KEGG   Homo sapiens (human): 8945
Entry
8945              CDS       T01001                                 
Symbol
BTRC, BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP
Name
(RefSeq) F-box/WD repeat-containing protein 1A isoform 1
  KO
K03362  F-box and WD-40 domain protein 1/11
Organism
hsa  Homo sapiens (human)
Pathway
hsa04114  Oocyte meiosis
hsa04120  Ubiquitin mediated proteolysis
hsa04218  Cellular senescence
hsa04310  Wnt signaling pathway
hsa04340  Hedgehog signaling pathway
hsa04390  Hippo signaling pathway
hsa04710  Circadian rhythm
hsa05131  Shigellosis
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06182  Shigella
nt06516  TNF signaling
  Element
N00942  Shigella OspG to TNF-NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    8945 (BTRC)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    8945 (BTRC)
   04340 Hedgehog signaling pathway
    8945 (BTRC)
   04390 Hippo signaling pathway
    8945 (BTRC)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    8945 (BTRC)
   04218 Cellular senescence
    8945 (BTRC)
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    8945 (BTRC)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    8945 (BTRC)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    8945 (BTRC)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    8945 (BTRC)
   03036 Chromosome and associated proteins [BR:hsa03036]
    8945 (BTRC)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   SCF complex
    Target recognizing subunit (F-box)
     8945 (BTRC)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     8945 (BTRC)
SSDB
Motif
Pfam: Beta-prop_WDR5 WD40 Beta-prop_WDR3_1st Beta-prop_THOC3 Beta-prop_IFT122_1st WD40_WDHD1_1st Beta-prop_WDR3_2nd WD40_Prp19 WD40_CDC20-Fz Beta-prop_TEP1_C Beta-prop_TEP1_2nd DSE1_N WD40_MABP1-WDR62_2nd EIF3I WD40_Gbeta WDR55 Beta-TrCP_D Beta-prop_WDR36-Utp21_2nd Beta-prop_SCAP Beta-prop_WDR75_1st Beta-prop_EML Beta-prop_CAF1B_HIR1 Beta-prop_EML_2 Beta-prop_WDR41 Beta-prop_WDR36-Utp21_1st Beta-prop_WDR90_POC16_2nd F-box-like Beta-prop_EIPR1 CFAP251_N Beta-prop_RIG_2nd ANAPC4_WD40 WD40_MABP1-WDR62_1st Beta-prop_Aladin WDR90_beta-prop_4th PAC11 ASA1 Beta-prop_IP5PC_F Beta-prop_SPT8 NBCH_WD40 Beta-prop_DCAF4 Beta-prop_DCAF12 F-box Beta-prop_VPS8 Beta-prop_IFT140_1st WD40_like Beta-prop_NOL10_N Beta-prop_HPS5 WD40_RFWD3 Beta-prop_WDR19_1st Beta-prop_Nup120_160 Beta-prop_WDR11_2nd F-box_5 Aq_678 DUF4508 PAN_3 MTUS1_CCDC69_CC1 DUF6188
Other DBs
NCBI-GeneID: 8945
NCBI-ProteinID: NP_378663
OMIM: 603482
HGNC: 1144
Ensembl: ENSP00000359206.3
UniProt: Q9Y297 A0A0S2Z4P6 B2R8L3 Q68DS0
Structure
Position
10:101354048..101557313
AA seq 605 aa
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDC
NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV
PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF
ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR
GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS
ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS
SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR
VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV
SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR
APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY
TYISR
NT seq 1818 nt   +upstreamnt  +downstreamnt
atggacccggccgaggcggtgctgcaagagaaggcactcaagtttatgtgctctatgccc
aggtctctgtggctgggctgctccagcctggcggacagcatgccttcgctgcgatgcctg
tataacccagggactggcgcactcacagctttccagaattcctcagagagagaagactgt
aataatggcgaaccccctaggaagataataccagagaagaattcacttagacagacatac
aacagctgtgccagactctgcttaaaccaagaaacagtatgtttagcaagcactgctatg
aagactgagaattgtgtggccaaaacaaaacttgccaatggcacttccagtatgattgtg
cccaagcaacggaaactctcagcaagctatgaaaaggaaaaggaactgtgtgtcaaatac
tttgagcagtggtcagagtcagatcaagtggaatttgtggaacatcttatatcccaaatg
tgtcattaccaacatgggcacataaactcgtatcttaaacctatgttgcagagagatttc
ataactgctctgccagctcggggattggatcatattgctgagaacattctgtcatacctg
gatgccaaatcactatgtgctgctgaacttgtgtgcaaggaatggtaccgagtgacctct
gatggcatgctgtggaagaagcttatcgagagaatggtcaggacagattctctgtggaga
ggcctggcagaacgaagaggatggggacagtatttattcaaaaacaaacctcctgacggg
aatgctcctcccaactctttttatagagcactttatcctaaaattatacaagacattgag
acaatagaatctaattggagatgtggaagacatagtttacagagaattcactgccgaagt
gaaacaagcaaaggagtttactgtttacagtatgatgatcagaaaatagtaagcggcctt
cgagacaacacaatcaagatctgggataaaaacacattggaatgcaagcgaattctcaca
ggccatacaggttcagtcctctgtctccagtatgatgagagagtgatcataacaggatca
tcggattccacggtcagagtgtgggatgtaaatacaggtgaaatgctaaacacgttgatt
caccattgtgaagcagttctgcacttgcgtttcaataatggcatgatggtgacctgctcc
aaagatcgttccattgctgtatgggatatggcctccccaactgacattaccctccggagg
gtgctggtcggacaccgagctgctgtcaatgttgtagactttgatgacaagtacattgtt
tctgcatctggggatagaactataaaggtatggaacacaagtacttgtgaatttgtaagg
accttaaatggacacaaacgaggcattgcctgtttgcagtacagggacaggctggtagtg
agtggctcatctgacaacactatcagattatgggacatagaatgtggtgcatgtttacga
gtgttagaaggccatgaggaattggtgcgttgtattcgatttgataacaagaggatagtc
agtggggcctatgatggaaaaattaaagtgtgggatcttgtggctgctttggacccccgt
gctcctgcagggacactctgtctacggacccttgtggagcattccggaagagtttttcga
ctacagtttgatgaattccagattgtcagtagttcacatgatgacacaatcctcatctgg
gacttcctaaatgatccagctgcccaagctgaacccccccgttccccttctcgaacatac
acctacatctccagataa

  All links  
Disease (1)   
   OMIM (1)   
Gene (24)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (29)   
   UniProt (4)   
   SWISS-PROT (1)   
   RefSeq(pep) (24)   
DNA sequence (72)   
   RefSeq(nuc) (24)   
   GenBank (24)   
   EMBL (24)   
3D Structure (8)   
   PDB (8)   
Protein domain (57)   
   Pfam (57)   
All databases (191)   

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