KEGG   Homo sapiens (human): 81607
Entry
81607             CDS       T01001                                 
Symbol
NECTIN4, EDSS1, LNIR, PRR4, PVRL4, nectin-4
Name
(RefSeq) nectin-4 precursor
  KO
K06593  poliovirus receptor-related 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03265  Virion - Ebolavirus, Lyssavirus and Morbillivirus
hsa04517  IgSF CAM signaling
hsa04520  Adherens junction
Network
nt06546  IgSF CAM signaling
  Element
N01949  NECTIN1 interanctions
N01952  NECTIN4 interactions
Disease
H00647  Ectodermal dysplasia-syndactyly syndrome
Drug target
Enfortumab: D11524
Enfortumab vedotin: D11525<JP/US>
Olaviztabart: D13314
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
    81607 (NECTIN4)
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    81607 (NECTIN4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    81607 (NECTIN4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules [BR:hsa04515]
    81607 (NECTIN4)
Cell adhesion molecules [BR:hsa04515]
 Immunoglobulin superfamily
  Nectin family
   81607 (NECTIN4)
SSDB
Motif
Pfam: V-set Ig_3 C2-set_2 ig I-set Ig_2 Ig_VEGFR-1-like_5th Ig_PDGFR_d4 Ig_6 DUF4692 Protocadherin EphA2_TM Chordopox_A13L HBEGF_C Ctr DUF3377 DUF2755 HI_0559 MAP17 Tudor_FlgD_C TMEM154 Baculo_11_kDa LapA_dom
Other DBs
NCBI-GeneID: 81607
NCBI-ProteinID: NP_112178
OMIM: 609607
HGNC: 19688
Ensembl: ENSP00000356991.3
UniProt: Q96NY8 K4PZ75
Structure
Position
1:complement(161070998..161089558)
AA seq 510 aa
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL
FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA
EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ
AMNHFVQENGTLRAKPTGNGIYINGRGHLV
NT seq 1533 nt   +upstreamnt  +downstreamnt
atgcccctgtccctgggagccgagatgtgggggcctgaggcctggctgctgctgctgcta
ctgctggcatcatttacaggccggtgccccgcgggtgagctggagacctcagacgtggta
actgtggtgctgggccaggacgcaaaactgccctgcttctaccgaggggactccggcgag
caagtggggcaagtggcatgggctcgggtggacgcgggcgaaggcgcccaggaactagcg
ctactgcactccaaatacgggcttcatgtgagcccggcttacgagggccgcgtggagcag
ccgccgcccccacgcaaccccctggacggctcagtgctcctgcgcaacgcagtgcaggcg
gatgagggcgagtacgagtgccgggtcagcaccttccccgccggcagcttccaggcgcgg
ctgcggctccgagtgctggtgcctcccctgccctcactgaatcctggtccagcactagaa
gagggccagggcctgaccctggcagcctcctgcacagctgagggcagcccagcccccagc
gtgacctgggacacggaggtcaaaggcacaacgtccagccgttccttcaagcactcccgc
tctgctgccgtcacctcagagttccacttggtgcctagccgcagcatgaatgggcagcca
ctgacttgtgtggtgtcccatcctggcctgctccaggaccaaaggatcacccacatcctc
cacgtgtccttccttgctgaggcctctgtgaggggccttgaagaccaaaatctgtggcac
attggcagagaaggagctatgctcaagtgcctgagtgaagggcagccccctccctcatac
aactggacacggctggatgggcctctgcccagtggggtacgagtggatggggacactttg
ggctttcccccactgaccactgagcacagcggcatctacgtctgccatgtcagcaatgag
ttctcctcaagggattctcaggtcactgtggatgttcttgacccccaggaagactctggg
aagcaggtggacctagtgtcagcctcggtggtggtggtgggtgtgatcgccgcactcttg
ttctgccttctggtggtggtggtggtgctcatgtcccgataccatcggcgcaaggcccag
cagatgacccagaaatatgaggaggagctgaccctgaccagggagaactccatccggagg
ctgcattcccatcacacggaccccaggagccagccggaggagagtgtagggctgagagcc
gagggccaccctgatagtctcaaggacaacagtagctgctctgtgatgagtgaagagccc
gagggccgcagttactccacgctgaccacggtgagggagatagaaacacagactgaactg
ctgtctccaggctctgggcgggccgaggaggaggaagatcaggatgaaggcatcaaacag
gccatgaaccattttgttcaggagaatgggaccctacgggccaagcccacgggcaatggc
atctacatcaatgggcggggacacctggtctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (11)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (12)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (35)   
   RefSeq(nuc) (9)   
   GenBank (13)   
   EMBL (13)   
3D Structure (4)   
   PDB (4)   
Protein domain (23)   
   Pfam (23)   
All databases (87)   

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