KEGG   Mirounga angustirostris (Northern elephant seal): 123860097
Entry
123860097         CDS       T11530                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mano  Mirounga angustirostris (Northern elephant seal)
Pathway
mano00562  Inositol phosphate metabolism
mano01100  Metabolic pathways
mano01521  EGFR tyrosine kinase inhibitor resistance
mano01522  Endocrine resistance
mano01524  Platinum drug resistance
mano04012  ErbB signaling pathway
mano04014  Ras signaling pathway
mano04015  Rap1 signaling pathway
mano04024  cAMP signaling pathway
mano04062  Chemokine signaling pathway
mano04066  HIF-1 signaling pathway
mano04068  FoxO signaling pathway
mano04070  Phosphatidylinositol signaling system
mano04071  Sphingolipid signaling pathway
mano04072  Phospholipase D signaling pathway
mano04081  Hormone signaling
mano04140  Autophagy - animal
mano04145  Phagocytosis
mano04150  mTOR signaling pathway
mano04151  PI3K-Akt signaling pathway
mano04152  AMPK signaling pathway
mano04210  Apoptosis
mano04211  Longevity regulating pathway
mano04213  Longevity regulating pathway - multiple species
mano04218  Cellular senescence
mano04360  Axon guidance
mano04370  VEGF signaling pathway
mano04380  Osteoclast differentiation
mano04510  Focal adhesion
mano04517  IgSF CAM signaling
mano04518  Integrin signaling
mano04550  Signaling pathways regulating pluripotency of stem cells
mano04611  Platelet activation
mano04613  Neutrophil extracellular trap formation
mano04620  Toll-like receptor signaling pathway
mano04625  C-type lectin receptor signaling pathway
mano04630  JAK-STAT signaling pathway
mano04650  Natural killer cell mediated cytotoxicity
mano04660  T cell receptor signaling pathway
mano04662  B cell receptor signaling pathway
mano04664  Fc epsilon RI signaling pathway
mano04666  Fc gamma R-mediated phagosome formation
mano04668  TNF signaling pathway
mano04670  Leukocyte transendothelial migration
mano04722  Neurotrophin signaling pathway
mano04725  Cholinergic synapse
mano04750  Inflammatory mediator regulation of TRP channels
mano04810  Regulation of actin cytoskeleton
mano04910  Insulin signaling pathway
mano04914  Progesterone-mediated oocyte maturation
mano04915  Estrogen signaling pathway
mano04917  Prolactin signaling pathway
mano04919  Thyroid hormone signaling pathway
mano04923  Regulation of lipolysis in adipocytes
mano04926  Relaxin signaling pathway
mano04929  GnRH secretion
mano04930  Type II diabetes mellitus
mano04931  Insulin resistance
mano04932  Non-alcoholic fatty liver disease
mano04933  AGE-RAGE signaling pathway in diabetic complications
mano04935  Growth hormone synthesis, secretion and action
mano04960  Aldosterone-regulated sodium reabsorption
mano04973  Carbohydrate digestion and absorption
mano05010  Alzheimer disease
mano05017  Spinocerebellar ataxia
mano05020  Prion disease
mano05100  Bacterial invasion of epithelial cells
mano05132  Salmonella infection
mano05135  Yersinia infection
mano05142  Chagas disease
mano05146  Amoebiasis
mano05160  Hepatitis C
mano05161  Hepatitis B
mano05162  Measles
mano05163  Human cytomegalovirus infection
mano05164  Influenza A
mano05165  Human papillomavirus infection
mano05166  Human T-cell leukemia virus 1 infection
mano05167  Kaposi sarcoma-associated herpesvirus infection
mano05168  Herpes simplex virus 1 infection
mano05169  Epstein-Barr virus infection
mano05170  Human immunodeficiency virus 1 infection
mano05171  Coronavirus disease
mano05200  Pathways in cancer
mano05203  Viral carcinogenesis
mano05205  Proteoglycans in cancer
mano05206  MicroRNAs in cancer
mano05207  Chemical carcinogenesis - receptor activation
mano05208  Chemical carcinogenesis - reactive oxygen species
mano05210  Colorectal cancer
mano05211  Renal cell carcinoma
mano05212  Pancreatic cancer
mano05213  Endometrial cancer
mano05214  Glioma
mano05215  Prostate cancer
mano05218  Melanoma
mano05220  Chronic myeloid leukemia
mano05221  Acute myeloid leukemia
mano05222  Small cell lung cancer
mano05223  Non-small cell lung cancer
mano05224  Breast cancer
mano05225  Hepatocellular carcinoma
mano05226  Gastric cancer
mano05230  Central carbon metabolism in cancer
mano05231  Choline metabolism in cancer
mano05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mano05415  Diabetic cardiomyopathy
mano05417  Lipid and atherosclerosis
mano05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mano00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123860097 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    123860097 (PIK3CD)
   04014 Ras signaling pathway
    123860097 (PIK3CD)
   04015 Rap1 signaling pathway
    123860097 (PIK3CD)
   04370 VEGF signaling pathway
    123860097 (PIK3CD)
   04630 JAK-STAT signaling pathway
    123860097 (PIK3CD)
   04668 TNF signaling pathway
    123860097 (PIK3CD)
   04066 HIF-1 signaling pathway
    123860097 (PIK3CD)
   04068 FoxO signaling pathway
    123860097 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    123860097 (PIK3CD)
   04072 Phospholipase D signaling pathway
    123860097 (PIK3CD)
   04071 Sphingolipid signaling pathway
    123860097 (PIK3CD)
   04024 cAMP signaling pathway
    123860097 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    123860097 (PIK3CD)
   04152 AMPK signaling pathway
    123860097 (PIK3CD)
   04150 mTOR signaling pathway
    123860097 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    123860097 (PIK3CD)
   04517 IgSF CAM signaling
    123860097 (PIK3CD)
   04518 Integrin signaling
    123860097 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    123860097 (PIK3CD)
   04140 Autophagy - animal
    123860097 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    123860097 (PIK3CD)
   04218 Cellular senescence
    123860097 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123860097 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    123860097 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123860097 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123860097 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    123860097 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    123860097 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    123860097 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    123860097 (PIK3CD)
   04660 T cell receptor signaling pathway
    123860097 (PIK3CD)
   04662 B cell receptor signaling pathway
    123860097 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    123860097 (PIK3CD)
   04666 Fc gamma R-mediated phagosome formation
    123860097 (PIK3CD)
   04670 Leukocyte transendothelial migration
    123860097 (PIK3CD)
   04062 Chemokine signaling pathway
    123860097 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123860097 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    123860097 (PIK3CD)
   04929 GnRH secretion
    123860097 (PIK3CD)
   04915 Estrogen signaling pathway
    123860097 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    123860097 (PIK3CD)
   04917 Prolactin signaling pathway
    123860097 (PIK3CD)
   04926 Relaxin signaling pathway
    123860097 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    123860097 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    123860097 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    123860097 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    123860097 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    123860097 (PIK3CD)
   04722 Neurotrophin signaling pathway
    123860097 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123860097 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    123860097 (PIK3CD)
   04380 Osteoclast differentiation
    123860097 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    123860097 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    123860097 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123860097 (PIK3CD)
   05206 MicroRNAs in cancer
    123860097 (PIK3CD)
   05205 Proteoglycans in cancer
    123860097 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    123860097 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    123860097 (PIK3CD)
   05203 Viral carcinogenesis
    123860097 (PIK3CD)
   05230 Central carbon metabolism in cancer
    123860097 (PIK3CD)
   05231 Choline metabolism in cancer
    123860097 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123860097 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123860097 (PIK3CD)
   05212 Pancreatic cancer
    123860097 (PIK3CD)
   05225 Hepatocellular carcinoma
    123860097 (PIK3CD)
   05226 Gastric cancer
    123860097 (PIK3CD)
   05214 Glioma
    123860097 (PIK3CD)
   05221 Acute myeloid leukemia
    123860097 (PIK3CD)
   05220 Chronic myeloid leukemia
    123860097 (PIK3CD)
   05218 Melanoma
    123860097 (PIK3CD)
   05211 Renal cell carcinoma
    123860097 (PIK3CD)
   05215 Prostate cancer
    123860097 (PIK3CD)
   05213 Endometrial cancer
    123860097 (PIK3CD)
   05224 Breast cancer
    123860097 (PIK3CD)
   05222 Small cell lung cancer
    123860097 (PIK3CD)
   05223 Non-small cell lung cancer
    123860097 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123860097 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    123860097 (PIK3CD)
   05161 Hepatitis B
    123860097 (PIK3CD)
   05160 Hepatitis C
    123860097 (PIK3CD)
   05171 Coronavirus disease
    123860097 (PIK3CD)
   05164 Influenza A
    123860097 (PIK3CD)
   05162 Measles
    123860097 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    123860097 (PIK3CD)
   05163 Human cytomegalovirus infection
    123860097 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123860097 (PIK3CD)
   05169 Epstein-Barr virus infection
    123860097 (PIK3CD)
   05165 Human papillomavirus infection
    123860097 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123860097 (PIK3CD)
   05135 Yersinia infection
    123860097 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    123860097 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123860097 (PIK3CD)
   05142 Chagas disease
    123860097 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123860097 (PIK3CD)
   05017 Spinocerebellar ataxia
    123860097 (PIK3CD)
   05020 Prion disease
    123860097 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123860097 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    123860097 (PIK3CD)
   05415 Diabetic cardiomyopathy
    123860097 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    123860097 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    123860097 (PIK3CD)
   04931 Insulin resistance
    123860097 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123860097 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123860097 (PIK3CD)
   01524 Platinum drug resistance
    123860097 (PIK3CD)
   01522 Endocrine resistance
    123860097 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mano04131]
    123860097 (PIK3CD)
Enzymes [BR:mano01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     123860097 (PIK3CD)
Membrane trafficking [BR:mano04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    123860097 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 123860097
NCBI-ProteinID: XP_045754704
Position
Unknown
AA seq 1080 aa
MPPGVDCPMEFWTKEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLVNSQISLL
IGKGLHEFDSLHDPEVNAFRTKMRQFCEEAAARRQQLGWEAWLQYSFPLQLEPSARSWGA
GTVRVPTRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGKHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSDPAPQVQKPR
TKPPPIPMKKPSSLSLWSLEQPFRVELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECCLYMWPSVPDEKGELLNPTGTVRSNPNTESAAALVICLPEVAP
YPVYYPTLDKILELGRHGEHGRFSEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
RFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALSDFVKVSSQKTTKPQTKELMHLCIR
QETYLEALSNLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWVMYSNEEAGSDGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDTQYLKCGRSWGVGRVVGHEPLCGAWF
MHNDAAPSSAPPVQKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3243 nt   +upstreamnt  +downstreamnt
atgccccctggggttgactgccccatggaattctggaccaaggaggagaatcagagtgtg
gccgttgacttcctgttgcccaccggggtctatctgaacttccctgtgtcccggaatgcc
aacctcagcaccatcaagaaggtgttgtggcaccgagcccagtatgagccactcttccac
atgctcagcgaccccgaggcctacgtgttcacctgcgtcaaccagaccgcagagcagcag
gaactggaggacgagcagcggcggctctgcgacatccagcccttcctgccagtgctgcgt
ctggtggcccgagagggggacagggtgaagaagctggtcaactcgcagatcagcctcctc
atcggcaaaggcctccatgagttcgactccttgcatgaccccgaagtgaacgcctttcgc
accaagatgcgccagttctgcgaggaggcggccgcccgccggcagcagctgggctgggag
gcctggcttcagtacagcttccctctgcagctggagccctcggcccggagctggggggcc
ggcaccgtgcgggtccccacccgggccctcctggtcaacgtcaagtttgagggcagcgag
gagagcttcaccttccaggtgtccaccaaggacgtgcccctggcgctgatggcctgtgcg
ctccggaagaaggccaccgtgttccggcagcccctggtggagcagcccgaggactacacg
ctgcaggtgaacggaaagcacgagtacctgtatggcagctaccccctgtgccagttccag
tacatctgcagctgcctgcacagcgggctgaccccccacctgaccatggtgcactcctcg
tccatcctggccatgcgggacgagcagagcgaccctgccccccaagtccagaaaccacgc
accaaaccaccccccattcccatgaagaagccttcttccctgtccctgtggtccctggag
cagcctttccgcgtggagctgattcagggcagcaaagtgaatgccgatgagcggatgaag
ctggtggtgcaagctgggctcttccatggcaacgagacgctgtgcaagacggtgtccagc
tcggaggtgagcgtgtgctcggagcccgtgtggaaacagcggctggagttcgacatcaac
atctgcgacctgcctcgcatggcccgtctctgctttgcactttacgccgtgatcgagaag
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gccaacctcatgctgttcgactacaaggaccagctcaagaccggggaatgctgcctgtat
atgtggccgtccgtcccagacgagaaaggggagctgctgaaccccacgggaacagtgcgg
agtaaccccaacacggagagcgctgcggccctcgtcatctgcctccctgaggtggccccc
taccctgtgtactaccccaccctggacaagattctggagctggggcggcacggggagcac
gggcgcttcagtgaggaggagcagctacagctgcgggaaatcctggagcggcggggctcc
ggggagctgtacgagcacgagaaggacctggtgtggaagatgcggcacgaggtccaggag
cgcttccccgaggcgctggcccgcctgctgctggtcaccaagtggaacaagcacgaggat
gtggcccagatgctctacctgctgtgctcctggcccgagctgcctgtcctgagcgccctg
gagctgctggacttcagcttccccgaccgccacgtgggctccttcgccatcaagtctctg
cggaagctgacggacgatgagcttttccagtacctgctgcagctggtgcaggtgctcaag
tacgaatcctacctcgactgcgagctgaccaagttcctgctggaccgggccctggccaac
cgcaagatcggccacttcctcttctggcacctccgctccgagatgcacgtgccctccgtg
gctctgcgctttggcctcatcatggaagcctactgccggggcagcacccaccacatgaag
gtgctgatgaagcagggggaggcgttgagcaagctgaaggccctgagtgacttcgtcaaa
gtgagctcccagaagaccaccaagccccagaccaaggagctgatgcacctgtgcatacgc
caggagacctacctggaggccctctccaacctgcagtccccgctggaccccagcacgctg
ctggctgaagtctgcgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg
gtgatgtacagcaacgaggaggcgggcagtgacggcagtgtgggcatcatctttaagaac
ggggacgacctccgccaggacatgctgactctgcagatgatccagctcatggatgttctg
tggaagcaggagggactagacctgaggatgaccccctatggctgcctctccacgggggac
cgcacaggcctcattgaggtggtgcttcactcagacaccatcgccaacatccagctcaac
aagagcaacatggcggccacagcagccttcaacaaggatgccctgctcaactggctcaag
tccaagaaccctggggaggccttggatcgagccatcgaggagtttaccctctcttgcgcc
ggctactgcgtggccacttacgtgctgggcatcggtgatcggcacagcgacaacatcatg
atccgcgagaatgggcagctgttccacattgattttggccactttctggggaatttcaag
accaagtttggaatcaaccgtgagcgagtcccgttcatcctcacgtatgactttgtgcac
gtgatccagcaggggaaaacgaataacagtgagaagtttgaaagattccggggttactgt
gagcgagcctacaccatcctgcggcgtcacgggctgctcttccttcacctcttcgccctg
atgcgggccgctggcctgccggagctcagctgttccaaagacacccagtatctcaagtgt
gggagaagctggggggtcgggagggtggtcggccacgagcccctctgtggtgcctggttc
atgcacaacgacgctgccccctcctccgctccccctgtgcagaaggactctctggcgttg
gggaagactgaggaggaggctctaaagcacttccgagtgaagtttaacgaagccctccgg
gagagctggaagaccaaagtgaactggctggcccacaatgtgtccaaagataacaggcaa
tag

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (5)   
   Pfam (5)   
All databases (15)   

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