KEGG   Homo sapiens (human): 51780
Entry
51780             CDS       T01001                                 
Symbol
KDM3B, 5qNCA, C5orf7, DIJOS, JMJD1B, NET22
Name
(RefSeq) lysine-specific demethylase 3B
  KO
K15601  [histone H3]-dimethyl-L-lysine9 demethylase [EC:1.14.11.65]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04714  Thermogenesis
Network
nt06529  Thermogenesis
  Element
N01688  ADRB3-UCP1 signaling pathway
Disease
H02521  Diets-Jongmans syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    51780 (KDM3B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    51780 (KDM3B)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.65  [histone H3]-dimethyl-L-lysine9 demethylase
     51780 (KDM3B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    51780 (KDM3B)
SSDB
Motif
Pfam: PWWP_KDM3B Tudor_KDM3B JmjC DUF7030 Cupin_2
Other DBs
NCBI-GeneID: 51780
NCBI-ProteinID: NP_057688
OMIM: 609373
HGNC: 1337
Ensembl: ENSP00000326563.5
UniProt: Q7LBC6
Structure
Position
5:138352685..138437027
AA seq 1761 aa
MADAAASPVGKRLLLLFADTAASASASAPAAAAASGDPGPALRTRAWRAGTVRAMSGAVP
QDLAIFVEFDGCNWKQHSWVKVHAEEVIVLLLEGSLVWAPREDPVLLQGIRVSIAQWPAL
TFTPLVDKLGLGSVVPVEYLLDRELRFLSDANGLHLFQMGTDSQNQILLEHAALRETVNA
LISDQKLQEIFSRGPYSVQGHRVKIYQPEGEEGWLYGVVSHQDSITRLMEVSVTESGEIK
SVDPRLIHVMLMDNSAPQSEGGTLKAVKSSKGKKKRESIEGKDGRRRKSASDSGCDPASK
KLKGDRGEVDSNGSDGGEASRGPWKGGNASGEPGLDQRAKQPPSTFVPQINRNIRFATYT
KENGRTLVVQDEPVGGDTPASFTPYSTATGQTPLAPEVGGAENKEAGKTLEQVGQGIVAS
AAVVTTASSTPNTVRISDTGLAAGTVPEKQKGSRSQASGENSRNSILASSGFGAPLPSSS
QPLTFGSGRSQSNGVLATENKPLGFSFGCSSAQEAQKDTDLSKNLFFQCMSQTLPTSNYF
TTVSESLADDSSSRDSFKQSLESLSSGLCKGRSVLGTDTKPGSKAGSSVDRKVPAESMPT
LTPAFPRSLLNARTPENHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSS
SSATTVTSKVAPSWPESHSSADSASLAKKKPLFITTDSSKLVSGVLGSALTSGGPSLSAM
GNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTFSNVFGRHSGGFLSSP
ADFSQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPEH
LMGKLGPNGERSAELLLGKSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQ
DGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLIFTRKGVLRVEGFLS
PQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAW
KRAVRGVREMCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWL
KCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQNKSVLRPAVT
NGMSQLPSINPSASSGNETTFSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASN
SNSELKAIRPPCPDTAPPSSALHWLADLATQKAKEETKEAGSLRSVLNKESHSPFGLDSF
NSTAKVSPLTPKLFNSLLLGPTASNNKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFS
TSSAGVKSKASLPNFLDHIIASVVENKKTSDASKRACNLTDTQKEVKEMVMGLNVLDPHT
SHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGD
QDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGEDFRDMMPT
RFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLH
LDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAK
DAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIVQFLGDA
VFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNII
YHAVKDAVGTLKAHESKLARS
NT seq 5286 nt   +upstreamnt  +downstreamnt
atggcggacgcggcggcctccccggtgggcaagcggctgctgctgctgttcgcggacact
gcggcctcagcctcggcctcggctcccgcggcggcagcggcgagcggagatccggggcct
gcgctgcgcactcgagcctggcgggccggcacggtgcgggccatgagcggggcggtgccc
caggacctagcgatctttgtagaatttgatggctgtaactggaagcaacactcctgggta
aaagttcatgctgaggaagttatcgtgcttctgctggaagggtctcttgtatgggcgccc
cgtgaggacccagtccttctccagggcattcgagtctccattgcacaatggccagccctg
acttttactccccttgtagataaactgggtttgggttctgtggttccagtggaatatctt
ctggatcgagagcttcggttcctgtcagatgccaatgggttgcatctgtttcagatggga
acagatagccaaaaccagattcttttggaacatgctgcactgagagaaacagttaatgct
ttgatcagtgaccaaaagctacaagagatattcagccgaggtccctacagtgttcaaggt
cacagggtcaaaatatatcagccagagggggaagaagggtggctctatggtgttgtgagc
catcaggactccatcactcgtcttatggaggtgtctgtaactgagagtggtgagatcaag
tcggtagatcccagactaatccatgtgatgctgatggataattcagcgcctcaaagcgag
gggggtacgttaaaagcagtaaaatcttccaaaggaaagaagaagagagaaagcatagag
gggaaagatggccggaggaggaaaagtgcttcggactctgggtgtgaccctgcatcaaag
aaattaaaaggagacaggggtgaagtagacagtaatgggagcgatggaggtgaggcaagc
cgagggccctggaaaggagggaatgccagtggagagccagggctggatcagagagccaag
cagccaccgtctacatttgtcccccagataaaccgcaacattcgctttgccacttacacc
aaagaaaacggcaggactctggtggtgcaggatgagcctgtaggtggggacacacctgca
tctttcactccatattctacagccacaggtcagacacctttggccccagaggtgggtgga
gccgaaaacaaagaggcaggaaaaacactggaacaagttggccagggcatagtggcttcc
gcagctgtggtcactaccgccagctccaccccaaacacagtgaggatctcagacactggc
cttgcagcagggactgtgccagaaaaacagaaaggcagccggtcgcaggcctcgggagag
aattcaagaaattctattctggcctcttctggatttggagcacctctccctagttcatcg
caacctttgacttttggaagtggaaggagccagtccaatggtgttctagccacagagaac
aaacctttgggcttctcttttggctgtagctctgcacaagaggcacagaaagacactgat
ctctccaaaaacttgttttttcaatgcatgtcccaaactttacctaccagtaactacttc
actactgtttcagagagtttggctgatgattcttctagtcgggactcattcaaacaaagc
cttgagagcctgagctcaggcctgtgtaaaggcagatccgttcttggaacagacactaag
ccaggctctaaggctggcagctctgtggaccggaaagtgcctgcagagtccatgcccacc
ctcactccagccttcccacggagcctcctaaatgcccgtaccccagagaatcatgaaaat
ctatttttacagccccccaaattgtcccgagaagagccttctaatcctttcctggcattt
gtggagaaagttgaacacagccctttcagtagttttgcatctcaggcatcaggtagctcc
tcttctgctaccactgtcacctccaaggtggcacccagctggcccgagtctcactcctct
gcagattcggcatctttagcaaagaagaaacccctcttcattacaactgactcctccaag
ctagtatctggtgttctgggctcagctcttaccagtgggggcccaagcctctctgccatg
gggaatggccgctccagctcgcccaccagcagcctcactcagcccattgagatgccaact
ctctcctctagccccacagaggagaggccaactgtggggcctgggcagcaggacaatccc
ctcctcaaaacctttagtaacgtctttggcaggcactcaggcggctttctgtcctccccg
gcagatttttcacaggagaacaaagctccttttgaagctgtgaaaaggttctcactggat
gaacgaagcttggcttgcagacaagactcggactccagcaccaacagtgacctgtcagat
ttgagtgactctgaggagcagctgcaggctaagacaggcctgaagggaattccagagcac
ctgatggggaagctgggccccaatggggagcgcagtgctgagctgttgctgggcaaaagc
aaagggaagcaggcccccaagggccggcctcggactgcccccctgaaagttggccagtca
gtgctgaaagatgtaagcaaagtgaagaagctgaagcaatctggagagcccttcctgcag
gatgggtcatgcatcaatgtggcacctcatctgcacaagtgtcgtgaatgccgcctggag
cggtaccggaagtttaaggaacaggagcaagatgattctactgtagcctgccgtttcttt
cacttccggaggttgatcttcactcgaaaaggggtactccgtgtggaggggtttttaagc
ccccagcaaagtgaccctgatgccatgaacctgtggattccctcttcctccctagcagaa
gggatagatctagagacctcaaaatacatcctggccaatgttggggaccagttctgccag
ctcgtaatgtctgagaaggaggccatgatgatggtggagccacaccagaaagtggcatgg
aagcgagctgtgcgtggtgtacgggagatgtgtgatgtgtgtgaaacaactctcttcaac
atccactgggtttgtcgcaaatgtggatttggggtctgccttgactgttaccggctcagg
aaaagccggccacgcagtgagacagaagagatgggtgatgaagaagttttctcctggttg
aagtgtgcaaagggacagtcccacgaaccagagaatctcatgcccacacaaattattcct
ggcacagctctttacaatattggagacatggtacatgctgcccggggcaagtggggaatt
aaagcaaactgcccttgtatcagtcgacagaacaaatctgtattgagacctgccgtcacc
aatgggatgtcacagcttcctagcataaaccctagtgcctcttctggaaacgaaactacc
ttctctggtggaggaggaccggcaccagtaacaactccagagccggaccatgttcccaaa
gccgacagcactgacatcagatctgaagagcctctgaaaacagacagttcggcatcaaat
agcaatagtgaactgaaagccatcaggcctccttgccctgacacggccccaccctcctcc
gccctgcactggttggcagatttagcaactcagaaggctaaagaagaaacaaaagaagca
gggtccctgaggtcggtgctcaataaagagtctcattcaccctttgggctggactcgttc
aactccactgcaaaggtctctccgctgactccaaagctttttaacagtctgttgctgggt
cccactgcctccaacaacaaaaccgaagggtctagccttcgagacctccttcactccggg
ccgggaaaacttcctcaaacccccttggacacaggcataccctttcccccggtcttctct
acatcctcagcaggagtgaagagcaaggccagcctacccaactttcttgaccacatcatt
gcctcagtggtagaaaataagaaaacctcagatgcttcaaagcgggcctgcaacttgact
gatacccagaaggaagtgaaggagatggtgatggggttaaatgtgctagatccccatact
tctcactcctggctttgtgatgggaggcttctgtgtctccatgaccccagcaacaaaaac
aattggaagatcttccgggagtgttggaagcaaggtcagccagtgctggtttcgggggta
cataaaaagctcaagtctgagctctggaagccagaagcctttagccaggaatttggagac
caggatgtagacttggtgaactgcaggaactgtgctataatttccgatgtgaaagttcgg
gatttctgggatggtttcgagatcatatgcaaacgactacggtcagaagatgggcagcca
atggtgctcaaactcaaggactggcctcctggggaagattttcgagacatgatgccaacc
aggtttgaagatctgatggagaaccttcctctgccagaatataccaaacgagatggcagg
ctcaatctggcctctaggctacctagctactttgtaaggcctgatctgggccccaagatg
tacaacgcctatgggttgataacagcagaagatagaagagttggtacaacaaatcttcac
ttagatgtgtctgatgctgttaatgtgatggtgtatgttgggattcccatcggggagggt
gctcatgatgaagaggtactcaagacaattgacgagggagatgccgatgaggtgacgaag
cagaggattcatgatggaaaagagaagccaggtgctttatggcacatctatgcagccaag
gatgcagagaagatccgggagctgctccgaaaggttggagaagaacaaggccaagagaac
ccccctgatcatgacccaattcatgaccaaagttggtacctggaccagaccctccgtaag
cgactctatgaggagtatggcgtgcaaggctgggctattgtgcagttcctaggtgatgct
gttttcatacctgctggagccccacaccaggttcacaatctatacagttgcataaaagta
gcagaagactttgtatctccagaacatgtaaagcactgtttccgcctgactcaggaattc
aggcatctctctaacactcatacaaatcatgaggataaactgcaggtgaagaacatcatt
taccatgcagtgaaagatgcggttggcaccctcaaggctcatgaatccaaactggcaagg
tcctag

  All links  
Disease (2)   
   OMIM (2)   
Gene (25)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (43)   
   RefSeq(nuc) (11)   
   GenBank (16)   
   EMBL (16)   
3D Structure (36)   
   PDB (36)   
Protein domain (5)   
   Pfam (5)   
All databases (124)   

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