KEGG   Homo sapiens (human): 57142
Entry
57142             CDS       T01001                                 
Symbol
RTN4, ASY, NI220/250, NOGO, NOGOA, NOGOB, NSP, NSP-CL, Nbla00271, Nbla10545, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C
Name
(RefSeq) reticulon-4 isoform A
  KO
K20720  reticulon-4
Organism
hsa  Homo sapiens (human)
Pathway
hsa05010  Alzheimer disease
Drug target
Ozanezumab: D10331
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    57142 (RTN4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    57142 (RTN4)
   03036 Chromosome and associated proteins [BR:hsa03036]
    57142 (RTN4)
Membrane trafficking [BR:hsa04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Others
   Others
    57142 (RTN4)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Spindle formation proteins
    57142 (RTN4)
SSDB
Motif
Pfam: Reticulon DUF639
Other DBs
NCBI-GeneID: 57142
NCBI-ProteinID: NP_065393
OMIM: 604475
HGNC: 14085
Ensembl: ENSP00000337838.6
UniProt: Q9NQC3
Structure
Position
2:complement(54972189..55137831)
AA seq 1192 aa
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA
AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP
SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG
SSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSP
LSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEM
GSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVV
SSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKV
DKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIF
PLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTE
EVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSF
EESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYE
EAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSE
MAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMI
EYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVY
SNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEI
ANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALAT
QAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVV
FGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESE
VAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTL
LILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE
NT seq 3579 nt   +upstreamnt  +downstreamnt
atggaagacctggaccagtctcctctggtctcgtcctcggacagcccaccccggccgcag
cccgcgttcaagtaccagttcgtgagggagcccgaggacgaggaggaagaagaggaggag
gaagaggaggacgaggacgaagacctggaggagctggaggtgctggagaggaagcccgcc
gccgggctgtccgcggccccagtgcccaccgcccctgccgccggcgcgcccctgatggac
ttcggaaatgacttcgtgccgccggcgccccggggacccctgccggccgctccccccgtc
gccccggagcggcagccgtcttgggacccgagcccggtgtcgtcgaccgtgcccgcgcca
tccccgctgtctgctgccgcagtctcgccctccaagctccctgaggacgacgagcctccg
gcccggcctccccctcctcccccggccagcgtgagcccccaggcagagcccgtgtggacc
ccgccagccccggctcccgccgcgcccccctccaccccggccgcgcccaagcgcaggggc
tcctcgggctcagtggatgagaccctttttgctcttcctgctgcatctgagcctgtgata
cgctcctctgcagaaaatatggacttgaaggagcagccaggtaacactatttcggctggt
caagaggatttcccatctgtcctgcttgaaactgctgcttctcttccttctctgtctcct
ctctcagccgcttctttcaaagaacatgaataccttggtaatttgtcaacagtattaccc
actgaaggaacacttcaagaaaatgtcagtgaagcttctaaagaggtctcagagaaggca
aaaactctactcatagatagagatttaacagagttttcagaattagaatactcagaaatg
ggatcatcgttcagtgtctctccaaaagcagaatctgccgtaatagtagcaaatcctagg
gaagaaataatcgtgaaaaataaagatgaagaagagaagttagttagtaataacatcctt
cataatcaacaagagttacctacagctcttactaaattggttaaagaggatgaagttgtg
tcttcagaaaaagcaaaagacagttttaatgaaaagagagttgcagtggaagctcctatg
agggaggaatatgcagacttcaaaccatttgagcgagtatgggaagtgaaagatagtaag
gaagatagtgatatgttggctgctggaggtaaaatcgagagcaacttggaaagtaaagtg
gataaaaaatgttttgcagatagccttgagcaaactaatcacgaaaaagatagtgagagt
agtaatgatgatacttctttccccagtacgccagaaggtataaaggatcgttcaggagca
tatatcacatgtgctccctttaacccagcagcaactgagagcattgcaacaaacattttt
cctttgttaggagatcctacttcagaaaataagaccgatgaaaaaaaaatagaagaaaag
aaggcccaaatagtaacagagaagaatactagcaccaaaacatcaaacccttttcttgta
gcagcacaggattctgagacagattatgtcacaacagataatttaacaaaggtgactgag
gaagtcgtggcaaacatgcctgaaggcctgactccagatttagtacaggaagcatgtgaa
agtgaattgaatgaagttactggtacaaagattgcttatgaaacaaaaatggacttggtt
caaacatcagaagttatgcaagagtcactctatcctgcagcacagctttgcccatcattt
gaagagtcagaagctactccttcaccagttttgcctgacattgttatggaagcaccattg
aattctgcagttcctagtgctggtgcttccgtgatacagcccagctcatcaccattagaa
gcttcttcagttaattatgaaagcataaaacatgagcctgaaaaccccccaccatatgaa
gaggccatgagtgtatcactaaaaaaagtatcaggaataaaggaagaaattaaagagcct
gaaaatattaatgcagctcttcaagaaacagaagctccttatatatctattgcatgtgat
ttaattaaagaaacaaagctttctgctgaaccagctccggatttctctgattattcagaa
atggcaaaagttgaacagccagtgcctgatcattctgagctagttgaagattcctcacct
gattctgaaccagttgacttatttagtgatgattcaatacctgacgttccacaaaaacaa
gatgaaactgtgatgcttgtgaaagaaagtctcactgagacttcatttgagtcaatgata
gaatatgaaaataaggaaaaactcagtgctttgccacctgagggaggaaagccatatttg
gaatcttttaagctcagtttagataacacaaaagataccctgttacctgatgaagtttca
acattgagcaaaaaggagaaaattcctttgcagatggaggagctcagtactgcagtttat
tcaaatgatgacttatttatttctaaggaagcacagataagagaaactgaaacgttttca
gattcatctccaattgaaattatagatgagttccctacattgatcagttctaaaactgat
tcattttctaaattagccagggaatatactgacctagaagtatcccacaaaagtgaaatt
gctaatgccccggatggagctgggtcattgccttgcacagaattgccccatgacctttct
ttgaagaacatacaacccaaagttgaagagaaaatcagtttctcagatgacttttctaaa
aatgggtctgctacatcaaaggtgctcttattgcctccagatgtttctgctttggccact
caagcagagatagagagcatagttaaacccaaagttcttgtgaaagaagctgagaaaaaa
cttccttccgatacagaaaaagaggacagatcaccatctgctatattttcagcagagctg
agtaaaacttcagttgttgacctcctgtactggagagacattaagaagactggagtggtg
tttggtgccagcctattcctgctgctttcattgacagtattcagcattgtgagcgtaaca
gcctacattgccttggccctgctctctgtgaccatcagctttaggatatacaagggtgtg
atccaagctatccagaaatcagatgaaggccacccattcagggcatatctggaatctgaa
gttgctatatctgaggagttggttcagaagtacagtaattctgctcttggtcatgtgaac
tgcacgataaaggaactcaggcgcctcttcttagttgatgatttagttgattctctgaag
tttgcagtgttgatgtgggtatttacctatgttggtgccttgtttaatggtctgacacta
ctgattttggctctcatttcactcttcagtgttcctgttatttatgaacggcatcaggca
cagatagatcattatctaggacttgcaaataagaatgttaaagatgctatggctaaaatc
caagcaaaaatccctggattgaagcgcaaagctgaatga

  All links  
Disease (1)   
   OMIM (1)   
Gene (49)   
   RefGene (26)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (18)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (121)   
   RefSeq(nuc) (13)   
   GenBank (54)   
   EMBL (54)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (188)   

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