KEGG   Homo sapiens (human): 80746
Entry
80746             CDS       T01001                                 
Symbol
TSEN2, PCH2B, SEN2, SEN2L
Name
(RefSeq) tRNA-splicing endonuclease subunit Sen2 isoform 1
  KO
K15322  tRNA-splicing endonuclease subunit Sen2 [EC:4.6.1.16]
Organism
hsa  Homo sapiens (human)
Disease
H00897  Pontocerebellar hypoplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    80746 (TSEN2)
Enzymes [BR:hsa01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.16  tRNA-intron lyase
     80746 (TSEN2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  tRNA spricing factors
   tRNA splicing endonuclease complex
    80746 (TSEN2)
SSDB
Motif
Pfam: tRNA_int_endo tRNA_int_endo_N
Other DBs
NCBI-GeneID: 80746
NCBI-ProteinID: NP_001138864
OMIM: 608753
HGNC: 28422
UniProt: Q8NCE0
Structure
Position
3:12480231..12539624
AA seq 465 aa
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQL
YGKGYFGKGILSRSRPSFTISDPKLVAKWKDMKTNMPIITSKRYQHSVEWAAELMRRQGQ
DESTVRRILKDYTKPLEHPPVKRNEEAQVHDKLNSGMVSNMEGTAGGERPSVVNGDSGKS
GGVGDPREPLGCLQEGSGCHPTTESFEKSVREDASPLPHVCCCKQDALILQRGLHHEDGS
QHIGLLHPGDRGPDHEYVLVEEAECAMSEREAAPNEELVQRNRLICRRNPYRIFEYLQLS
LEEAFFLVYALGCLSIYYEKEPLTIVKLWKAFTVVQPTFRTTYMAYHYFRSKGWVPKVGL
KYGTDLLLYRKGPPFYHASYSVIIELVDDHFEGSLRRPLSWKSLAALSRVSVNVSKELML
CYLIKPSTMTDKEMESPECMKRIKVQEVILSRWVSSRERSDQDDL
NT seq 1398 nt   +upstreamnt  +downstreamnt
atggcagaagcagttttccatgccccaaagaggaaaagaagagtgtatgagacttacgag
tctccattgccaatcccttttggtcaggaccatggtcctctgaaagaattcaagatattc
cgtgctgaaatgattaacaacaatgtgattgtgaggaatgcggaggacattgagcagctc
tatgggaaaggttattttggaaaaggtattctttcaagaagccgtccaagcttcacaatt
tcagatcctaaactggttgctaaatggaaagatatgaagacaaacatgcctatcatcaca
tcaaagaggtatcagcatagtgttgagtgggcagcagagctgatgcgtagacaggggcag
gatgagagtacagtgcgcagaatcctcaaggattacacgaaaccgcttgagcatcctcct
gtgaaaaggaatgaagaggctcaagtgcatgacaagcttaactctggaatggtttccaac
atggaaggcacagcagggggagagagaccttctgtggtaaacggggactctggaaagtca
ggtggtgtgggtgatccccgtgagccattaggctgcctgcaggagggctctggctgccac
ccaacaacagagagctttgagaaaagcgtgcgagaggatgcctcacctctgccccatgtc
tgttgctgcaaacaagatgctctcatcctccagcgtggccttcatcatgaagacggcagc
cagcacatcggcctcctgcatcctggggacagagggcctgaccatgagtacgtgctggtc
gaggaagcggagtgtgccatgagcgagagggaggctgccccaaatgaggaattggtgcaa
agaaacaggttaatatgcagaagaaatccatataggatctttgagtatttgcaactcagc
ctagaagaggcctttttcttggtctatgctctgggatgtttaagtatttactatgagaag
gagcctttaacgatagtgaagctctggaaagctttcactgtagttcagcccacgttcaga
accacctacatggcctaccattactttcgaagcaagggctgggtgcccaaagtgggactc
aagtacgggacagatttactgctatatcggaaaggccctccattttaccatgcaagttat
tctgtcattatcgagctagttgatgaccattttgaaggctctctccgcaggcctctcagt
tggaagtccctggctgccttgagcagagtttccgttaatgtctctaaggaacttatgctg
tgctatttgattaaaccctctactatgactgacaaggaaatggagtcaccagaatgtatg
aaaaggattaaagttcaggaggtgattctgagtcgatgggtttcttcacgagagaggagt
gaccaagacgatctttaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (15)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (35)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (33)   
DNA sequence (113)   
   RefSeq(nuc) (77)   
   GenBank (18)   
   EMBL (18)   
3D Structure (5)   
   PDB (5)   
Protein domain (2)   
   Pfam (2)   
All databases (172)   

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