 
Symbol
PARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193
Name
(RefSeq) protein mono-ADP-ribosyltransferase PARP4
  KO
K10798  protein mono-ADP-ribosyltransferase 3/4 [EC:2.4.2.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
hsa04210  Apoptosis
Drug target
Veliparib: D09692
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    143 (PARP4)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    143 (PARP4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    143 (PARP4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     143 (PARP4)
SSDB
Motif
Pfam: PARP4_MVP-ID WGR-like_PARP4 PARP VIT BRCT VWA VWA_3 VIT_2 VWA_2 BRCT_2 PARP_reg PTCB-BRCT VWA_CoxE
Other DBs
NCBI-GeneID: 143
NCBI-ProteinID: NP_006428
OMIM: 607519
HGNC: 271
Ensembl: ENSP00000371419.3
UniProt: Q9UKK3
Structure
Position
13:complement(24420931..24512778)
AA seq 1724 aa
MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQ
LNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCP
DSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVELQCSRDSR
DCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQL
ASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGI
LLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVC
ETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRV
NETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSD
SLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVT
TDFEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQL
PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFP
LDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGN
LPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTK
QSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYL
PRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIAL
HALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYL
SLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCG
AGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFL
NDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGI
LHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAK
EDVDFLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSED
FEEDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILA
PAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQS
ASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQLHFS
LPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDLCL
LEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCFLEVKEEDE
IVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQKGIQSLGVKGR
ECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEAIKQASEWVRRTE
GQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG
NT seq 5175 nt   +upstreamnt  +downstreamnt
atggtgatgggaatctttgcaaattgtatcttctgtttgaaagtgaagtacttacctcag
cagcagaagaaaaagctacaaactgacattaaggaaaatggcggaaagttttccttttcg
ttaaatcctcagtgcacacatataatcttagataatgctgatgttctgagtcagtaccaa
ctgaattctatccaaaagaaccacgttcatattgcaaacccagattttatatggaaatct
atcagggaaaagagactcttggatgtaaagaattatgatccttataagcccctggacatc
acaccacctcctgatcagaaggcgagcagttctgaagtgaaaacagaaggtctatgcccg
gacagtgccacagaggaggaagacactgtggaactcactgagtttggtatgcagaatgtt
gaaattcctcatcttcctcaagattttgaagttgcaaaatataacaccttggagaaagtg
ggaatggagggaggccaggaagctgtggtggtggagcttcagtgttcgcgggactccagg
gactgtcctttcctgatatcctcacacttcctcctggatgatggcatggagactagaaga
cagtttgctataaagaaaacctctgaagatgcaagtgaatactttgaaaattacattgaa
gaactgaagaaacaaggatttctactaagagaacatttcacacctgaagcaacccaatta
gcatctgaacaattgcaagcattgcttttggaggaagtcatgaattcaagcactctgagc
caagaggtgagcgatttagtagagatgatttgggcagaggccctgggccacctggaacac
atgcttctcaagccagtgaacaggattagcctcaacgatgtgagcaaggcagaggggatt
ctccttctagtaaaggcagcactgaaaaatggagaaacagcagagcaattgcaaaagatg
atgacagagttttacagactgatacctcacaaaggcacaatgcccaaagaagtgaacctg
ggactattggctaagaaagcagacctctgccagctaataagagacatggttaatgtctgt
gaaactaatttgtccaaacccaacccaccatccctggccaaataccgagctttgaggtgc
aaaattgagcatgttgaacagaatactgaagaatttctcagggttagaaaagaggttttg
cagaatcatcacagtaagagcccagtggatgtcttgcagatatttagagttggcagagtg
aatgaaaccacagagtttttgagcaaacttggtaatgtgaggcccttgttgcatggttct
cctgtacaaaacatcgtgggaatcttgtgtcgagggttgcttttacccaaagtagtggaa
gatcgtggtgtgcaaagaacagacgtcggaaaccttggaagtgggatttatttcagtgat
tcgctcagtacaagtatcaagtactcacacccgggagagacagatggcaccagactcctg
ctcatttgtgacgtagccctcggaaagtgtatggacttacatgagaaggacttttcctta
actgaagcaccaccaggctacgacagtgtgcatggagtttcgcaaacagcctctgtcacc
acagactttgaggatgatgaatttgttgtctataaaaccaatcaggttaaaatgaaatat
attattaaattttccatgcctggagatcagataaaggactttcatcctagtgatcatact
gaattagaggaatacagacctgagttttcaaatttttcaaaggttgaagattaccagtta
ccagatgccaaaacttccagcagcaccaaggccggcctccaggatgcctctgggaacttg
gttcctctggaggatgtccacatcaaagggagaatcatagacactgtagcccaggtcatt
gtttttcagacatacacaaataaaagtcacgtgcccattgaggcaaaatatatctttcct
ttggatgacaaggccgctgtgtgtggcttcgaagccttcatcaatgggaagcacatagtt
ggagagattaaagagaaggaagaagcccagcaagagtacctagaagccgtgacccagggc
catggcgcttacctgatgagtcaggatgctccggacgtttttactgtaagtgttggaaac
ttaccccctaaggctaaggttcttataaaaattacctacatcacagaactcagcatcctg
ggcactgttggtgtctttttcatgcccgccaccgtagcaccctggcaacaggacaaggct
ttgaatgaaaaccttcaggatacagtagagaagatttgtataaaagaaataggaacaaag
caaagcttctctttgactatgtctattgagatgccgtatgtgattgaattcattttcagt
gatacacatgaactgaaacaaaagcgcacagactgcaaagctgtcattagcaccatggaa
ggcagctccttagacagcagtggattttctctccacatcggtttgtctgctgcctatctc
ccaagaatgtgggttgaaaaacatccagaaaaagaaagcgaggcttgcatgcttgtcttt
caacccgatctcgatgtcgacctccctgacctagccagtgagagcgaagtgattatttgt
cttgactgctccagttccatggagggtgtgacattcttgcaagccaagcaaatcgccttg
catgcgctgtccttggtgggtgagaagcagaaagtaaatattatccagttcggcacaggt
tacaaggagctattttcgtatcctaagcatatcacaagcaataccatggcagcagagttc
atcatgtctgccacacctaccatggggaacacagacttctggaaaacactccgatatctt
agcttattgtaccctgctcgagggtcacggaacatcctcctggtgtctgatgggcacctc
caggatgagagcctgacattacagctcgtgaagaggagccgcccgcacaccaggttattc
gcctgcggtatcggttctacagcaaatcgtcacgtcttaaggattttgtcccagtgtggt
gccggagtatttgaatattttaatgcaaaatccaagcatagttggagaaaacagatagaa
gaccaaatgaccaggctatgttctccgagttgccactctgtctccgtcaaatggcagcaa
ctcaatccagatgtgcccgaggccctgcaggccccagcccaggtgccgtccttgtttctc
aatgatcgactccttgtctatggattcattcctcactgcacacaggcaactctgtgtgca
ctaattcaagagaaagaatttcgtacaatggtgtcgactactgagcttcagaagacaact
ggaactatgatccacaagctggcagcccgagctctaatcagagattatgaagatggcatt
cttcacgaaaatgaaaccagtcatgagatgaaaaaacaaaccttgaaatctctgattatt
aaactcagtaaagaaaactctctcataacacaatttacaagctttgtggcagttgagaaa
agggatgagaatgagtcgccttttcctgatattccaaaagtttctgaacttattgccaaa
gaagatgtagacttcctgccctacatgagctggcagggggagccccaagaagccgtcagg
aaccagtctcttttagcatcctctgagtggccagaattacgtttatccaaacgaaaacat
aggaaaattccattttccaaaagaaaaatggaattatctcagccagaagtttctgaagat
tttgaagaggatggcttaggtgtactaccagctttcacatcaaatttggaacgtggaggt
gtggaaaagctattggatttaagttggacagagtcatgtaaaccaacagcaactgaacca
ctatttaagaaagtcagtccatgggaaacatctacttctagcttttttcctattttggct
ccggccgttggttcctatcttcccccgactgcccgcgctcacagtcctgcttccttgtct
tttgcctcatatcgtcaggtagctagtttcggttcagctgctcctcccagacagtttgat
gcatctcaattcagccaaggccctgtgcctggcacttgtgctgactggatcccacagtcg
gcgtcttgtcccacaggacctccccagaacccaccttcttcaccctattgtggcattgtt
ttttcagggagctcattaagctctgcacagtctgctccactgcaacatcctggaggcttt
actaccaggccttctgctggcaccttccctgagctggattctccccagcttcatttctct
cttcctacagaccctgatcccatcagaggttttgggtcttatcatccctctgcttcctct
ccttttcattttcaaccttccgcagcctctttgactgccaaccttaggctgccaatggcc
tctgctttacctgaggctctttgcagtcagtcccggactaccccagtagatctctgtctt
ctagaagaatcagtaggcagtctcgaaggaagtcgatgtcctgtctttgcttttcaaagt
tctgacacagaaagtgatgagctatcagaagtacttcaagacagctgctttttacaaata
aaatgtgatacaaaagatgacagtatcctgtgctttctggaagtaaaagaagaggatgaa
atagtgtgcatacaacactggcaggatgctgtgccttggacagaactcctcagtctacag
acagaggatggcttctggaaacttacaccagaactgggacttatattaaatcttaataca
aatggtttgcacagctttcttaaacaaaaaggcattcaatctctaggtgtaaaaggaaga
gaatgtctcctggacctaattgccacaatgctggtactacagtttattcgcaccaggttg
gaaaaagagggaatagtgttcaaatcactgatgaaaatggatgacgcttctatttccagg
aatattccctgggcttttgaggcaataaagcaagcaagtgaatgggtaagaagaactgaa
ggacagtacccatctatctgcccacggcttgaactggggaacgactgggactctgccacc
aagcagttgctgggactccagcccataagcactgtgtcccctcttcatagagtcctccat
tacagtcaaggctaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (28)   
   RefGene (23)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (11)   
   PDB (11)   
Protein domain (13)   
   Pfam (13)   
All databases (77)   

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