KEGG   Homo sapiens (human): 5687
Entry
5687              CDS       T01001                                 

Gene name
PSMA6, IOTA, PROS27, p27K
Definition
(RefSeq) proteasome 20S subunit alpha 6
  KO
K02730  20S proteasome subunit alpha 1 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5687 (PSMA6)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5687 (PSMA6)
   05012 Parkinson disease
    5687 (PSMA6)
   05014 Amyotrophic lateral sclerosis
    5687 (PSMA6)
   05016 Huntington disease
    5687 (PSMA6)
   05017 Spinocerebellar ataxia
    5687 (PSMA6)
   05020 Prion disease
    5687 (PSMA6)
   05022 Pathways of neurodegeneration - multiple diseases
    5687 (PSMA6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5687 (PSMA6)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5687 (PSMA6)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5687 (PSMA6)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5687 (PSMA6)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    5687 (PSMA6)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N
Other DBs
NCBI-GeneID: 5687
NCBI-ProteinID: NP_002782
OMIM: 602855
HGNC: 9535
Ensembl: ENSG00000100902
Vega: OTTHUMG00000140221
Pharos: P60900(Tbio)
UniProt: P60900 A0A140VK44
Structure
PDB: 

Position
14q13.2
AA seq 246 aa
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
ALAERD
NT seq 741 nt   +upstreamnt  +downstreamnt
atgtcccgtggttccagcgccggttttgaccgccacattaccattttttcacccgagggt
cggctctaccaagtagaatatgcttttaaggctattaaccagggtggccttacatcagta
gctgtcagagggaaagactgtgcagtaattgtcacacagaagaaagtacctgacaaatta
ttggattccagcacagtgactcacttattcaagataactgaaaacattggttgtgtgatg
accggaatgacagctgacagcagatcccaggtacagagggcacgctatgaggcagctaac
tggaaatacaagtatggctatgagattcctgtggacatgctgtgtaaaagaattgccgat
atttctcaggtctacacacagaatgctgaaatgaggcctcttggttgttgtatgatttta
attggtatagatgaagagcaaggccctcaggtatataagtgtgatcctgcaggttactac
tgtgggtttaaagccactgcagcgggagttaaacaaactgagtcaaccagcttccttgaa
aaaaaagtgaagaagaaatttgattggacatttgaacagacagtggaaactgcaattaca
tgcctgtctactgttctatcaattgatttcaaaccttcagaaatagaagttggagtagtg
acagttgaaaatcctaaattcaggattcttacagaagcagagattgatgctcaccttgtt
gctctagcagagagagactaa

KEGG   Homo sapiens (human): 5683
Entry
5683              CDS       T01001                                 

Gene name
PSMA2, HC3, MU, PMSA2, PSC2
Definition
(RefSeq) proteasome 20S subunit alpha 2
  KO
K02726  20S proteasome subunit alpha 2 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5683 (PSMA2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5683 (PSMA2)
   05012 Parkinson disease
    5683 (PSMA2)
   05014 Amyotrophic lateral sclerosis
    5683 (PSMA2)
   05016 Huntington disease
    5683 (PSMA2)
   05017 Spinocerebellar ataxia
    5683 (PSMA2)
   05020 Prion disease
    5683 (PSMA2)
   05022 Pathways of neurodegeneration - multiple diseases
    5683 (PSMA2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5683 (PSMA2)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5683 (PSMA2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5683 (PSMA2)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5683 (PSMA2)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    5683 (PSMA2)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N
Other DBs
NCBI-GeneID: 5683
NCBI-ProteinID: NP_002778
OMIM: 176842
HGNC: 9531
Ensembl: ENSG00000106588
Vega: OTTHUMG00000023916
Pharos: P25787(Tbio)
UniProt: P25787 A0A024RA52
Structure
PDB: 

Position
7p14.1
AA seq 234 aa
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
NT seq 705 nt   +upstreamnt  +downstreamnt
atggcggagcgcgggtacagcttttcgctgactacattcagcccgtctggtaaacttgtc
cagattgaatatgctttggctgctgtagctggaggagccccgtccgtgggaattaaagct
gcaaatggtgtggtattagcaactgagaaaaaacagaaatccattctgtatgatgagcga
agtgtacacaaagtagaaccaattaccaagcatataggtttggtgtacagtggcatgggc
cccgattacagagtgcttgtgcacagagctcgaaaactagctcaacaatactatcttgtg
taccaagaacccattcctacagctcagctggtacagagagtagcttctgtgatgcaagaa
tatactcagtcaggtggtgttcgtccatttggagtttctttacttatttgtggttggaat
gagggacgaccatatttatttcagtcagatccatctggagcttactttgcctggaaagct
acagcaatgggaaagaactatgtgaatgggaagactttccttgagaaaagatataatgaa
gatctggaacttgaagatgccattcatacagccatcttaaccctaaaggaaagctttgaa
gggcaaatgacagaggataacatagaagttggaatctgcaatgaagctggatttaggagg
cttactccaactgaagttaaggattacttggctgccatagcataa

KEGG   Homo sapiens (human): 5685
Entry
5685              CDS       T01001                                 

Gene name
PSMA4, HC9, HsT17706, PSC9
Definition
(RefSeq) proteasome 20S subunit alpha 4
  KO
K02728  20S proteasome subunit alpha 3 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5685 (PSMA4)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5685 (PSMA4)
   05012 Parkinson disease
    5685 (PSMA4)
   05014 Amyotrophic lateral sclerosis
    5685 (PSMA4)
   05016 Huntington disease
    5685 (PSMA4)
   05017 Spinocerebellar ataxia
    5685 (PSMA4)
   05020 Prion disease
    5685 (PSMA4)
   05022 Pathways of neurodegeneration - multiple diseases
    5685 (PSMA4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5685 (PSMA4)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5685 (PSMA4)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5685 (PSMA4)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5685 (PSMA4)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    5685 (PSMA4)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N TRP_N Phenol_monoox
Other DBs
NCBI-GeneID: 5685
NCBI-ProteinID: NP_001096137
OMIM: 176846
HGNC: 9533
Ensembl: ENSG00000041357
Vega: OTTHUMG00000143859
Pharos: P25789(Tbio)
UniProt: P25789
Structure
PDB: 

Position
15q25.1
AA seq 261 aa
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF
FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA
YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK
EGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKH
EEEEAKAEREKKEKEQKEKDK
NT seq 786 nt   +upstreamnt  +downstreamnt
atgtctcgaagatatgactccaggaccactatattttctccagaaggtcgcttataccaa
gttgaatatgccatggaagctattggacatgcaggcacctgtttgggaattttagcaaat
gatggtgttttgcttgcagcagagagacgcaacatccacaagcttcttgatgaagtcttt
ttttctgaaaaaatttataaactcaatgaggacatggcttgcagtgtggcaggcataact
tctgatgctaatgttctgactaatgaactaaggctcattgctcaaaggtatttattacag
tatcaggagccaataccttgtgagcagttggttacagcgctgtgtgatatcaaacaagct
tatacacaatttggaggaaaacgtccctttggtgtttcattgctgtacattggctgggat
aagcactatggctttcagctctatcagagtgaccctagtggaaattacgggggatggaag
gccacatgcattggaaataatagcgctgcagctgtgtcaatgttgaaacaagactataaa
gaaggagaaatgaccttgaagtcagcacttgctttagctatcaaagtactaaataagacc
atggatgttagtaaactctctgctgaaaaagtggaaattgcaacactaacaagagagaat
ggaaagacagtaatcagagttctcaaacaaaaagaagtggagcagttgatcaaaaaacat
gaggaagaagaagccaaagctgagcgtgagaagaaagaaaaagaacagaaagaaaaggat
aaatag

KEGG   Homo sapiens (human): 5688
Entry
5688              CDS       T01001                                 

Gene name
PSMA7, C6, HEL-S-276, HSPC, RC6-1, XAPC7
Definition
(RefSeq) proteasome 20S subunit alpha 7
  KO
K02731  20S proteasome subunit alpha 4 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5688 (PSMA7)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5688 (PSMA7)
   05012 Parkinson disease
    5688 (PSMA7)
   05014 Amyotrophic lateral sclerosis
    5688 (PSMA7)
   05016 Huntington disease
    5688 (PSMA7)
   05017 Spinocerebellar ataxia
    5688 (PSMA7)
   05020 Prion disease
    5688 (PSMA7)
   05022 Pathways of neurodegeneration - multiple diseases
    5688 (PSMA7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5688 (PSMA7)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5688 (PSMA7)
   03051 Proteasome [BR:hsa03051]
    5688 (PSMA7)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5688 (PSMA7)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5688 (PSMA7)
Membrane trafficking [BR:hsa04131]
 Endosome - Lysosome transport
  Rab GTPases and associated proteins
   Rab associated proteins
    5688 (PSMA7)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    5688 (PSMA7)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N Peptidase_C65 DUF5069
Other DBs
NCBI-GeneID: 5688
NCBI-ProteinID: NP_002783
OMIM: 606607
HGNC: 9536
Ensembl: ENSG00000101182
Vega: OTTHUMG00000032895
Pharos: O14818(Tbio)
UniProt: O14818 A0A0K0K1K4
Structure
PDB: 

Position
20q13.33
AA seq 248 aa
MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVR
KICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQ
SNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEA
IETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENE
KKKQKKAS
NT seq 747 nt   +upstreamnt  +downstreamnt
atgagctacgaccgcgccatcaccgtcttctcgcccgacggccacctcttccaagtggag
tacgcgcaggaggccgtcaagaagggctcgaccgcggttggtgttcgaggaagagacatt
gttgttcttggtgtggagaagaagtcagtggccaaactgcaggatgaaagaacagtgcgg
aagatctgtgctttggatgacaacgtctgcatggcctttgcaggcctcaccgccgatgca
aggatagtcatcaacagggcccgggtggagtgccagagccaccggctgactgtggaggac
ccggtcactgtggagtacatcacccgctacatcgccagtctgaagcagcgttatacgcag
agcaatgggcgcaggccgtttggcatctctgccctcatcgtgggtttcgactttgatggc
actcctaggctctatcagactgacccctcgggcacataccatgcctggaaggccaatgcc
ataggtcggggtgccaagtcagtgcgcgagttcctggagaagaactatactgacgaagcc
attgaaacagatgatctgaccattaagctggtgatcaaggcactcctggaagtggttcag
tcaggtggcaaaaacattgaacttgctgtcatgaggcgagatcaatccctcaagatttta
aatcctgaagaaattgagaagtatgttgctgaaattgaaaaagaaaaagaagaaaacgaa
aagaagaaacaaaagaaagcatcatga

KEGG   Homo sapiens (human): 143471
Entry
143471            CDS       T01001                                 

Gene name
PSMA8, PSMA7L
Definition
(RefSeq) proteasome 20S subunit alpha 8
  KO
K02731  20S proteasome subunit alpha 4 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    143471 (PSMA8)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    143471 (PSMA8)
   05012 Parkinson disease
    143471 (PSMA8)
   05014 Amyotrophic lateral sclerosis
    143471 (PSMA8)
   05016 Huntington disease
    143471 (PSMA8)
   05017 Spinocerebellar ataxia
    143471 (PSMA8)
   05020 Prion disease
    143471 (PSMA8)
   05022 Pathways of neurodegeneration - multiple diseases
    143471 (PSMA8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    143471 (PSMA8)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    143471 (PSMA8)
   03051 Proteasome [BR:hsa03051]
    143471 (PSMA8)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     143471 (PSMA8)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   143471 (PSMA8)
Membrane trafficking [BR:hsa04131]
 Endosome - Lysosome transport
  Rab GTPases and associated proteins
   Rab associated proteins
    143471 (PSMA8)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    143471 (PSMA8)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N Myb_DNA-bind_5
Other DBs
NCBI-GeneID: 143471
NCBI-ProteinID: NP_653263
OMIM: 617841
HGNC: 22985
Ensembl: ENSG00000154611
Vega: OTTHUMG00000179426
Pharos: Q8TAA3(Tdark)
UniProt: Q8TAA3
Position
18q11.2
AA seq 256 aa
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT
VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA
TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL
EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI
EKEKEEAEKKKSKKSV
NT seq 771 nt   +upstreamnt  +downstreamnt
atggcgtctcgatatgacagggcgatcactgtcttctccccagacggacacctttttcaa
gttgaatatgcccaggaagcggtgaagaaaggatccaccgcggtcggaattcgaggtacc
aatatagttgttcttggggtagaaaaaaaatctgttgccaagcttcaagatgaaagaact
gtgaggaaaatttgtgcccttgatgaccatgtctgcatggcttttgcagttttgacaatt
tttataggacttactgctgatgctagagtagtaataaacagagcccgtgtggagtgccag
agccataagcttacggttgaggacccagtcactgtagaatacataactcgcttcatagca
actttaaagcagaaatatacccaaagcaatggacgaagaccttttggtatttctgcctta
attgtaggttttgatgatgatggtatctcaagattgtatcagacagatccttctggtact
tatcatgcttggaaggcaaatgcaataggccgaagtgctaaaactgttcgagaatttcta
gaaaagaattacacagaagatgccatagcaagtgacagtgaagctatcaagttagcaata
aaagctttgctagaagttgtccagtctggtggaaaaaacattgaacttgctataataaga
agaaatcaacctttgaagatgtttagtgcaaaagaagttgaattatatgtaactgaaata
gaaaaggaaaaggaagaagcagagaagaaaaaatcaaagaaatctgtctaa

KEGG   Homo sapiens (human): 5686
Entry
5686              CDS       T01001                                 

Gene name
PSMA5, PSC5, ZETA
Definition
(RefSeq) proteasome 20S subunit alpha 5
  KO
K02729  20S proteasome subunit alpha 5 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5686 (PSMA5)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5686 (PSMA5)
   05012 Parkinson disease
    5686 (PSMA5)
   05014 Amyotrophic lateral sclerosis
    5686 (PSMA5)
   05016 Huntington disease
    5686 (PSMA5)
   05017 Spinocerebellar ataxia
    5686 (PSMA5)
   05020 Prion disease
    5686 (PSMA5)
   05022 Pathways of neurodegeneration - multiple diseases
    5686 (PSMA5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5686 (PSMA5)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5686 (PSMA5)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5686 (PSMA5)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5686 (PSMA5)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    5686 (PSMA5)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N
Other DBs
NCBI-GeneID: 5686
NCBI-ProteinID: NP_002781
OMIM: 176844
HGNC: 9534
Ensembl: ENSG00000143106
Vega: OTTHUMG00000012001
Pharos: P28066(Tbio)
UniProt: P28066 A0A109NGN6
Structure
PDB: 

Position
1p13.3
AA seq 241 aa
MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME
PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA
LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS
LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD
I
NT seq 726 nt   +upstreamnt  +downstreamnt
atgtttcttacccggtctgagtacgacaggggcgtgaatactttttctcccgaaggaaga
ttatttcaagtggaatatgccattgaggctatcaagcttggttctacagccattgggatc
cagacatcagagggtgtgtgcctagctgtggagaagagaattacttccccactgatggag
cccagcagcattgagaaaattgtagagattgatgctcacataggttgtgccatgagtggg
ctaattgctgatgctaagactttaattgataaagccagagtggagacacagaaccactgg
ttcacctacaatgagacaatgacagtggagagtgtgacccaagctgtgtccaatctggct
ttgcagtttggagaagaagatgcagatccaggtgccatgtctcgtccctttggagtagca
ttattatttggaggagttgatgagaaaggaccccagctgtttcatatggacccatctggg
acctttgtacagtgtgatgctcgagcaattggctctgcttcagagggtgcccagagctcc
ttgcaagaagtttaccacaagtctatgactttgaaagaagccatcaagtcttcactcatc
atcctcaaacaagtaatggaggagaagctgaatgcaacaaacattgagctagccacagtg
cagcctggccagaatttccacatgttcacaaaggaagaacttgaagaggttatcaaggac
atttaa

KEGG   Homo sapiens (human): 5682
Entry
5682              CDS       T01001                                 

Gene name
PSMA1, HC2, HEL-S-275, NU, PROS30
Definition
(RefSeq) proteasome 20S subunit alpha 1
  KO
K02725  20S proteasome subunit alpha 6 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5682 (PSMA1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5682 (PSMA1)
   05012 Parkinson disease
    5682 (PSMA1)
   05014 Amyotrophic lateral sclerosis
    5682 (PSMA1)
   05016 Huntington disease
    5682 (PSMA1)
   05017 Spinocerebellar ataxia
    5682 (PSMA1)
   05020 Prion disease
    5682 (PSMA1)
   05022 Pathways of neurodegeneration - multiple diseases
    5682 (PSMA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5682 (PSMA1)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5682 (PSMA1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5682 (PSMA1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5682 (PSMA1)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5682 (PSMA1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    5682 (PSMA1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   5682 (PSMA1)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N
Other DBs
NCBI-GeneID: 5682
NCBI-ProteinID: NP_002777
OMIM: 602854
HGNC: 9530
Ensembl: ENSG00000129084
Vega: OTTHUMG00000165825
Pharos: P25786(Tclin)
UniProt: P25786
Structure
PDB: 

Position
11p15.2
AA seq 263 aa
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT
QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM
ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP
QRKAQPAQPADEPAEKADEPMEH
NT seq 792 nt   +upstreamnt  +downstreamnt
atgtttcgaaatcagtatgacaatgatgtcactgtttggagcccccagggcaggattcat
caaattgaatatgcaatggaagctgttaaacaaggttcagccacagttggtctgaaatca
aaaactcatgcagttttggttgcattgaaaagggcgcaatcagagcttgcagctcatcag
aaaaaaattctccatgttgacaaccatattggtatctcaattgcggggcttactgctgat
gctagactgttatgtaattttatgcgtcaggagtgtttggattccagatttgtattcgat
agaccactgcctgtgtctcgtcttgtatctctaattggaagcaagacccagataccaaca
caacgatatggccggagaccatatggtgttggtctccttattgctggttatgatgatatg
ggccctcacattttccaaacctgtccatctgctaactattttgactgcagagccatgtcc
attggagcccgttcccaatcagctcgtacttacttggagagacatatgtctgaatttatg
gagtgtaatttaaatgaactagttaaacatggtctgcgtgccttaagagagacgcttcct
gcagaacaggacctgactacaaagaatgtttccattggaattgttggtaaagacttggag
tttacaatctatgatgatgatgatgtgtctccattcctggaaggtcttgaagaaagacca
cagagaaaggcacagcctgctcaacctgctgatgaacctgcagaaaaggctgatgaacca
atggaacattaa

KEGG   Homo sapiens (human): 5684
Entry
5684              CDS       T01001                                 

Gene name
PSMA3, HC8, PSC3
Definition
(RefSeq) proteasome 20S subunit alpha 3
  KO
K02727  20S proteasome subunit alpha 7 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5684 (PSMA3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5684 (PSMA3)
   05012 Parkinson disease
    5684 (PSMA3)
   05014 Amyotrophic lateral sclerosis
    5684 (PSMA3)
   05016 Huntington disease
    5684 (PSMA3)
   05017 Spinocerebellar ataxia
    5684 (PSMA3)
   05020 Prion disease
    5684 (PSMA3)
   05022 Pathways of neurodegeneration - multiple diseases
    5684 (PSMA3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5684 (PSMA3)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5684 (PSMA3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5684 (PSMA3)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5684 (PSMA3)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    5684 (PSMA3)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N
Other DBs
NCBI-GeneID: 5684
NCBI-ProteinID: NP_002779
OMIM: 176843
HGNC: 9532
Ensembl: ENSG00000100567
Vega: OTTHUMG00000140319
Pharos: P25788(Tbio)
UniProt: P25788 A0A140VK43
Structure
PDB: 

Position
14q23.1
AA seq 255 aa
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE
EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV
HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL
QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA
KESLKEEDESDDDNM
NT seq 768 nt   +upstreamnt  +downstreamnt
atgagctcaatcggcactgggtatgacctgtcagcctctacattctctcctgacggaaga
gtttttcaagttgaatatgctatgaaggctgtggaaaatagtagtacagctattggaatc
agatgcaaagatggtgttgtctttggggtagaaaaattagtcctttctaaactttatgaa
gaaggttccaacaaaagactttttaatgttgatcggcatgttggaatggcagtagcaggt
ttgttggcagatgctcgttctttagcagacatagcaagagaagaagcttccaacttcaga
tctaactttggctacaacattccactaaaacatcttgcagacagagtggccatgtatgtg
catgcatatacactctacagtgctgttagaccttttggctgcagtttcatgttagggtct
tacagtgtgaatgacggtgcgcaactctacatgattgacccatcaggtgtttcatacggt
tattggggctgtgccatcggcaaagccaggcaagctgcaaagacggaaatagagaagctt
cagatgaaagaaatgacctgccgtgatatcgttaaagaagttgcaaaaataatttacata
gtacatgacgaagttaaggataaagcttttgaactagaactcagctgggttggtgaatta
actaatggaagacatgaaattgttccaaaagatataagagaagaagcagagaaatatgct
aaggaatctctgaaggaagaagatgaatcagatgatgataatatgtaa

KEGG   Homo sapiens (human): 5694
Entry
5694              CDS       T01001                                 

Gene name
PSMB6, DELTA, LMPY, Y
Definition
(RefSeq) proteasome 20S subunit beta 6
  KO
K02738  20S proteasome subunit beta 1 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5694 (PSMB6)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5694 (PSMB6)
   05012 Parkinson disease
    5694 (PSMB6)
   05014 Amyotrophic lateral sclerosis
    5694 (PSMB6)
   05016 Huntington disease
    5694 (PSMB6)
   05017 Spinocerebellar ataxia
    5694 (PSMB6)
   05020 Prion disease
    5694 (PSMB6)
   05022 Pathways of neurodegeneration - multiple diseases
    5694 (PSMB6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5694 (PSMB6)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5694 (PSMB6)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5694 (PSMB6)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5694 (PSMB6)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5694 (PSMB6)
SSDB
Motif
Pfam: Proteasome DUF1502
Other DBs
NCBI-GeneID: 5694
NCBI-ProteinID: NP_002789
OMIM: 600307
HGNC: 9543
Ensembl: ENSG00000142507
Vega: OTTHUMG00000090777
Pharos: P28072(Tbio)
UniProt: P28072 Q6IAT9
Structure
PDB: 

Position
17p13.2
AA seq 239 aa
MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
NT seq 720 nt   +upstreamnt  +downstreamnt
atggcggctaccttactagctgctcggggagccgggccagcaccggcttgggggccggag
gcgttcactccagactgggaaagccgagaagtttccactgggaccactatcatggccgtg
cagtttgacgggggcgtggttctgggggcggactccagaacaaccactgggtcctacatc
gccaatcgagtgactgacaagctgacacctattcacgaccgcattttctgctgtcgctca
ggctcagctgctgatacccaggcagtagctgatgctgtcacctaccagctcggtttccac
agcattgaactgaatgagcctccactggtccacacagcagccagcctctttaaggagatg
tgttaccgataccgggaagacctgatggcgggaatcatcatcgcaggctgggaccctcaa
gaaggagggcaggtgtactcagtgcctatggggggtatgatggtaaggcagtcctttgcc
attggaggctccgggagctcctacatctatggctatgttgatgctacctaccgggaaggc
atgaccaaggaagagtgtctgcaattcactgccaatgctctcgctttggccatggagcgg
gatggctccagtggaggagtgatccgcctggcagccattgcagagtcaggggtagagcgg
caagtacttttgggagaccagatacccaaattcgccgttgccactttaccacccgcctga

KEGG   Homo sapiens (human): 5695
Entry
5695              CDS       T01001                                 

Gene name
PSMB7, Z
Definition
(RefSeq) proteasome 20S subunit beta 7
  KO
K02739  20S proteasome subunit beta 2 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5695 (PSMB7)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5695 (PSMB7)
   05012 Parkinson disease
    5695 (PSMB7)
   05014 Amyotrophic lateral sclerosis
    5695 (PSMB7)
   05016 Huntington disease
    5695 (PSMB7)
   05017 Spinocerebellar ataxia
    5695 (PSMB7)
   05020 Prion disease
    5695 (PSMB7)
   05022 Pathways of neurodegeneration - multiple diseases
    5695 (PSMB7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5695 (PSMB7)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5695 (PSMB7)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5695 (PSMB7)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5695 (PSMB7)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5695 (PSMB7)
SSDB
Motif
Pfam: Proteasome Pr_beta_C
Other DBs
NCBI-GeneID: 5695
NCBI-ProteinID: NP_002790
OMIM: 604030
HGNC: 9544
Ensembl: ENSG00000136930
Vega: OTTHUMG00000021042
Pharos: Q99436(Tbio)
UniProt: Q99436 E9KL30
Structure
PDB: 

Position
9q33.3
AA seq 277 aa
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
NT seq 834 nt   +upstreamnt  +downstreamnt
atggcggctgtgtcggtgtatgctccaccagttggaggcttctcttttgataactgccgc
aggaatgccgtcttggaagccgattttgcaaagaggggatacaagcttccaaaggtccgg
aaaactggcacgaccatcgctggggtggtctataaggatggcatagttcttggagcagat
acaagagcaactgaagggatggttgttgctgacaagaactgttcaaaaatacacttcata
tctcctaatatttattgttgtggtgctgggacagctgcagacacagacatgacaacccag
ctcatttcttccaacctggagctccactccctctccactggccgtcttcccagagttgtg
acagccaatcggatgctgaagcagatgcttttcaggtatcaaggttacattggtgcagcc
ctagttttagggggagtagatgttactggacctcacctctacagcatctatcctcatgga
tcaactgataagttgccttatgtcaccatgggttctggctccttggcagcaatggctgta
tttgaagataagtttaggccagacatggaggaggaggaagccaagaatctggtgagcgaa
gccatcgcagctggcatcttcaacgacctgggctccggaagcaacattgacctctgcgtc
atcagcaagaacaagctggattttctccgcccatacacagtgcccaacaagaaggggacc
aggcttggccggtacaggtgtgagaaagggactactgcagtcctcactgagaaaatcact
cctctggagattgaggtgctggaagaaacagtccaaacaatggacacttcctga

KEGG   Homo sapiens (human): 5691
Entry
5691              CDS       T01001                                 

Gene name
PSMB3, HC10-II
Definition
(RefSeq) proteasome 20S subunit beta 3
  KO
K02735  20S proteasome subunit beta 3 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5691 (PSMB3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5691 (PSMB3)
   05012 Parkinson disease
    5691 (PSMB3)
   05014 Amyotrophic lateral sclerosis
    5691 (PSMB3)
   05016 Huntington disease
    5691 (PSMB3)
   05017 Spinocerebellar ataxia
    5691 (PSMB3)
   05020 Prion disease
    5691 (PSMB3)
   05022 Pathways of neurodegeneration - multiple diseases
    5691 (PSMB3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5691 (PSMB3)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5691 (PSMB3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5691 (PSMB3)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5691 (PSMB3)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5691 (PSMB3)
SSDB
Motif
Pfam: Proteasome
Other DBs
NCBI-GeneID: 5691
NCBI-ProteinID: NP_002786
OMIM: 602176
HGNC: 9540
Ensembl: ENSG00000277791
Vega: OTTHUMG00000188503
Pharos: P49720(Tdark)
UniProt: P49720 A0A384NL22
Structure
PDB: 

Position
17q12
AA seq 205 aa
MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF
ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV
SGMGVIVHIIEKDKITTRTLKARMD
NT seq 618 nt   +upstreamnt  +downstreamnt
atgtctattatgtcctataacggaggggccgtcatggccatgaaggggaagaactgtgtg
gccatcgctgcagacaggcgcttcgggatccaggcccagatggtgaccacggacttccag
aagatctttcccatgggtgaccggctgtacatcggtctggccgggctcgccactgacgtc
cagacagttgcccagcgcctcaagttccggctgaacctgtatgagttgaaggaaggtcgg
cagatcaaaccttataccctcatgagcatggtggccaacctcttgtatgagaaacggttt
ggcccttactacactgagccagtcattgccgggttggacccgaagacctttaagcccttc
atttgctctctagacctcatcggctgccccatggtgactgatgactttgtggtcagtggc
acctgcgccgaacaaatgtacggaatgtgtgagtccctctgggagcccaacatggatccg
gatcacctgtttgaaaccatctcccaagccatgctgaatgctgtggaccgggatgcagtg
tcaggcatgggagtcattgtccacatcatcgagaaggacaaaatcaccaccaggacactg
aaggcccgaatggactaa

KEGG   Homo sapiens (human): 5690
Entry
5690              CDS       T01001                                 

Gene name
PSMB2, HC7-I
Definition
(RefSeq) proteasome 20S subunit beta 2
  KO
K02734  20S proteasome subunit beta 4 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Drug target
Marizomib: D09640
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5690 (PSMB2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5690 (PSMB2)
   05012 Parkinson disease
    5690 (PSMB2)
   05014 Amyotrophic lateral sclerosis
    5690 (PSMB2)
   05016 Huntington disease
    5690 (PSMB2)
   05017 Spinocerebellar ataxia
    5690 (PSMB2)
   05020 Prion disease
    5690 (PSMB2)
   05022 Pathways of neurodegeneration - multiple diseases
    5690 (PSMB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5690 (PSMB2)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5690 (PSMB2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5690 (PSMB2)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5690 (PSMB2)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5690 (PSMB2)
SSDB
Motif
Pfam: Proteasome
Other DBs
NCBI-GeneID: 5690
NCBI-ProteinID: NP_002785
OMIM: 602175
HGNC: 9539
Ensembl: ENSG00000126067
Vega: OTTHUMG00000004169
Pharos: P49721(Tclin)
UniProt: P49721 A0A140VJS6
Structure
PDB: 

Position
1p34.3
AA seq 201 aa
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
RIIDKNGIHDLDNISFPKQGS
NT seq 606 nt   +upstreamnt  +downstreamnt
atggagtacctcatcggtatccaaggccccgactatgttcttgtcgcctccgaccgggtg
gccgccagcaatattgtccagatgaaggacgatcatgacaagatgtttaagatgagtgaa
aagatattactcctgtgtgttggagaggctggagacactgtacagtttgcagaatatatt
cagaaaaacgtgcaactttataagatgcgaaatggatatgaattgtctcccacggcagca
gctaacttcacacgccgaaacctggctgactgtcttcggagtcggaccccatatcatgtg
aacctcctcctggctggctatgatgagcatgaagggccagcgctgtattacatggactac
ctggcagccttggccaaggccccttttgcagcccacggctatggtgccttcctgactctc
agtatcctcgaccgatactacacaccgactatctcacgtgagagggcagtggaactcctt
aggaaatgtctggaggagctccagaaacgcttcatcctgaatctgccaaccttcagtgtt
cgaatcattgacaaaaatggcatccatgacctggataacatttccttccccaaacagggc
tcctaa

KEGG   Homo sapiens (human): 5693
Entry
5693              CDS       T01001                                 

Gene name
PSMB5, LMPX, MB1, X
Definition
(RefSeq) proteasome 20S subunit beta 5
  KO
K02737  20S proteasome subunit beta 5 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Drug target
Bortezomib: D03150<JP/US>
Carfilzomib: D08880<JP/US>
Delanzomib: D10110
Ixazomib (DG01269): D10130 D10131<JP/US>
Marizomib: D09640
Oprozomib: D10318
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5693 (PSMB5)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5693 (PSMB5)
   05012 Parkinson disease
    5693 (PSMB5)
   05014 Amyotrophic lateral sclerosis
    5693 (PSMB5)
   05016 Huntington disease
    5693 (PSMB5)
   05017 Spinocerebellar ataxia
    5693 (PSMB5)
   05020 Prion disease
    5693 (PSMB5)
   05022 Pathways of neurodegeneration - multiple diseases
    5693 (PSMB5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5693 (PSMB5)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5693 (PSMB5)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5693 (PSMB5)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5693 (PSMB5)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5693 (PSMB5)
SSDB
Motif
Pfam: Proteasome DUF3991
Other DBs
NCBI-GeneID: 5693
NCBI-ProteinID: NP_002788
OMIM: 600306
HGNC: 9542
Ensembl: ENSG00000100804
Vega: OTTHUMG00000028713
Pharos: P28074(Tclin)
UniProt: P28074
Structure
PDB: 

Position
14q11.2
AA seq 263 aa
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
NT seq 792 nt   +upstreamnt  +downstreamnt
atggcgcttgccagcgtgttggagagaccgctaccggtgaaccagcgcgggtttttcgga
cttgggggtcgtgcagatctgctggatctaggtccagggagtctcagtgatggtctgagc
ctggccgcgccaggctggggtgtcccagaagagccaggaatcgaaatgcttcatggaaca
accaccctggccttcaagttccgccatggagtcatagttgcagctgactccagggctaca
gcgggtgcttacattgcctcccagacggtgaagaaggtgatagagatcaacccatacctg
ctaggcaccatggctgggggcgcagcggattgcagcttctgggaacggctgttggctcgg
caatgtcgaatctatgagcttcgaaataaggaacgcatctctgtagcagctgcctccaaa
ctgcttgccaacatggtgtatcagtacaaaggcatggggctgtccatgggcaccatgatc
tgtggctgggataagagaggccctggcctctactacgtggacagtgaagggaaccggatt
tcaggggccaccttctctgtaggttctggctctgtgtatgcatatggggtcatggatcgg
ggctattcctatgacctggaagtggagcaggcctatgatctggcccgtcgagccatctac
caagccacctacagagatgcctactcaggaggtgcagtcaacctctaccacgtgcgggag
gatggctggatccgagtctccagtgacaatgtggctgatctacatgagaagtatagtggc
tctaccccctga

KEGG   Homo sapiens (human): 5689
Entry
5689              CDS       T01001                                 

Gene name
PSMB1, HC5, PMSB1, PSC5
Definition
(RefSeq) proteasome 20S subunit beta 1
  KO
K02732  20S proteasome subunit beta 6 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Drug target
Delanzomib: D10110
Marizomib: D09640
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5689 (PSMB1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5689 (PSMB1)
   05012 Parkinson disease
    5689 (PSMB1)
   05014 Amyotrophic lateral sclerosis
    5689 (PSMB1)
   05016 Huntington disease
    5689 (PSMB1)
   05017 Spinocerebellar ataxia
    5689 (PSMB1)
   05020 Prion disease
    5689 (PSMB1)
   05022 Pathways of neurodegeneration - multiple diseases
    5689 (PSMB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5689 (PSMB1)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5689 (PSMB1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5689 (PSMB1)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5689 (PSMB1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5689 (PSMB1)
SSDB
Motif
Pfam: Proteasome Cytochrom_C1
Other DBs
NCBI-GeneID: 5689
NCBI-ProteinID: NP_002784
OMIM: 602017
HGNC: 9537
Ensembl: ENSG00000008018
Vega: OTTHUMG00000016087
Pharos: P20618(Tclin)
UniProt: P20618 A0A140VK45
Structure
PDB: 

Position
6q27
AA seq 241 aa
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
D
NT seq 726 nt   +upstreamnt  +downstreamnt
atgttgtcctctacagccatgtattcggctcctggcagagacttggggatggaaccgcac
agagccgcgggccctttgcagctgcgattttcgccctacgttttcaacggaggtactata
ctggcaattgctggagaagattttgcaattgttgcttctgatactcgattgagtgaaggg
ttttcaattcatacgcgggatagccccaaatgttacaaattaacagacaaaacagtcatt
ggatgcagcggttttcatggagactgtcttacgctgacaaagattattgaagcaagacta
aagatgtataagcattccaataataaggccatgactacgggggcaattgctgcaatgctg
tctacaatcctgtattcaaggcgcttctttccatactatgtttacaacatcatcggtgga
cttgatgaagaaggaaagggggctgtatacagctttgatccagtagggtcttaccagaga
gactccttcaaggctggaggctcagcaagtgccatgctacagcccctgcttgacaaccag
gttggttttaagaacatgcagaatgtggagcatgttccgctgtccttggacagagccatg
cggctggtgaaagatgtcttcatttctgcggctgagagagatgtgtacactggggacgca
ctccggatctgcatagtgaccaaagagggcatcagggaggaaactgtttccttaaggaag
gactga

KEGG   Homo sapiens (human): 5692
Entry
5692              CDS       T01001                                 

Gene name
PSMB4, HN3, HsN3, PRAAS3, PROS-26, PROS26
Definition
(RefSeq) proteasome 20S subunit beta 4
  KO
K02736  20S proteasome subunit beta 7 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5692 (PSMB4)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5692 (PSMB4)
   05012 Parkinson disease
    5692 (PSMB4)
   05014 Amyotrophic lateral sclerosis
    5692 (PSMB4)
   05016 Huntington disease
    5692 (PSMB4)
   05017 Spinocerebellar ataxia
    5692 (PSMB4)
   05020 Prion disease
    5692 (PSMB4)
   05022 Pathways of neurodegeneration - multiple diseases
    5692 (PSMB4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5692 (PSMB4)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5692 (PSMB4)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5692 (PSMB4)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5692 (PSMB4)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5692 (PSMB4)
SSDB
Motif
Pfam: Proteasome
Other DBs
NCBI-GeneID: 5692
NCBI-ProteinID: NP_002787
OMIM: 602177
HGNC: 9541
Ensembl: ENSG00000159377
Vega: OTTHUMG00000012494
Pharos: P28070(Tbio)
UniProt: P28070 A0A140VK46
Structure
PDB: 

Position
1q21.3
AA seq 264 aa
MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK
FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE
LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP
SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK
GVEIEGPLSTETNWDIAHMISGFE
NT seq 795 nt   +upstreamnt  +downstreamnt
atggaagcgtttttggggtcgcggtccggactttgggcggggggtccggccccaggacag
ttttaccgcattccgtccactcccgattccttcatggatccggcgtctgcactttacaga
ggtccaatcacgcggacccagaaccccatggtgaccgggacctcagtcctcggcgttaag
ttcgagggcggagtggtgattgccgcagacatgctgggatcctacggctccttggctcgt
ttccgcaacatctctcgcattatgcgagtcaacaacagtaccatgctgggtgcctctggc
gactacgctgatttccagtatttgaagcaagttctcggccagatggtgattgatgaggag
cttctgggagatggacacagctatagtcctagagctattcattcatggctgaccagggcc
atgtacagccggcgctcgaagatgaaccctttgtggaacaccatggtcatcggaggctat
gctgatggagagagcttcctcggttatgtggacatgcttggtgtagcctatgaagcccct
tcgctggccactggttatggtgcatacttggctcagcctctgctgcgagaagttctggag
aagcagccagtgctaagccagaccgaggcccgcgacttagtagaacgctgcatgcgagtg
ctgtactaccgagatgcccgttcttacaaccggtttcaaatcgccactgtcaccgaaaaa
ggtgttgaaatagagggaccattgtctacagagaccaactgggatattgcccacatgatc
agtggctttgaatga

KEGG   Homo sapiens (human): 5701
Entry
5701              CDS       T01001                                 

Gene name
PSMC2, MSS1, Nbla10058, RPT1, S7
Definition
(RefSeq) proteasome 26S subunit, ATPase 2
  KO
K03061  26S proteasome regulatory subunit T1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5701 (PSMC2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5701 (PSMC2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5701 (PSMC2)
   05012 Parkinson disease
    5701 (PSMC2)
   05014 Amyotrophic lateral sclerosis
    5701 (PSMC2)
   05016 Huntington disease
    5701 (PSMC2)
   05017 Spinocerebellar ataxia
    5701 (PSMC2)
   05020 Prion disease
    5701 (PSMC2)
   05022 Pathways of neurodegeneration - multiple diseases
    5701 (PSMC2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5701 (PSMC2)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    ATPase subunits
     5701 (PSMC2)
SSDB
Motif
Pfam: AAA AAA_lid_3 AAA_22 AAA_5 AAA_16 AAA_2 DUF815 RuvB_N AAA_18 AAA_7 AAA_28 AAA_33 Sigma54_activ_2 Mg_chelatase AAA_14 TIP49 IstB_IS21 AAA_24 Prot_ATP_ID_OB RNA_helicase HMW1C_N T2SSE AAA_3 Sigma54_activat
Other DBs
NCBI-GeneID: 5701
NCBI-ProteinID: NP_002794
OMIM: 154365
HGNC: 9548
Ensembl: ENSG00000161057
Vega: OTTHUMG00000157206
Pharos: P35998(Tbio)
UniProt: P35998 A0A140VK70
Structure
PDB: 

Position
7q22.1
AA seq 433 aa
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKIN
ELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAK
FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGC
KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRV
IGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTML
ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHAR
SMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY
AKFSATPRYMTYN
NT seq 1302 nt   +upstreamnt  +downstreamnt
atgccggattacctcggtgccgatcagcggaagaccaaagaggatgagaaggacgacaag
cccatccgagctctggatgagggggatattgccttgttgaaaacttatggtcagagcact
tactctaggcagatcaagcaagttgaagatgacattcagcaacttctcaagaaaattaat
gagctcactggtattaaagaatctgacactggcctggccccaccagcactctgggatttg
gctgcagataagcagacactccagagtgaacagcctttacaggttgccaggtgtacaaag
ataatcaatgctgattcggaggacccaaaatacattatcaacgtaaagcagtttgccaag
tttgtggtggaccttagtgatcaggtggcacctactgacattgaagaagggatgagagtg
ggcgtggatagaaataaatatcaaattcacattccattgcctcctaagattgacccaaca
gttaccatgatgcaggtggaagagaaacctgatgtcacatacagtgatgttggtggctgt
aaggaacagattgagaaactgcgagaagtagttgaaaccccattacttcatccagagagg
tttgtgaaccttggcattgagcctcccaagggcgtgctgctctttggtccacccggtaca
ggcaagacactctgtgcgcgggcagttgctaatcggactgatgcgtgcttcattcgagtt
attggatctgagcttgtacagaaatacgtcggtgagggggctcgaatggttcgtgaactc
tttgaaatggccagaacaaaaaaagcctgccttatcttctttgatgaaattgatgctatt
ggaggggctcgttttgatgatggtgctggaggtgacaatgaagtgcagagaacaatgttg
gaactgatcaatcagcttgatggttttgatcctagaggcaatattaaagtgctgatggcc
actaacagacctgatactttggatccagcactgatgaggccagggagattggatagaaaa
attgaatttagcttgcccgatctagagggtcggacccacatatttaagattcacgctcgt
tcaatgagtgttgaaagagatatcagatttgaactgttagcacgactgtgtccaaatagc
actggtgctgagattagaagcgtctgcacagaggctggtatgtttgccatcagagcacgg
cgaaaaattgctaccgagaaggatttcttggaagctgtaaataaggtcattaagtcttat
gccaaattcagtgctactcctcgttacatgacatacaactga

KEGG   Homo sapiens (human): 5700
Entry
5700              CDS       T01001                                 

Gene name
PSMC1, P26S4, RPT2, S4, p56
Definition
(RefSeq) proteasome 26S subunit, ATPase 1
  KO
K03062  26S proteasome regulatory subunit T2
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05165  Human papillomavirus infection
hsa05169  Epstein-Barr virus infection
hsa05203  Viral carcinogenesis
Network
nt06130  Cell cycle (viruses)
nt06166  Human papillomavirus (HPV)
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00365  HPV E7 to cell cycle G1/S
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5700 (PSMC1)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    5700 (PSMC1)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5700 (PSMC1)
   05165 Human papillomavirus infection
    5700 (PSMC1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5700 (PSMC1)
   05012 Parkinson disease
    5700 (PSMC1)
   05014 Amyotrophic lateral sclerosis
    5700 (PSMC1)
   05016 Huntington disease
    5700 (PSMC1)
   05017 Spinocerebellar ataxia
    5700 (PSMC1)
   05020 Prion disease
    5700 (PSMC1)
   05022 Pathways of neurodegeneration - multiple diseases
    5700 (PSMC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5700 (PSMC1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    ATPase subunits
     5700 (PSMC1)
SSDB
Motif
Pfam: AAA AAA_lid_3 Prot_ATP_ID_OB AAA_2 AAA_22 DUF815 RuvB_N AAA_5 AAA_16 AAA_18 IstB_IS21 AAA_25 ATPase AAA_28 AAA_33 AAA_3 RNA_helicase AAA_14 TIP49 Mg_chelatase PhoH AAA_7 Prot_ATP_OB_N NACHT AAA_24 NB-ARC AAA_30 ABC_tran Parvo_NS1 TsaE Sigma54_activat
Other DBs
NCBI-GeneID: 5700
NCBI-ProteinID: NP_002793
OMIM: 602706
HGNC: 9547
Ensembl: ENSG00000100764
Vega: OTTHUMG00000171019
Pharos: P62191(Tbio)
UniProt: P62191 Q53XL8
Structure
PDB: 

Position
14q32.11
AA seq 440 aa
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
KSKENVLYKKQEGTPEGLYL
NT seq 1323 nt   +upstreamnt  +downstreamnt
atgggtcaaagtcagagtggtggtcatggtcctggaggtggcaagaaggatgacaaggac
aagaaaaagaaatatgaacctcctgtaccaactagagtggggaaaaagaagaagaaaaca
aagggaccagatgctgccagcaaactgccactggtgacacctcacactcagtgccggtta
aaattactgaagttagagagaattaaagactatcttctcatggaggaagaattcattaga
aatcaggaacaaatgaaaccattagaagaaaagcaagaggaggaaagatcaaaagtggat
gatctgagggggaccccgatgtcagtaggaaccttggaagagatcattgatgacaatcat
gccatcgtgtctacatctgtgggctcagaacactacgtcagcattctttcatttgtagac
aaggatctgctggaacctggctgctcggtcctgctcaaccacaaggtgcatgccgtgata
ggggtgctgatggatgacacggatcccctggtcacagtgatgaaggtagaaaaggccccc
caggagacctatgcagatattggggggttggacaaccaaattcaggaaattaaggaatct
gtggagcttcctctcacccatcctgaatattatgaagagatgggtataaagcctcctaag
ggggtcattctctatggtccacctggcacaggtaaaaccttgttagccaaagcagtagca
aaccaaacctcagccactttcttgagagtggttggctctgaacttattcagaagtaccta
ggtgatgggcccaaactcgtacgggaattgttccgagttgctgaagaacatgcaccgtcc
atcgtgtttattgatgaaattgacgccattgggacaaaaagatatgactccaattctggt
ggtgagagagaaattcagcgaacaatgttggaactgctgaaccagttggatggatttgat
tctaggggagatgtgaaagttatcatggccacaaaccgaatagaaactttggatccagca
cttatcagaccaggccgcattgacaggaagattgagttccccctgcctgatgaaaagacg
aagaagcgcatctttcagattcacacaagcaggatgacgctggctgatgatgtaaccctg
gacgacctgatcatggctaaagatgacctctctggtgctgacatcaaggcaatctgtaca
gaagctggtctgatggccttaagagaacgtagaatgaaagtaacaaatgaagacttcaaa
aaatctaaagaaaatgttctttataagaaacaggaaggcacccctgaggggctgtatctc
taa

KEGG   Homo sapiens (human): 5704
Entry
5704              CDS       T01001                                 

Gene name
PSMC4, MIP224, RPT3, S6, TBP-7, TBP7
Definition
(RefSeq) proteasome 26S subunit, ATPase 4
  KO
K03063  26S proteasome regulatory subunit T3
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5704 (PSMC4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5704 (PSMC4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5704 (PSMC4)
   05012 Parkinson disease
    5704 (PSMC4)
   05014 Amyotrophic lateral sclerosis
    5704 (PSMC4)
   05016 Huntington disease
    5704 (PSMC4)
   05017 Spinocerebellar ataxia
    5704 (PSMC4)
   05020 Prion disease
    5704 (PSMC4)
   05022 Pathways of neurodegeneration - multiple diseases
    5704 (PSMC4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5704 (PSMC4)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    ATPase subunits
     5704 (PSMC4)
SSDB
Motif
Pfam: AAA Prot_ATP_ID_OB AAA_lid_3 AAA_2 AAA_5 AAA_16 RuvB_N DUF815 AAA_22 RNA_helicase AAA_14 Mg_chelatase NTPase_1 AAA_28 AAA_18 IstB_IS21 AAA_33 Sigma54_activat NACHT TIP49 CENP-F_leu_zip AAA_3 ATPase_2 TsaE AAA_7 AAA_24 AAA_17 AAA_25 Zeta_toxin DUF3450 NB-ARC DivIVA Parvo_NS1 ABC_tran
Other DBs
NCBI-GeneID: 5704
NCBI-ProteinID: NP_006494
OMIM: 602707
HGNC: 9551
Ensembl: ENSG00000013275
Vega: OTTHUMG00000182577
Pharos: P43686(Tbio)
UniProt: P43686 A8K2M0
Structure
PDB: 

Position
19q13.2
AA seq 418 aa
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
NT seq 1257 nt   +upstreamnt  +downstreamnt
atggaggagataggcatcttggtggagaaggctcaggatgagatcccagcactgtccgtg
tcccggccccagaccggcctgtccttcctgggccctgagcctgaggacctggaggacctg
tacagccgctacaagaagctgcagcaagagctggagttcctggaggtgcaggaggaatac
atcaaagatgagcaaaagaacctgaaaaaggaatttctccatgcccaggaggaggtgaag
cgaatccaaagcatcccgctggtcatcggacaatttctggaggctgtggatcagaataca
gccatcgtgggctctaccacaggctccaactattatgtgcgcatcctgagcaccatcgat
cgggagctgctcaagcccaacgcctcagtggccctccacaagcacagcaatgcactggtg
gacgtgctgccccccgaagccgacagcagcatcatgatgctcacctcagaccagaagcca
gatgtgatgtacgcggacatcggaggcatggacatccagaagcaggaggtgcgggaggcc
gtggagctcccgctcacgcatttcgagctctacaagcagatcggcatcgatcccccccga
ggcgtcctcatgtatggcccacctggctgtgggaagaccatgttggcaaaggcggtggca
catcacacaacagctgcattcatccgggtcgtgggctcggagtttgtacagaagtatctg
ggtgagggcccccgcatggtccgggatgtgttccgcctggccaaggagaatgcacctgcc
atcatcttcatagacgagattgatgccatcgccaccaagagattcgatgctcagacaggg
gccgacagggaggttcagaggatcctgctggagctgctgaatcagatggatggatttgat
cagaatgtcaatgtcaaggtaatcatggccacaaacagagcagacaccctggatccggcc
ctgctacggccaggacggctggaccgtaaaattgaatttccacttcctgaccgccgccag
aagagattgattttctccactatcactagcaagatgaacctctctgaggaggttgacttg
gaagactatgtggcccggccagataagatttcaggagctgatattaactccatctgtcag
gagagtggaatgttggctgtccgtgaaaaccgctacattgtcctggccaaggacttcgag
aaagcatacaagactgtcatcaagaaggacgagcaggagcatgagttttacaagtga

KEGG   Homo sapiens (human): 5706
Entry
5706              CDS       T01001                                 

Gene name
PSMC6, RPT5, SUG2, p42
Definition
(RefSeq) proteasome 26S subunit, ATPase 6
  KO
K03064  26S proteasome regulatory subunit T4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5706 (PSMC6)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5706 (PSMC6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5706 (PSMC6)
   05012 Parkinson disease
    5706 (PSMC6)
   05014 Amyotrophic lateral sclerosis
    5706 (PSMC6)
   05016 Huntington disease
    5706 (PSMC6)
   05017 Spinocerebellar ataxia
    5706 (PSMC6)
   05020 Prion disease
    5706 (PSMC6)
   05022 Pathways of neurodegeneration - multiple diseases
    5706 (PSMC6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5706 (PSMC6)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    ATPase subunits
     5706 (PSMC6)
SSDB
Motif
Pfam: AAA AAA_lid_3 Prot_ATP_ID_OB AAA_16 AAA_5 AAA_2 AAA_22 RuvB_N AAA_18 AAA_33 Prot_ATP_OB_N DUF815 AAA_7 AAA_14 AAA_3 RNA_helicase TIP49 IstB_IS21 Mg_chelatase TPR_MLP1_2 AAA_11 TsaE Wtap AAA_24 ATPase AAA_25 NACHT AAA_28 AAA_19 Med4
Other DBs
NCBI-GeneID: 5706
NCBI-ProteinID: NP_002797
OMIM: 602708
HGNC: 9553
Ensembl: ENSG00000100519
Vega: OTTHUMG00000152333
Pharos: P62333(Tbio)
UniProt: P62333 A0A087X2I1
Structure
PDB: 

Position
14q22.1
AA seq 389 aa
MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEV
LKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVY
NMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGK
TLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGG
RRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIH
IDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD
FVVQEDFMKAVRKVADSKKLESKLDYKPV
NT seq 1170 nt   +upstreamnt  +downstreamnt
atggcggaccctagagataaggcgcttcaggactaccgcaagaagttgcttgaacacaag
gagatcgacggccgtcttaaggagttaagggaacaattaaaagaacttaccaagcagtat
gaaaagtctgaaaatgatctgaaggccctacagagtgttgggcagatcgtgggtgaagtg
cttaaacagttaactgaagaaaaattcattgttaaagctaccaatggaccaagatatgtt
gtgggttgtcgtcgacagcttgacaaaagtaagctgaagccaggaacaagagttgctttg
gatatgactacactaactatcatgagatatttgccgagagaggtggatccactggtttat
aacatgtctcatgaggaccctgggaatgtttcttattctgagattggagggctatcagaa
cagatccgggaattaagagaggtgatagaattacctcttacaaacccagagttatttcag
cgtgtaggaataatacctccaaaaggctgtttgttatatggaccaccaggtacgggaaaa
acactcttggcacgagccgttgctagccagctggactgcaatttcttaaaggttgtatct
agttctattgtagacaagtacattggtgaaagtgctcgtttgatcagagaaatgtttaat
tatgctagagatcatcaaccatgcatcatttttatggatgaaatagatgctattggtggt
cgtcggttttctgagggtacttcagctgacagagagattcagagaacgttaatggagtta
ctgaatcaaatggatggatttgatactctgcatagagttaaaatgatcatggctacaaac
agaccagatacactggatcctgctttgctgcgtccaggaagattagatagaaaaatacat
attgatttgccaaatgaacaagcaagattagacatactgaaaatccatgcaggtcccatt
acaaagcatggtgaaatagattatgaagcaattgtgaagctttcggatggctttaatgga
gcagatctgagaaatgtttgtactgaagcaggtatgttcgcaattcgtgctgatcatgat
tttgtagtacaggaagacttcatgaaagcagtcagaaaagtggctgattctaagaagctg
gagtctaaattggactacaaacctgtgtaa

KEGG   Homo sapiens (human): 5702
Entry
5702              CDS       T01001                                 

Gene name
PSMC3, RPT5, TBP1
Definition
(RefSeq) proteasome 26S subunit, ATPase 3
  KO
K03065  26S proteasome regulatory subunit T5
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5702 (PSMC3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5702 (PSMC3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5702 (PSMC3)
   05012 Parkinson disease
    5702 (PSMC3)
   05014 Amyotrophic lateral sclerosis
    5702 (PSMC3)
   05016 Huntington disease
    5702 (PSMC3)
   05017 Spinocerebellar ataxia
    5702 (PSMC3)
   05020 Prion disease
    5702 (PSMC3)
   05022 Pathways of neurodegeneration - multiple diseases
    5702 (PSMC3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5702 (PSMC3)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    ATPase subunits
     5702 (PSMC3)
SSDB
Motif
Pfam: AAA Prot_ATP_ID_OB AAA_lid_3 AAA_5 AAA_16 RuvB_N AAA_2 AAA_22 AAA_33 DUF815 Mg_chelatase PhoH AAA_11 IstB_IS21 Sigma54_activat DUF5827 ATPase AAA_24 AAA_7 DUF3713 RNA_helicase
Other DBs
NCBI-GeneID: 5702
NCBI-ProteinID: NP_002795
OMIM: 186852
HGNC: 9549
Ensembl: ENSG00000165916
Vega: OTTHUMG00000167692
Pharos: P17980(Tbio)
UniProt: P17980 A0A140VK42
Structure
PDB: 

Position
11p11.2
AA seq 439 aa
MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
MEGILEVQAKKKANLQYYA
NT seq 1320 nt   +upstreamnt  +downstreamnt
atgaatctgctgccgaatattgagagtccagtgactcggcaggagaagatggcgaccgtg
tgggatgaggccgagcaagatggaattggggaggaggtgctcaagatgtccacggaggag
atcatccagcgcacacggctgctggacagtgagatcaagatcatgaagagtgaagtgttg
agagtcacccatgagctccaagccatgaaggacaagataaaagagaacagtgagaaaatc
aaagtgaacaagaccctgccgtaccttgtctccaacgtcatcgagctcctggatgttgat
cctaatgaccaagaggaggatggtgccaatattgacctggactcccagaggaagggcaag
tgtgctgtgatcaaaacctctacacgacagacgtacttccttcctgtgattgggttggtg
gatgctgaaaagctaaagccaggagacctggtgggtgtgaacaaagactcctatctgatc
ctggagacgctgcccacagagtatgactcgcgggtgaaggccatggaggtagacgagagg
cccacggagcaatacagtgacattgggggtttggacaagcagatccaggagctggtggag
gccattgtcttgccaatgaaccacaaggagaagtttgagaacttggggatccaacctcca
aaaggggtgctgatgtatgggcccccagggacggggaagaccctcctggcccgggcctgt
gccgcacagactaaggccaccttcctaaagctggctggcccccagctggtgcagatgttc
attggagatggtgccaagctagtccgggatgcctttgccctggccaaggagaaagcgccc
tctatcatcttcattgatgagttggatgccatcggcaccaagcgctttgacagtgagaag
gctggggaccgggaggtgcagaggacaatgctggagcttctgaaccagctggatggcttc
cagcccaacacccaagttaaggtaattgcagccacaaacagggtggacatcctggacccc
gccctcctccgctcgggccgccttgaccgcaagatagagttcccgatgcccaatgaggag
gcccgggccagaatcatgcagatccactcccgaaagatgaatgtcagtcctgacgtgaac
tacgaggagctggcccgctgcacagatgacttcaatggggcccagtgcaaggctgtgtgt
gtggaggcgggcatgatcgcactgcgcaggggtgccacggagctcacccacgaggactac
atggaaggcatcctggaggtgcaggccaagaagaaagccaacctacaatactacgcctag

KEGG   Homo sapiens (human): 5705
Entry
5705              CDS       T01001                                 

Gene name
PSMC5, RPT6, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG
Definition
(RefSeq) proteasome 26S subunit, ATPase 5
  KO
K03066  26S proteasome regulatory subunit T6
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5705 (PSMC5)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5705 (PSMC5)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5705 (PSMC5)
   05012 Parkinson disease
    5705 (PSMC5)
   05014 Amyotrophic lateral sclerosis
    5705 (PSMC5)
   05016 Huntington disease
    5705 (PSMC5)
   05017 Spinocerebellar ataxia
    5705 (PSMC5)
   05020 Prion disease
    5705 (PSMC5)
   05022 Pathways of neurodegeneration - multiple diseases
    5705 (PSMC5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5705 (PSMC5)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    ATPase subunits
     5705 (PSMC5)
SSDB
Motif
Pfam: AAA AAA_lid_3 Prot_ATP_ID_OB AAA_2 AAA_5 AAA_16 AAA_22 RuvB_N TIP49 AAA_33 IstB_IS21 AAA_18 Mg_chelatase AAA_3 ATPase PhoH AAA_28 Sigma54_activat AAA_24 AAA_14 AAA_7 AAA_17 AAA_25 Parvo_NS1 DUF815 RNA_helicase TsaE AAA_19 AAA_11 Zeta_toxin Prominin
Other DBs
NCBI-GeneID: 5705
NCBI-ProteinID: NP_002796
OMIM: 601681
HGNC: 9552
Ensembl: ENSG00000087191
Vega: OTTHUMG00000179013
Pharos: P62195(Tbio)
UniProt: P62195 A0A140VJS3
Structure
PDB: 

Position
17q23.3
AA seq 406 aa
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
NT seq 1221 nt   +upstreamnt  +downstreamnt
atggcgcttgacggaccagagcagatggagctggaggaggggaaggcaggcagcggactc
cgccaatattatctgtccaagattgaagaactccagctgattgtgaatgataagagccaa
aacctccggaggctgcaggcacagaggaacgaactaaatgctaaagttcgcctattgcgg
gaggagctacagctgctgcaggagcagggctcctatgtgggggaagtagtccgggccatg
gataagaagaaagtgttggtcaaggtacatcctgaaggtaaatttgttgtagacgtggac
aaaaacattgacatcaatgatgtgacacccaattgccgggtggctctaaggaatgacagc
tacactctgcacaagatcctgcccaacaaggtagacccattagtgtcactgatgatggtg
gagaaagtaccagattcaacttatgagatgattggtggactggacaaacagatcaaggag
atcaaagaagtgatcgagctgcctgttaagcatcctgagctcttcgaagcactgggcatt
gctcagcccaagggagtgctgctgtatggacctccaggcactgggaagacactgttggcc
cgggctgtggctcatcatacggactgtacctttattcgtgtctctggctctgaactggta
cagaaattcataggggaaggggcaagaatggtgagggagctgtttgtcatggcacgggaa
catgctccatctatcatcttcatggacgaaatcgactccatcggctcctcgcggctggag
gggggttctggaggggacagtgaagtgcagcgcacgatgctggagttgctcaaccagctc
gacggctttgaggccaccaagaacatcaaggttatcatggctactaataggattgatatc
ctggactcggcactgcttcgcccagggcgcattgacagaaaaattgaattcccacccccc
aatgaggaggcccggctggacattttgaagattcattctcggaagatgaacctgacccgg
gggatcaacctgagaaaaattgctgagctcatgccaggagcatcaggggctgaagtgaag
ggcgtgtgcacagaagctggcatgtatgccctgcgagaacggcgagtccatgtcactcag
gaggactttgagatggcagtagccaaggtcatgcagaaggacagtgagaaaaacatgtcc
atcaagaaattatggaagtga

KEGG   Homo sapiens (human): 5708
Entry
5708              CDS       T01001                                 

Gene name
PSMD2, P97, RPN1, S2, TRAP2
Definition
(RefSeq) proteasome 26S subunit ubiquitin receptor, non-ATPase 2
  KO
K03028  26S proteasome regulatory subunit N1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5708 (PSMD2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5708 (PSMD2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5708 (PSMD2)
   05012 Parkinson disease
    5708 (PSMD2)
   05014 Amyotrophic lateral sclerosis
    5708 (PSMD2)
   05016 Huntington disease
    5708 (PSMD2)
   05017 Spinocerebellar ataxia
    5708 (PSMD2)
   05020 Prion disease
    5708 (PSMD2)
   05022 Pathways of neurodegeneration - multiple diseases
    5708 (PSMD2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5708 (PSMD2)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5708 (PSMD2)
SSDB
Motif
Pfam: RPN1_RPN2_N RPN1_C PC_rep HEAT_2 THAP
Other DBs
NCBI-GeneID: 5708
NCBI-ProteinID: NP_002799
OMIM: 606223
HGNC: 9559
Ensembl: ENSG00000175166
Vega: OTTHUMG00000156796
Pharos: Q13200(Tbio)
UniProt: Q13200
Structure
PDB: 

Position
3q27.1
AA seq 908 aa
MEEGGRDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQELSEEDKQLQDELEMLV
ERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKR
FAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQ
REPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYV
PEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGR
HGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGG
SGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLW
DVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLG
SIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQ
TIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAY
AGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALI
AMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPE
VSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCP
YHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPL
PVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVIL
RKNPNYDL
NT seq 2727 nt   +upstreamnt  +downstreamnt
atggaggagggaggccgggacaaggcgccggtgcagccccagcagtctccagcggcggcc
cccggcggcacggacgagaagccgagcggcaaggagcggcgggatgccggggacaaggac
aaagaacaggagctgtctgaagaggataaacagcttcaagatgaactggagatgctcgtg
gaacgactaggggagaaggatacatccctgtatcgaccagcgctggaggaattgcgaagg
cagattcgttcttctacaacttccatgacttcagtgcccaagcctctcaaatttctgcgt
ccacactatggcaaactgaaggaaatctatgagaacatggcccctggggagaataagcgt
tttgctgctgacatcatctccgttttggccatgaccatgagtggggagcgtgagtgcctc
aagtatcggctagtgggctcccaggaggaattggcatcatggggtcatgagtatgtcagg
catctggcaggagaagtggctaaggagtggcaggagctggatgacgcagagaaggtccag
cgggagcctctgctcactctggtgaaggaaatcgtcccctataacatggcccacaatgca
gagcatgaggcttgcgacctgcttatggaaattgagcaggtggacatgctggagaaggac
attgatgaaaatgcatatgcaaaggtctgcctttatctcaccagttgtgtgaattacgtg
cctgagcctgagaactcagccctactgcgttgtgccctgggtgtgttccgaaagtttagc
cgcttccctgaagctctgagattggcattgatgctcaatgacatggagttggtagaagac
atcttcacctcctgcaaggatgtggtagtacagaaacagatggcattcatgctaggccgg
catggggtgttcctggagctgagtgaagatgtcgaggagtatgaggacctgacagagatc
atgtccaatgtacagctcaacagcaacttcttggccttagctcgggagctggacatcatg
gagcccaaggtgcctgatgacatctacaaaacccacctagagaacaacaggtttgggggc
agtggctctcaggtggactctgcccgcatgaacctggcctcctcttttgtgaatggcttt
gtgaatgcagcttttggccaagacaagctgctaacagatgatggcaacaaatggctttac
aagaacaaggaccacggaatgttgagtgcagctgcatctcttgggatgattctgctgtgg
gatgtggatggtggcctcacccagattgacaagtacctgtactcctctgaggactacatt
aagtcaggagctcttcttgcctgtggcatagtgaactctggggtccggaatgagtgtgac
cctgctctggcactgctctcagactatgttctccacaacagcaacaccatgagacttggt
tccatctttgggctaggcttggcttatgctggctcaaatcgtgaagatgtcctaacactg
ctgctgcctgtgatgggagattcaaagtccagcatggaggtggcaggtgtcacagcttta
gcctgtggaatgatagcagtagggtcctgcaatggagatgtaacttccactatccttcag
accatcatggagaagtcagagactgagctcaaggatacttatgctcgttggcttcctctt
ggactgggtctcaaccacctggggaagggtgaggccatcgaggcaatcctggctgcactg
gaggttgtgtcagagccattccgcagttttgccaacacactggtggatgtgtgtgcatat
gcaggctctgggaatgtgctgaaggtgcagcagctgctccacatttgtagcgaacacttt
gactccaaagagaaggaggaagacaaagacaagaaggaaaagaaagacaaggacaagaag
gaagcccctgctgacatgggagcacatcagggagtggctgttctggggattgcccttatt
gctatgggggaggagattggtgcagagatggcattacgaacctttggccacttgctgaga
tatggggagcctacactccggagggctgtacctttagcactggccctcatctctgtttca
aatccacgactcaacatcctggataccctaagcaaattctctcatgatgctgatccagaa
gtttcctataactccatttttgccatgggcatggtgggcagtggtaccaataatgcccgt
ctggctgcaatgctgcgccagttagctcaatatcatgccaaggacccaaacaacctcttc
atggtgcgcttggcacagggcctgacacatttagggaagggcacccttaccctctgcccc
taccacagcgaccggcagcttatgagccaggtggccgtggctggactgctcactgtgctt
gtctctttcctggatgttcgaaacattattctaggcaaatcacactatgtattgtatggg
ctggtggctgccatgcagccccgaatgctggttacgtttgatgaggagctgcggccattg
ccagtgtctgtccgtgtgggccaggcagtggatgtggtgggccaggctggcaagccgaag
actatcacagggttccagacgcatacaaccccagtgttgttggcccacggggaacgggca
gaattggccactgaggagtttcttcctgttacccccattctggaaggttttgttatcctt
cggaagaaccccaattatgatctctaa

KEGG   Homo sapiens (human): 5707
Entry
5707              CDS       T01001                                 

Gene name
PSMD1, P112, Rpn2, S1
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 1
  KO
K03032  26S proteasome regulatory subunit N2
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5707 (PSMD1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5707 (PSMD1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5707 (PSMD1)
   05012 Parkinson disease
    5707 (PSMD1)
   05014 Amyotrophic lateral sclerosis
    5707 (PSMD1)
   05016 Huntington disease
    5707 (PSMD1)
   05017 Spinocerebellar ataxia
    5707 (PSMD1)
   05020 Prion disease
    5707 (PSMD1)
   05022 Pathways of neurodegeneration - multiple diseases
    5707 (PSMD1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5707 (PSMD1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5707 (PSMD1)
SSDB
Motif
Pfam: RPN2_C PC_rep HEAT_2 HEAT_EZ Tim54
Other DBs
NCBI-GeneID: 5707
NCBI-ProteinID: NP_002798
OMIM: 617842
HGNC: 9554
Ensembl: ENSG00000173692
Vega: OTTHUMG00000133223
Pharos: Q99460(Tbio)
UniProt: Q99460
Structure
PDB: 

Position
2q37.1
AA seq 953 aa
MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFA
ALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPE
GEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYS
LKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKED
NLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETE
EKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV
RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEAL
QLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLG
LGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQ
HEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIR
RLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICC
AGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDK
HDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLS
LAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAK
KKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRY
QPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD
NT seq 2862 nt   +upstreamnt  +downstreamnt
atgatcacctcggccgctggaattatttctcttctggatgaagatgaaccacagcttaag
gaatttgcactacacaaattgaatgcagttgttaatgacttctgggcagaaatttccgag
tccgtagacaaaatagaggttttatacgaagatgaaggtttccggagtcggcagtttgca
gccttagtggcatctaaagtattttatcacctgggggcttttgaggagtctctgaattat
gctcttggagcaggggacctcttcaatgtcaatgataactctgaatatgtggaaactatt
atagcaaaatgcattgatcactacaccaaacaatgtgtggaaaatgcagatttgcctgaa
ggagaaaaaaaaccaattgaccagagattggaaggcatcgtaaataaaatgttccagcga
tgtctagatgatcacaagtataaacaggctattggcattgctctggagacacgaagactg
gacgtctttgaaaagaccatactggagtcgaatgatgtcccaggaatgttagcttatagc
cttaagctctgcatgtctttaatgcagaataaacagtttcggaataaagtactaagagtt
ctagttaaaatctacatgaacttggagaaacctgatttcatcaatgtttgtcagtgctta
attttcttagatgatcctcaggctgtgagtgatatcttagagaaactggtaaaggaagac
aacctcctgatggcatatcagatttgttttgatttgtatgaaagtgctagccagcagttt
ttgtcatctgtaatccagaatcttcgaactgttggcacccctattgcttctgtgcctgga
tccactaatacgggtactgttccgggatcagagaaagacagtgactcgatggaaacagaa
gaaaagacaagcagtgcatttgtaggaaagacaccagaagccagtccagagcctaaggac
cagactttgaaaatgattaaaattttaagtggtgaaatggctattgagttacatctgcag
ttcttaatacgaaacaataatacagacctcatgattctaaaaaacacaaaggatgcagta
cggaattctgtatgtcatactgcaaccgttatagcaaactcttttatgcactgtgggaca
accagtgaccagtttcttagagataatttggaatggttagccagagccactaactgggca
aaatttactgctacagccagtttgggtgtaattcataagggtcatgaaaaagaagcatta
cagttaatggcaacataccttcccaaggatacttctccaggatcagcctatcaggaaggt
ggaggtctctatgcactaggtcttattcatgccaatcatggtggtgatataattgactat
ctgcttaatcagcttaagaacgccagcaatgatatcgttagacacggtggcagtctgggc
cttggtttggcagccatgggaactgcacgtcaagatgtttatgatttgctaaaaacaaac
ctttatcaggatgatgcagtaacaggggaagcagctggcctggccctaggtttggttatg
ttgggctctaaaaatgctcaggctattgaggacatggttggttatgcacaagaaactcaa
catgagaagattctgcgtggtcttgcagttggcatagctttagtaatgtatgggaggatg
gaagaggctgatgctctcattgaatctctctgtcgtgacaaggacccaattcttcgaagg
tctggaatgtatactgtagccatggcttattgtggctctggtaacaacaaagcaattcga
cgcctgctacatgttgctgtaagtgatgttaatgatgatgtcaggagggcagcagtagaa
tcacttgggttcattctattcagaacccctgaacagtgcccaagtgttgtctctttgttg
tcagagagttacaaccctcatgtgcgctacggagctgcaatggccttggggatatgctgt
gctggtacaggaaacaaggaagccattaatttgctagaaccaatgacaaacgaccccgtg
aactacgtgaggcaaggggcactcatagcttcagctctcatcatgatccagcagactgaa
atcacttgtccaaaggtgaatcagttcagacagctgtattccaaagtcatcaatgataag
catgatgatgtcatggccaagtttggcgctattctggcccagggcatactggatgcaggt
ggtcataatgtcacaatctccttgcagtccaggactgggcatactcatatgccttctgtg
gttggcgtccttgtatttacccagttttggttctggtttcctctttcacacttcctgtca
ttggcttatacccctacctgtgtcattggccttaacaaggacttaaagatgccgaaagtt
cagtataaatcgaactgtaaaccatccacatttgcatatcctgcccctctggaagtacca
aaagaaaaagaaaaggaaaaggtttctactgctgtattatctataactgccaaggctaaa
aagaaggaaaaagaaaaggaaaaaaaggaggaggagaaaatggaagtggatgaggcagag
aaaaaggaggaaaaagagaagaaaaaagaacctgagccaaacttccagttattggataac
ccagcccgagttatgcctgcccagcttaaggtcctaaccatgccggagacctgtagatac
cagcctttcaaaccactctctattggaggcatcatcattctgaaggataccagtgaagac
attgaggagctggtggaacctgtggcagcacatggcccaaaaatcgaggaggaggaacaa
gagccagaacccccagaaccatttgagtatattgatgattaa

KEGG   Homo sapiens (human): 5709
Entry
5709              CDS       T01001                                 

Gene name
PSMD3, P58, RPN3, S3, TSTA2
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 3
  KO
K03033  26S proteasome regulatory subunit N3
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5709 (PSMD3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5709 (PSMD3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5709 (PSMD3)
   05012 Parkinson disease
    5709 (PSMD3)
   05014 Amyotrophic lateral sclerosis
    5709 (PSMD3)
   05016 Huntington disease
    5709 (PSMD3)
   05017 Spinocerebellar ataxia
    5709 (PSMD3)
   05020 Prion disease
    5709 (PSMD3)
   05022 Pathways of neurodegeneration - multiple diseases
    5709 (PSMD3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5709 (PSMD3)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5709 (PSMD3)
SSDB
Motif
Pfam: Rpn3_C PCI CSN8_PSD8_EIF3K TSKS TPR_2
Other DBs
NCBI-GeneID: 5709
NCBI-ProteinID: NP_002800
OMIM: 617676
HGNC: 9560
Ensembl: ENSG00000108344
Vega: OTTHUMG00000133251
Pharos: O43242(Tbio)
UniProt: O43242
Structure
PDB: 

Position
17q21.1
AA seq 534 aa
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAA
EHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGF
FTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATL
RHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQL
EYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPY
FLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLA
DIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRI
SFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
NT seq 1605 nt   +upstreamnt  +downstreamnt
atgaagcaggagggctcggcgcggcgccgcggcgcggacaaggcgaaaccgccgcccggc
ggaggagaacaagaacccccaccgccgccggccccccaggatgtggagatgaaagaggag
gcagcgacgggtggcgggtcgacgggggaggcagacggcaagacggcggcggcagcggct
gagcactcccagcgagagctggacacagtcaccttggaggacatcaaggagcacgtgaaa
cagctagagaaagcggtttcaggcaaggagccgagattcgtgctgcgggccctgcggatg
ctgccttccacatcacgccgcctcaaccactatgttctgtataaggctgtgcagggcttc
ttcacttcaaataatgccactcgagactttttgctccccttcctggaagagcccatggac
acagaggctgatttacagttccgtccccgcacgggaaaagctgcgtcgacacccctcctg
cctgaagtggaagcctatctccaactcctcgtggtcatcttcatgatgaacagcaagcgc
tacaaagaggcacagaagatctctgatgatctgatgcagaagatcagtactcagaaccgc
cgggccctagaccttgtagccgcaaagtgttactattatcacgcccgggtctatgagttc
ctggacaagctggatgtggtgcgcagcttcttgcatgctcggctccggacagctacgctt
cggcatgacgcagacgggcaggccaccctgttgaacctcctgctgcggaattacctacac
tacagcttgtacgaccaggctgagaagctggtgtccaagtctgtgttcccagagcaggcc
aacaacaatgagtgggccaggtacctctactacacagggcgaatcaaagccatccagctg
gagtactcagaggcccggagaacgatgaccaacgcccttcgcaaggcccctcagcacaca
gctgtcggcttcaaacagacggtgcacaagcttctcatcgtggtggagctgttgctgggg
gagatccctgaccggctgcagttccgccagccctccctcaagcgctcactcatgccctat
ttccttctgactcaagctgtcaggacaggaaacctagccaagttcaaccaggtcctggat
cagtttggggagaagtttcaagcagatgggacctacaccctaattatccggctgcggcac
aacgtgattaagacaggtgtacgcatgatcagcctctcctattcccgaatctccttggct
gacatcgcccagaagctgcagttggatagccccgaagatgcagagttcattgttgccaag
gccatccgggatggtgtcattgaggccagcatcaaccacgagaagggctatgtccaatcc
aaggagatgattgacatctattccacccgagagccccagctagccttccaccagcgcatc
tccttctgcctagatatccacaacatgtctgtcaaggccatgaggtttcctcccaaatcg
tacaacaaggacttggagtctgcagaggaacggcgtgagcgagaacagcaggacttggag
tttgccaaggagatggcagaagatgatgatgacagcttcccttga

KEGG   Homo sapiens (human): 5715
Entry
5715              CDS       T01001                                 

Gene name
PSMD9, Rpn4, p27
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 9
  KO
K06693  26S proteasome regulatory subunit N4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5715 (PSMD9)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5715 (PSMD9)
   05012 Parkinson disease
    5715 (PSMD9)
   05014 Amyotrophic lateral sclerosis
    5715 (PSMD9)
   05016 Huntington disease
    5715 (PSMD9)
   05017 Spinocerebellar ataxia
    5715 (PSMD9)
   05020 Prion disease
    5715 (PSMD9)
   05022 Pathways of neurodegeneration - multiple diseases
    5715 (PSMD9)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5715 (PSMD9)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5715 (PSMD9)
SSDB
Motif
Pfam: Nas2_N PDZ_6 PDZ_2 PDZ GRASP55_65
Other DBs
NCBI-GeneID: 5715
NCBI-ProteinID: NP_002804
OMIM: 603146
HGNC: 9567
Ensembl: ENSG00000110801
Vega: OTTHUMG00000168945
Pharos: O00233(Tbio)
UniProt: O00233
Position
12q24.31
AA seq 223 aa
MSDEEARQSGGSSQAGVVTVSDVQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCE
GYPRSDVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAHKEAM
SRKLGQSESQGPPRAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLHNIGSVV
QHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR
NT seq 672 nt   +upstreamnt  +downstreamnt
atgtccgacgaggaagcgaggcagagcggaggctcctcgcaggccggcgtcgtgactgtc
agcgacgtccaggagctgatgcggcgcaaggaggagatagaagcgcagatcaaggccaac
tatgacgtgctggaaagccaaaaaggcattgggatgaacgagccgctggtggactgtgag
ggctacccccggtcagacgtggacctgtaccaagtccgcaccgccaggcacaacatcata
tgcctgcagaatgatcacaaggcagtgatgaagcaggtggaggaggccctgcaccagctg
cacgctcgcgacaaggagaagcaggcccgggacatggctgaggcccacaaagaggccatg
agccgcaaactgggtcagagtgagagccagggccctccacgggccttcgccaaagtgaac
agcatcagccccggctccccagccagcatcgcgggtctgcaagtggatgatgagattgtg
gagttcggctctgtgaacacccagaacttccagtcactgcataacattggcagtgtggtg
cagcacagtgaggggaagcccctgaatgtgacagtgatccgcaggggggaaaaacaccag
cttagacttgttccaacacgctgggcaggaaaaggactgctgggctgcaacattattcct
ctgcaaagatga

KEGG   Homo sapiens (human): 5718
Entry
5718              CDS       T01001                                 

Gene name
PSMD12, Rpn5, STISS, p55
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 12
  KO
K03035  26S proteasome regulatory subunit N5
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5718 (PSMD12)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5718 (PSMD12)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5718 (PSMD12)
   05012 Parkinson disease
    5718 (PSMD12)
   05014 Amyotrophic lateral sclerosis
    5718 (PSMD12)
   05016 Huntington disease
    5718 (PSMD12)
   05017 Spinocerebellar ataxia
    5718 (PSMD12)
   05020 Prion disease
    5718 (PSMD12)
   05022 Pathways of neurodegeneration - multiple diseases
    5718 (PSMD12)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5718 (PSMD12)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5718 (PSMD12)
SSDB
Motif
Pfam: PCI RPN5_C
Other DBs
NCBI-GeneID: 5718
NCBI-ProteinID: NP_002807
OMIM: 604450
HGNC: 9557
Ensembl: ENSG00000197170
Vega: OTTHUMG00000140376
Pharos: O00232(Tbio)
UniProt: O00232 A0A0S2Z489
Structure
PDB: 

Position
17q24.2
AA seq 456 aa
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM
VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI
KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK
ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY
LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP
KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE
HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD
PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
NT seq 1371 nt   +upstreamnt  +downstreamnt
atggcggacggcggctcggagcgggctgacgggcgcatcgtcaagatggaggtggactac
agcgccacggtggatcagcgcctacccgagtgtgcgaagctagccaaggaaggaagactt
caagaagtcattgaaacccttctctctctggaaaagcagactcgtactgcttccgatatg
gtatcgacatcccgtatcttagttgcagtagtgaagatgtgctatgaggctaaagaatgg
gatttacttaatgaaaatattatgcttttgtccaaaaggcggagtcagttaaaacaagct
gttgccaaaatggttcaacagtgctgtacttatgttgaggaaatcacagaccttcctatc
aaacttcgattaattgatactctacgaatggttaccgaaggcaagatttatgttgaaatt
gagcgtgcgcgactgactaaaacattagcaactataaaagaacaaaatggtgatgtgaaa
gaggcagcctccattttacaggagttacaggtggaaacctacgggtcaatggaaaagaaa
gagcgagtggaatttattttggagcaaatgaggctctgcctagctgtgaaggattacatt
cgaacacaaatcatcagcaagaaaattaacaccaaatttttccaggaagaaaatacagag
aaattaaagttgaagtactataatttaatgattcagctggatcaacatgagggatcctat
ttgtctatttgtaagcactacagagcaatatatgatactccctgtatacaggcagaaagt
gaaaaatggcagcaggctctgaagagtgttgtactctatgttatcctggctccttttgac
aatgaacagtcagatttggttcaccgaataagtggtgacaagaagttagaagaaattccc
aaatacaaggatcttttaaagctttttaccacaatggagttgatgcgttggtccacactt
gttgaggactatggaatggaattaagaaaaggttcccttgagagtcctgcaacggatgtt
tttggttctacagaggaaggtgaaaaaaggtggaaagacttgaagaacagagttgttgaa
cataatattagaataatggccaagtattatactcggataacaatgaaaaggatggcacag
cttctggatctatctgttgatgagtccgaagcctttctctcaaatctagtagttaacaag
accatctttgctaaagtagacagattagcaggaattatcaacttccagagacccaaggat
ccaaataatttattaaatgactggtctcagaaactgaactcattaatgtctctggttaac
aaaactacgcatctcatagccaaagaggagatgatacataatctacaataa

KEGG   Homo sapiens (human): 5717
Entry
5717              CDS       T01001                                 

Gene name
PSMD11, Rpn6, S9, p44.5
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 11
  KO
K03036  26S proteasome regulatory subunit N6
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5717 (PSMD11)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5717 (PSMD11)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5717 (PSMD11)
   05012 Parkinson disease
    5717 (PSMD11)
   05014 Amyotrophic lateral sclerosis
    5717 (PSMD11)
   05016 Huntington disease
    5717 (PSMD11)
   05017 Spinocerebellar ataxia
    5717 (PSMD11)
   05020 Prion disease
    5717 (PSMD11)
   05022 Pathways of neurodegeneration - multiple diseases
    5717 (PSMD11)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5717 (PSMD11)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5717 (PSMD11)
SSDB
Motif
Pfam: RPN6_N PCI RPN6_C_helix TPR_12 DDRGK DUF2153 AAA_16
Other DBs
NCBI-GeneID: 5717
NCBI-ProteinID: NP_001257411
OMIM: 604449
HGNC: 9556
Ensembl: ENSG00000108671
Vega: OTTHUMG00000132811
Pharos: O00231(Tbio)
UniProt: O00231
Structure
PDB: 

Position
17q11.2
AA seq 422 aa
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
LT
NT seq 1269 nt   +upstreamnt  +downstreamnt
atggcggcggcggcggtggtggagttccagagagcccagtctctactcagcaccgaccgg
gaggcctccatcgacatcctccactccatcgtgaagcgtgacattcaggaaaacgatgaa
gaggcagtgcaagtcaaagagcagagcatcctggaactgggatctctcctggcaaagact
ggacaagctgcagagcttggaggactcctgaagtatgtacgacccttcttgaattccatc
agcaaggctaaagcagctcgcctggtccgatctcttcttgatctgtttcttgatatggaa
gcagctacagggcaggaggtcgagctgtgtttagagtgcatcgaatgggccaagtcagag
aaaagaactttcttacgccaagctttggaggcaagactggtgtctttgtactttgatacc
aagaggtaccaggaagcattgcatttgggttctcagctgctgcgggagttgaaaaagatg
gacgacaaagctcttttggtggaagtacagcttttagaaagcaaaacataccatgccctg
agcaacctgccgaaagcccgagctgccttaacttctgctcgaaccacagcaaatgccatc
tactgcccccctaaattgcaggccaccttggacatgcagtcgggtattatccatgcagca
gaagagaaggactggaaaactgcgtactcatacttctatgaggcatttgagggttatgac
tccatcgacagccccaaggccatcacatctctgaagtacatgttgctgtgcaaaatcatg
ctcaacaccccagaagatgtccaggctttggtgagcgggaagcttgcacttcggtatgca
gggaggcagacagaagcattaaaatgcgtggctcaggctagcaagaacagatcactggca
gattttgaaaaggctctgacagattaccgggcagagctccgggatgacccaatcatcagc
acacacttggccaagttgtatgataacttactagaacagaatctgatccgagtcattgag
cctttttccagagtacagattgaacacatatctagtctcatcaaactctccaaggccgac
gtggaaaggaaattatcacagatgattcttgacaagaaatttcatgggattttggaccag
ggggagggtgtcctgattattttcgatgaacccccagtagataaaacttacgaagctgct
ctggaaacaattcagaacatgagcaaagtagtggattccctctacaacaaagccaagaaa
ctgacatag

KEGG   Homo sapiens (human): 9861
Entry
9861              CDS       T01001                                 

Gene name
PSMD6, Rpn7, S10, SGA-113M, p42A, p44S10
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 6
  KO
K03037  26S proteasome regulatory subunit N7
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    9861 (PSMD6)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    9861 (PSMD6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    9861 (PSMD6)
   05012 Parkinson disease
    9861 (PSMD6)
   05014 Amyotrophic lateral sclerosis
    9861 (PSMD6)
   05016 Huntington disease
    9861 (PSMD6)
   05017 Spinocerebellar ataxia
    9861 (PSMD6)
   05020 Prion disease
    9861 (PSMD6)
   05022 Pathways of neurodegeneration - multiple diseases
    9861 (PSMD6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    9861 (PSMD6)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     9861 (PSMD6)
SSDB
Motif
Pfam: RPN7 PCI
Other DBs
NCBI-GeneID: 9861
NCBI-ProteinID: NP_055629
OMIM: 617857
HGNC: 9564
Ensembl: ENSG00000163636
Vega: OTTHUMG00000158765
Pharos: Q15008(Tbio)
UniProt: Q15008
Structure
PDB: 

Position
3p14.1
AA seq 389 aa
MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKS
LDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGA
LTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRL
KVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKV
IKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMR
IHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPD
SKNWQYQETIKKGDLLLNRVQKLSRVINM
NT seq 1170 nt   +upstreamnt  +downstreamnt
atgccgctggagaacctggaggaggagggtctgcccaagaaccccgacttgcgtatcgcg
cagctgcgcttcctgctcagcctgcccgagcaccgcggagacgctgccgtgcgcgacgag
ctgatggcggccgtccgcgataacaacatggctccttactatgaagccttgtgcaaatcc
ctcgactggcagatagacgtggacctactcaataaaatgaagaaggcaaatgaagatgag
ttgaagcgtttggatgaggagctggaagatgcagagaagaatctaggagagagcgaaatt
cgcgatgcaatgatggcaaaggccgagtacctctgccggataggtgacaaagagggagct
ctgacagcctttcgcaagacatatgacaaaactgtggccctgggtcaccgattggatatt
gtattctatctccttaggattggcttattttatatggataatgatctcatcacacgaaac
acagaaaaggccaaaagcttaatagaagaaggaggagactgggacaggagaaaccgccta
aaagtgtatcagggtctttattgtgtggctattcgtgatttcaaacaggcagctgaactc
ttccttgacactgtttcaacatttacatcctatgaactcatggattataaaacatttgtg
acttatactgtctatgtcagtatgattgccttagaaagaccagatctcagggaaaaggtc
attaaaggagcagagattcttgaagtgttgcacagtcttccagcagttcggcagtatctg
ttttcactctatgaatgccgttactctgttttcttccaatcattagcggttgtggaacag
gaaatgaaaaaggactggctttttgcccctcattatcgatactatgtaagagaaatgaga
attcatgcatacagtcagctgctggaatcatataggtcattaacccttggctatatggca
gaagcgtttggtgttggtgtggaattcattgatcaggaactgtccaggtttattgctgcc
gggagactacactgcaaaatagataaagtgaatgaaatagtagaaaccaacagacctgat
agcaagaactggcagtaccaagaaactatcaagaaaggagatctgctactaaacagagtt
caaaaactttccagagtaattaatatgtaa

KEGG   Homo sapiens (human): 5713
Entry
5713              CDS       T01001                                 

Gene name
PSMD7, MOV34, P40, Rpn8, S12
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 7
  KO
K03038  26S proteasome regulatory subunit N8
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5713 (PSMD7)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5713 (PSMD7)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5713 (PSMD7)
   05012 Parkinson disease
    5713 (PSMD7)
   05014 Amyotrophic lateral sclerosis
    5713 (PSMD7)
   05016 Huntington disease
    5713 (PSMD7)
   05017 Spinocerebellar ataxia
    5713 (PSMD7)
   05020 Prion disease
    5713 (PSMD7)
   05022 Pathways of neurodegeneration - multiple diseases
    5713 (PSMD7)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5713 (PSMD7)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5713 (PSMD7)
SSDB
Motif
Pfam: MitMem_reg JAB Connexin Coilin_N
Other DBs
NCBI-GeneID: 5713
NCBI-ProteinID: NP_002802
OMIM: 157970
HGNC: 9565
Ensembl: ENSG00000103035
Vega: OTTHUMG00000137601
Pharos: P51665(Tbio)
UniProt: P51665
Structure
PDB: 

Position
16q23.1
AA seq 324 aa
MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDE
DDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSV
LVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIK
DTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDV
SLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDR
KEDKEKDKDKEKSDVKKEEKKEKK
NT seq 975 nt   +upstreamnt  +downstreamnt
atgccggagctggcagtgcagaaggtggtggtccaccccctggtgctgctcagtgtggtg
gatcatttcaaccgaatcggcaaggttggaaaccagaagcgtgttgttggtgtgcttttg
gggtcatggcaaaagaaagtacttgatgtatcgaacagttttgcagttccttttgatgaa
gatgacaaagacgattctgtatggtttttagaccatgattatttggaaaacatgtatgga
atgtttaagaaagtcaatgccagggaaagaatagttggctggtaccacacaggccctaaa
ctacacaagaatgacattgccatcaacgaactcatgaaaagatactgtcctaattccgta
ttggtcatcattgatgtgaagccgaaggacctagggctgcctacagaagcgtacatttca
gtggaagaagtccatgatgatggaactccaacctcgaaaacatttgaacacgtgaccagt
gaaattggagcagaggaagctgaggaagttggagttgaacacttgttacgagatatcaaa
gacacgacggtgggcactctgtcccagcggatcacaaaccaggtccatggtttgaaggga
ctgaactccaagcttctggatatcaggagctacctggaaaaagtcgccacaggcaagctg
cccatcaaccaccagatcatctaccagctgcaggacgtcttcaacctgctgccagatgtc
agcctgcaggagttcgtcaaggccttttacctgaagaccaatgaccagatggtggtagtg
tacttggcctcgctgatccgttccgtggtcgccctgcacaacctcatcaacaacaagatt
gccaaccgggatgcagagaagaaagaagggcaggagaaagaagagagcaaaaaggatagg
aaagaggacaaggagaaagataaagataaggaaaagagtgatgtaaagaaagaggagaaa
aaggagaaaaagtaa

KEGG   Homo sapiens (human): 5719
Entry
5719              CDS       T01001                                 

Gene name
PSMD13, HSPC027, Rpn9, S11, p40.5
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 13
  KO
K03039  26S proteasome regulatory subunit N9
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5719 (PSMD13)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5719 (PSMD13)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5719 (PSMD13)
   05012 Parkinson disease
    5719 (PSMD13)
   05014 Amyotrophic lateral sclerosis
    5719 (PSMD13)
   05016 Huntington disease
    5719 (PSMD13)
   05017 Spinocerebellar ataxia
    5719 (PSMD13)
   05020 Prion disease
    5719 (PSMD13)
   05022 Pathways of neurodegeneration - multiple diseases
    5719 (PSMD13)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5719 (PSMD13)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5719 (PSMD13)
SSDB
Motif
Pfam: PCI Rpn9_C
Other DBs
NCBI-GeneID: 5719
NCBI-ProteinID: NP_002808
OMIM: 603481
HGNC: 9558
Ensembl: ENSG00000185627
Vega: OTTHUMG00000119072
Pharos: Q9UNM6(Tbio)
UniProt: Q9UNM6
Structure
PDB: 

Position
11p15.5
AA seq 376 aa
MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLY
ENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGA
LKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFL
GCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAF
NSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSA
KITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDV
KSMEMLVEHQAHDILT
NT seq 1131 nt   +upstreamnt  +downstreamnt
atgaaggacgtaccgggcttcctacagcagagccagaactccgggcccgggcagcccgct
gtgtggcaccgtctggaggagctctacacgaagaagttgtggcatcagctgacacttcag
gtgcttgattttgtgcaggatccgtgctttgcccaaggagatggtctcattaagctttat
gaaaactttatcagtgaatttgaacacagggtgaaccctttgtccctcgtggaaatcatt
cttcatgtagttagacagatgactgatcctaatgtggctcttacttttctggaaaagact
cgtgagaaggtgaaaagtagtgatgaggcagtgatcctgtgtaaaacagcaattggagct
ctaaaattaaacatcggggacctacaggttacaaaggaaacaattgaagatgttgaagaa
atgctcaacaaccttcctggtgtgacatcggttcacagtcgtttctatgatctctccagt
aaatactatcaaacaatcggaaaccacgcgtcctactacaaagatgctctgcggtttttg
ggctgtgttgacatcaaggatctaccagtgtctgagcagcaggagagagccttcacgctg
gggctagcaggacttctcggcgagggagtttttaactttggagaactcctcatgcaccct
gtgctggagtccctgaggaatactgaccggcagtggctgattgacaccctctatgccttc
aacagtggcaacgtagagcggttccagactctgaagactgcctggggccagcagcctgat
ttagcagctaatgaagcccagcttctgaggaaaattcagttgttgtgcctcatggagatg
actttcacacgacctgccaatcacagacaactcacttttgaagaaattgccaaaagtgct
aaaatcacagtgaatgaggtggagcttctggtgatgaaggccctttcggtggggctggtg
aaaggcagtatagacgaggtggacaaacgagtccacatgacctgggtgcagccccgagtg
ttggatttgcaacagatcaagggaatgaaggaccgcctggagttctggtgcacggatgtg
aagagcatggagatgctggtggagcaccaggcccatgacatcctcacctag

KEGG   Homo sapiens (human): 5710
Entry
5710              CDS       T01001                                 

Gene name
PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5
Definition
(RefSeq) proteasome 26S subunit ubiquitin receptor, non-ATPase 4
  KO
K03029  26S proteasome regulatory subunit N10
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5710 (PSMD4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5710 (PSMD4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5710 (PSMD4)
   05012 Parkinson disease
    5710 (PSMD4)
   05014 Amyotrophic lateral sclerosis
    5710 (PSMD4)
   05016 Huntington disease
    5710 (PSMD4)
   05017 Spinocerebellar ataxia
    5710 (PSMD4)
   05020 Prion disease
    5710 (PSMD4)
   05022 Pathways of neurodegeneration - multiple diseases
    5710 (PSMD4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5710 (PSMD4)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5710 (PSMD4)
SSDB
Motif
Pfam: VWA_2 VWA Ssl1 UIM RAP80_UIM
Other DBs
NCBI-GeneID: 5710
NCBI-ProteinID: NP_002801
OMIM: 601648
HGNC: 9561
Ensembl: ENSG00000159352
Vega: OTTHUMG00000012349
Pharos: P55036(Tbio)
UniProt: P55036
Structure
PDB: 

Position
1q21.3
AA seq 377 aa
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV
LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN
EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA
DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA
ASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEF
GQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLA
SQATKDGKKDKKEEDKK
NT seq 1134 nt   +upstreamnt  +downstreamnt
atggtgttggaaagcactatggtgtgtgtggacaacagtgagtatatgcggaatggagac
ttcttacccaccaggctgcaggcccagcaggatgctgtcaacatagtttgtcattcaaag
acccgcagcaaccctgagaacaacgtgggccttatcacactggctaatgactgtgaagtg
ctgaccacactcaccccagacactggccgtatcctgtccaagctacatactgtccaaccc
aagggcaagatcaccttctgcacgggcatccgcgtggcccatctggctctgaagcaccga
caaggcaagaatcacaagatgcgcatcattgcctttgtgggaagcccagtggaggacaat
gagaaggatctggtgaaactggctaaacgcctcaagaaggagaaagtaaatgttgacatt
atcaattttggggaagaggaggtgaacacagaaaagctgacagcctttgtaaacacgttg
aatggcaaagatggaaccggttctcatctggtgacagtgcctcctgggcccagtttggct
gatgctctcatcagttctccgattttggctggtgaaggtggtgccatgctgggtcttggt
gccagtgactttgaatttggagtagatcccagtgctgatcctgagctggccttggccctt
cgtgtatctatggaagagcagcggcagcggcaggaggaggaggcccggcgggcagctgca
gcttctgctgctgaggccgggattgctacgactgggactgaagactcagacgatgccctg
ctgaagatgaccatcagccagcaagagtttggccgcactgggcttcctgacctaagcagt
atgactgaggaagagcagattgcttatgccatgcagatgtccctgcagggagcagagttt
ggccaggcggaatcagcagacattgatgccagctcagctatggacacatctgagccagcc
aaggaggaggatgattacgacgtgatgcaggaccccgagttccttcagagtgtcctagag
aacctcccaggtgtggatcccaacaatgaagccattcgaaatgctatgggctccctggcc
tcccaggccaccaaggacggcaagaaggacaagaaggaggaagacaagaagtga

KEGG   Homo sapiens (human): 10213
Entry
10213             CDS       T01001                                 

Gene name
PSMD14, PAD1, POH1, RPN11
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 14
  KO
K03030  26S proteasome regulatory subunit N11
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    10213 (PSMD14)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    10213 (PSMD14)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10213 (PSMD14)
   05012 Parkinson disease
    10213 (PSMD14)
   05014 Amyotrophic lateral sclerosis
    10213 (PSMD14)
   05016 Huntington disease
    10213 (PSMD14)
   05017 Spinocerebellar ataxia
    10213 (PSMD14)
   05020 Prion disease
    10213 (PSMD14)
   05022 Pathways of neurodegeneration - multiple diseases
    10213 (PSMD14)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    10213 (PSMD14)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    10213 (PSMD14)
   03051 Proteasome [BR:hsa03051]
    10213 (PSMD14)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M67
   10213 (PSMD14)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   JAMM
    10213 (PSMD14)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     10213 (PSMD14)
SSDB
Motif
Pfam: JAB MitMem_reg Prok-JAB DUF4525
Other DBs
NCBI-GeneID: 10213
NCBI-ProteinID: NP_005796
OMIM: 607173
HGNC: 16889
Ensembl: ENSG00000115233
Vega: OTTHUMG00000153882
Pharos: O00487(Tbio)
UniProt: O00487 A0A140VKF2
Structure
PDB: 

Position
2q24.2
AA seq 310 aa
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
NT seq 933 nt   +upstreamnt  +downstreamnt
atggacagacttcttagacttggaggaggtatgcctggactgggccaggggccacctaca
gatgctcctgcagtggacacagcagaacaagtctatatctcttccctggcactgttaaaa
atgttaaaacatggccgtgctggagttccaatggaagttatgggtttgatgcttggagaa
tttgttgatgattataccgtcagagtgattgatgtgtttgctatgccacagtcaggaaca
ggtgtcagtgtggaggcagttgatccagtgttccaagctaaaatgttggatatgttgaag
cagacaggaaggccggagatggttgttggttggtatcacagtcaccctggctttggttgt
tggctttctggtgtggatatcaacactcagcagagctttgaagccttgtcggagagagct
gtggcagtggttgtggatcccattcagagtgtaaaaggaaaggttgttattgatgccttc
agattgatcaatgctaatatgatggtcttaggacatgaaccaagacaaacaacttcgaat
ctgggtcacttaaacaagccatctatccaggcattaattcatggactaaacagacattat
tactccattactattaactatcggaaaaatgaactggaacagaagatgttgctaaatttg
cataagaagagttggatggaaggtttgacacttcaggactacagtgaacattgtaaacac
aatgaatcagtggtaaaagagatgttggaattagccaagaattacaataaggctgtagaa
gaagaagataagatgacacctgaacagctggcaataaagaatgttggcaagcaggacccc
aaacgtcatttggaggaacatgtggatgtacttatgacctcaaatattgtccagtgttta
gcagctatgttggatactgtcgtatttaaataa

KEGG   Homo sapiens (human): 5714
Entry
5714              CDS       T01001                                 

Gene name
PSMD8, HEL-S-91n, HIP6, HYPF, Nin1p, Rpn12, S14, p31
Definition
(RefSeq) proteasome 26S subunit, non-ATPase 8
  KO
K03031  26S proteasome regulatory subunit N12
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5714 (PSMD8)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5714 (PSMD8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5714 (PSMD8)
   05012 Parkinson disease
    5714 (PSMD8)
   05014 Amyotrophic lateral sclerosis
    5714 (PSMD8)
   05016 Huntington disease
    5714 (PSMD8)
   05017 Spinocerebellar ataxia
    5714 (PSMD8)
   05020 Prion disease
    5714 (PSMD8)
   05022 Pathways of neurodegeneration - multiple diseases
    5714 (PSMD8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5714 (PSMD8)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5714 (PSMD8)
SSDB
Motif
Pfam: CSN8_PSD8_EIF3K
Other DBs
NCBI-GeneID: 5714
NCBI-ProteinID: NP_002803
OMIM: 617844
HGNC: 9566
Ensembl: ENSG00000099341
Vega: OTTHUMG00000150691
Pharos: P48556(Tbio)
UniProt: P48556 V9HW09
Structure
PDB: 

Position
19q13.2
AA seq 350 aa
MFIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAA
SRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLK
LVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKE
QLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGS
YNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMT
DYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
NT seq 1053 nt   +upstreamnt  +downstreamnt
atgttcattaagggcagggctccgagggcgccacctcgagagcgacggcgggctacccgg
ggcgggctgaggcaggttgtagccccgccccgggccttgggctccacctctcggccccac
ttccgccgggcaagcgtttgtaggcggcgctgccgtaaatcaggcggtctgcttgccgca
tcacgcaagatggcggccgcggcggtgaacggggcggcaggcttctcgagctccgggccc
gcggcaacctcgggcgctgttctgcaggccgcgaccggcatgtacgagcaactcaagggc
gagtggaaccgtaaaagccccaatcttagcaagtgcggggaagagctgggtcgactcaag
ctagttcttctggagctcaacttcttgccaaccacagggaccaagctgaccaaacagcag
ctaattctggcccgtgacatactggagatcggggcccaatggagcatcctacgcaaggac
atcccctccttcgagcgctacatggcccagctcaaatgctactactttgattacaaggag
cagctccccgagtcagcctatatgcaccagctcttgggcctcaacctcctcttcctgctg
tcccagaaccgggtggctgagttccacacggagttggagcggctgcctgccaaggacata
cagaccaatgtctacatcaagcacccagtgtccctggagcaatacctgatggagggcagc
tacaacaaagtgttcctggccaagggtaacatccccgccgagagctacaccttcttcatt
gacatcctgctcgacactatcagggatgagatcgctgggtgcatcgagaaggcctacgag
aaaatccttttcactgaggccacccggatcctcttcttcaacacacccaaaaagatgaca
gactacgccaagaagcgagggtgggtcctgggccccaacaactactacagttttgccagc
cagcagcagaagccggaagacaccaccattccctccacagaactggccaaacaggtcatc
gagtatgcccggcagctggagatgatcgtctga

KEGG   Homo sapiens (human): 11047
Entry
11047             CDS       T01001                                 

Gene name
ADRM1, ARM-1, ARM1, GP110, PSMD16
Definition
(RefSeq) ADRM1 26S proteasome ubiquitin receptor
  KO
K06691  26S proteasome regulatory subunit N13
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    11047 (ADRM1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    11047 (ADRM1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    11047 (ADRM1)
   05012 Parkinson disease
    11047 (ADRM1)
   05014 Amyotrophic lateral sclerosis
    11047 (ADRM1)
   05016 Huntington disease
    11047 (ADRM1)
   05017 Spinocerebellar ataxia
    11047 (ADRM1)
   05020 Prion disease
    11047 (ADRM1)
   05022 Pathways of neurodegeneration - multiple diseases
    11047 (ADRM1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    11047 (ADRM1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     11047 (ADRM1)
SSDB
Motif
Pfam: RPN13_C Proteasom_Rpn13 ASXH GerD DUF1631
Other DBs
NCBI-GeneID: 11047
NCBI-ProteinID: NP_008933
OMIM: 610650
HGNC: 15759
Ensembl: ENSG00000130706
Vega: OTTHUMG00000032904
Pharos: Q16186(Tbio)
UniProt: Q16186
Structure
PDB: 

Position
20q13.33
AA seq 407 aa
MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFC
WKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEH
CRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGL
GGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASAT
SPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPI
LANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFG
LPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
NT seq 1224 nt   +upstreamnt  +downstreamnt
atgacgacctcaggcgcgctctttccaagcctggtgccaggctctcggggcgcctccaac
aagtacttggtggagtttcgggcgggaaagatgtccctgaaggggaccaccgtgactccg
gataagcggaaagggctggtgtacattcagcagacggacgactcgcttattcacttctgc
tggaaggacaggacgtccgggaacgtggaagacgacttgatcatcttccctgacgactgt
gagttcaagcgggtgccgcagtgccccagcgggagggtctacgtgctgaagttcaaggca
gggtccaagcggcttttcttctggatgcaggaacccaagacagaccaggatgaggagcat
tgccggaaagtcaacgagtatctgaacaaccccccgatgcctggggcgctgggggccagc
ggaagcagcggccacgaactctctgcgctaggcggtgagggtggcctgcagagcctgctg
ggaaacatgagccacagccagctcatgcagctcatcggaccagccggccttggaggactg
ggtgggctgggggccctgactggacctggcctggccagcttactggggagcagtgggcct
ccagggagcagctcctcctccagctcccggagccagtcggcagcggtcaccccgtcatcc
accacctcttccacccgtgccaccccagccccttctgctccagcagctgcctcagcaact
agcccgagccccgcgcccagttccgggaatggagccagcacagcagccagcccgacccag
cccatccagctgagcgacctccagagcatcctggccacgatgaacgtaccagccgggcca
gcaggcggccagcaagtggacctggccagtgtgctgacgccggagataatggctcccatc
ctcgccaacgcggatgtccaggagcgcctgcttccctacttgccatctggggagtcgctg
ccgcagaccgcggatgagatccagaataccctgacctcgccccagttccagcaggccctg
ggcatgttcagcgcagccttggcctcggggcagctgggccccctcatgtgccagttcggt
ctgcctgcagaggctgtggaggccgccaacaagggcgatgtggaagcgtttgccaaagcc
atgcagaacaacgccaagcccgagcagaaagagggcgacacgaaggacaagaaggacgaa
gaggaggacatgagcctggactga

KEGG   Homo sapiens (human): 7979
Entry
7979              CDS       T01001                                 

Gene name
SEM1, C7orf76, DSS1, ECD, PSMD15, SHFD1, SHFM1, SHSF1, Shfdg1
Definition
(RefSeq) SEM1 26S proteasome subunit
  KO
K10881  26 proteasome complex subunit DSS1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa03440  Homologous recombination
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06420  Ubiquitin-proteasome system
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    7979 (SEM1)
  09124 Replication and repair
   03440 Homologous recombination
    7979 (SEM1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    7979 (SEM1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7979 (SEM1)
   05012 Parkinson disease
    7979 (SEM1)
   05014 Amyotrophic lateral sclerosis
    7979 (SEM1)
   05016 Huntington disease
    7979 (SEM1)
   05017 Spinocerebellar ataxia
    7979 (SEM1)
   05020 Prion disease
    7979 (SEM1)
   05022 Pathways of neurodegeneration - multiple diseases
    7979 (SEM1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    7979 (SEM1)
   04131 Membrane trafficking [BR:hsa04131]
    7979 (SEM1)
   03051 Proteasome [BR:hsa03051]
    7979 (SEM1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    7979 (SEM1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    TREX-2 complex
     7979 (SEM1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Tethering complex
   Exocyst complex assembly proteins
    7979 (SEM1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     7979 (SEM1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     7979 (SEM1)
SSDB
Motif
Pfam: DSS1_SEM1
Other DBs
NCBI-GeneID: 7979
NCBI-ProteinID: NP_006295
OMIM: 601285
HGNC: 10845
Ensembl: ENSG00000127922
Vega: OTTHUMG00000150680
Pharos: P60896(Tbio)
UniProt: P60896 Q6IBB7
Structure
PDB: 

Position
7q21.3
AA seq 70 aa
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL
EKHGYKMETS
NT seq 213 nt   +upstreamnt  +downstreamnt
atgtcagagaaaaagcagccggtagacttaggtctgttagaggaagacgacgagtttgaa
gagttccctgccgaagactgggctggcttagatgaagatgaagatgcacatgtctgggag
gataattgggatgatgacaatgtagaggatgacttctctaatcagttacgagctgaacta
gagaaacatggttataagatggagacttcatag

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