KEGG   Homo sapiens (human): 5170
Entry
5170              CDS       T01001                                 
Symbol
PDPK1, PDK1, PDPK2, PDPK2P, PRO0461
Name
(RefSeq) 3-phosphoinositide-dependent protein kinase 1 isoform 1
  KO
K06276  3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa03320  PPAR signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04360  Axon guidance
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04931  Insulin resistance
hsa04960  Aldosterone-regulated sodium reabsorption
hsa05145  Toxoplasmosis
hsa05205  Proteoglycans in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05213  Endometrial cancer
hsa05215  Prostate cancer
hsa05223  Non-small cell lung cancer
hsa05231  Choline metabolism in cancer
hsa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    5170 (PDPK1)
   04071 Sphingolipid signaling pathway
    5170 (PDPK1)
   04151 PI3K-Akt signaling pathway
    5170 (PDPK1)
   04152 AMPK signaling pathway
    5170 (PDPK1)
   04150 mTOR signaling pathway
    5170 (PDPK1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    5170 (PDPK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5170 (PDPK1)
  09143 Cell growth and death
   04210 Apoptosis
    5170 (PDPK1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5170 (PDPK1)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    5170 (PDPK1)
   04664 Fc epsilon RI signaling pathway
    5170 (PDPK1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5170 (PDPK1)
   03320 PPAR signaling pathway
    5170 (PDPK1)
   04919 Thyroid hormone signaling pathway
    5170 (PDPK1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5170 (PDPK1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    5170 (PDPK1)
  09158 Development and regeneration
   04360 Axon guidance
    5170 (PDPK1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    5170 (PDPK1)
   05208 Chemical carcinogenesis - reactive oxygen species
    5170 (PDPK1)
   05231 Choline metabolism in cancer
    5170 (PDPK1)
  09162 Cancer: specific types
   05215 Prostate cancer
    5170 (PDPK1)
   05213 Endometrial cancer
    5170 (PDPK1)
   05223 Non-small cell lung cancer
    5170 (PDPK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    5170 (PDPK1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5170 (PDPK1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5170 (PDPK1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    5170 (PDPK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5170 (PDPK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5170 (PDPK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     5170 (PDPK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  PDK1 family
   5170 (PDPK1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    5170 (PDPK1)
SSDB
Motif
Pfam: Pkinase PH_3 PK_Tyr_Ser-Thr Kinase-like ABC1 Pkinase_fungal Haspin_kinase APH Kdo
Other DBs
NCBI-GeneID: 5170
NCBI-ProteinID: NP_002604
OMIM: 605213
HGNC: 8816
Ensembl: ENSP00000344220.4
UniProt: O15530
Structure
Position
16:2538021..2603188
AA seq 556 aa
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK
ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN
SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD
SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE
GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ
EVWRQRYQSHPDAAVQ
NT seq 1671 nt   +upstreamnt  +downstreamnt
atggccaggaccaccagccagctgtatgacgccgtgcccatccagtccagcgtggtgtta
tgttcctgcccatccccatcaatggtgaggacccagactgagtccagcacgccccctggc
attcctggtggcagcaggcagggccccgccatggacggcactgcagccgagcctcggccc
ggcgccggctccctgcagcatgcccagcctccgccgcagcctcggaagaagcggcctgag
gacttcaagtttgggaaaatccttggggaaggctctttttccacggttgtcctggctcga
gaactggcaacctccagagaatatgcgattaaaattctggagaagcgacatatcataaaa
gagaacaaggtcccctatgtaaccagagagcgggatgtcatgtcgcgcctggatcacccc
ttctttgttaagctttacttcacatttcaggacgacgagaagctgtatttcggccttagt
tatgccaaaaatggagaactacttaaatatattcgcaaaatcggttcattcgatgagacc
tgtacccgattttacacggctgagattgtgtctgctttagagtacttgcacggcaagggc
atcattcacagggaccttaaaccggaaaacattttgttaaatgaagatatgcacatccag
atcacagattttggaacagcaaaagtcttatccccagagagcaaacaagccagggccaac
tcattcgtgggaacagcgcagtacgtttctccagagctgctcacggagaagtccgcctgt
aagagttcagacctttgggctcttggatgcataatataccagcttgtggcaggactccca
ccattccgagctggaaacgagtatcttatatttcagaagatcattaagttggaatatgac
tttccagaaaaattcttccctaaggcaagagacctcgtggagaaacttttggttttagat
gccacaaagcggttaggctgtgaggaaatggaaggatacggacctcttaaagcacacccg
ttcttcgagtccgtcacgtgggagaacctgcaccagcagacgcctccgaagctcaccgct
tacctgccggctatgtcggaagacgacgaggactgctatggcaattatgacaatctcctg
agccagtttggctgcatgcaggtgtcttcgtcctcctcctcacactccctgtcagcctcc
gacacgggcctgccccagaggtcaggcagcaacatagagcagtacattcacgatctggac
tcgaactcctttgaactggacttacagttttccgaagatgagaagaggttgttgttggag
aagcaggctggcggaaacccttggcaccagtttgtagaaaataatttaatactaaagatg
ggcccagtggataagcggaagggtttatttgcaagacgacgacagctgttgctcacagaa
ggaccacatttatattatgtggatcctgtcaacaaagttctgaaaggtgaaattccttgg
tcacaagaacttcgaccagaggccaagaattttaaaactttctttgtccacacgcctaac
aggacgtattatctgatggaccccagcgggaacgcacacaagtggtgcaggaagatccag
gaggtttggaggcagcgataccagagccacccggacgccgctgtgcagtga

  All links  
Disease (1)   
   OMIM (1)   
Gene (18)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (21)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (55)   
   RefSeq(nuc) (19)   
   GenBank (18)   
   EMBL (18)   
3D Structure (70)   
   PDB (70)   
Protein domain (9)   
   Pfam (9)   
All databases (174)   

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