KEGG   Homo sapiens (human): 55755
Entry
55755             CDS       T01001                                 
Symbol
CDK5RAP2, C48, Cep215, MCPH3
Name
(RefSeq) CDK5 regulatory subunit-associated protein 2 isoform a
  KO
K16542  CDK5 regulatory subunit-associated protein 2
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01544  Microtubule nucleation
Disease
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    55755 (CDK5RAP2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Pericentriolar materials (PCM)
    Other PCM proteins
     55755 (CDK5RAP2)
   Centrosome duplication proteins
    Regulators of centriole replication
     55755 (CDK5RAP2)
SSDB
Motif
Pfam: Pde4dip Cnn_1N CC_CDK5RAP2 Par-4_C DUF7632
Other DBs
NCBI-GeneID: 55755
NCBI-ProteinID: NP_060719
OMIM: 608201
HGNC: 18672
Ensembl: ENSP00000343818.4
UniProt: Q96SN8 B3KVI2
Structure
Position
9:complement(120388875..120580167)
AA seq 1893 aa
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
NT seq 5682 nt   +upstreamnt  +downstreamnt
atgatggacttggtgttggaagaggacgtcaccgtccctgggacgctcagcggctgcagt
ggccttgttcccagtgtaccagatgacctggatggcatcaaccccaatgctgggttggga
aatggtctgctcccaaatgtgtcagaagaaacagtgtctcccaccagagcacggaacatg
aaggactttgaaaatcaaatcactgaattgaagaaagaaaactttaacctaaagctccgc
atctatttccttgaggaaagaatgcaacaggaatttcatggccccactgaacatatctac
aaaactaacattgagctcaaggtggaagtagaaagtctgaagcgggaactccaggagaga
gagcagctgctcatcaaagcctccaaagcagttgagagcttagctgaagcaggtggctct
gaaatccagcgggtgaaagaagatgctcgaaagaaggtgcagcaggtggaagatctccta
actaaaagaatactccttttggaaaaggatgtgacagccgcccaggcagaactggaaaag
gcctttgcagggacagagacggagaaggctcttcggttgcgtttggaaagcaagctttca
gagatgaagaagatgcacgagggggacttggcgatggctctggtcctggatgagaaagac
agactgattgaggagttgaagctgtctttgaagagcaaagaagctttaattcagtgcctt
aaagaggagaaatctcagatggcatgtcctgatgagaatgtgtcatctggagagctccga
ggactttgtgctgctccaagggaagaaaaggagagagaaactgaggctgcacaaatggag
catcagaaggagagaaacagctttgaagagaggatccaggcacttgaagaggacctgaga
gagaaggaaagagaaattgctacagagaagaaaaatagtctaaagagggataaagccatt
cagggtttaaccatggcattaaaatcaaaggaaaaaaaggttgaagaacttaactctgaa
attgaaaagctcagtgctgcctttgctaaagccagagaggccctacagaaagcacagacc
caggaatttcaggggtctgaagactatgagactgctctatcaggaaaggaagccctttcg
gctgcgctgcgctcacaaaacctcaccaagagtacagagaaccacagactgcgtagaagc
attaagaagatcacccaggagctgagtgacttgcagcaggagagggagagactggagaag
gacctggaggaagcccatcgagagaagagcaaaggagactgcaccatccgtgatcttaga
aatgaagttgaaaaattacgcaatgaagtgaatgaaagagagaaagcaatggaaaatcgt
tacaagagtcttctgagtgaaagcaataaaaaattgcacaatcaagagcaagtgatcaaa
catctaacagaaagtaccaatcagaaggacgtgttgcttcagaaattcaatgaaaaagat
ttggaagtaatacagcagaactgctatttaatggctgcagaggatcttgagctcaggagt
gaaggcttaataacagaaaagtgctcttctcaacagccaccaggcagcaaaaccatcttc
tctaaggaaaagaaacaatcatcagactatgaagagctgattcaggtcttaaagaaagag
caggacatctatacccatctggtcaaatctctgcaggaatcagacagtatcaacaacctg
caggctgagttaaacaagatttttgccctgcggaagcaactggagcaggatgtgctttca
tatcagaatttgcggaagaccttggaggagcagatcagcgaaattcggaggcgggaagaa
gaatcattttcactttatagtgatcaaacatcttatctaagtatttgccttgaagaaaac
aatcggtttcaagtggaacatttttctcaagaagaacttaagaaaaaggtcagtgacctt
atacagctagtgaaggagctgtatacagacaaccagcacctgaagaaaaccatttttgat
ctctcctgcatgggtttccagggaaatgggtttccagatagacttgcgtctacagaacaa
acagagcttctggctagcaaggaggacgaggacacgatcaaaattggggaggatgacgag
attaatttcctgagtgaccagcatttgcagcagagtaatgagattatgaaagacctttcc
aaaggaggctgcaaaaatggatacttaaggcacacggagtctaagatttcagattgtgat
ggggcccacgcacctggctgcctagaagaaggtgcattcataaacctgcttgcccctttg
ttcaatgagaaggccacattattactggaatccaggccagaccttctgaaagtggtacgg
gaactgcttctgggacaactattcttgacagagcaggaagtttctggagaacaccttgat
ggtaaaactgagaagacacctaagcaaaaaggtgaacttgtacattttgtccaaaccaac
tcattttccaagccacatgatgaactgaagttgtcttgtgaggcccagctagtaaaggca
ggcgaagtgcccaaggtaggactgaaagatgcctcagtgcagactgtggccacggagggc
gacctgctgagattcaagcatgaagcaacaagagaggcttgggaagagaaaccgatcaac
actgcactcagcgcagagcatcggccagagaacctgcacggggtgcctgggtggcaggct
gccctcctttccctccctggtattaccaacagagaggctaagaagtcccgcttgccaatc
ctaataaaaccatcccggtcattaggaaatatgtatcgtctccctgccacccaggaggtg
gtgacgcagctgcagagccagatcttggagctgcagggggagctgaaggagtttaaaact
tgtaataagcaacttcaccaaaagttaattctggctgaagcagtgatggaggggaggcca
acgcccgacaaaacgttgctgaatgctcagccccctgtgggagcagcctaccaggacagc
ccaggagagcagaaaggaattaaaaccacatcttctgtctggagagacaaggaaatggac
agtgatcagcaaagaagctacgagattgactctgagatttgcccacctgatgaccttgcc
agcttgccatcatgcaaagaaaatcctgaagatgttctgagcccaacttcagtagctact
tacctgagttccaagagtcagccttctgctaaagtcagtgtgatggggactgatcagtca
gagagcattaatacctcaaatgagacagaatacttaaaacagaaaatccatgacttggaa
actgagctggaaggctaccagaatttcatatttcagcttcaaaagcactcccagtgcagt
gaggccataattacagttttgtgtgggacagaaggggcccaggatggcttgagcaagccc
aagaatggttctgatggggaagaaatgaccttttcaagtttgcaccaagtgcgatacgtg
aaacacgtgaaaatcctcggtccgctggccccagagatgattgacagcagggtgctggag
aacctcaaacagcagctggaggaacaggaatacaagctgcagaaggagcagaatttgaac
atgcaacttttcagtgagatccataatctgcagaataagttcagagatctctcacctccc
agatacgattcattagttcagtcccaagccagggagctctcccttcaacggcagcagatt
aaggatggccatggcatctgtgtcatctcccgtcaacacatgaacaccatgattaaggca
tttgaggagttgctgcaggccagtgatgtggattactgtgtggccgagggtttccaggaa
cagctgaatcaatgtgctgagctgctggagaaattggaaaagctatttctcaacggaaaa
tcagttggagtggaaatgaacacccagaatgaactgatggagaggattgaggaagacaac
ttaacctaccaacatcttctgcctgaatctcctgagccttcagcctctcatgcgctctct
gattatgaaacatctgaaaagtccttcttctcacgagaccagaagcaagataatgagaca
gagaagacttcagttatggtgaacagtttttctcaagacttactaatggaacacatacag
gaaattcgaactttgagaaagcgtttagaagaatctattaaaacaaatgagaagctacgg
aaacagttggaacggcaaggatctgaatttgttcaaggttctacaagcatttttgcttct
ggttcagagcttcatagttctctaacatcagaaattcatttcttgaggaagcagaaccag
gccctcaatgcaatgctcattaaaggatccagagataaacagaaggagaatgacaaatta
cgagagtccctctccaggaagaccgtgagcctggagcaccttcagcgggagtatgccagc
gtgaaggaagaaaatgaaaggctgcagaaagaaggcagcgagaaggagagacacaaccag
cagctgatccaggaggtccgctgcagcggccaggagctgagcagggtgcaggaggaggtg
aagttgaggcagcagctgctctcacagaatgacaagctattgcagtctctccgagtggag
ctgaaggcgtatgagaagctggatgaagagcacaggagactgagagaggcgtcgggagaa
ggctggaaggggcaggatcctttcagggacctgcacagcctcctgatggagatccaggct
ctgcgcttgcaactagaaaggagcatcgaaaccagcagcactctgcagagcaggctcaag
gaacagctggcaaggggggcagagaaggcacaggaaggagccctcactctggctgtccaa
gccgtgtccatccctgaggtgccccttcagcctgacaaacacgatggtgacaaatatccc
atggaaagtgataattcatttgatctgtttgattcctcccaggcagtgacaccaaaatca
gtttcagagactcctccactctctgggaatgacacggactccctctcctgcgacagtggc
agttcggcaactagcactccgtgtgtgtcccgcctggtcactggccaccacctgtgggcc
agcaagaatggccgccatgtcctgggcctgattgaggactatgaggccctgctcaaacag
atcagccagggacagaggctccttgctgaaatggacattcaaacccaagaggctcccagc
tccacaagtcaagagctgggaacaaagggtccacacccagcaccactgagcaagtttgtg
agcagtgtgagcacggccaagctgaccctggaagaggcctacaggcggctgaagcttctc
tggagagtctcactccccgaggatggccagtgcccccttcactgtgagcagattggagaa
atgaaggcagaggtcaccaaactacataaaaaattgtttgaacaagaaaagaagttgcaa
aacaccatgaagcttttgcagctgagcaagcgccaggaaaaagtcatctttgatcaattg
gtcgtaacccacaaaatccttcggaaggccagaggaaacctggagcttaggcctggggga
gcccatccaggaacatgcagtcccagcagaccaggctcctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (55)   
   RefGene (35)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (15)   
   OC (1)   
Protein sequence (23)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (91)   
   RefSeq(nuc) (25)   
   GenBank (33)   
   EMBL (33)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   Pfam (5)   
All databases (180)   

Download RDF
DBGET integrated database retrieval system