KEGG   PATHWAY: loa03410
loa03410                    Pathway                                

Base excision repair - Loa loa (eye worm)
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Genetic Information Processing; Replication and repair
Pathway map
loa03410  Base excision repair

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Loa loa (eye worm) [GN:loa]
LOAG_16817  hypothetical protein [KO:K03660] [EC:3.2.2.-]
LOAG_18420  hypothetical protein [KO:K10773] [EC:]
LOAG_01467  uracil-DNA glycosylase [KO:K03648] [EC:]
LOAG_10727  hypothetical protein [KO:K10771] [EC:]
LOAG_01360  exodeoxyribonuclease III [KO:K10771] [EC:]
LOAG_10202  proliferating cell nuclear antigen [KO:K04802]
LOAG_07617  DNA-directed DNA polymerase III [KO:K02327] [EC:]
LOAG_16701  hypothetical protein [KO:K02328]
LOAG_16711  DNA polymerase [KO:K02324] [EC:]
LOAG_18179  DNA polymerase epsilon subunit 2 [KO:K02325] [EC:]
LOAG_09571  DNA polymerase epsilon p17 subunit [KO:K02326] [EC:]
LOAG_06875  DNA ligase [KO:K10747] [EC:]
LOAG_18491  DNA ligase [KO:K10776] [EC:]
LOAG_17111  WGR domain-containing protein [KO:K24070] [EC:]
LOAG_07925  hypothetical protein [KO:K10798] [EC:]
LOAG_07847  flap endonuclease-1 [KO:K04799] [EC:3.-.-.-]
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
Acta Biochim Pol 54:413-34 (2007)
Almeida KH, Sobol RW.
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
DNA Repair (Amst) 6:695-711 (2007)
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
J Bacteriol 193:4495-508 (2011)
Ikeda S, Seki S.
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway

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