KEGG   Homo sapiens (human): 1499
Entry
1499              CDS       T01001                                 
Symbol
CTNNB1, CTNNB, EVR7, MRD19, NEDSDV, armadillo
Name
(RefSeq) catenin beta-1 isoform 1
  KO
K02105  catenin beta 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04518  Integrin signaling
hsa04519  Cadherin signaling
hsa04520  Adherens junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04670  Leukocyte transendothelial migration
hsa04916  Melanogenesis
hsa04919  Thyroid hormone signaling pathway
hsa04934  Cushing syndrome
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05100  Bacterial invasion of epithelial cells
hsa05132  Salmonella infection
hsa05160  Hepatitis C
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06215  WNT signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06505  WNT signaling
nt06549  Cadherin signaling
  Element
N00056  Wnt signaling pathway, Canonical pathway
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
N00061  CDH1-reduced expression to beta-catenin signaling pathway
N00175  KSHV LANA to Wnt signaling pathway
N00242  Mutation-inactivated AXIN to Wnt signaling pathway
N00257  Loss of CDH1 to beta-catenin signaling pathway
N00258  Mutation-inactivated CDH1 to beta-catenin signaling pathway
N01124  Salmonella AvrA to beta-catenin signaling pathway
N01999  Clasical cadherin-catenin cell adhesion system
N02000  Clasical cadherin to Hippo signaling pathway
N02001  Clasical cadherin to Wnt signaling pathway
N02003  deltaPCDH8/10/18/20 to Wnt signaling
N02009  Desmosomal cadherin to Wint signaling pathway
Disease
H00018  Gastric cancer
H00020  Colorectal cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00032  Thyroid cancer
H00048  Hepatocellular carcinoma
H00589  Familial exudative vitreoretinopathy
H00773  Autosomal dominant intellectual developmental disorder
H00947  Pilomatricoma
H01667  Medulloblastoma
H02301  Nephroblastoma
H02302  Hepatoblastoma
Drug target
Foscenvivint: D12445
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    1499 (CTNNB1)
   04310 Wnt signaling pathway
    1499 (CTNNB1)
   04390 Hippo signaling pathway
    1499 (CTNNB1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    1499 (CTNNB1)
   04518 Integrin signaling
    1499 (CTNNB1)
   04519 Cadherin signaling
    1499 (CTNNB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    1499 (CTNNB1)
   04520 Adherens junction
    1499 (CTNNB1)
   04550 Signaling pathways regulating pluripotency of stem cells
    1499 (CTNNB1)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    1499 (CTNNB1)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    1499 (CTNNB1)
   04916 Melanogenesis
    1499 (CTNNB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1499 (CTNNB1)
   05205 Proteoglycans in cancer
    1499 (CTNNB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    1499 (CTNNB1)
   05225 Hepatocellular carcinoma
    1499 (CTNNB1)
   05226 Gastric cancer
    1499 (CTNNB1)
   05216 Thyroid cancer
    1499 (CTNNB1)
   05217 Basal cell carcinoma
    1499 (CTNNB1)
   05215 Prostate cancer
    1499 (CTNNB1)
   05213 Endometrial cancer
    1499 (CTNNB1)
   05224 Breast cancer
    1499 (CTNNB1)
  09172 Infectious disease: viral
   05160 Hepatitis C
    1499 (CTNNB1)
   05163 Human cytomegalovirus infection
    1499 (CTNNB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1499 (CTNNB1)
   05165 Human papillomavirus infection
    1499 (CTNNB1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    1499 (CTNNB1)
   05100 Bacterial invasion of epithelial cells
    1499 (CTNNB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1499 (CTNNB1)
   05022 Pathways of neurodegeneration - multiple diseases
    1499 (CTNNB1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1499 (CTNNB1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    1499 (CTNNB1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    1499 (CTNNB1)
   04934 Cushing syndrome
    1499 (CTNNB1)
SSDB
Motif
Pfam: Arm ARM_ARMC5 WRM1_C BAR1_C ARM_PUB Cnd1 HEAT_2 HEAT_EZ Adaptin_N TPR_CCP1_N KAP ARMC9_ARM Atx10homo_assoc Germane Queuosine_synth
Other DBs
NCBI-GeneID: 1499
NCBI-ProteinID: NP_001091679
OMIM: 116806
HGNC: 2514
UniProt: P35222
Structure
Position
3:41199505..41240443
AA seq 781 aa
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
NT seq 2346 nt   +upstreamnt  +downstreamnt
atggctactcaagctgatttgatggagttggacatggccatggaaccagacagaaaagcg
gctgttagtcactggcagcaacagtcttacctggactctggaatccattctggtgccact
accacagctccttctctgagtggtaaaggcaatcctgaggaagaggatgtggatacctcc
caagtcctgtatgagtgggaacagggattttctcagtccttcactcaagaacaagtagct
gatattgatggacagtatgcaatgactcgagctcagagggtacgagctgctatgttccct
gagacattagatgagggcatgcagatcccatctacacagtttgatgctgctcatcccact
aatgtccagcgtttggctgaaccatcacagatgctgaaacatgcagttgtaaacttgatt
aactatcaagatgatgcagaacttgccacacgtgcaatccctgaactgacaaaactgcta
aatgacgaggaccaggtggtggttaataaggctgcagttatggtccatcagctttctaaa
aaggaagcttccagacacgctatcatgcgttctcctcagatggtgtctgctattgtacgt
accatgcagaatacaaatgatgtagaaacagctcgttgtaccgctgggaccttgcataac
ctttcccatcatcgtgagggcttactggccatctttaagtctggaggcattcctgccctg
gtgaaaatgcttggttcaccagtggattctgtgttgttttatgccattacaactctccac
aaccttttattacatcaagaaggagctaaaatggcagtgcgtttagctggtgggctgcag
aaaatggttgccttgctcaacaaaacaaatgttaaattcttggctattacgacagactgc
cttcaaattttagcttatggcaaccaagaaagcaagctcatcatactggctagtggtgga
ccccaagctttagtaaatataatgaggacctatacttacgaaaaactactgtggaccaca
agcagagtgctgaaggtgctatctgtctgctctagtaataagccggctattgtagaagct
ggtggaatgcaagctttaggacttcacctgacagatccaagtcaacgtcttgttcagaac
tgtctttggactctcaggaatctttcagatgctgcaactaaacaggaagggatggaaggt
ctccttgggactcttgttcagcttctgggttcagatgatataaatgtggtcacctgtgca
gctggaattctttctaacctcacttgcaataattataagaacaagatgatggtctgccaa
gtgggtggtatagaggctcttgtgcgtactgtccttcgggctggtgacagggaagacatc
actgagcctgccatctgtgctcttcgtcatctgaccagccgacaccaagaagcagagatg
gcccagaatgcagttcgccttcactatggactaccagttgtggttaagctcttacaccca
ccatcccactggcctctgataaaggctactgttggattgattcgaaatcttgccctttgt
cccgcaaatcatgcacctttgcgtgagcagggtgccattccacgactagttcagttgctt
gttcgtgcacatcaggatacccagcgccgtacgtccatgggtgggacacagcagcaattt
gtggagggggtccgcatggaagaaatagttgaaggttgtaccggagcccttcacatccta
gctcgggatgttcacaaccgaattgttatcagaggactaaataccattccattgtttgtg
cagctgctttattctcccattgaaaacatccaaagagtagctgcaggggtcctctgtgaa
cttgctcaggacaaggaagctgcagaagctattgaagctgagggagccacagctcctctg
acagagttacttcactctaggaatgaaggtgtggcgacatatgcagctgctgttttgttc
cgaatgtctgaggacaagccacaagattacaagaaacggctttcagttgagctgaccagc
tctctcttcagaacagagccaatggcttggaatgagactgctgatcttggacttgatatt
ggtgcccagggagaaccccttggatatcgccaggatgatcctagctatcgttcttttcac
tctggtggatatggccaggatgccttgggtatggaccccatgatggaacatgagatgggt
ggccaccaccctggtgctgactatccagttgatgggctgccagatctggggcatgcccag
gacctcatggatgggctgcctccaggtgacagcaatcagctggcctggtttgatactgac
ctgtaa

  All links  
Disease (8)   
   OMIM (8)   
Gene (48)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   RIKEN BRC-DNA (27)   
   OC (1)   
Protein sequence (21)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (51)   
   RefSeq(nuc) (19)   
   GenBank (16)   
   EMBL (16)   
3D Structure (50)   
   PDB (50)   
Protein domain (15)   
   Pfam (15)   
All databases (193)   

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