KEGG   Homo sapiens (human): 441925
Entry
441925            CDS       T01001                                 
Symbol
BECN2, BECN1L1, BECN1P1
Name
(RefSeq) beclin-2
  KO
K08334  beclin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04136  Autophagy - other
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04145  Phagocytosis
hsa04215  Apoptosis - multiple species
hsa04371  Apelin signaling pathway
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    441925 (BECN2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    441925 (BECN2)
   04140 Autophagy - animal
    441925 (BECN2)
   04136 Autophagy - other
    441925 (BECN2)
   04137 Mitophagy - animal
    441925 (BECN2)
  09143 Cell growth and death
   04215 Apoptosis - multiple species
    441925 (BECN2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    441925 (BECN2)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    441925 (BECN2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    441925 (BECN2)
   05014 Amyotrophic lateral sclerosis
    441925 (BECN2)
   05016 Huntington disease
    441925 (BECN2)
   05017 Spinocerebellar ataxia
    441925 (BECN2)
   05022 Pathways of neurodegeneration - multiple diseases
    441925 (BECN2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    441925 (BECN2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    441925 (BECN2)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Autophagosome formation proteins
   PI3K complex
    441925 (BECN2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Autophagy-related proteins
    441925 (BECN2)
SSDB
Motif
Pfam: APG6 APG6_N GAS FKBP15 BH3 DUF7830
Other DBs
NCBI-GeneID: 441925
NCBI-ProteinID: NP_001277622
OMIM: 615687
HGNC: 38606
Ensembl: ENSP00000488361.1
UniProt: A8MW95
Structure
Position
1:241957767..241959062
AA seq 431 aa
MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD
GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKAAGDIFDIVSGQAVVDHPLCEE
CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL
EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR
VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA
NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ
FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW
SLIWVASRYQK
NT seq 1296 nt   +upstreamnt  +downstreamnt
atgtcttccatccgcttcctgtgccagcgctgccaccaggccctgaagctgagcggctcc
tcggagtctaggagcctccctgcagccccggcgcccacctctgggcaggctgagcccgga
gacacccgggagcccggcgtcaccaccagggaggtgacagacgctgaggagcaacaggac
ggtgcctctagcagatcccctccaggcgatggcagtgtgtccaagggccatgccaacatc
ttcaccctgctgggggagcttggcgccatgcacatgctcagtagcatccagaaggcagct
ggtgacatttttgacatagtctctggccaagcagttgtggaccatcccctgtgtgaagaa
tgcaccgacagtcttttagagcagctggacatccagctcgctctcacagaagctgacagt
cagaactaccaacgctgcctggagaccggggagctggcgaccagcgaggacgaggcggcg
gcgctgcgggcggagctgcgggacctggagctggaggaggccaggctggtgcaggagctg
gaggatgtggacaggaacaatgcaagagcagcggcggatctccaggcagcccaggcagag
gctgcggagctggaccagcaggagaggcagcactacagggactacagtgccttgaagcgg
cagcagctggaactgcttgatcagctggggaacgtggagaaccagctgcagtatgccagg
gtccagagggaccggctgaaggaaatcaactgtttcaccgccacgtttgagatctgggtg
gagggccccttgggcgtcatcaataacttcaggttgggccgcctccccactgtccgtgtg
ggctggaatgagattaacactgcctggggacaggcggccttgctgctccttaccctggcc
aatacaattggactgcagtttcagaggtatcgactcatcccctgcggaaaccattcgtat
ctgaagtctttaacagatgaccgcactgagctgccgttgttctgttatggggggcaggat
gttttcctcaataacaagtatgaccgcgcgatggtggccttcctggactgcatgcagcag
ttcaaggaagaggctgagaagggtgagctgggcctctctctgccctacgggatccaggtg
gagacaggcctgatggaggacgttggcggccgaggggaatgctattccatcagaacccat
ctgaacacgcaggagctgtggacaaaggcactcaagttcatgcttataaatttcaagtgg
agtctcatctgggttgcctcaaggtatcaaaagtag

  All links  
Disease (1)   
   OMIM (1)   
Gene (15)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
3D Structure (4)   
   PDB (4)   
Protein domain (6)   
   Pfam (6)   
All databases (32)   

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