KEGG   Homo sapiens (human): 25759
Entry
25759             CDS       T01001                                 
Symbol
SHC2, SCK, SHCB, SLI
Name
(RefSeq) SHC adaptor protein 2
  KO
K17447  SHC-transforming protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
hsa05034  Alcoholism
hsa05100  Bacterial invasion of epithelial cells
hsa05214  Glioma
hsa05220  Chronic myeloid leukemia
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06526  MAPK signaling
  Element
N01595  Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    25759 (SHC2)
   04014 Ras signaling pathway
    25759 (SHC2)
   04370 VEGF signaling pathway
    25759 (SHC2)
   04072 Phospholipase D signaling pathway
    25759 (SHC2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    25759 (SHC2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    25759 (SHC2)
   04062 Chemokine signaling pathway
    25759 (SHC2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    25759 (SHC2)
   04915 Estrogen signaling pathway
    25759 (SHC2)
   04917 Prolactin signaling pathway
    25759 (SHC2)
   04926 Relaxin signaling pathway
    25759 (SHC2)
   04935 Growth hormone synthesis, secretion and action
    25759 (SHC2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    25759 (SHC2)
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    25759 (SHC2)
   05226 Gastric cancer
    25759 (SHC2)
   05214 Glioma
    25759 (SHC2)
   05220 Chronic myeloid leukemia
    25759 (SHC2)
   05224 Breast cancer
    25759 (SHC2)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    25759 (SHC2)
  09165 Substance dependence
   05034 Alcoholism
    25759 (SHC2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    25759 (SHC2)
   01522 Endocrine resistance
    25759 (SHC2)
SSDB
Motif
Pfam: PID SH2
Other DBs
NCBI-GeneID: 25759
NCBI-ProteinID: NP_036567
OMIM: 605217
HGNC: 29869
Ensembl: ENSG00000129946
Pharos: P98077(Tbio)
UniProt: P98077
Position
19:complement(416589..461033)
AA seq 582 aa
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA
DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA
AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR
EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ
VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL
RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT
QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL
DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE
QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV
VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP
NT seq 1749 nt   +upstreamnt  +downstreamnt
atgacgcagggtccgggcgggcgcgcgcccccggcgccccccgcgccccccgagcccgag
gcgcccaccaccttctgcgcgttgctgccccgaatgccgcagtggaagttcgcggccccg
ggcggcttcctgggccgcggcccggcggcggcgcgggcggctggggcctcggggggcgcg
gacccccaacccgagccggcgggcccggggggcgtcccggcgctggcggccgccgtcctg
ggcgcctgcgagccccgctgcgccgcgccctgtcccctgcccgcgctcagccgctgtcgg
ggcgcggggtcgcgggggtcgcggggcgggcggggggcggcggggtccggggacgccgcc
gccgccgccgagtggatccggaagggcagcttcatccacaaacccgcgcacggctggcta
caccccgacgccagggtcctggggcccggggtctcctacgtcgtgcggtacatgggctgc
atcgaggttctccgctctatgcgctccctggactttaacacgcgcacgcaggtgaccagg
gaagccatcaaccggctccatgaggccgtgcctggcgtccggggatcctggaagaaaaag
gcccccaacaaggccctggcgtccgtcctgggcaagagcaaccttcgctttgccggcatg
agcatctccatccacatctccactgatggcctcagcctctccgtgcctgccacgcgccag
gtcatcgccaaccaccacatgccgtccatctccttcgcgtcaggcggagacacggacatg
acggattacgtggcctacgtcgccaaggaccccatcaaccagagagcctgccacatcctg
gagtgctgtgagggcctggcacagagcatcatcagcaccgtgggccaagctttcgagctg
cgcttcaagcagtacctgcacagcccgcccaaggtggcgctgcccccagaaaggctggca
gggccggaggagtcggcctggggggacgaggaggactctttggagcacaattactacaac
agcatcccggggaaggagccgccgctgggcgggctagtggactccaggctggccctgaca
cagccctgcgccctcacggccctcgaccagggcccatctccttctctaagagatgcctgc
agcctgccatgggacgtggggtccaccggtacagctccaccgggggacggctacgtgcag
gcggacgcccggggccccccggaccacgaggagcacctgtatgtcaacacccagggtctg
gacgcccccgagccggaggacagccccaaaaaggatctgtttgacatgcgaccctttgag
gatgccctgaagttgcatgagtgctcagtggcggcaggcgtgacagcagcccctcttccc
ttggaggaccagtggcccagcccccctacccgccgggcccctgtggcccccacggaggaa
cagctgcgtcaggagccctggtaccacggccggatgagccgccgggcggcagagaggatg
cttcgagctgacggggacttccttgtgcgagacagcgtcaccaaccccgggcagtatgtc
ctcaccggcatgcacgccgggcagcccaagcacctgctgctcgtggaccccgagggcgtg
gtacggacgaaggacgtgctgtttgagagcatcagccacctgatcgaccaccacctgcag
aacgggcagcccatcgtggccgccgagagtgagctgcacctgcgtggcgtggtctcacgg
gagccctga

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (22)   
   KEGG PATHWAY (22)   
Network (1)   
   KEGG NETWORK (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (30)   
   RefSeq(nuc) (8)   
   GenBank (11)   
   EMBL (11)   
Protein domain (2)   
   Pfam (2)   
All databases (90)   

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KEGG   Homo sapiens (human): 399694
Entry
399694            CDS       T01001                                 
Symbol
SHC4, RaLP, SHCD
Name
(RefSeq) SHC adaptor protein 4
  KO
K17449  SHC-transforming protein 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
hsa05034  Alcoholism
hsa05100  Bacterial invasion of epithelial cells
hsa05206  MicroRNAs in cancer
hsa05214  Glioma
hsa05220  Chronic myeloid leukemia
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06526  MAPK signaling
  Element
N01595  Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    399694 (SHC4)
   04014 Ras signaling pathway
    399694 (SHC4)
   04072 Phospholipase D signaling pathway
    399694 (SHC4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    399694 (SHC4)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    399694 (SHC4)
   04062 Chemokine signaling pathway
    399694 (SHC4)
  09152 Endocrine system
   04910 Insulin signaling pathway
    399694 (SHC4)
   04915 Estrogen signaling pathway
    399694 (SHC4)
   04917 Prolactin signaling pathway
    399694 (SHC4)
   04926 Relaxin signaling pathway
    399694 (SHC4)
   04935 Growth hormone synthesis, secretion and action
    399694 (SHC4)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    399694 (SHC4)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    399694 (SHC4)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    399694 (SHC4)
   05226 Gastric cancer
    399694 (SHC4)
   05214 Glioma
    399694 (SHC4)
   05220 Chronic myeloid leukemia
    399694 (SHC4)
   05224 Breast cancer
    399694 (SHC4)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    399694 (SHC4)
  09165 Substance dependence
   05034 Alcoholism
    399694 (SHC4)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    399694 (SHC4)
   01522 Endocrine resistance
    399694 (SHC4)
SSDB
Motif
Pfam: PID SH2 Delta_lysin
Other DBs
NCBI-GeneID: 399694
NCBI-ProteinID: NP_976224
OMIM: 617372
HGNC: 16743
Ensembl: ENSG00000185634
Pharos: Q6S5L8(Tbio)
UniProt: Q6S5L8
Position
15:complement(48823741..48963919)
AA seq 630 aa
MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH
PALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ
ESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRH
FLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV
HIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKC
SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGN
QRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL
VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN
SLPIISSGSEVSLKQPVRKDNNPALLHSNK
NT seq 1893 nt   +upstreamnt  +downstreamnt
atgcgagaacgcggccaggacagcctggcaggactcgtgctgtatgtaggactcttcggg
caccccgggatgctgcacagggccaagtacagccgctttcggaacgagtcgatcacgtcc
ttggacgaaggtagctccggaggctcggtcgggaacaagggctcgccgcagcctccccac
cccgccctggcacctcacctgccgactgaagatgccaccttgccgtcgcaggagagcccc
accccactgtgcaccttgatcccccgcatggcaagcatgaagctggccaacccggccact
ttgctgagtctgaaaaacttttgcctgggtaccaaagaggtgcctcggctgaagctccag
gaaagccgggacccaggttccagcggcccctcttccccagaaaccagtttaagtaggtcc
gggactgcacctccaccgcagcaggacctggtgggacacagggcaaccgccctaacccct
gattcgtgcccgcttcctggccctggggagccaacacttaggagcaggcaggacaggcac
tttctacagcacctgttggggatgggcatgaactactgtgtgaggtacatgggctgtgtt
gaagtgctgcaatcaatgagatcactggattttggaatgagaacccaagttacaagggaa
gcaataagtcgcctgtgtgaagctgtccccggggcaaatggagccattaaaaagcgaaag
cctccagttaagttcctatcaacagtccttggcaaaagtaatcttcagttttcaggaatg
aatataaaactgaccatctcaacatgcagtctcacattgatgaatcttgacaaccaacag
attattgcaaatcatcatatgcagtctatttcatttgcctctggaggggatcctgatact
acagactatgttgcctacgtagctaaagatccagttaatcaacgagcctgtcacatattg
gaatgccacaatggaatggcccaagacgtcataagtaccatagggcaggcttttgaactc
cggtttaaacagtacttgaaaaatccttctttgaatacttcttgtgaaagtgaggaggtg
catattgatagccatgccgaggagagagaagatcatgaatattacaatgaaattccaggg
aagcagccaccagtaggtggtgtttcagatatgcggatcaaagttcaagccacggaacaa
atggcttactgccccatacagtgtgaaaagttgtgctatttgcctggaaactccaagtgc
agcagtgtatatgagaactgtttagaacaaagcagggcaataggtaatgtccatccaaga
ggggtgcagtcccagcgagatacctcattattgaagcacacgtgccgagtggatctcttt
gatgacccctgctacattaatacacaggctcttcaaagtacacctggctctgctggaaat
caaaggtcagcccaaccactggggagcccatggcactgcggaaaggcaccagaaactgtt
cagccgggtgccacagcccagcctgccagctcacattctttgccacacattaagcagcag
ctgtggagcgaagaatgctatcatggcaagctgagcaggaaggcggcagagagcctcttg
gtaaaggatggggactttttggttcgagagagtgcaacatcccctggccaatatgtgctg
agtggactacagggaggccaagcaaaacatcttctcctggtggatcctgaaggcaaggtg
aggaccaaggatcatgtatttgataatgtcggccaccttatcagataccatatggataac
agtttgccaatcatctcctctggaagcgaagtaagccttaaacaaccagtgagaaaagat
aataatccagcacttttgcattccaacaaatga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (22)   
   KEGG PATHWAY (22)   
Network (1)   
   KEGG NETWORK (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
   PHAROS (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (20)   
   RefSeq(nuc) (6)   
   GenBank (7)   
   EMBL (7)   
Protein domain (3)   
   Pfam (3)   
All databases (86)   

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KEGG   Homo sapiens (human): 53358
Entry
53358             CDS       T01001                                 
Symbol
SHC3, N-Shc, NSHC, RAI, SHCC
Name
(RefSeq) SHC adaptor protein 3
  KO
K17448  SHC-transforming protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
hsa05034  Alcoholism
hsa05100  Bacterial invasion of epithelial cells
hsa05214  Glioma
hsa05220  Chronic myeloid leukemia
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06526  MAPK signaling
  Element
N01595  Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    53358 (SHC3)
   04014 Ras signaling pathway
    53358 (SHC3)
   04072 Phospholipase D signaling pathway
    53358 (SHC3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    53358 (SHC3)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    53358 (SHC3)
   04062 Chemokine signaling pathway
    53358 (SHC3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    53358 (SHC3)
   04915 Estrogen signaling pathway
    53358 (SHC3)
   04917 Prolactin signaling pathway
    53358 (SHC3)
   04926 Relaxin signaling pathway
    53358 (SHC3)
   04935 Growth hormone synthesis, secretion and action
    53358 (SHC3)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    53358 (SHC3)
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    53358 (SHC3)
   05226 Gastric cancer
    53358 (SHC3)
   05214 Glioma
    53358 (SHC3)
   05220 Chronic myeloid leukemia
    53358 (SHC3)
   05224 Breast cancer
    53358 (SHC3)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    53358 (SHC3)
  09165 Substance dependence
   05034 Alcoholism
    53358 (SHC3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    53358 (SHC3)
   01522 Endocrine resistance
    53358 (SHC3)
SSDB
Motif
Pfam: PID SH2
Other DBs
NCBI-GeneID: 53358
NCBI-ProteinID: NP_058544
OMIM: 605263
HGNC: 18181
Ensembl: ENSG00000148082
Pharos: Q92529(Tbio)
UniProt: Q92529
Position
9:complement(89005771..89178818)
AA seq 594 aa
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
NT seq 1785 nt   +upstreamnt  +downstreamnt
atgcttccacgcaccaagtataaccgcttcaggaatgactcggtgacatcggtcgatgac
cttctccacagcctgtcggtgagcggcggcggaggcaaggtttcggcggcgcgcgcgacc
ccggcggcggctccctacttggtgtccggcgaggcgctgcgcaaggcgcccgacgatggg
cccggcagcctgggccacctgctccacaaggtgtcccacctgaaactctccagctcgggc
ctccgcggcctgtcgtcggccgcccgggagcgggcgggcgcgcggctctcgggcagctgc
agcgcgcccagcctggccgccccggacggcagtgcgccctcggcgccccgcgccccggcc
atgagcgccgccaggaagggccggcccggcgacgagccgctgcccaggccccctcggggg
gcgccgcacgccagcgaccaggtgctggggcccggagtcacctacgtggtcaagtacttg
gggtgcattgaagttctgcgctcaatgaggtctcttgacttcagtacaagaacacaaatt
accagggaagccatcagccgcgtctgtgaagctgtgcctggtgcgaagggagccttcaag
aagagaaagcctccaagcaaaatgctgtccagcatcttgggaaagagcaacctccagttt
gcgggaatgagcatctctctgaccatctccacggccagtctgaacctgcgaactccggac
tccaaacagatcatagcgaatcaccacatgcggtccatctccttcgcctctgggggagac
ccggacacaactgactatgttgcatatgtggctaaggaccctgttaatcgcagagcttgt
cacattttggaatgctgtgatgggctggcccaggatgtcatcggctccatcggacaagcc
tttgagctccggtttaagcaatatttacagtgtcctaccaagattcccgctctccatgat
cgaatgcagagtctggatgagccatggacggaagaggagggagatggctcagaccaccca
tactacaacagcatcccaagcaagatgcctcctccagggggctttcttgatactagactg
aaacccagaccccatgctcctgacacagcccagtttgcaggaaaagagcagacttattac
cagggaagacacttaggagacacttttggcgaagactggcagcaaacacctttaaggcaa
gggtcctcggacatctacagcacgccagaagggaaactgcacgtggcccccacgggagaa
gcacccacctacgtcaacactcagcagatcccaccacaggcctggccggctgcggtcagc
agtgctgagagcagcccaaggaaagacctctttgacatgaaaccttttgaagatgctctc
aagaaccagcccttggggcccgtgttaagcaaggcagcctccgtggagtgcatcagccct
gtgtcacctagagccccagatgccaagatgctggaggaactgcaagccgagacttggtac
caaggagagatgagcaggaaggaggcagaggggctgctggagaaagacggagacttcctg
gtcaggaagagcaccaccaacccgggctcctttgtcctcacgggcatgcacaatggccag
gccaagcacctgctgctcgtggacccagaaggcacgatccggacaaaggacagagtcttt
gacagtatcagccacctcatcaaccaccacctagaaagcagcctgcccattgtctctgca
gggagtgagctgtgtctccagcagccagtggagaggaagcagtga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (21)   
   KEGG PATHWAY (21)   
Network (1)   
   KEGG NETWORK (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
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   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
Protein domain (2)   
   Pfam (2)   
All databases (63)   

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KEGG   Homo sapiens (human): 6464
Entry
6464              CDS       T01001                                 
Symbol
SHC1, SHC, SHCA
Name
(RefSeq) SHC adaptor protein 1
  KO
K06279  SHC-transforming protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
hsa05034  Alcoholism
hsa05100  Bacterial invasion of epithelial cells
hsa05206  MicroRNAs in cancer
hsa05214  Glioma
hsa05220  Chronic myeloid leukemia
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06526  MAPK signaling
  Element
N01595  Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    6464 (SHC1)
   04014 Ras signaling pathway
    6464 (SHC1)
   04072 Phospholipase D signaling pathway
    6464 (SHC1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    6464 (SHC1)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    6464 (SHC1)
   04062 Chemokine signaling pathway
    6464 (SHC1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    6464 (SHC1)
   04915 Estrogen signaling pathway
    6464 (SHC1)
   04917 Prolactin signaling pathway
    6464 (SHC1)
   04926 Relaxin signaling pathway
    6464 (SHC1)
   04935 Growth hormone synthesis, secretion and action
    6464 (SHC1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    6464 (SHC1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    6464 (SHC1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    6464 (SHC1)
   05226 Gastric cancer
    6464 (SHC1)
   05214 Glioma
    6464 (SHC1)
   05220 Chronic myeloid leukemia
    6464 (SHC1)
   05224 Breast cancer
    6464 (SHC1)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    6464 (SHC1)
  09165 Substance dependence
   05034 Alcoholism
    6464 (SHC1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    6464 (SHC1)
   01522 Endocrine resistance
    6464 (SHC1)
SSDB
Motif
Pfam: PID SH2 Delta_lysin
Other DBs
NCBI-GeneID: 6464
NCBI-ProteinID: NP_892113
OMIM: 600560
HGNC: 10840
Ensembl: ENSG00000160691
Pharos: P29353(Tchem)
UniProt: P29353
Structure
Position
1:complement(154962298..154974376)
AA seq 583 aa
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRE
LFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA
EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG
VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
NT seq 1752 nt   +upstreamnt  +downstreamnt
atggatctcctgccccccaagcccaagtacaatccactccggaatgagtctctgtcatcg
ctggaggaaggggcttctgggtccacccccccggaggagctgccttccccatcagcttca
tccctggggcccatcctgcctcctctgcctggggacgatagtcccactaccctgtgctcc
ttcttcccccggatgagcaacctgaggctggccaacccggctggggggcgcccagggtct
aagggggagccaggaagggcagctgatgatggggaggggatcgtaggggcagccatgcca
gactcaggccccctacccctcctccaggacatgaacaagctgagtggaggcggcgggcgc
aggactcgggtggaagggggccagcttgggggcgaggagtggacccgccacgggagcttt
gtcaataagcccacgcggggctggctgcatcccaacgacaaagtcatgggacccggggtt
tcctacttggttcggtacatgggttgtgtggaggtcctccagtcaatgcgtgccctggac
ttcaacacccggactcaggtcaccagggaggccatcagtctggtgtgtgaggctgtgccg
ggtgctaagggggcgacaaggaggagaaagccctgtagccgcccgctcagctctatcctg
gggaggagtaacctgaaatttgctggaatgccaatcactctcaccgtctccaccagcagc
ctcaacctcatggccgcagactgcaaacagatcatcgccaaccaccacatgcaatctatc
tcatttgcatccggcggggatccggacacagccgagtatgtcgcctatgttgccaaagac
cctgtgaatcagagagcctgccacattctggagtgtcccgaagggcttgcccaggatgtc
atcagcaccattggccaggccttcgagttgcgcttcaaacaatacctcaggaacccaccc
aaactggtcacccctcatgacaggatggctggctttgatggctcagcatgggatgaggag
gaggaagagccacctgaccatcagtactataatgacttcccggggaaggaaccccccttg
gggggggtggtagacatgaggcttcgggaaggagccgctccaggggctgctcgacccact
gcacccaatgcccagacccccagccacttgggagctacattgcctgtaggacagcctgtt
gggggagatccagaagtccgcaaacagatgccacctccaccaccctgtccaggcagagag
ctttttgatgatccctcctatgtcaacgtccagaacctagacaaggcccggcaagcagtg
ggtggtgctgggccccccaatcctgctatcaatggcagtgcaccccgggacctgtttgac
atgaagcccttcgaagatgctcttcgcgtgcctccacctccccagtcggtgtccatggct
gagcagctccgaggggagccctggttccatgggaagctgagccggcgggaggctgaggca
ctgctgcagctcaatggggacttcctggtacgggagagcacgaccacacctggccagtat
gtgctcactggcttgcagagtgggcagcctaagcatttgctactggtggaccctgagggt
gtggttcggactaaggatcaccgctttgaaagtgtcagtcaccttatcagctaccacatg
gacaatcacttgcccatcatctctgcgggcagcgaactgtgtctacagcaacctgtggag
cggaaactgtga

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (22)   
   KEGG PATHWAY (22)   
Network (1)   
   KEGG NETWORK (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
   PHAROS (1)   
Protein sequence (81)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (79)   
DNA sequence (113)   
   RefSeq(nuc) (79)   
   GenBank (17)   
   EMBL (17)   
3D Structure (11)   
   PDB (11)   
Protein domain (3)   
   Pfam (3)   
All databases (256)   

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