KEGG   Macaca fascicularis (crab-eating macaque): 102140615
Entry
102140615         CDS       T02918                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf00562  Inositol phosphate metabolism
mcf01100  Metabolic pathways
mcf04015  Rap1 signaling pathway
mcf04020  Calcium signaling pathway
mcf04022  cGMP-PKG signaling pathway
mcf04062  Chemokine signaling pathway
mcf04070  Phosphatidylinositol signaling system
mcf04071  Sphingolipid signaling pathway
mcf04072  Phospholipase D signaling pathway
mcf04081  Hormone signaling
mcf04082  Neuroactive ligand signaling
mcf04261  Adrenergic signaling in cardiomyocytes
mcf04270  Vascular smooth muscle contraction
mcf04310  Wnt signaling pathway
mcf04371  Apelin signaling pathway
mcf04540  Gap junction
mcf04611  Platelet activation
mcf04613  Neutrophil extracellular trap formation
mcf04621  NOD-like receptor signaling pathway
mcf04713  Circadian entrainment
mcf04720  Long-term potentiation
mcf04723  Retrograde endocannabinoid signaling
mcf04724  Glutamatergic synapse
mcf04725  Cholinergic synapse
mcf04726  Serotonergic synapse
mcf04728  Dopaminergic synapse
mcf04730  Long-term depression
mcf04742  Taste transduction
mcf04750  Inflammatory mediator regulation of TRP channels
mcf04911  Insulin secretion
mcf04912  GnRH signaling pathway
mcf04915  Estrogen signaling pathway
mcf04916  Melanogenesis
mcf04918  Thyroid hormone synthesis
mcf04919  Thyroid hormone signaling pathway
mcf04921  Oxytocin signaling pathway
mcf04922  Glucagon signaling pathway
mcf04924  Renin secretion
mcf04925  Aldosterone synthesis and secretion
mcf04926  Relaxin signaling pathway
mcf04927  Cortisol synthesis and secretion
mcf04928  Parathyroid hormone synthesis, secretion and action
mcf04929  GnRH secretion
mcf04933  AGE-RAGE signaling pathway in diabetic complications
mcf04934  Cushing syndrome
mcf04935  Growth hormone synthesis, secretion and action
mcf04961  Endocrine and other factor-regulated calcium reabsorption
mcf04970  Salivary secretion
mcf04971  Gastric acid secretion
mcf04972  Pancreatic secretion
mcf04973  Carbohydrate digestion and absorption
mcf05010  Alzheimer disease
mcf05016  Huntington disease
mcf05017  Spinocerebellar ataxia
mcf05022  Pathways of neurodegeneration - multiple diseases
mcf05142  Chagas disease
mcf05143  African trypanosomiasis
mcf05146  Amoebiasis
mcf05163  Human cytomegalovirus infection
mcf05200  Pathways in cancer
mcf05415  Diabetic cardiomyopathy
mcf05417  Lipid and atherosclerosis
Module
mcf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102140615 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102140615 (PLCB1)
   04310 Wnt signaling pathway
    102140615 (PLCB1)
   04371 Apelin signaling pathway
    102140615 (PLCB1)
   04020 Calcium signaling pathway
    102140615 (PLCB1)
   04070 Phosphatidylinositol signaling system
    102140615 (PLCB1)
   04072 Phospholipase D signaling pathway
    102140615 (PLCB1)
   04071 Sphingolipid signaling pathway
    102140615 (PLCB1)
   04022 cGMP-PKG signaling pathway
    102140615 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102140615 (PLCB1)
   04081 Hormone signaling
    102140615 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102140615 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102140615 (PLCB1)
   04613 Neutrophil extracellular trap formation
    102140615 (PLCB1)
   04621 NOD-like receptor signaling pathway
    102140615 (PLCB1)
   04062 Chemokine signaling pathway
    102140615 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    102140615 (PLCB1)
   04922 Glucagon signaling pathway
    102140615 (PLCB1)
   04929 GnRH secretion
    102140615 (PLCB1)
   04912 GnRH signaling pathway
    102140615 (PLCB1)
   04915 Estrogen signaling pathway
    102140615 (PLCB1)
   04921 Oxytocin signaling pathway
    102140615 (PLCB1)
   04926 Relaxin signaling pathway
    102140615 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    102140615 (PLCB1)
   04918 Thyroid hormone synthesis
    102140615 (PLCB1)
   04919 Thyroid hormone signaling pathway
    102140615 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    102140615 (PLCB1)
   04916 Melanogenesis
    102140615 (PLCB1)
   04924 Renin secretion
    102140615 (PLCB1)
   04925 Aldosterone synthesis and secretion
    102140615 (PLCB1)
   04927 Cortisol synthesis and secretion
    102140615 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102140615 (PLCB1)
   04270 Vascular smooth muscle contraction
    102140615 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    102140615 (PLCB1)
   04971 Gastric acid secretion
    102140615 (PLCB1)
   04972 Pancreatic secretion
    102140615 (PLCB1)
   04973 Carbohydrate digestion and absorption
    102140615 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102140615 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    102140615 (PLCB1)
   04725 Cholinergic synapse
    102140615 (PLCB1)
   04728 Dopaminergic synapse
    102140615 (PLCB1)
   04726 Serotonergic synapse
    102140615 (PLCB1)
   04720 Long-term potentiation
    102140615 (PLCB1)
   04730 Long-term depression
    102140615 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    102140615 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    102140615 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    102140615 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102140615 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102140615 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102140615 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102140615 (PLCB1)
   05142 Chagas disease
    102140615 (PLCB1)
   05143 African trypanosomiasis
    102140615 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102140615 (PLCB1)
   05016 Huntington disease
    102140615 (PLCB1)
   05017 Spinocerebellar ataxia
    102140615 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    102140615 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102140615 (PLCB1)
   05415 Diabetic cardiomyopathy
    102140615 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102140615 (PLCB1)
   04934 Cushing syndrome
    102140615 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcf04131]
    102140615 (PLCB1)
Enzymes [BR:mcf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102140615 (PLCB1)
Membrane trafficking [BR:mcf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102140615 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102140615 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 102140615
NCBI-ProteinID: XP_005568429
Ensembl: ENSMFAG00000043247
UniProt: A0A2K5VG07
Position
10:complement(join(78433695..78433922,78526876..78526962,78527573..78527630,78528413..78528502,78528610..78528686,78542377..78542557,78551482..78551701,78556285..78556338,78559581..78559713,78574226..78574335,78575354..78575458,78576458..78576557,78578317..78578481,78581520..78581674,78585808..78585932,78587900..78587984,78590480..78590576,78592842..78592909,78597503..78597680,78598712..78598796,78606516..78606598,78617744..78617901,78630118..78630264,78655881..78656047,78657292..78657392,78665122..78665197,78666605..78666658,78668376..78668455,78686048..78686185,78933841..78933909,79156279..79156356,79174165..79174263))
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGIKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSFAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMELMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTCSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSETPSEVRTTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSS
EELGGDIPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcatcaaattcgtcaagtgggatgatgactcaactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctactggatctcagccttgtcaaagatgccagatgtgggagacacgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcag
cgcatgatcacggtggtgtatgggcctgacctcgtgaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgc
cctcgacctgaaattgataacatcttttcagaatttggtgccaaaagcaaaccatatctt
accgttgaccagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaa
atactttatccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
aacagcagcttcgccaaaaaaggacaaatatcagtggatgggttcatgcgctatctgagt
ggagaagaaaacggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactg
gctggaaactcctctgttgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
gagctggactgctggaagggacgaactgcagaagaggaacctgtcatcacccatggcttc
accatgacaactgaaatatctttcaaggaagtgatagaagcaattgcggagtgtgcattt
aagacttcaccttttccaattctcctttcatttgagaaccatgtggattccccaaagcag
caagccaagatggcggagtactgccgactgatctttggggatgcccttctcatggagccc
ctggaaaaatatccactggaatctggagttcctcttccaagccctatggagttaatgtat
aaaattttggtgaaaaataagaagaaatcacacaagtcatcagaaggaagcggcaaaaag
aagctctcagaacaagcctccaacacctgcagcgactcctccagcatgttcgagccctca
tccccaggagccggagaagctgatacggaaagtgacgacgatgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggaccgctggaagtgaggctatggccacagaggaaatg
tctaacctggtgaactacattcagccggtcaagtttgagtcatttgaaatttcaaaaaaa
agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcacc
aagtctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacacgtgtggattcatccaactatatgcctcagctcttctggaatgcgggttgtcag
atggtggcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtat
gaatacaacggaaagagtggctatcgattgaagccagagttcatgaggaggcctgacaag
cattttgatccatttactgaaggcatcgtagatgggatagtggcaaacactttgtctgtt
aagattatatcaggtcagtttctttctgataagaaagttgggacttacgtggaagtggat
atgtttggtttgcctgtggatacaaggaggaaggcatttaagaccaagacatcccaagga
aatgctgtgaatcctgtctgggaagaagaacctattgtgttcaaaaaggtggttcttcct
actctggcctgtttgagaatagcagtttatgaagaaggaggtaaattcattggccaccgt
atcttgccagtgcaagccattcggccaggctatcactatatatgtctaaggaatgaaagg
aaccagcctctgatgctgcctgctgtctttgtctacatagaagtgaaagactatgtgcca
gacacatatgcagatgtcattgaagctttatcaaacccaatccggtatgtgaacctgatg
gagcagagagctaagcaattggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggagaaacaccatcagagactccaagtgaagtgagaacaactccagca
gaaaacggggtgaatcacactacatccctgacacccaagccaccctcccaggctctccac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gtcttaacagaagtggaagcacagaccatcgaagagctaaagcaacagaaatcgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaagagacaccacaagaaa
accactgaccttatcaaagaacacactacgaagtataatgaaattcagaatgactacttg
agaaggagagcagctttggaaaagtccgccaaaaaggacagtaagaaaaaatcggaaccc
agcagccctgatcatggttcatcaacgattgagcaagacctcgctgccctggatgctgaa
atgacccaaaaattgatagacttgaaggacaaacaacagcagcagctgcttaatcttcgg
caagaacagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
aagttgacggatgtcgcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatc
tgtgagaaagaaaagaaagaattaaagaagaaaatggataaaaaaaggcaggagaagata
acagaagctaaatctaaagacaaaagtcagatggaagaggagaagacagagatgatccgg
tcatatatccaggaagtggtgcagtacatcaagaggctagaagaggcgcaaagtaaacgg
caagaaaaactcgtagagaaacacaaggaaatacgtcagcagatcctggatgaaaagccc
aagctgcaggtggagctggagcaagaataccaagacaaattcaaaagactgcccctcgag
attttggaattcgtgcaggaagccatgaaaggaaagatcagtgaagacagcaatcacggt
tctgcccctctctccctgtcctcagaccctggaaaagtgaaccacaagactccctccagt
gaggagctgggaggagacatcccaggaaaagaatttgatactcctctgtga

  All links  
Gene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (6)   
   Pfam (6)   
All databases (21)   

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