KEGG   Leopardus geoffroyi (Geoffroy's cat): 123580491
Entry
123580491         CDS       T10761                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
lgf  Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf00562  Inositol phosphate metabolism
lgf01100  Metabolic pathways
lgf04015  Rap1 signaling pathway
lgf04020  Calcium signaling pathway
lgf04022  cGMP-PKG signaling pathway
lgf04062  Chemokine signaling pathway
lgf04070  Phosphatidylinositol signaling system
lgf04071  Sphingolipid signaling pathway
lgf04072  Phospholipase D signaling pathway
lgf04081  Hormone signaling
lgf04082  Neuroactive ligand signaling
lgf04261  Adrenergic signaling in cardiomyocytes
lgf04270  Vascular smooth muscle contraction
lgf04310  Wnt signaling pathway
lgf04371  Apelin signaling pathway
lgf04540  Gap junction
lgf04611  Platelet activation
lgf04613  Neutrophil extracellular trap formation
lgf04621  NOD-like receptor signaling pathway
lgf04713  Circadian entrainment
lgf04720  Long-term potentiation
lgf04723  Retrograde endocannabinoid signaling
lgf04724  Glutamatergic synapse
lgf04725  Cholinergic synapse
lgf04726  Serotonergic synapse
lgf04728  Dopaminergic synapse
lgf04730  Long-term depression
lgf04742  Taste transduction
lgf04750  Inflammatory mediator regulation of TRP channels
lgf04911  Insulin secretion
lgf04912  GnRH signaling pathway
lgf04915  Estrogen signaling pathway
lgf04916  Melanogenesis
lgf04918  Thyroid hormone synthesis
lgf04919  Thyroid hormone signaling pathway
lgf04921  Oxytocin signaling pathway
lgf04922  Glucagon signaling pathway
lgf04924  Renin secretion
lgf04925  Aldosterone synthesis and secretion
lgf04926  Relaxin signaling pathway
lgf04927  Cortisol synthesis and secretion
lgf04928  Parathyroid hormone synthesis, secretion and action
lgf04929  GnRH secretion
lgf04933  AGE-RAGE signaling pathway in diabetic complications
lgf04934  Cushing syndrome
lgf04935  Growth hormone synthesis, secretion and action
lgf04961  Endocrine and other factor-regulated calcium reabsorption
lgf04970  Salivary secretion
lgf04971  Gastric acid secretion
lgf04972  Pancreatic secretion
lgf04973  Carbohydrate digestion and absorption
lgf05010  Alzheimer disease
lgf05016  Huntington disease
lgf05017  Spinocerebellar ataxia
lgf05022  Pathways of neurodegeneration - multiple diseases
lgf05142  Chagas disease
lgf05143  African trypanosomiasis
lgf05146  Amoebiasis
lgf05163  Human cytomegalovirus infection
lgf05200  Pathways in cancer
lgf05415  Diabetic cardiomyopathy
lgf05417  Lipid and atherosclerosis
Module
lgf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:lgf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123580491 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    123580491 (PLCB1)
   04310 Wnt signaling pathway
    123580491 (PLCB1)
   04371 Apelin signaling pathway
    123580491 (PLCB1)
   04020 Calcium signaling pathway
    123580491 (PLCB1)
   04070 Phosphatidylinositol signaling system
    123580491 (PLCB1)
   04072 Phospholipase D signaling pathway
    123580491 (PLCB1)
   04071 Sphingolipid signaling pathway
    123580491 (PLCB1)
   04022 cGMP-PKG signaling pathway
    123580491 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    123580491 (PLCB1)
   04081 Hormone signaling
    123580491 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    123580491 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123580491 (PLCB1)
   04613 Neutrophil extracellular trap formation
    123580491 (PLCB1)
   04621 NOD-like receptor signaling pathway
    123580491 (PLCB1)
   04062 Chemokine signaling pathway
    123580491 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    123580491 (PLCB1)
   04922 Glucagon signaling pathway
    123580491 (PLCB1)
   04929 GnRH secretion
    123580491 (PLCB1)
   04912 GnRH signaling pathway
    123580491 (PLCB1)
   04915 Estrogen signaling pathway
    123580491 (PLCB1)
   04921 Oxytocin signaling pathway
    123580491 (PLCB1)
   04926 Relaxin signaling pathway
    123580491 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    123580491 (PLCB1)
   04918 Thyroid hormone synthesis
    123580491 (PLCB1)
   04919 Thyroid hormone signaling pathway
    123580491 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    123580491 (PLCB1)
   04916 Melanogenesis
    123580491 (PLCB1)
   04924 Renin secretion
    123580491 (PLCB1)
   04925 Aldosterone synthesis and secretion
    123580491 (PLCB1)
   04927 Cortisol synthesis and secretion
    123580491 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123580491 (PLCB1)
   04270 Vascular smooth muscle contraction
    123580491 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    123580491 (PLCB1)
   04971 Gastric acid secretion
    123580491 (PLCB1)
   04972 Pancreatic secretion
    123580491 (PLCB1)
   04973 Carbohydrate digestion and absorption
    123580491 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    123580491 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    123580491 (PLCB1)
   04725 Cholinergic synapse
    123580491 (PLCB1)
   04728 Dopaminergic synapse
    123580491 (PLCB1)
   04726 Serotonergic synapse
    123580491 (PLCB1)
   04720 Long-term potentiation
    123580491 (PLCB1)
   04730 Long-term depression
    123580491 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    123580491 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    123580491 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    123580491 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    123580491 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123580491 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    123580491 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123580491 (PLCB1)
   05142 Chagas disease
    123580491 (PLCB1)
   05143 African trypanosomiasis
    123580491 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123580491 (PLCB1)
   05016 Huntington disease
    123580491 (PLCB1)
   05017 Spinocerebellar ataxia
    123580491 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    123580491 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123580491 (PLCB1)
   05415 Diabetic cardiomyopathy
    123580491 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123580491 (PLCB1)
   04934 Cushing syndrome
    123580491 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lgf04131]
    123580491 (PLCB1)
Enzymes [BR:lgf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123580491 (PLCB1)
Membrane trafficking [BR:lgf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123580491 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123580491 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 123580491
NCBI-ProteinID: XP_045301238
Position
A3:34147378..34846651
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNDSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFETSKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKPFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASDPGKLNHRPPSS
EELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagccggtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgtcactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaaacatgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcggacgcttggagcat
cgcatgataacggtggtgtacgggcctgacttagttaacatctcccatttgaatctcgtg
gctttccaagaggaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagagacgcatttctggaaaaagcctatacgaagctgaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgc
cctcgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccatacctt
acggttgatcagatgatggattttatcaacctgaagcagcgagatcctcggctaaatgaa
atactttacccacctttaaagcaagagcaagtccaagtactgattgagaagtatgagccc
aacgatagccttgccaaaaaaggacagatatcagtggatggctttatgcgctatctgagt
ggagaagaaaatggagtcgtttcgcctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaattcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaaaggacggactgcagaagaggaaccagtcatcacccatgggttc
accatgacaactgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcattt
aagacgtcaccttttccgattctgctttcatttgagaaccacgtagattccccaaagcag
caagccaagatggcagagtattgccgactgatctttggagatgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcgcataagtcatcagaaggaagtggcaaaaag
aagctctcagaacaagcctccaacacgtacagtgactcctccagcgtgtttgagccctca
tctccaggagccggggaagctgatactgagagtgacgatgatgacgatgatgacgactgt
aaaaaatcttcaatggatgagggtactgctggcagtgaggccatggccacagaagagatg
tctaacctggtgaactatattcagccagtcaagttcgagtcctttgaaacttcaaaaaaa
agaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggactcgagcaactgaca
aagtctccagtggaatttgtagaatataacaaaatgcagctcagcaggatatatccaaaa
ggaacccgtgtggattcatccaactacatgcctcagctcttctggaatgctggttgccaa
atggttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtat
gaatacaatgggaaaagtggctacagattaaagccagagttcatgaggagacccgacaag
cactttgatccattcactgaaggcatcgtagatgggatagtggccaacactttatctgtg
aagattatttcaggtcagtttctttctgataagaaagttgggacctatgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaagga
aatgctgtaaatcctgtctgggaagaagagcccattgtgttcaaaaaggtggttcttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttatcggtcaccgg
atcttgcctgtacaggcaattcggccaggctatcactacatctgtctgcggaatgagagg
aaccagcctctgatgctcccagctgtctttgtctacatagaggtgaaagactatgtccca
gatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatg
gagcagagagcaaagcaactggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacaccatcagaagctccaagtgaagccaggacaactccagca
gaaaacggagtgaatcacactacatccctggcacccaaaccaccctcccaggctccccac
agccaaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtggaagcacagactatcgaagagctaaagcaacagaaaccgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggtgaaaagacaccacaagaaa
accactgaccttatcaaagaacacactacaaaatataatgaaattcagaatgactacttg
agaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcagaaccc
agcagtcctgaccatggttcgtcaacaattgagcaagatcttgctgccctagatgctgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagaacagtattacagtgagaaataccagaagcgagaacatattaaactgcttattcag
aaattgacggatgttgccgaagaatgtcagaacaatcagctgaagaagctcaaagaaatc
tgtgagaaggagaagaaggaattaaagaagaaaatggataaaaaaaggcaggagaagatc
acagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccgg
tcatacatccaggaggtggtacagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatccgtcagcagatcctggatgaaaagccc
aagctgcagatggatctggagcaagagtaccaagacaagttcaaaagactgcccctggag
atcttggagttcgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacagt
tctgcccctccctccctggcctcagaccctggaaaactgaaccacaggcctccttccagt
gaggagctagaaggggacaacccaggaaaagagtttgatactcctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (6)   
   Pfam (6)   
All databases (14)   

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